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201610 / Taiwan Institute of Economic Research 2 (1/3) (2/3) (dopamine)(serotonin) (norepinephrine) 度療療 Taiwan Institute of Economic Research 3 Taiwan Institute of Economic Research 4

(3/3) (discontinuation syndrome) TCA MAOI SSRI SNRI DNRI SM NSM 料來理 Taiwan Institute of Economic Research 5 (WHO)3 50003%5,000 50% 10% 10-25%5-12% (GBD2000) 2020 Taiwan Institute of Economic Research 6 (1/2) 2002 158.9% 5.2%15% 2009 1515.1% 2015355 2014 1174968 5069 6 (2/2) 405 12%89 76.3% 309 Taiwan Institute of Economic Research 7 Taiwan Institute of Economic Research 8

201587202093 2015-2020(CAGR)1.25% 201553202056 2015-2020(CAGR)1.25% Taiwan Institute of Economic Research 9 Taiwan Institute of Economic Research 10 (1/2) (tryptophan) (serotonin) (2/2) GABA (γ-aminobutyric acid) GABA GABA GABA GABAB6 B6 Taiwan Institute of Economic Research 11 Taiwan Institute of Economic Research 12

/(1/4) 0.0111 91 0.5~1 GABA(IP6) γ- /(2/4) (St. JohnswortHypericum perforatum 2008Linde 29 Taiwan Institute of Economic Research 13 Taiwan Institute of Economic Research 14 /(3/4) (Passionflower) (Morinda Citrifolia) /(4/4) 2014 2013 (trehalose) Taiwan Institute of Economic Research 15 Taiwan Institute of Economic Research 16

(1/2) / 1 3,600 12 N/A N/A / 300 ( ) 2 900 150 1-3 1. N/A /12 2. 3 (GABA) (GABA) 2,880 /100 4 250 /20 5 3,895 /750ml 6 Home 2,970 Dr.Happy /90 Banana 7-8 GABA 9-10 1,980 (GABA) /60 3,200 B /160 (GABA) 1,180 /40 1,760 /120 29 30 1. N/A 2. 25 1-3 1. 2. N/A 520 50C.C. 1. N/A 120 C.C45 2. 3. 50 1 1. N/A 230 2. 66 60 89 51 2 1. N/A 2. Taiwan Institute of Economic Research 20165-617 1~2 2 2 1. 2. N/A 302-430 1. N/A 1-2 2. 3. 3-41-2 1. N/A (2/2) / 11 TENZYME 12 13 GABA BD 3,160 GABAGSH (Biogenics) /240 (GABA) + 14 SAMe ( ) 15 Nature made St. John s wort (SAMe( 20GABA B6 B12Nicotinamide 599 /30 500 /30 1,200 /40 328 /40 16 B6 1,200 /60 17 BioHerb 3,680 /180 18 ( GABA) 19 20 PFI PFI( GABAγ-)( 21 AWBIO 61 L-Theanine) Aquamin-F 2,980 /300 3,960 /120 1,880 /120 ()3,300 GABA /120 Taiwan Institute of Economic Research 59 31~2 1. N/A 2. 3. 4. 20 11 1. N/A 17 1. 2. 68 6021-1. 2 2. 6122-4 16 1. 2. 3. 60 3 1. 20 1. 30 15 1~2 1. 1~2 2. 74 1. 3~4 27 1. 1 1-2 2. 2. 2 165 11 1. 26( 2. 2) N/A N/A N/A N/A N/A N/A N/A N/A N/A 18 20165-6 () () 利數利數年 1997 1 1 1998 0 0 1999 5 5 2000 0 0 2001 1 2 2002 0 0 2003 1 5 2004 0 0 2005 3 8 2006 1 1 2007 8 12 2008 3 14 2009 3 4 2010 3 9 2011 5 28 2012 6 16 2013 5 5 2014 3 3 2015 3 3 51 116 (CN) 15 (US) 8 (KR) 8 (JP) 4 (DE) 4 (JP) 3 23% 29% 8% 8% 16% 16% 11 (CN) (US) (KR) (JP) (DE) Taiwan Institute of Economic Research 19 Taiwan Institute of Economic Research 20

licorice 7 dicotyledons 6 ginseng 5 5 Laurel family 3 goldthread 3 3 3 Grass family 3 Taiwan Institute of Economic Research (CN) licorice 7 dicotyledons (KR) (US) (MT) 2 1 ginseng 4 1 5 Laurel family 1 2 goldthread 3 3 3 Grass family 2 1 21 1 WO16072710A1 2015- Tranquilizing composition containing Fugenbio Co., Ltd. (KR) 11-03 as actie ingredient exopolysaccharide produced by means of ceriporia lacerata 2 WO16061872A1 2014- Sober-up tea Xian, Shufen (CN) 12-03 3 WO15188280A1 2015- Methods and compositions addressing 06-12 depressed mood 4 WO15176801A1 2015-05-08 Transdermal therapeutic system containing laender oil 5 WO15067759A1 2014- Method for the management of cancer Legacy Healthcare Ltd 11-07 and treatment of cancer comorbidities Taiwan Institute of Economic Research 22 Centre For Addiction And (CA) angiosperms Mental Health Heath or Blueberry family Lts Lohmann Therapie- (DE) Mint family Systeme Ag (MT) Soapberry family dicotyledons 6 WO14154158A1 2014- Traditional chinese medicine Chengdu Diao Group Tianfu (CN) 03-27 composition for treating depression, Pharmaceutical Co Ltd and preparation method therefor milketch 7 WO14043025A1 2013- Multiple folate formulation and use Jaymac Pharmaceuticals Llc (US) Cypress family 09-09 thereof 8 WO13151281A1 2013- Composition containing mori cortex Korea Food Res Inst (KR) Mulberry 03-29 radicis extract as actie ingredient for preenting or treating depression 9 WO13149102A1 2013- Compositions comprising scopolamine Gen Hospital Corp (US) Potato family 03-29 and ketamine in the treatment of depression 10 WO13143843A1 2013- New alerian extracts and uses thereof Brattstroem Axel (DE) Valerian family 03-13 - 2020 - - - 50% 10% Taiwan Institute of Economic Research 23 Taiwan Institute of Economic Research 24

TGAP http:/// http://agbio.coa.go.tw/ TEL: (02)2586-5000 FAX: (02)2597-9641 麗劉李羽林羅玲李玲 Taiwan Institute of Economic Research 25 Taiwan Institute of Economic Research