f zu{ } 18 í } 12 214 3 19 Çf Chinese Journal of Tissue Engineering Research March 19, 214 Vol.18, No.12 ù Œñ q d Å ø y fq n h d( { œ à Þ 2661) s 1 qg pë ³²g ± ù Œñ q ø y fqÿj gì ø üz öø ìm Å ~på d ùgg ø y nq o Ø~ q kgvýø y Ço q 2 ù Œñ q qø y f n ƒo qo à o qéã à o ý poqöm i p² À ² ¾ƒ² qáè Åv Ž ºÀ mg ø mg Œñ q fú ü mgâ ü çn ü y gè ù g Œñ mgâ, j y ü Œñ q nùgqœñ qí npºº ùâ pí ˆn Ž}~ j ˆnpg rq ±Œñ q d ø y Éø üq 1 y à }Égù Œñ q d Å É̈n 2- ¾ù Œñ q ü 4- ¾d Å ø²ÿâ ü ý 3 5 7 d öø ü À ý} 7 ý 14 d ù Œñ q Éøn üi pd Å (P <.5) ù Œñ q ø Éøfq 2- ¾ù Œñ q ü o 7 d Ÿ d Å ø Éøf 4- ¾d Å dˆn 2- ù Œñ q q ø¼ gâs ƒ ˆn 4- d Å üq ø¼ù ƒ ±  s xœñ q d ²üø y Éøq ü Œ q ü d ÂŒ ø ü Âç Œ qø ìm 1987 { x à Ôd Ì { œ à Þ 2661 doi:1.3969/j.issn.295-4344. 214.12.12 [http://www.crter.org] f É ú:r394.2 h u:a ú:295-4344 (214)12-1877-6 ÈÍ 214-2-2 h d. ù Œñ q d Å ø y fq n[j].f zu{ 214 18(12):1877-1882. Absorbable collagen suture and non-absorbable silk suture in oral implantation Xu Hai-yang, Xu Hao, Zhang Li, Qu Xiao-xin, Zhao Bao-dong (Department of Oral Implantation, Affiliated Hospital of Qingdao University, Qingdao 2661, Shandong Province, China) Abstract BACKGROUND: Collagen suture is made of collagen from animals, and has been widely used because it is absorbable, non-rejection and easy to produce, and convenient in use. OBJECTIVE: To evaluate the effects of collagen suture and silk suture in wound healing after oral implant surgery. METHODS: 1 patients undergoing oral implantation were randomly assigned into collagen suture group and silk suture group. A 2- circular needle with absorbable collagen sutures and a 4- circular needle with non-absorbable silk sutures were employed for tension-free suture in the two groups. After 3, 5, 7 days of oral implantation, suture threads and wound healing were observed. The suture was removed at 14 days, and patients were reviewed at 14 days. RESULTS AND CONCLUSION: The wound healing was better in the collagen suture group than the silk suture group at grade I (P <.5). At 7 days postoperatively, the suture thread was mostly absorbed in the collagen group but not in the silk suture group. In addition, material alba was invisible in the collagen suture group but clear in the silk suture group. These results indicate that the collagen suture is more proper for tension-free suture than the silk suture, which is better matched to the healing time and keeps a better oral environment. Subject headings: absorbable implants; sutures; collagen; biodegradation, environmental; surgical staplers Xu HY, Xu H, Zhang L, Qu XX, Zhao BD. Absorbable collagen suture and non-absorbable silk suture in oral implantation. Zhongguo Zuzhi Gongcheng Yanjiu. 214;18(12):1877-1882. Xu Hai-yang, Studying for master s degree, Department of Oral Implantation, Affiliated Hospital of Qingdao University, Qingdao 2661, Shandong Province, China Corresponding author: Zhao Bao-dong, Master, Professor, Master s supervisor, Chief physician, Department of Oral Implantation, Affiliated Hospital of Qingdao University, Qingdao 2661, Shandong Province, China Accepted: 214-2-2 ISSN 295-4344 CN 21-1581/R CODEN: ZLKHAH 1877
Introduction rx yçm pø ¼µø ü og Ìq {ºñ g gø ±gã dçm gø Ø ý ± Chen} [1-3] 21 r pq ø Ø q Ë ü qpo p qq ø Äg kxöˆn g Œ ¹ üq mž~n ±g qpo ö gåµe öˆ ÁÈ p±g qåµ po ˆ yçmi ŵpo Ÿ Çà Şo rºu{ [4-17] ˆn wï} kpo [18] š ø Ø ˆn±g q kö ŽŒºÁË ø ü ² sø Ø ~ po ø y çmöj qfú ý~ ±g qpo r p嵈 ø y š Ãsç q ² q g Á yüüø y düy nq ö Ÿö n y fq g t y ƒ t Î mg Ÿˆ ø [9-21] d ²Ågsz y ƒqr [22] Buser} [23] 24 q hf Çoø¼ qrº mg ñê üq xö µ Çorº xø ¼µ çq ük Ågs q ê qd ü Ä qø¼ q Ä ºpø y qu{í² ø çm šk Ëqˆ yçm s ýo ù ü ø j q ö q ü Øq d y ˆq s ² oö ø Ø q q ö s ü ø Ø q q ² öq  z ø Ø öùxég Ø Ÿ Ø üq ç fú ø npé Ø Ÿ Ø s üq ü À Ãsø y qö qfê ˆnø y ²Ÿf Úq ²y üpÿ qø q q ²~ öíf Î ÅqÉà ø y µü ö±v q qéã dü öƒ g y ƒ xr ø y q ü ê ö Ÿqösq qq Éà öoq k Ø q kö ƒq Øe [24] ²ˆ r ˆnq Åq u{ h ø q x²npø Ø Å º ø y Å q nu{û Ÿ ³²j qq hxö² q ü u{² g ²Ÿø¼ u{q ²g Ͳ Çø¼ ü qg ö²n 4-d Å g nqø ¼µ ù º Ž z ±ƒ ù 1878 }~ ø ìm} j npø qù gt ü qšm (Šdr jr )ù ü ¹  6 d ú ùmgâ q ˆ n ü Œñ ˆ ~ê d ƒ x f n ƒ¼ ô q  g71 d 67 d ¹ É ¹ ö  } n ù ü r pˆ tƒq d q n ²ø ü p ü ºÂ ͱg  ³i Í d ±Î [25-27] öjù Œñ q g f ²Å n pg q xö ry f Œñ q d ²Ÿ [28-29] j ² npø q ³ Œñ n ³²u{üy ü qí x rg  [3-32] ü ²no yn hùq µ Í qê ù Œñ q gø y É ø [26 33] 4-d Å ²Ÿ ² Ÿg iðqg È Íf 3-ù Œ ñ q ü d Šü n öj3- ù Œñ q p5 d ô øqº ÁqŒ g2- ýö ù Œñ q ü q ¾3/8 24 mmà go ¾1/2 22 mmà ˆi ²üø¼ ü Í ³² q g u{ ² iýqœñ q ÿœ ø y qg Ä gœñ q ø y q n Í q n 1 Subjects and methods g ü Åà Âö Íp213 4Ž12 Å Â çãø y f Ä213 4Ž12 Å Â çãø y f ²Ÿy s  Ú2545 ýfçêè Äy ç À fúñ 13 mm ø ìm fu p fu q y вŸ ø à  e q öž ü ¹ Î ö± o f ² ²fýöÈ ý IJŸ ö μm fú ôã} } 1 ºfn64 36 Ú2545 35.6 o ~ˆu ü l Égù Œ ñ q d Å ü5 2- ¾ù Œñ q ü ( ü P.O. Box 12, Shenyang 1118
A B C D 1 ø y Éø Œñ q Figure 1 Collagen suture in oral implantation f A gfúy Ð 2- ¾ ù Œñ q B g 2- ¾ù Œñ q ü ¾ƒö ƒ C gy ý ˆnù Œñ q üµƒ D gy ý} 5 z µƒ Çj } ~ x Œñ q qµƒ )«Ž ê µçnîy q ¹ú ¾g1/2 22 mm ê µçnîy q ¹ú ¾g1/2 22 mmà 4- ¾d Å ( ü f )«Ž mf ço ¹ú ¾g1/2 16 mmà ø y Éø Œñ q d ü Ø fçf Èž²²f ýéø n Î Òy ÉyØ Î m ˆnk¾ ƒ ¾ ý ¾ Íü² ö y ƒ1è y ƒ ýˆnmkr À  ç Î m ƒ ˆn2- ¾ù Œñ q ü 4- ¾d Å ²Ÿ e ü ü nê  ü ü ü24¾ f ü3¾( 1) ˆn ¾ fƒ 3f e ÉÌ 3fƒ ²Ÿ à ý o3 d ÉÌp ý}3 5 7 ö ý7 d( ý14 d) Éø À Éø ü À  Éø v gn ü Éø v µé gj ü Éø¹µ g d ü üù qø¼â  7 dý y ç q À gã gü t rü z Ä g Éø üq À üù qø¼â  çq À É ü} ²Ÿ kýˆn SPSS 1.±zŸ É ˆnn 2 Í P <.5 g s i 2 Results 2.1 e ð Àóu ò õ ² É õ g «Ÿ1 2.2 Ê ~ { hî«2- ¾ù Œñ q ü }3 ø fú Ÿ 1 ø y qg À Table 1 The clinical situation of the patients undergoing oral implantation Ø ± }5 ø p ü }7 ø ü 4- ¾d Å ý}1 à ²ù u ö Œ ý}5 À ± ý}7 ø pz d µçjoø ž ooqáè ø ìm Å ˆn2- ¾ù Œñ q q ø¼ gâs ƒ ˆn4- ¾d Å üq ø¼ù ƒ ± Âs  ŠŒñ qù ²Ÿ Âq ˆnù Œñ q q f 15fƒ Çjo5 d ¹ q À 15fƒ gêhöm Çjü 3fƒ ü p7 d q À(Ÿ2) ISSN 295-4344 CN 21-1581/R CODEN: ZLKHAH 1879 (n=5) Èr ù Œñ q d Å Ì(n n/ ) Ú(x _ ±s ) (n /ºw ) Î(x _ ±s cm) fu À fú ƒˆ fúñ (x _ ±s mm) à Â(x _ ±s ) 27/23 35±4 47/3 165±3 36 14 ÈêÈýf 1.5±.5.5±.1 28/22 36±5 49/1 166±3.5 35 15 ÈêÈýf 1.5±.5.5±.1 Ÿ g v ± d ²Ÿ ÇjŒ x ²Ÿ ý É Ÿ 2 ù Œñ q d Å q Table 2 The number of patients with absorbed sutures ý(d) ù Œñ q d Å 3 5 7 15 135 Ÿ 5 f 3 fƒ (n)
A 2 d Å qã Figure 2 Follow-up visit of patients in the silk suture group f A gd qø À B fgd ý 7 d qø À ùx d Ãýqpo(~ ) Ÿ 3 Œñ q d qéø ü À Table 3 Wound healing of patients in the two groups [n(%)] ü Ì ù Œñ q d Å n 14(93) 129(86) j 1(7) 21(14) d () () Ÿ 5 f 3 fƒ n ü ü~ ö që ü j ü ü ü oö v ž z } äœ d ü ÉøäŒ ÄÉ 2.3 Ê ~ à ã ù Œñ q Éøn üi pd Å ( 2=6.93 P <.5) Ÿ3 2.4 Ê ~ r ð ý Çj ºq ö ÐýüÈm ƒ öm Çj ØŒ }q oz 2.5 Ê ~ h ý7 d ˆnŒñ qù q ò q5f ƒ Çjø ü ÇÃx º ƒ ç d Å 18ü ¾s q ÇÃv ¹ ( 2) 3 Discussion ² Ùgu{Ÿ üq ü ø Ø q ü s±g q Ì q } [34] öj ü qø ³ ü q ö ø ü po «l} [35] Êöjr p d t ù r oö ƒ Ìp üø q ü š oùg Íq ø Ø qg u{í r± pq º ŵ ˆ rµ ˆø ü d o²q [36] ºfü²q s pø üq [37] g² qu{ Ãs v Íê v ù Íù v ø ü Âç Í  ü  ˆ B ü ²Ÿo± qu{ ºf } [38] öj nqù Œñ q Šj Šjr dr } 15 d 3 d xö69 d ¹ Ø ˆŒñ qí qœñ q 58 džÿœ Œ ŵ ˆ ø üü È höj f qø ü ²zâ ž oö Œ øq } [39-48] ˆ oo Íf 1999 Çfq È yµƒ ê få v Í 1 g q ²1 5 ö m y µƒq Éà ~ s Î d q À 1f ù³ [49] dd g gžnptƒ ³ g n fùxrí ˆno ³d qø¼ Éø ˆnoù Œñ q qéø ü} Çjo iq d µ ~Çj¾sÇžq À ý7 d µé q¾s vù ±g qçã Œñ q g ƒ ± Âs Ìpø qìmkã o µq o ƒoø qéã d g ²  ƒ Âs dâ rgg q«~ qž ÄŠ Œ Ø q ö o d u{ÿ Œñ qº ¼mö žqøœv npg [5-52] ü ~p4- ¾ d Å ºpø ìm d Å g ê d qâãgì ¼ ÂsÉg ý ù Œñ q g gê [53-59] iââãqáè d g º ù ƒ â  q Ž Égö Âs x ø ìm Åù Œñ q ~~pd Š͈nq2- ¾ù Œñ q ü ˆ n hùq µ ² kí q Ä ²2 z Œ öùg fµÿjç qmg» v q  ùxrçù q  ü Ârç Œ ø üq ºÀ o ² rpˆnqœñ gê d k ˆno rš ˆ   À [26, 33] üqm k öø j ùœ Œñ q q ³ üz q g Ð ý u oè  Íf ç ˆnÅ Œ²É }ç xù ˆnù Œñ q q fù 15fƒ Çjo5 d ¹ q À d15fƒ g êhöm Çjü 3fƒ ü q À oø üq oøq ü v g n fùxrç pø¼ 188 P.O. Box 12, Shenyang 1118
øq ü Œñ qù q ü ýq öø q ü ~pd Å gvýqy Ío q i y q o q ² Œ ø çm q q npø o ü Ä q p qy ÉøgÌ ² ŸoÎ ºfˆno Î Î qy ØoØ q Ä Àq ü ²Ÿøq ü g ³ Ä Àq  pg q d üq À Ä 1 d úq  Œ ü d ù ~ Œñ q Ãs à ~Çjnp² Žø qéã ²y À Œˆn2-qù Œñ q ²Ÿ ü g² q Âö ~ ü «qéã gì p Î öî q çq ü g ç Å s Îq Éà goœ ƒø qéã ü k çq ü g Œñ q ö o q p ÿ ùx³²ø ú Œñ q q k ²Í À q rº qä ü ö Œñ q q ¹Â ²fÁÈq À Ž { œ à Þ é À í Âù o d «h Ð Â Ô ò À n d É ò ò d ÌrÀ{ À À í q d k e À à eã Ú «n p òî ñ q rd ½ { œ üì» d ß Ê ~ n Ê ~ u à p Ò«óu Þ Æg c c c c Å ð d u k À í ð À d 4 õ h References [1] Chen L, Arbieva ZH, Guo S, et al. Positional differences in the wound transcriptome of skin and oral mucosa. BMC Genomics. 21;11:471. [2] Ferguson MW, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 249;359(1445):839-85. [3] Hantash BM, Zhao L, Knowles JA, et al. Adult and fetal wound healing. Front Biosci. 28;13:51-61. [4] David-Raoudi M, Tranchepain F, Deschrevel B, et al. Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing. Wound Repair Regen. 28;16(2):274-287. [5] Prosdocimi M, Bevilacqua C. Exogenous hyaluronic acid and wound healing: an updated vision. Panminerva Med. 212; 54(2):129-135. [6] Samuels P, Tan AK. Fetal scarless wound healing. J Otolaryngol. 1999;28(5):296-32. [7] Schor SL, Grey AM, Ellis I, et al. Migration stimulating factor (MSF): its structure, mode of action and possible function in health and disease. Symp Soc Exp Biol. 1993;47:235-251. [8] Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol. 27;127(5): 998-18. [9] Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999;7(2):79-89. [1] Noble PW. Hyaluronan and its catabolic products in tissue injury and repair. Matrix Biol. 22;21(1):25-29. [11] Price RD, Myers S, Leigh IM, et al. The role of hyaluronic acid in wound healing: assessment of clinical evidence. Am J Clin Dermatol. 25;6(6):393-42. [12] Conway K, Price P, Harding KG, et al. The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing. Wound Repair Regen. 26;14(1):2-1. [13] Anderson I. The properties of hyaluronan and its role in wound healing. Prof Nurse. 21;17(4):232-235. [14] Krzysiek-Maczka G. Skin cells as steroid target; the steroid action in some skin diseases and wound healing. Przegl Lek. 25;62(3):181-187. [15] Rappl LM. Physiological changes in tissues denervated by spinal cord injury tissues and possible effects on wound healing. Int Wound J. 28;5(3):435-444. [16] Norman D. An exploration of two opposing theories of wound contraction. J Wound Care. 24;13(4):138-14. [17] Pellard S. An overview of the two widely accepted, but contradictory, theories on wound contraction. J Wound Care. 26;15(2):9-92. [18] g.q wï oåµpoö 42 [J]. nç, 211,28(2):132. [19] é,,u k,}. yœ Œsq «ø Ø ofq n[j]. ø ç,211,2(3): 273-277. [2] x,øx,â Ú,}.Œ «fî üîî «Œq Î n[j].f zu{,212,16(25):4561-4565. [21], d,i,}.ø fy f μm q [J].f zu{ g,21,14(16):2911-2915. [22],,Œy,}.v yø z y ƒ ± fq n[j].äs (ç f),27,39(1):21-25. [23] Buser D, Martin W, Belser UC. Optimizing esthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations. Int J Oral Maxillofac Implants. 24; 19 Suppl:43-61. [24] Í, é, s,}. ý y ƒ qg ö }[J]. f ø y,29,14(2):4-41. [25],.Å «ü ƒ¼ q Íu{[J].}p¾ç,1994,15(5):452-453. [26] k,, lm. ü ƒýq ok [J]. ÍÙgy,28,,(3):22-25. ISSN 295-4344 CN 21-1581/R CODEN: ZLKHAH 1881
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