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1 Vol. 32, No 年 3 15 異 欄 Borraginol-N supp /pill Dopamine HCl, Baxter 400 mg/250 ml /bag ethyl sminobenzoate, dibucaine HCl, cetrimide, diphenhydramine HCl dopamine HCl 1. Borraginol-N supp /pillethyl Aminobenzoate, dibucaine HCl, cetrimide, diphenhydramine HCl 8 BOR8HF Sokerz supp /pill policresulen, cinchocaine HCl 8 SOK8HF 量 不 療 1. Dopamine HCl, Baxter 400 mg/250 ml/bag dopamine HCl 8 DOP1DG18 不 度 2 15 車 3 15 復 2011/2/ /2/ /3/15 異 欄 2011 年 2 2 Etanercept Enbrel for injection in prefilled syringe 5 見 Q & A 7 見 易 8

2 () 2. 類 Dopmin 200 mg/5 ml /amp dopamine HCl 8 DO 1DG01 Dopamine HCl inj 200 mg/5 ml/amp 5% dextrose 250 ml 2011 年 2 Avandia F.C. Tablet 4 mg/tab (rosiglitazone maleate) 4 1. Avandia (rosiglitazone): REMS - Risk of Cardiovascular Events FDA rosiglitazone () FDA 2010/9/23 Rosiglitazone ( Avandia)( Avandamet rosiglitazone metformin Avandaryl rosiglitazone glimepiride) 了 rosiglitazone 更 列 rosiglitazone 療 降 糖 糖 見 pioglitazone (ActosActoplus MetActoplus Met XR Duetact) 連 參 FDA tion/safetyalertsforhumanmedicalproducts/ucm htm 2011/2/4 2. American Regent Injectable Products: Recall - Visible Particulates in Products 見 Sodium Thiosulfate Injection USP 10% Potassium Phosphates Injection, USP 若 不 良 ph 離 狀 FDA 療 不 Regent 立 Sodium Thiosulfate Injection, USP, 10% (100 mg/ml), 10 ml Single Dose VialNDC # 年 1 Potassium Phosphates Injection, USP, 15 mm/5 ml Phosphorus; 22 meq/5 ml Potassium 5 ml Single Dose VialNDC # 年 1 連 參 FDA tion/safetyalertsforhumanmedicalproducts/ucm htm

3 2011/2/5 ( potassium phosphate 不 量 不 不 ) Potassium Phosphate Injection, 20 ml/amp (K: 4.4 meq/ml, P: 3.0 mm/ml) 良 3. Terbutaline: Label Change - Warnings Against Use for Treatment of Preterm Labor FDA terbutaline 不 療 terbutaline 不 來 療 療 料 量 terbutaline 療 不 良 糖 律 不 塞 Terbutaline 療 () 療 度 刺 更 復 FDA terbutaline 料 更 FDA 料 論 terbutaline 療 ( ) terbutaline 療 不 良 益 FDA 療 連 參 FDA tion/safetyalertsforhumanmedicalproducts/ucm htm 2011/2/17 ( 不 ) Bricanyl Neb Soln 2.5 mg/1 ml 2 ml/amp (terbutaline sulfate) 5 /2 4. Antipsychotic drugs: Class Labeling Change - Treatment During Pregnancy and Potential Risk to Newborns including Haldol, FazaClo, Fanapt, Clozaril, Risperdal, Zyprexa, Seroquel, Abilify, Geodon, Invega, Loxitane, Moban, Navane, Orap, Saphris, Stelazine, Thorazine, Symbyax FDA 更 精 神 料 更 精 神 不 狀 狀 狀 力 不 狀 數 數 療 精 神 精 神 若 不 連 參 FDA tion/safetyalertsforhumanmedicalproducts/ucm htm 2011/2/22 Abilify Tablet 15 mg/tab (aripiprazole) 立 復 Clozaril Tablet 100 mg/tab (clozapine) 律 Dogmatyl Tablet 200 mg/tab (sulpiride) Dogmatyl Tablet 50 mg/tab (sulpiride)

4 Fluanxol Depot Injection 20 mg/1 ml/amp (flupentixol decanoate) 福 祿 Flucan Injection 25 mg/1 ml/amp (fluphenazine decanoate) 復 Flurazin F.C. Tablet 5 mg/tab (trifluoperazine HCl) 祿 Geodon Capsule 40 mg/cap (ziprasidone) Haldol Injection 5 mg/1 ml/amp (haloperidol) 度 Haldol Tablet 5 mg/tab (haloperidol) 度 Halosten Tablet 1 mg/tab (haloperidol) 樂 1 Invega Extended Release Tablets 3 mg/tab (paliperidone) 3 Lodopin Tablet 50 mg/tab (zotepine) Novamin Tablet 5 mg/tab (prochlorperazine maleate) 諾 Novamin Injection 5 mg/1 ml/amp (prochlorperazine maleate) 諾 Risperdal Film-coated Tablet 3 mg/tab (risperidone) 理 Risperdal Film-coated Tablet 1 mg/tab (risperidone) 理 Risperdal Consta Suspension for Injection 25 mg/vial (risperidone) Seroquel Tablet 25 mg quetiapine/tab (quetiapine fumarate) 樂 Seroquel XR 200 mg quetiapine/tab (quetiapine fumarate) 樂 Solian Tablet 200 mg/tab (amisulpride) 利 Winsumin Tablet 50 mg/tab (chlorpromazine HCl) 糖 Zyprexa 10 mg Powder for Solution for Injection (olanzapine) 金 10 Zyprexa Zydis Orodispersible Tablet 5 mg/tab 1. 理 說 propoxyphene 益 propoxyphene 律 不 不 良 理 行 參 100 年 2 15 行 更 理 propoxyphene 不 良 料 臨 料 行 量 390 mg 600 mg 不 良 料 律 不 量 列 老 年 不 良 率 度 量 數 數 年 臨 療 不 良 5 度 度 1 理 年 4 paracetamol EMA FDA 臨 料 流 行 料 propoxyphene 離 行

5 Etanercept Enbrel for injection in pre-filled syringe 狀 龍 Enbrel for injection in pre-filled syringe etanercept 25 mg 0.5 ml 理 Etanercept 類 (TNF) p75fc TNF 類 (cytokine) TNF 力 率 28% to 53% (in vitro) 不 39 ± 16% unchanged 146 hours 1. ( DMARDS methotrexate) 療 類 2. methotrexate 療 度 度 類 3. 療 行 4. 療 5. 療 ( cyclosporine methotrexate 療 (PUVA)) 度 度 不 良 ( 療 ) 療 復 易 ( 糖 不 易 糖 尿 ) anakinra 療 anakinra 兩 臨 療 不 TNF TNF 療 惡 惡 淋 49 療 類 臨 度 列 療 惡 年 狀 度 暴 露 療 狀 療 不

6 療 數 年 療 療 療 見 不 良 療 狀 ( 例 ) 立 立 行 數 療 神 立 狀 益 療 methotrexate 行 惡 Wegener s Granulomatosis 不 罹 療 anakinra 療 anakinra 兩 7 兩 臨 療 不 量 類 25 mg 50 mg 25 mg50 mg 量 25 mg 兩 50 mg12 25 mg24 狀 若 12 度 療 量 療 量 25 mg 兩 老 年 ( 65) 量 量 年 (2~18) 量 0.4 mg/kg (max. 25 mg) 量 3 4 B 量 不 立 不

7 2 ~ 8 冷 不 冷 參 料 1. McEvoy GK, ed. AHFS: Drug Information. Bethesda, MD: American Society of Health- System Pharmacists; 2009: DRUGDEX System:Klasco RK (Ed): DRUGDEX System (electronic version). Thomson Micromedex, Greenwood Village, Colorado, USA. Available at: (cited: 03/05/2010). 3. Klasco RK (Ed): DRUGDEX System (electronic version). Thomson Micromedex, Greenwood Village, Colorado, USA. Available at: (cited:03/05/2010). 4. The circular from the manufacturer of etanercept. 5. Drug Facts and Comparisons 64th ed. Missouri: Facts and Comparisons, 2010: 見 Q & A Q: 38 A: 療 量 量 率 糖 塞 量 兩 了 25~26 便 更 度 了 1 行 若 3 度 Q: A: 不 都 都 度 度 淚 淚 理 不 見 來 數 39 不 不 不 量 異 不 狀

8 見 易 A B Actein Effervescent Tablet 600 mg/tab (acetylcysteine) Encore 300 mg/3 ml/amp (acetylcysteine) Adalat 5 mg/cap (nifedipine) ADALAT OROS 30 mg/tab (nifedipine) Adriblastina 10 mg/vial 療 () (doxorubicin HCl) Lipo-Dox 20 mg/10 ml/vial 療 (doxorubicin HCl (liposome)) Akineton 2 mg/tab (biperiden HCl) Aldactone 25 mg/tab (spironolactone) Aldactone 25 mg/tab (spironolactone) ( 4) Alpraline 0.5 mg/tab (alprazolam) ALLOPURINOL 100 mg/tab (allopurinol) ( 4) Alpraline 0.5 mg/tab (alprazolam) ALLOPURINOL 100 mg/tab (allopurinol) Diphenidol SC 25 mg/tab (diphenidol HCL) ( 4) Alpraline 0.5 mg/tab (alprazolam) ( 4) Ativan 0.5 mg/tab (lorazepam) ( 4) Alpraline 0.5 mg/tab (alprazolam) ( 4) Eurodin 2 mg/tab (estazolam) Aminophylline 100 mg/tab (aminophylline) Amoxicillin 250 mg/cap (amoxicillin trihydrate) Amoxicillin 250 mg/cap (amoxicillin trihydrate) Amolin Susp 25 mg/1 ml 60 ml/btl (amoxicillin) Amoxicillin 250 mg/cap (amoxicillin trihydrate) Augmentin 1 g/tab (amoxicillin, clavulanate potassium) Amoxicillin 250 mg/cap (amoxicillin trihydrate) Cephalexin 250 mg/cap (cephalexin monohydrate) Aprovel FC 150 mg/tab (irbesartan) Avandia FC 4 mg/tab (rosiglitazone) Aprovel FC 150 mg/tab (irbesartan) 160 Diovan FC 160 mg/tab (valsartan) AROMASIN 25 mg/tab (exemestane) Nolvadex 10 mg/tab (tamoxifen citrate) Atrovent Neb Soln 250 mcg/1 ml 2 ml/amp (ipratropium bromide) Combivent UDV Inh Soln 2.5 ml/amp (ipratropium bromide, 0.5mg salbutamole (sulfate)) Atrovent Neb Soln 250 mcg/1 ml 2 ml/amp (ipratropium bromide) Ventolin Nebules 5 mg/2.5 ml/amp (salbutamol sulfate) Augmentin IV (based on amoxicillin content) 500 mg/vial (amoxicillin 500 mg, clavulanic acid 100 Prostaphlin 500 mg/vial (oxacillin sodium) mg) 0.5 Baraclude 0.5 mg/tab for CDC Approval (entecavir) 1 Baraclude 1 mg/tab for CDC Approval (entecavir) 25 Betaloc ZOK 25 mg/tab (metoprolol succinate) Betaloc ZOK 100 mg/tab (metoprolol succinate) Calcium Carbonate 0.5 g/tab (calcium carbonate) MgO 250 mg/tab (magnesium oxide) Capoten 25 mg/tab (captopril) Catapres mg/tab (clonidine HCL) Capoten 25 mg/tab (captopril) Cordarone 200 mg/tab (amiodarone HCL) Cefa 1000 mg/vial (cefazolin sodium) Cefmetazon 500 mg/vial (cefmetazole sodium) Cefmetazon 500 mg/vial (cefmetazole sodium) Tatumcef 500 mg/vial (ceftazidime pentahydrate) CELEBREX 200 mg/cap (celecoxib) Cephalexin 250 mg/cap (cephalexin monohydrate) Cephalexin 250 mg/cap (cephalexin monohydrate) Diphenidol SC 25 mg/tab (diphenidol HCl) Cephalexin 250 mg/cap (cephalexin monohydrate) Tinten 500 mg/tab (acetaminophen) Cephalexin 250 mg/cap (cephalexin monohydrate) Ulexin Granules 25 mg/1 ml 60 ml/btl (cephalexin monohydrate) ( 2) Codeine 15 mg/tab (codeine phosphate) ( 2) Codeine 30 mg/tab (codeine phosphate) Combivir/tab (lamivudine, zidovudine) Viramune 200 mg/tab (nevirapine)

9 A B Compound Glycyrrhiza Mixture 200 ml/btl (compound opium and glycyrrhiza mixture) Cough Mixture 120 ml/btl (cough mixture) Concor 5 mg/tab (bisoprolol hemifumarate) Crestor 10 mg/tab (rosuvastatin (calcium)) Cordarone Inj 150 mg/3 ml/amp (amiodarone Cordarone 200 mg/tab (amiodarone HCl) HCl) 5 Coumadin 5 mg/tab (warfarin sodium) 1 Coumadin 1 mg/tab (warfarin sodium) COZAAR 50 mg/tab (losartan potassium) Norvasc 5 mg/tab (amlodipine besylate) Crestor 10 mg/tab (rosuvastatin (calcium)) 160 Diovan FC 160 mg/tab (valsartan) Crestor 10 mg/tab (rosuvastatin (calcium)) Lipitor 10 mg/tab (atorvastatin) Danzen EC 10 mg/tab (serrapeptase) Lonzumin 25 mg/tab (buclizine HCl) Dilatrend 25 mg/tab (carvedilol) 6.25 DILATREND 6.25 mg/tab (carvedilol) Diphenhydramini HCl 30 mg/1 ml/amp (diphenhydramine HCl) Primperan Inj 10 mg/2 ml/amp (metoclopramide HCl) Diphenhydramini HCl 30 mg/1 ml/amp (diphenhydramine HCl) Rinderon Inj 4 mg/1 ml/amp (betamethasone sodium phosphate) 200 Dogmatyl 200 mg/tab (sulpiride) Dogmatyl 50 mg/tab (sulpiride) ( 4) 5 Dormicum 5 mg/1 ml/amp (midazolam HCl) ( 4) Dormicum 15 mg/3 ml/amp (midazolam HCl) Doxaben 1 mg/tab (doxazosin mesylate) DOXABEN XL 4 mg/tab (doxazosin m esylate) Dulcolax EC 5 mg/tab (bisacodyl) Dulcolax Supp 10 mg/pill (bisacodyl) Dulcolax EC 5 mg/tab (bisacodyl) Pariet 20 mg/tab (rabeprazole sodium) Encore 300 mg/3 ml/amp (acetylcysteine) Siruta Inh Soln 200 mg/1 ml 3 ml/amp (mesna) ( 尿 ) EURICON 50 mg/tab (benzbromarone) ( 4) Eurodin 2 mg/tab (estazolam) Extraneal PD Solution Ultrabag 7.5% 2 L/bag (peritoneal dialysis solution with icodextrin) Extraneal 7.5% 2 L/bag (peritoneal dialysis solution with 7.5% icodextrin) ( 2) Fentanyl Transdermal Patch 25 mcg/1 hr/pce (PPCD) (fentanyl citrate) ( 2) 50 Fentanyl Transdermal Patch 50 mcg/1 hr/pce (PPCD) (fentanyl citrate) Filgrastim 75 mcg/0.3 ml/amp (filgrastim) 300 Filgrastim 300 mcg/0.7 ml/amp (filgrastim) 2% Fresofol 1000 mg/50 ml/vial (propofol) Recofol 200 mg/20 ml/amp (propofol) Gaster D 20 mg/tab (famotidine) Gascon 40 mg/tab (dimethicone) Gastro-Timelets SR 30 mg/cap (metoclopramide HCl) Prometin 5 mg/tab (metoclopramide HCl) Gascon 40 mg/tab (dimethicone) Mucosolvan 30 mg/tab (ambroxol HCl) Solu-Cortef 100 mg/vial (hydrocortisone sodium Gentamicin inj 80 mg/2 ml/vial (gentamicin sulfate) succinate) Gentamycin Oph Soln 0.3% 5 ml/btl (gentamicin Oftalmolosa Cusi Oph Oint 0.3% 5 g/tube (gentamicin sulfate) sulfate) Gliben 5 mg/tab (glyburide) Glibudon 500 mg/tab (metformin HCl) Glibudon 500 mg/tab (metformin HCl) 850 Glucophage 850 mg/tab (metformin HCl) Glucose inj 50% 500 ml/bag (dextrose) 3 Sodium Chloride inj 3% 500 ml/bag (sodium chloride) Glucose inj 50% 500 ml/bag (dextrose) Vitagen 50% 20 ml/amp (dextrose) HumaPen LUXURA/set (insulin delivery device) () HumaPen LUXURA HD/set ( 度 0.5U) (insulin delivery device)

10 A B ( 4) Imovane 7.5 mg/tab (zopiclone) ( 4) Stilnox 10 mg/tab (zolpidem hemitartrate) KCl 20mEq+NS 100mL Inj 20 meq/100 ml/bag (D5W) KCl 20mEq+D5W 100mL Inj 20 meq/100 (potassium chloride 20 meq + 0.9% sodium chloride ml/bag () (potassium chloride mL) meq + 5% dextrose 100mL) 5% KCl Soln 0.67 meq/ml (potassium chloride) KI Soln 10%/mL (potassium iodide) Klaricid 250 mg/tab (clarithromycin) Klaricid XL 500 mg/tab (clarithromycin) Lactulose Liquid 600 mg/1 ml 500 ml/btl (lactulose) Lactulose Liquid 600 mg/ml ( ml) (lactulose) Lactulose Liquid 600 mg/ml ( ml) (lactulose) Mycostatin Susp 0.1 MU/1 ml 24 ml/btl (nystatin) Lipofundin MCT/LCT 10% 250 ml/btl (fat emulsion) Lipofundin MCT/LCT 10% 500 ml/btl (fat emulsion) Medicon 15 mg/tab (dextromethorphan HBr) MEDICON SYR 2.5 mg/1 ml 60 ml/btl (dextromethorphan hbr, potassium cresolsulfonate) Meptin 25 mcg/tab (procaterol HCl) Meptin Liq 5 mcg/1 ml 60 ml/btl (procaterol HCl) MgO 250 mg/tab (magnesium oxide) Nacid 500 mg/tab (hydrotalcite) MgO 250 mg/tab (magnesium oxide) Tinten 500 mg/tab (acetaminophen) ( 1) 0.1% Morphine Soln 1 mg/ml (morphine HCl) ( 1) 0.5% Morphine Soln 5 mg/ml (morphine HCl) Mucosolvan 30 mg/tab (ambroxol hcl) Soltan Liq 3 mg/1 ml 100 ml/btl (ambroxol HCl) Natrilix SR 1.5 mg/tab (indapamide) Plavix 75 mg/tab (clopidogrel) Nitrostat Sublingual 0.6 mg/1 tab 25 tab/btl (nitroglycerin) Nitroderm TTS 25 mg/pce (nitroglycerin) Novomix Penfill 300 U/3 ml/pen (insulin aspart and insulin aspart protamine) NovoRapid penfill Penfill 300 U/3 ml/pen (insulin aspart) Pantoloc Inj 40 mg/vial (pantoprazole sodium) Pantoloc 40 mg/tab (pantoprazole sodium) Pariet 20 mg/tab (rabeprazole sodium) Plavix 75 mg/tab (clopidogrel) Peace Syrup 60 ml/btl (pseudoephedrine HCl, triprolidine HCl) Pecolin Susp 120 ml/btl (kaolin, pectin) Peg-Intron for CDC Approval 80 mcg/vial (peginterferon alfa-2b) Pegasys for CDC Approval 180 mcg/0.5 ml/syrg (peginterferon alfa-2a) Penicillin G Sodium 3 MU/vial (penicillin G sodium) PCN Test (Penicillin G Skin Test) 1000 U/1 ml 2 ml/vial (penicillin G sodium skin test) Proscar 5 mg/tab (finasteride) Propecia 1 mg/tab (finasteride) 1 Prograf 1 mg/cap (tacrolimus) 0.5 Prograf 0.5 mg/cap (tacrolimus) Pulmicort Turbuhaler 200 mcg/1 dose 100 doses/btl (budesonide) Pulmicort Respule 1 mg/2 ml/amp (budesonide) Pulmicort Turbuhaler 200 mcg/1 dose 100 doses/btl (budesonide) Pulmicort Nasal Aqua 64 mcg/1 dose 120 doses/btl (budesonide) Rasitol Inj 20 mg/2 ml/amp (furosemide) Rolikan 16.6 meq/20 ml/amp (sodium bicarbonate) 5 Renitec 5 mg/tab (enalapril maleate) 20 Renitec 20 mg/tab (enalapril maleate) Seretide 250 Accuhaler 60 doses/box (salmeterol 250 Seretide Evohaler 120 doses/box (salmeterol xinafoate, fluticasone propionate) Seretide 250 Accuhaler 60 doses/box (salmeterol xinafoate, fluticasone propionate) xinafoate, fluticasone propionate) 125 Seretide Evohaler 120 doses/box (salmeterol xinafoate, fluticasone propionate)

11 A B 5mg Singulair Chewable 5 mg/tab (montelukast sodium) Singulair 10 mg/tab (montelukast sodium) Solu-Cortef 100 mg/vial (hydrocortisone sodium succinate) 40 Solu-Medrol 40 mg/vial (methylprednisolone sodium succinate) 40 Solu-Medrol 40 mg/vial (methylprednisolone sodium succinate) 500 Solu-Medrol 500 mg/vial (methylprednisolone sodium succinate) Solian 200 mg/tab (amisulpride) SOLAXIN 200 mg/tab (chlorzoxazone) SOLAXIN 200 mg/tab (chlorzoxazone) Strocain/tab (oxethazaine, polymigel) Taita No ml/btl (dextrose and electrolyte solution) Taita No ml/btl (dextrose and electrolyte solution) Taita No ml/btl (dextrose and electrolyte solution) Taita No ml/btl (dextrose and electrolyte solution) Tetracycline Oph Oint 1% 5 g/tube (tetracycline hcl) Tetracycline 250 mg/cap (tetracycline HCl) 25 Tofranil 25 mg/tab (imipramine HCl) 10 Tofranil 10 mg/tab (imipramine HCl) Urso 100 mg/tab (ursodiol) Userm 100 mg/tab (tolperison HCl) Varivax-Varicella 0.5 ml/vial (varicella virus vaccine) 0.5 Vaxigrip, adult 0.5 ml/syrg 流 (influenza virus vaccine) VENTAVIS Nebuliser Solution 10 mcg/1 ml 2 ml/amp (iloprost) Ventolin Nebules 5 mg/2.5 ml/amp (salbutamol sulfate) (MDI) Ventolin Inhaler 100 mcg/1 dose 200 doses/btl (salbutamol micronised) Ventolin Nebules 5 mg/2.5 ml/amp (salbutamol sulfate) 20% Vitagen 20% 20 ml/amp (dextrose) Vitagen 50% 20 ml/amp (dextrose) Voren Supp 12.5 mg/pill (diclofenac sodium) Votan SR 100 mg/tab (diclofenac sodium) 2% Xylocaine IV 100 mg/5 ml/amp (lidocaine HCl) Xylocaine for local anesthesia 2% 20 ml/vial (lidocaine HCl) Zinnat 250 mg/tab (cefuroxime axetil) Zinnat Susp 25 mg/1 ml 50 ml/btl (cefuroxime axetil)