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,,,,,95 98 160, 1999 204,, 70%,,,, 1996,,,,,,,,,,,,,,, (, ),,,, 3
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,,,,,, ( ) 1980, 1992, 30 110,,,, 24,, 2001 2.,, 1994, ( ),, 300 :,,, ;,, ;,, : (1 ) ; (2 ) ; (3 ) 19
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,,, 7.,,,,,,,,,,,,,, 7 50
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, : ; ; ; 1998 6, 5000 1998 12 25,, 1998 6, 5000,,,, 150,, 54
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,,,, 200,,,, 50, 20,, 52, 60, 3000, ;,, BBS,, 1997 9,,,, 2000 9,,,,,,,, 56
1000,,,,,,,,,,, 3,,,,, lingks2 go 1500,,,, 57
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1995, 2.,,,,,,, 96-750, 15 CAI, CAI,, 3.,,,,,,,,,,,,,,,,,,,,, 2000, 105
, : ;,,,, ;,, ; ;,, ;,,, 317, :,,,,,,,,, ;, ;,,,, 17, 2,,,,,, 106
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,,, 108
( ),,,,,,21, ;, : (1 ) ; ( 2 ) ; ( 3) ; ( 4 ) ; ( 5 ) ; ( 6), 1989,,, 109
,,,,, 1.,, 2. 1996,, 12,,,,,,,,,, 1998 110
(1 ), 21,, ; ; ; ; (2 ) :,, 40,,,, 2.5, 1.5,, 1.0 (3 ),, :, 11.5 ;, 12.5 ;, 7 (4 ) :,,, (5 ) :,, 1998, 111
,,,,,, 3., 1998 2001 3 4 : (1 ), ; (2 ) : 4,,,,,, 52, 35, 67.3 %, 3, 5.8%, 4, 7.7%, 10, 19.2% (3 ) :,,,,,,,,,, (4 ) :,, 1/ 3; 112
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( ) 1995,, 21,,,,, 1.,,,,,,, 114
,,,, 1996 C. Robin Ganellin, Kansas Lester A, Mitscher Michingan John G. Topliss Annual Reports in Medicinal Chemistry-30 67,,, (1 ) : 80 % ;50% ;,90%,,,,, (2 ), :70% 93%, ; ( biological chemistry, ) :,, ; QSAR, 115
;, ; Ganellin,,,,,,,,,,,,,,,,,,,,, 21, 116
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(5 ),,,, (6 ),,,,,,,, 3. 4,,,, 4 + 2( )4 + 3, 21,,,,,,,,, : (1 ) (2 ) ( ) (3 ) 118
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, 2 ; (3 ) 1998, 3 ; (4 ) 3, ; (5 ) 4, ; (6 ), ; (7 ),, ; (8) 5 ; (9 ) 22 140, ; (10 ), 2000, 120
( ) 1982 1986 1990 1993,,,,,,,, :, 21, 21, 1993,,,,, 1993 4, ;1995,,, ; 1998,,,,,,, 121
, 16 1993 1996,, 21,, 21, 1996 4, 6,,,, 1997 : ( 180 150 ),,, ;,, ;, 1998,, 1999,,,,, 150 136,, 21, 12 18, ( ) 11 28, 14,,,,,,, 122
,,,,, 1996, 80,, 1998, 246,,,,,,,, 27 1999, 37,,,,,, 2000,, 50 300 ;,,,2000, 212 ;,,, 1997 ( ) 3 ( 4 ), 7 ( 14 ), 4 ( 17 ) 1998 8, 5 123
, CAI, CAI, CAI 1994, CAI 5, 1997 CAI 15, 100,, 90% 1999, Web,,,, 1997 10,, 1992,, 1992 30, 1995 120,1997 150, 1998 350,, 1998,,, 746, 108, 14.5% ; 269, 35.9 %, 302, 40.3%, 76.2% 1999,,, 2000 A 124
,,, :,, 1999,,, ;, 40% 60%, ;,,,,,, ( Maior ),,, ( Minor ) ( Double Major), 1989,,, 1996,,,, 2000,, 9600 2500 125
2172, 453 2, 21%,,,,,,,,, ( ),,,,, ( ),, 1998 10, 1999 20, 2000 32,, 2000 2, 1,, 1998 8 SCI Brain Research Neuroscience 7, 4 2000 9, 15, ( Honor Degree),,,, 126
,,,, 1999 9,,,,,, 4,, 14 2000 9,,,,,,,,,,,,,, : : A B ( ) C D E 2000, 5 16, 2 ; 1999 8,1998 6 127
,,,, 1987, 10,,,, 1996,,,, ;,, 350,,,,, 4,,,,,,,,, 1999, 211 2707,,,, 4, 128
Internet 300,,, 1993, 8 ( ) 1995 1998,, 13,, 1991 1998 2172,,,,,,,, 1997, 1998,, 8 6 A, 5 1999, 129
( ) 1993,,,,,,,,,,,, 1998 10, 1999 15, 2000 23, 10.5% 12.2 % 15.1 % ; 1998 8, 1999 17, 2000 21, 8.4% 13.8 % 13.8%,,,, 130
, 4, 10 1998 2000, 30,,,,,, WTO,,,,,, :,,,,,, 1996,, 150 ;,, 22, 12, 8 % 131
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, 2001,,,,, :,,,,,,,, ;,,,,,, ;,,,,,,,,,, 134
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,,,,,, 1995,,,,,,,,,,,,,,,,,,,,,,,,,,, 144
, ( ),,,,,,,,, :,,,,,,,,,,,,,,,,,,,, 1996, 1999 62 145
2000,, 2000 1 9 4000 ( 8000 ), 2000 9, 30,,, 99,,,,,,,,,,,,,,, 1997 146
( ) ( ) 40,,,,,,,,,,,,,,,,,,,, 147
( ) 1959 ( ), 1964 ( ),,,,, 21,, :,,, 1964,,,, 80,,, 148
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,,,,,, : (1 ) (2 ), (3 ), (4 ),,,,,,,,, GPS GIS,, GPS GIS,,,,,,,, 1997 11,,,,, : 150
,, (2 ),, (3 ),,, 2000,,,,,,,,,,,, 1997, ( ) 10,,,,,,,, 8,,, 151
, 90, 40,,,, 10, 200, 20,,,,,,, 21 152
), 1998 1999,,,, : 1.,,,,,, 8,,, 2.,,,,,,,,,,, 153
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,,,,,,,,,,,, 2.,,,,,,, 1998 2 3, 8268,,, 158
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3., ( 11 ), 1999 ( 1998 ) Analytical Chemistry ( 120 ) ;, ( 100 ) ;,,, 4., : ( ) ; ( ) ; 21 (038 ) ; 21 ( 037 ) 16, 1.,,,,,, 160
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( ),, 21,,, 1997 1999 30,,,,,,,, 162
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,, 10 (, 1990 1991 ) ( 1997 ) (, 1997 ) ( 1994 ) ( 1994 ) ( 1998 ),, 500,,, 16, 700,,,,,, 164
( ) 1. 21, 1998 2, ( ), 2. 2000 7,,,,, ;, 3.,,, 165
, 1999 5,, CAI 1999 8, 4.,,,,,,, 5., 6.,,,,, 7.,,,, ;, 8.,, 166
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,, (3 ) (4 ) (5 ),,,, 1993,, 21,,,,, 171
( ), 1991,, 11,,,, 1996 9,,,,,,,,,,,,, 1991,, : 172
,, ; ;,,, 24,,,,,,,,,, 24,,,,,,, : ;, 173
,, ;,,,, ;, ;,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, 174
,,,,,,,,,,,,, 21 96%, 1994 1995 7,, 14 50 %,,,,,,,, 3.,,,,,,,, 175
, ;,,,,, ;, ; ;,,,,,,,,,,,,,,,,,,,,,,,,, 21,, 176
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1998 3 1999 12,, 182
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,, 1998,,,1998,,,1998 : ( 21 ),,,,1998,,,,, 1992,1999 :,,,, 1994 :,,,1993,,, 1990,,,1990,,, 1999 (3 ), 1999,,, 973 (4 ),,, 184
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2000.3, 2, 19000, 1990 2000, 6 ( 7 ), 62000 2.,,, ( ), ( ),, ( ),, 3., :,,,,1999 ( ),,,,1999,,,, 1999 186
) ( ) ( ), 1982 8, 10,,, 80, 1989,, ( ) (, 1992 8 ) ( ),,, 1994, 1996 3,, ;, 188
, ;, ;,,, ;,,, 48.9,, 7 26,,,,,,,,,,,,,,, 189
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,, (4 ),,, ;, (5 ), ; ;,, (6 ) 4.5,,,,,,,,,, ( 1999.12.03 ) :,, (,2000 3 ), 191
; ; :,,,,, :,,,,, 192
( ), 1998 1999, 1999,,,,,, ; ; ; ; 1999 2000 6, 700 ; 6,?,,, 193
,,,, ; ;,,,,, :,,,, :,,, :,,,,,,,, :,,,,,,,,, : 194
,, :,,,,,,,,,, :,,, :,,,,,,,,, ; ;,,,,, 6 (1999 5 ) 3 4,,,,,, 195
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,,, 30 40, 60 70,,,,,,,, 198
( ),,,,,,, 1994 9,,, 1998 9,,,,,,, ;,,,, 199
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,,, ; ;,,,,, 1998 80%,,,,,,,,,,,,, (, ), 6 3 ( 25 36% ), 6 8 ( 24 58% ), 4 2 203
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,,,,,,,,,,,,,,,,,,,,,,,, 4 2, 2,, 206,
,,,,,,,,,,,, 1.,, :,,, ; 10,,,, ;,,,,,, 2. 207
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,,,,, 1.,,, ; C1 2. ;,, ;,, ( ),,, : 224
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4. 2,,,,, 5.,,, 8,,, -, XRD NMR TG-DTA, 6.,,, 7.,, 1999,,,, 1. ( ), 227
,,,, 2. CAI,,, 3.,,,, 4.,, 8,,,,,, 4,, 4 1996,, ;,, 228
,,,,,,,,,8 (160 ),, 90 %, 229
( ) 1984,,,,,,,,,,, ( ),,,, 230
,,,,,,,, G.Schaller, S.O Brein D.Kleiman,, :,, S.Viederman,, :,,,,, ; ; ; ;, 2,,,,,, 1994, 231
2000 7,,,,,,, WWF GIS,,, ;,,, 1984,,,,,,,,, 1500,, 13,,,,, 72,,,,,,,,,, 232
,,,,, 1985, 2, 11 8, 4,, 1997, 5 233
( ), 1995 21, 1998,,,,,,,, 21,,,,???, 234
, ;,, 21,,,,,,,,,,,,,,,, 973,, 5, 3, 2 2, 1,, 235
,,,,,,, ;,,, NIH,, SCI 4500,,,,,,,,,,,,,,,, : 236
1.,,,,,,,1998, : 13,,,,,,,, ;, 2.,,,,,,,,,,,,,,, 237
,,,,,,, 1995,,,, 1998 1998,,, 21 2000 7,, :, ; ;,,,,, 2000, 2004 3.,,,, 2000,, 238
,,,,,,,,,, 4.,,,,,,, 200,, :,,,, DNA GFP ( ),, DNA( ladder) 239
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, :,, ;, ;,,, ;, 140 120, 100 80,,, 21, 21 1999,, 2000 6 21 3.,,,, 249
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,,, ( ),, 1989, 1993 90 1994, 91,, 92 93 94 1995, 92,, 93, 94, 1999 94,, 264
( ) 21,,,,,,,,,, 1996 2,,, 7,,,,,,,,,,,,,,,,, 265
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,,,,, ;, 3.,,,,,,,,,,,,,,,,,, 14 ( 4 ),,,,,,,,,,,,,, 267
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( ) 19, 1929, Tyler.R.W,,, 60 40, 70, ( COPA), 20 80,, 20 60,,20 70, 20,,,,, 20 40,, 20 80, 275
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,, 21,,,,,,,,,,,,,,,, : (1 ),,,,,,,, (2 ),,,, 277
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,,, 1.,,,,,,,,,, 2 3 ;,,,,,, 2., 30,,, 3.,,,,,,, 315
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,,,,,,,,, 15 %, 85%,,,,,,,,,,,,,,,,,,,,,,, 4.,,,, 19, 6,, 361
,,,,,,,,,,,,,,,,,,,, 5,,,,, 1996 9,,,,,,,, 30 8 3000, 6000,, ; 38, 7,,, 93.3%,,, ; :,, ; :,,, 362
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,, (2 ),,, (3 ), 4 (4 ) 5,, (1 ) 94 95 96 (2 ) ( ) 366
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, 2.,,, : 20,??,,,,, 26,,,,,?,,,,,,,,,,, 88.71%,,,,, 370
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( ) 1.,,,,,,,,,,,,, 1990, 1992 1993,,, 2., 1996 372
,, 3.,,,,,, 4.,,,,, 5., ; (1 ),,,,,,, (2 ),,,, (3 ) 1996, 373
,,,,, 500, 500 400 374
( ), 19 70,, 1996,, ( ), : (1 ),,, (2),,, (3 ),,,, (4 ) ( ), 375
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20,,,,,, 13,, 50 1998, 68 ( ),,,,,,, MIS, MIS,,,,, 382
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,,, :,, (7 ),, (8 ) Web,, 385
( ) 1. ( ), 117, 5.4 12, 3, 5 800 3, 6, 3, 5, 700, 1800, 170,,,, 1995 10,1996, 1999 12 : (1 ) ( 1996, 1997 1, 1998 9 ) : ( Internet), (2 ) ( 1996, 1999 ) : ( ) ( 386
(3 ) ( 1998 ) : ( ) ; (4 ) ( 1997, 1999 ) :,,,, (5 ) 2. (1 ) / :, (2 ), :,, :, ;, ;,,, ; (,, ) : ; ; : ;, ( ), 387
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,, (5 ) Windows,, Internet,, (6 ),,,, (7 ) Web, ASP (1 ) 1996,, ( ), 2 3, 211, (2) 1999 ( ), 2000,,,, (3 ),, (4 ) 390
1999 12,,,, 391
) ( ) ( 1996 ) 5,,,, ( 1997 ) 41, : (, 1999, 4 ) : 1., ( ),, ;,,,,,,,,,,, 392
,, : ( ),,,,,,, ( ) 2.,,,,,,,,,,,, :,,,,,,, ( 1999, 4 ) 393
,,, 20,,,,,,,,,,, :,,,,,,,,,,,, ( 1999, 4 ) 4.,, 1998 7, 2000 6,,, 3 394
,,,,,, 200, 1500 1996 1999, ( ),,, 1997 6,,, :, ( [1997 ]6 ), 2000 6, 2001,,, 395
( ) 1993, :,,,,, :,, ;,,,,,,,, :,,,,,,,,, 1990 1996 :,, ; 396
,,,,,,,,,,,,,,, 1993, :,, 1998,,,,,, 1993 1998, 350,,,,, 400, 226, 3, 82, 1993, ;, 1998 397
30,,,, 1997 12, 2000 8, 1998 7 7 ;1999 7 9 ;2000 7 9, 6,,,,,,,, : 80%, 20 % ;, 80 %, 20%,,,,,,,,,,,,,, : 398
,,,,,, 5000 ;,,,,, 3,, 2000 7, 4,,,,,,,,,,, 2000 7,, ;,,,,,,,, ; 2000,,, 1 ; 10 399
,, 50 : 1.,,,,,,,,, ;,,,,,,,,,,,, ; 1998 ; 1999, 1999 ; 2000,,,,,, 2 2., 400
,,,,,,, 200, 10,,,,,, 3.,,, ; ;,,,,,,,,,,,, 401
,,,, :, 15 20,, ;,,, 6,, 25 30, ;,, 5,, 402
( ) - 1991,,,, : 1.,, :,,,, 403
SAS SPSS ; Eviews TSP ; 2000 ; ; Office 97 WPS 2000, Internet Explorer Netscape ; Foxmail Frontpage,,, Windows NT Station; Windows 98; Unix Novell,,,,,,,,,,, ; 2., 1996, SAS Novell NT 3.,, 1 2, 1997, Windows WPS ; 1998 Office Lotus; 1999, 2000 404
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Windows 98 C,,,,,,,,,,, 16, 5, 14.6 5.,, Web,, 26,, (1 ),,,,,, (2 ), 406
, (4 ),,,,,, 150,,,,,,, MBA,,,,, 200, 1996, 211 400, 211 1998, 2000,, 30, 407
( ) 5100, 19 400 92%, 25 %,1999, 380 80, 246 1998 46 12 1996, :,, 3/ 4,,,, ;, ;,,,,, 408
10, (1 ),,,,, (2 ),,,, (3 ),, 1996 1, 1997,,, : (1 ) 35%,, (2 ), 40%, 409
2001 2001, 82 82,, 5, 18 ; 36, 17,,,,,,,,,,, 2003 3 6 410