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Vol. 32, No. 03 100 年 3 15 異欄 Borraginol-N supp /pill Dopamine HCl, Baxter 400 mg/250 ml /bag ethyl sminobenzoate, dibucaine HCl, cetrimide, diphenhydramine HCl dopamine HCl 1. Borraginol-N supp /pillethyl Aminobenzoate, dibucaine HCl, cetrimide, diphenhydramine HCl 8 BOR8HF11 2 16 2. Sokerz supp /pill policresulen, cinchocaine HCl 8 SOK8HF31 208 2 16 量不療 1. Dopamine HCl, Baxter 400 mg/250 ml/bag dopamine HCl 8 DOP1DG18 不度 2 15 車 3 15 復 2011/2/16 2011/2/16 2011/3/15 異欄 2011 年 2 2 Etanercept Enbrel for injection in prefilled syringe 5 見 Q & A 7 見易 8

() 2. 類 Dopmin 200 mg/5 ml /amp dopamine HCl 8 DO 1DG01 Dopamine HCl inj 200 mg/5 ml/amp 5% dextrose 250 ml 2011 年 2 Avandia F.C. Tablet 4 mg/tab (rosiglitazone maleate) 4 1. Avandia (rosiglitazone): REMS - Risk of Cardiovascular Events FDA rosiglitazone () FDA 2010/9/23 Rosiglitazone ( Avandia)( Avandamet rosiglitazone metformin Avandaryl rosiglitazone glimepiride) 了 rosiglitazone 更列 rosiglitazone 療降糖糖見 pioglitazone (ActosActoplus MetActoplus Met XR Duetact) 連參 FDA http://www.fda.gov/safety/medwatch/safetyinforma tion/safetyalertsforhumanmedicalproducts/ucm226 994.htm 2011/2/4 2. American Regent Injectable Products: Recall - Visible Particulates in Products 見 Sodium Thiosulfate Injection USP 10% Potassium Phosphates Injection, USP 若不良 ph 離狀 FDA 療不 Regent 立 Sodium Thiosulfate Injection, USP, 10% (100 mg/ml), 10 ml Single Dose VialNDC # 0517-1019-05 0056 2012 年 1 Potassium Phosphates Injection, USP, 15 mm/5 ml Phosphorus; 22 meq/5 ml Potassium 5 ml Single Dose VialNDC # 0517-2305-25 0048 2012 年 1 連參 FDA http://www.fda.gov/safety/medwatch/safetyinforma tion/safetyalertsforhumanmedicalproducts/ucm226 994.htm

2011/2/5 ( potassium phosphate 不量不不 ) Potassium Phosphate Injection, 20 ml/amp (K: 4.4 meq/ml, P: 3.0 mm/ml) 良 3. Terbutaline: Label Change - Warnings Against Use for Treatment of Preterm Labor FDA terbutaline 不療 terbutaline 不來療療料量 terbutaline 療不良糖律不塞 Terbutaline 療 () 療度刺更復 FDA terbutaline 料更 FDA 料論 terbutaline 療 ( 48-72 ) terbutaline 療不良益 FDA 療連參 FDA http://www.fda.gov/safety/medwatch/safetyinforma tion/safetyalertsforhumanmedicalproducts/ucm239 312.htm 2011/2/17 ( 不 ) Bricanyl Neb Soln 2.5 mg/1 ml 2 ml/amp (terbutaline sulfate) 5 /2 4. Antipsychotic drugs: Class Labeling Change - Treatment During Pregnancy and Potential Risk to Newborns including Haldol, FazaClo, Fanapt, Clozaril, Risperdal, Zyprexa, Seroquel, Abilify, Geodon, Invega, Loxitane, Moban, Navane, Orap, Saphris, Stelazine, Thorazine, Symbyax FDA 更精神料更精神不狀狀狀力不狀數數療精神精神若不連參 FDA http://www.fda.gov/safety/medwatch/safetyinforma tion/safetyalertsforhumanmedicalproducts/ucm239 559.htm 2011/2/22 Abilify Tablet 15 mg/tab (aripiprazole) 立復 Clozaril Tablet 100 mg/tab (clozapine) 律 Dogmatyl Tablet 200 mg/tab (sulpiride) Dogmatyl Tablet 50 mg/tab (sulpiride)

Fluanxol Depot Injection 20 mg/1 ml/amp (flupentixol decanoate) 福祿 Flucan Injection 25 mg/1 ml/amp (fluphenazine decanoate) 復 Flurazin F.C. Tablet 5 mg/tab (trifluoperazine HCl) 祿 Geodon Capsule 40 mg/cap (ziprasidone) Haldol Injection 5 mg/1 ml/amp (haloperidol) 度 Haldol Tablet 5 mg/tab (haloperidol) 度 Halosten Tablet 1 mg/tab (haloperidol) 樂 1 Invega Extended Release Tablets 3 mg/tab (paliperidone) 3 Lodopin Tablet 50 mg/tab (zotepine) Novamin Tablet 5 mg/tab (prochlorperazine maleate) 諾 Novamin Injection 5 mg/1 ml/amp (prochlorperazine maleate) 諾 Risperdal Film-coated Tablet 3 mg/tab (risperidone) 理 Risperdal Film-coated Tablet 1 mg/tab (risperidone) 理 Risperdal Consta Suspension for Injection 25 mg/vial (risperidone) Seroquel Tablet 25 mg quetiapine/tab (quetiapine fumarate) 樂 Seroquel XR 200 mg quetiapine/tab (quetiapine fumarate) 樂 Solian Tablet 200 mg/tab (amisulpride) 利 Winsumin Tablet 50 mg/tab (chlorpromazine HCl) 糖 Zyprexa 10 mg Powder for Solution for Injection (olanzapine) 金 10 Zyprexa Zydis Orodispersible Tablet 5 mg/tab 1. 理說 propoxyphene 益 propoxyphene 律不不良理行參 100 年 2 15 行更理 propoxyphene 不良料臨料行量 390 mg 600 mg 不良料律不量列老年不良率度量數數年臨療不良 5 度度 1 理年 4 paracetamol EMA FDA 臨料流行料 propoxyphene 離行

Etanercept Enbrel for injection in pre-filled syringe 狀龍 Enbrel for injection in pre-filled syringe etanercept 25 mg 0.5 ml 理 Etanercept 類 (TNF) p75fc TNF 類 (cytokine) TNF 力率 28% to 53% (in vitro) 不 39 ± 16% unchanged 146 hours 1. ( DMARDS methotrexate) 療類 2. methotrexate 療度度類 3. 療行 4. 療 5. 療 ( cyclosporine methotrexate 療 (PUVA)) 度度不良 ( 療 ) 療復易 ( 糖不易糖尿 ) anakinra 療 anakinra 兩臨療不 TNF TNF 療惡惡淋 49 療類臨度列療惡年狀度暴露療狀療不

療數年療療療見不良療狀 ( 例 ) 立立行數療神立狀益療 methotrexate 行惡 Wegener s Granulomatosis 不罹療 anakinra 療 anakinra 兩 7 兩臨療不量類 25 mg 50 mg 25 mg50 mg 量 25 mg 兩 50 mg12 25 mg24 狀若 12 度療量療量 25 mg 兩老年 ( 65) 量量 18 64 年 (2~18) 量 0.4 mg/kg (max. 25 mg) 量 3 4 B 量不立不

2 ~ 8 冷不冷參料 1. McEvoy GK, ed. AHFS: Drug Information. Bethesda, MD: American Society of Health- System Pharmacists; 2009: 3735 3742. 2. DRUGDEX System:Klasco RK (Ed): DRUGDEX System (electronic version). Thomson Micromedex, Greenwood Village, Colorado, USA. Available at: http://www.thomsonhc.com (cited: 03/05/2010). 3. Klasco RK (Ed): DRUGDEX System (electronic version). Thomson Micromedex, Greenwood Village, Colorado, USA. Available at: http://www.thomsonhc.com (cited:03/05/2010). 4. The circular from the manufacturer of etanercept. 5. Drug Facts and Comparisons 64th ed. Missouri: Facts and Comparisons, 2010: 2593 2597. 見 Q & A Q: 38 A: 療量量率糖塞量兩了 25~26 便更度了 1 行若 3 度 Q: A: 不都都度度淚淚理不見來數 39 不不不量異不 38 3 38 狀

見易 A B Actein Effervescent Tablet 600 mg/tab (acetylcysteine) Encore 300 mg/3 ml/amp (acetylcysteine) Adalat 5 mg/cap (nifedipine) ADALAT OROS 30 mg/tab (nifedipine) Adriblastina 10 mg/vial 療 () (doxorubicin HCl) Lipo-Dox 20 mg/10 ml/vial 療 (doxorubicin HCl (liposome)) Akineton 2 mg/tab (biperiden HCl) Aldactone 25 mg/tab (spironolactone) Aldactone 25 mg/tab (spironolactone) ( 4) Alpraline 0.5 mg/tab (alprazolam) ALLOPURINOL 100 mg/tab (allopurinol) ( 4) Alpraline 0.5 mg/tab (alprazolam) ALLOPURINOL 100 mg/tab (allopurinol) Diphenidol SC 25 mg/tab (diphenidol HCL) ( 4) Alpraline 0.5 mg/tab (alprazolam) ( 4) Ativan 0.5 mg/tab (lorazepam) ( 4) Alpraline 0.5 mg/tab (alprazolam) ( 4) Eurodin 2 mg/tab (estazolam) Aminophylline 100 mg/tab (aminophylline) Amoxicillin 250 mg/cap (amoxicillin trihydrate) Amoxicillin 250 mg/cap (amoxicillin trihydrate) Amolin Susp 25 mg/1 ml 60 ml/btl (amoxicillin) Amoxicillin 250 mg/cap (amoxicillin trihydrate) Augmentin 1 g/tab (amoxicillin, clavulanate potassium) Amoxicillin 250 mg/cap (amoxicillin trihydrate) Cephalexin 250 mg/cap (cephalexin monohydrate) Aprovel FC 150 mg/tab (irbesartan) Avandia FC 4 mg/tab (rosiglitazone) Aprovel FC 150 mg/tab (irbesartan) 160 Diovan FC 160 mg/tab (valsartan) AROMASIN 25 mg/tab (exemestane) Nolvadex 10 mg/tab (tamoxifen citrate) Atrovent Neb Soln 250 mcg/1 ml 2 ml/amp (ipratropium bromide) Combivent UDV Inh Soln 2.5 ml/amp (ipratropium bromide, 0.5mg salbutamole (sulfate)) Atrovent Neb Soln 250 mcg/1 ml 2 ml/amp (ipratropium bromide) Ventolin Nebules 5 mg/2.5 ml/amp (salbutamol sulfate) Augmentin IV (based on amoxicillin content) 500 mg/vial (amoxicillin 500 mg, clavulanic acid 100 Prostaphlin 500 mg/vial (oxacillin sodium) mg) 0.5 Baraclude 0.5 mg/tab for CDC Approval (entecavir) 1 Baraclude 1 mg/tab for CDC Approval (entecavir) 25 Betaloc ZOK 25 mg/tab (metoprolol succinate) Betaloc ZOK 100 mg/tab (metoprolol succinate) Calcium Carbonate 0.5 g/tab (calcium carbonate) MgO 250 mg/tab (magnesium oxide) Capoten 25 mg/tab (captopril) Catapres 0.075 mg/tab (clonidine HCL) Capoten 25 mg/tab (captopril) Cordarone 200 mg/tab (amiodarone HCL) Cefa 1000 mg/vial (cefazolin sodium) Cefmetazon 500 mg/vial (cefmetazole sodium) Cefmetazon 500 mg/vial (cefmetazole sodium) Tatumcef 500 mg/vial (ceftazidime pentahydrate) CELEBREX 200 mg/cap (celecoxib) Cephalexin 250 mg/cap (cephalexin monohydrate) Cephalexin 250 mg/cap (cephalexin monohydrate) Diphenidol SC 25 mg/tab (diphenidol HCl) Cephalexin 250 mg/cap (cephalexin monohydrate) Tinten 500 mg/tab (acetaminophen) Cephalexin 250 mg/cap (cephalexin monohydrate) Ulexin Granules 25 mg/1 ml 60 ml/btl (cephalexin monohydrate) ( 2) Codeine 15 mg/tab (codeine phosphate) ( 2) Codeine 30 mg/tab (codeine phosphate) Combivir/tab (lamivudine, zidovudine) Viramune 200 mg/tab (nevirapine)

A B Compound Glycyrrhiza Mixture 200 ml/btl (compound opium and glycyrrhiza mixture) Cough Mixture 120 ml/btl (cough mixture) Concor 5 mg/tab (bisoprolol hemifumarate) Crestor 10 mg/tab (rosuvastatin (calcium)) Cordarone Inj 150 mg/3 ml/amp (amiodarone Cordarone 200 mg/tab (amiodarone HCl) HCl) 5 Coumadin 5 mg/tab (warfarin sodium) 1 Coumadin 1 mg/tab (warfarin sodium) COZAAR 50 mg/tab (losartan potassium) Norvasc 5 mg/tab (amlodipine besylate) Crestor 10 mg/tab (rosuvastatin (calcium)) 160 Diovan FC 160 mg/tab (valsartan) Crestor 10 mg/tab (rosuvastatin (calcium)) Lipitor 10 mg/tab (atorvastatin) Danzen EC 10 mg/tab (serrapeptase) Lonzumin 25 mg/tab (buclizine HCl) Dilatrend 25 mg/tab (carvedilol) 6.25 DILATREND 6.25 mg/tab (carvedilol) Diphenhydramini HCl 30 mg/1 ml/amp (diphenhydramine HCl) Primperan Inj 10 mg/2 ml/amp (metoclopramide HCl) Diphenhydramini HCl 30 mg/1 ml/amp (diphenhydramine HCl) Rinderon Inj 4 mg/1 ml/amp (betamethasone sodium phosphate) 200 Dogmatyl 200 mg/tab (sulpiride) Dogmatyl 50 mg/tab (sulpiride) ( 4) 5 Dormicum 5 mg/1 ml/amp (midazolam HCl) ( 4) Dormicum 15 mg/3 ml/amp (midazolam HCl) Doxaben 1 mg/tab (doxazosin mesylate) DOXABEN XL 4 mg/tab (doxazosin m esylate) Dulcolax EC 5 mg/tab (bisacodyl) Dulcolax Supp 10 mg/pill (bisacodyl) Dulcolax EC 5 mg/tab (bisacodyl) Pariet 20 mg/tab (rabeprazole sodium) Encore 300 mg/3 ml/amp (acetylcysteine) Siruta Inh Soln 200 mg/1 ml 3 ml/amp (mesna) ( 尿 ) EURICON 50 mg/tab (benzbromarone) ( 4) Eurodin 2 mg/tab (estazolam) Extraneal PD Solution Ultrabag 7.5% 2 L/bag (peritoneal dialysis solution with icodextrin) Extraneal 7.5% 2 L/bag (peritoneal dialysis solution with 7.5% icodextrin) ( 2) Fentanyl Transdermal Patch 25 mcg/1 hr/pce (PPCD) (fentanyl citrate) ( 2) 50 Fentanyl Transdermal Patch 50 mcg/1 hr/pce (PPCD) (fentanyl citrate) Filgrastim 75 mcg/0.3 ml/amp (filgrastim) 300 Filgrastim 300 mcg/0.7 ml/amp (filgrastim) 2% Fresofol 1000 mg/50 ml/vial (propofol) Recofol 200 mg/20 ml/amp (propofol) Gaster D 20 mg/tab (famotidine) Gascon 40 mg/tab (dimethicone) Gastro-Timelets SR 30 mg/cap (metoclopramide HCl) Prometin 5 mg/tab (metoclopramide HCl) Gascon 40 mg/tab (dimethicone) Mucosolvan 30 mg/tab (ambroxol HCl) Solu-Cortef 100 mg/vial (hydrocortisone sodium Gentamicin inj 80 mg/2 ml/vial (gentamicin sulfate) succinate) Gentamycin Oph Soln 0.3% 5 ml/btl (gentamicin Oftalmolosa Cusi Oph Oint 0.3% 5 g/tube (gentamicin sulfate) sulfate) Gliben 5 mg/tab (glyburide) Glibudon 500 mg/tab (metformin HCl) Glibudon 500 mg/tab (metformin HCl) 850 Glucophage 850 mg/tab (metformin HCl) Glucose inj 50% 500 ml/bag (dextrose) 3 Sodium Chloride inj 3% 500 ml/bag (sodium chloride) Glucose inj 50% 500 ml/bag (dextrose) Vitagen 50% 20 ml/amp (dextrose) HumaPen LUXURA/set (insulin delivery device) () HumaPen LUXURA HD/set ( 度 0.5U) (insulin delivery device)

A B ( 4) Imovane 7.5 mg/tab (zopiclone) ( 4) Stilnox 10 mg/tab (zolpidem hemitartrate) KCl 20mEq+NS 100mL Inj 20 meq/100 ml/bag (D5W) KCl 20mEq+D5W 100mL Inj 20 meq/100 (potassium chloride 20 meq + 0.9% sodium chloride ml/bag () (potassium chloride 20 100mL) meq + 5% dextrose 100mL) 5% KCl Soln 0.67 meq/ml (potassium chloride) KI Soln 10%/mL (potassium iodide) Klaricid 250 mg/tab (clarithromycin) Klaricid XL 500 mg/tab (clarithromycin) Lactulose Liquid 600 mg/1 ml 500 ml/btl (lactulose) Lactulose Liquid 600 mg/ml ( ml) (lactulose) Lactulose Liquid 600 mg/ml ( ml) (lactulose) Mycostatin Susp 0.1 MU/1 ml 24 ml/btl (nystatin) Lipofundin MCT/LCT 10% 250 ml/btl (fat emulsion) Lipofundin MCT/LCT 10% 500 ml/btl (fat emulsion) Medicon 15 mg/tab (dextromethorphan HBr) MEDICON SYR 2.5 mg/1 ml 60 ml/btl (dextromethorphan hbr, potassium cresolsulfonate) Meptin 25 mcg/tab (procaterol HCl) Meptin Liq 5 mcg/1 ml 60 ml/btl (procaterol HCl) MgO 250 mg/tab (magnesium oxide) Nacid 500 mg/tab (hydrotalcite) MgO 250 mg/tab (magnesium oxide) Tinten 500 mg/tab (acetaminophen) ( 1) 0.1% Morphine Soln 1 mg/ml (morphine HCl) ( 1) 0.5% Morphine Soln 5 mg/ml (morphine HCl) Mucosolvan 30 mg/tab (ambroxol hcl) Soltan Liq 3 mg/1 ml 100 ml/btl (ambroxol HCl) Natrilix SR 1.5 mg/tab (indapamide) Plavix 75 mg/tab (clopidogrel) Nitrostat Sublingual 0.6 mg/1 tab 25 tab/btl (nitroglycerin) Nitroderm TTS 25 mg/pce (nitroglycerin) Novomix Penfill 300 U/3 ml/pen (insulin aspart and insulin aspart protamine) NovoRapid penfill Penfill 300 U/3 ml/pen (insulin aspart) Pantoloc Inj 40 mg/vial (pantoprazole sodium) Pantoloc 40 mg/tab (pantoprazole sodium) Pariet 20 mg/tab (rabeprazole sodium) Plavix 75 mg/tab (clopidogrel) Peace Syrup 60 ml/btl (pseudoephedrine HCl, triprolidine HCl) Pecolin Susp 120 ml/btl (kaolin, pectin) Peg-Intron for CDC Approval 80 mcg/vial (peginterferon alfa-2b) Pegasys for CDC Approval 180 mcg/0.5 ml/syrg (peginterferon alfa-2a) Penicillin G Sodium 3 MU/vial (penicillin G sodium) PCN Test (Penicillin G Skin Test) 1000 U/1 ml 2 ml/vial (penicillin G sodium skin test) Proscar 5 mg/tab (finasteride) Propecia 1 mg/tab (finasteride) 1 Prograf 1 mg/cap (tacrolimus) 0.5 Prograf 0.5 mg/cap (tacrolimus) Pulmicort Turbuhaler 200 mcg/1 dose 100 doses/btl (budesonide) Pulmicort Respule 1 mg/2 ml/amp (budesonide) Pulmicort Turbuhaler 200 mcg/1 dose 100 doses/btl (budesonide) Pulmicort Nasal Aqua 64 mcg/1 dose 120 doses/btl (budesonide) Rasitol Inj 20 mg/2 ml/amp (furosemide) Rolikan 16.6 meq/20 ml/amp (sodium bicarbonate) 5 Renitec 5 mg/tab (enalapril maleate) 20 Renitec 20 mg/tab (enalapril maleate) Seretide 250 Accuhaler 60 doses/box (salmeterol 250 Seretide Evohaler 120 doses/box (salmeterol xinafoate, fluticasone propionate) Seretide 250 Accuhaler 60 doses/box (salmeterol xinafoate, fluticasone propionate) xinafoate, fluticasone propionate) 125 Seretide Evohaler 120 doses/box (salmeterol xinafoate, fluticasone propionate)

A B 5mg Singulair Chewable 5 mg/tab (montelukast sodium) Singulair 10 mg/tab (montelukast sodium) Solu-Cortef 100 mg/vial (hydrocortisone sodium succinate) 40 Solu-Medrol 40 mg/vial (methylprednisolone sodium succinate) 40 Solu-Medrol 40 mg/vial (methylprednisolone sodium succinate) 500 Solu-Medrol 500 mg/vial (methylprednisolone sodium succinate) Solian 200 mg/tab (amisulpride) SOLAXIN 200 mg/tab (chlorzoxazone) SOLAXIN 200 mg/tab (chlorzoxazone) Strocain/tab (oxethazaine, polymigel) Taita No.1 500 ml/btl (dextrose and electrolyte solution) Taita No. 5 400 ml/btl (dextrose and electrolyte solution) Taita No. 4 500 ml/btl (dextrose and electrolyte solution) Taita No. 5 400 ml/btl (dextrose and electrolyte solution) Tetracycline Oph Oint 1% 5 g/tube (tetracycline hcl) Tetracycline 250 mg/cap (tetracycline HCl) 25 Tofranil 25 mg/tab (imipramine HCl) 10 Tofranil 10 mg/tab (imipramine HCl) Urso 100 mg/tab (ursodiol) Userm 100 mg/tab (tolperison HCl) Varivax-Varicella 0.5 ml/vial (varicella virus vaccine) 0.5 Vaxigrip, adult 0.5 ml/syrg 流 (influenza virus vaccine) VENTAVIS Nebuliser Solution 10 mcg/1 ml 2 ml/amp (iloprost) Ventolin Nebules 5 mg/2.5 ml/amp (salbutamol sulfate) (MDI) Ventolin Inhaler 100 mcg/1 dose 200 doses/btl (salbutamol micronised) Ventolin Nebules 5 mg/2.5 ml/amp (salbutamol sulfate) 20% Vitagen 20% 20 ml/amp (dextrose) Vitagen 50% 20 ml/amp (dextrose) Voren Supp 12.5 mg/pill (diclofenac sodium) Votan SR 100 mg/tab (diclofenac sodium) 2% Xylocaine IV 100 mg/5 ml/amp (lidocaine HCl) Xylocaine for local anesthesia 2% 20 ml/vial (lidocaine HCl) Zinnat 250 mg/tab (cefuroxime axetil) Zinnat Susp 25 mg/1 ml 50 ml/btl (cefuroxime axetil)