FCIS FCS Scott A. Samuels Donald W. Glazer Michael Goller Ranjeev Krishana Thomas Malley Thomas Malley Ranjeev Krishana Donald W. Glazer Michael Golle

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2 B E I G E N E, L T D

3 FCIS FCS Scott A. Samuels Donald W. Glazer Michael Goller Ranjeev Krishana Thomas Malley Thomas Malley Ranjeev Krishana Donald W. Glazer Michael Goller The offices of Mourant Governance Services (Cayman) Limited 94 Solaris Avenue Camana Bay Grand Cayman KY Cayman Islands B E I G E N E, L T D

4 Mourant Ozannes Morgan Stanley & Co. Inc Mourant Governance Services (Cayman) Limited 94 Solaris Avenue, Camana Bay Grand Cayman KY Cayman Islands 3 B E I G E N E, L T D

5 BeiGene, Ltd. (1) zanubrutinib (BGB-3111) (BTK) (2) tislelizumab (BGB-A317) PD-1 (3) pamiparib (BGB-290) PARP1 PARP zanubrutinib tislelizumab 2019 zanubrutinib 1 lifirafenib(bgb-283) RAF BGB-A333 PD-L1 BGB-A425 T 3(TIM-3) 2017 tislelizumab tislelizumab ABRAXANE REVLIMID VIDAZA (Fort Lee) (Emeryville) (San Mateo) B E I G E N E, L T D

6 tislelizumab (chl) 70 chl Lugano(2014) 72.9% 50% tislelizumab 1 PD-1 chl chl BLA SEC 8-K % 61.4% zanubrutinib WM zanubrutinib WM zanubrutinib WM zanubrutinib WM pamiparib tislelizumab IIIB IV NSCLC ,600, ,107, B E I G E N E, L T D

7 tislelizumab 2017 pamiparib lifirafenib 2013 ABRAXANE REVLIMID VIDAZA B E I G E N E, L T D

8 zanubrutinib BTK tislelizumab PD-1 pamiparib PARP1 PARP2 lifirafenib BRAF BGB-A333 PD-L1 BGB-A425 TIM-3 7 B E I G E N E, L T D

9 18A.08(3) B E I G E N E, L T D

10 ABRAXANE REVLIMID VIDAZA 9 B E I G E N E, L T D

11 % 54,676 54,676 30,672 30,672 85,348 85,348 (10,806) (10,806) (273,951) (90,018) (183,933) 204% (74,075) (19,546) (54,529) 279% (375) (375) (359,207) (109,564) (249,643) 228% (273,859) (109,564) (164,295) 150% 3,444 (1,796) 5, % % (269,611) (110,922) (158,689) 143% 6,780 (381) 7, % (262,831) (111,303) (151,528) 136% (1,348) (135) (1,213) 899% BeiGene, Ltd. (261,483) (111,168) (150,315) 135% B E I G E N E, L T D

12 % 54,676 54,676 25,730 25,730 4,942 4,942 85,348 85, ABRAXANE REVLIMID VIDAZA VIDAZA (Merck KGaA, Darmstadt Germany) B E I G E N E, L T D

13 % % 143,299 46,758 96, % 28,331 5,341 22, % 102,321 37,919 64, % 273,951 90, , % zanubrutinib tislelizumab pamiparib lifirafenib 1.8 sitravitinib a) 26.0 b) 13.5 c) 9.9 d) 8.8 e) 6.2 B E I G E N E, L T D

14 % B E I G E N E, L T D

15 (Merck KGaA, Darmstadt Germany) ,107, , (221,638) (87,597) (360,220) 113, , ,600 1, , ,492 B E I G E N E, L T D

16 Mirati B E I G E N E, L T D

17 ,198.9 Mirati B E I G E N E, L T D

18 zanubrutinib tislelizumab pamiparib 17 B E I G E N E, L T D

19 ,275 11,982 18,903 6, ,751 9,067 9, ,698 39,846 55,957 55, ,983 77,006 28, ,356 40,578 B E I G E N E, L T D

20 % % B E I G E N E, L T D

21 B E I G E N E, L T D

22 % 6.5% 21 B E I G E N E, L T D

23 % 17.1% B E I G E N E, L T D

24 , B E I G E N E, L T D

25 XV XV 352 (1) 34,110,070 (2) 4.44% 10,000,000 (3) 1.30% 102,188 (4) 0.01% 7,952,787 (5) 1.03% 29,872,444 (6) 3.89% 1,021,880 (7) 0.13% 16,214,750 (8) 2.11% 224,372 (9) 0.03% 5,000,000 (10) 0.65% 657,346 (11) 0.09% Donald W. Glazer 4,528,366 (12) 0.59% 38,160 (13) 0.00% Michael Goller 226,724 (14) 0.03% Ranjeev Krishana 226,724 (15) 0.03% Thomas Malley 1,139,472 (16) 0.15% 63,290 (17) 0.01% 226,724 (18) 0.03% B E I G E N E, L T D

26 (1) 768,463,184 (2) (1) 16,270,707 (2) 16,689,898 (3) 1,149,465 (3) Roth IRA PENSCO (4) The John Oyler Legacy Trust (5) (6) Oyler Investment LLC Oyler Investment LLC 99% (7) The Oyler Family Legacy Trust (8) (1) 7,526,966 (2) 8,286,143 (3) 401,641 (9) (10) Wang Investment LLC Wang Investment LLC 99% (11) (1) 648,056 (2) 9,290 (12) (1)Glazer 4,301,642 (2) Glazer Glazer 217,434 (3)Glazer 9,290 (13) Glazer Glazer (14) (1) Goller Goller 217,434 (2)Goller 9,290 (15) (1) Krishana Krishana 217,434 (2)Krishana 9,290 (16) (1)Malley 390,000 (2) Malley Malley 740,182 (3)Malley 9,290 (17) 63, B E I G E N E, L T D

27 (18) (1) 217,434 (2) 9,290 XV (a) XV (b) 352 (c) B E I G E N E, L T D

28 XV (1) Julian C. Baker (2) 161,880, % Felix J. Baker (2) 161,880, % Baker Bros. Advisors (GP) LLC. (2) 161,745, % Baker Bros. Advisors LP (2) 161,745, % Baker Brothers Life 145,425, % Sciences Capital, L.P. (2) Hillhouse Capital 76,563, % Management Ltd. (3) Gaoling Fund, L.P. (3) 58,995, % Fidelity Management & 76,202, % Research Company (4) FMR Co., Inc. (4) 71,180, % FMR LLC (4) 77,169, % Fidelity Mt. Vernon Street Trust (4) 38,393, % Wellington Management 49,576, % Group LLP (5) 27 B E I G E N E, L T D

29 (1) 768,463,184 (2) Julian C. Baker Felix J. Baker Baker Bros. Advisors (GP) LLC Baker Bros. Advisors (GP) LLC Baker Bros. Advisors LP. Baker Bros. Advisors LP. 667, L.P. Baker Brothers Life Sciences, L.P. Julian C. Baker Felix J. Baker Baker Bros. Advisors (GP) LLC Baker Bros. Advisors L.P. 667, L.P. 16,319,660 Baker Brothers Life Sciences, L.P. 145,425,622 Julian C. Baker Felix J. Baker 92,326 FBB3 LLC 43,069 (3) (i)58,995,800 Gaoling Fund, L.P. (ii)4,121,589 YHG Investment, L.P. (iii)13,445,978 Hillhouse BGN Holdings Limited Hillhouse Capital Management, Ltd. YHG Investment, L.P. Gaoling Fund, L.P. Hillhouse Fund II, L.P. Hillhouse BGN Holdings Limited Hillhouse Capital Management, Ltd. Gaoling Fund, L.P. 58,995,800 YHG Investment, L.P. 4,121,589 Hillhouse BGN Holdings Limited 13,445,978 Hillhouse Fund II, L.P. Hillhouse BGN Holdings Limited 13,445,978 (4) Johnson Abigail P. Johnson FMR LLC B FMR LLC 49Johnson B B B Fidelity Management & Research Company 76,202,408 69,720,508 FMR Co., Inc 12,048,805 71,180,714 Fidelity Management & Research(Hong Kong) Limited 4,694,900 Fidelity Mt. Vernon Street Trust 38,393,094 Fidelity Mt. Vernon Street Trust 274,453 36,118,641 FMR Co., Inc. 71,180,714 FMR Co., Inc. 4,617,100 66,563,614 (5) Wellington Management Group LLP 38,453,845 Wellington Management Company LLP Wellington Management Singapore Pte Ltd Wellington Management Hong Kong Ltd Wellington Management International Ltd Wellington Wellington Investment Advisors Holdings LLP Wellington Management Global Holdings, Ltd. Wellington Wellington Investment Advisors Holdings LLP Wellington Group Holdings LLP Wellington Group Holdings LLP Wellington Management Group LLP Wellington Management Group (LLP) Wellington Investment Advisors Holdings LLP Wellington Management Global Holdings, Ltd. Wellington Group Holdings LLP Wellington 38,453, B E I G E N E, L T D

30 ,550, ,598, Thomas Malley ,235 88, , , , , , , ,900, ,000 4,445, ,630,682 1,413,698 84,055 13,132, ,550,936 1,868,698 84,055 19,598, B E I G E N E, L T D

31 ,251, ,918, B E I G E N E, L T D

32 Donald W. Glazer Michael Goller Ranjeev Krishana Thomas Malley ,047,500 2,047, , , , , ,310,088 1,310, ,613,430 1,613, , , , , , , , , ,442 17, , , ,442 17, , , ,442 17, , , ,442 17, , , ,442 17, ,290 63, , , ,442 17, B E I G E N E, L T D

33 ,752,500 1,752, ,250,000 1,250, , ,208 Amy Peterson ,600,000 1,600, ,016,178 1,016, , , ,367,500 1,367, , , , , , , ,338,152 3,584,835 4,075,046 4,723,951 70,123,990 90,251,295 8,465,886 4,075,046 4,723,951 89,918, % B E I G E N E, L T D

34 ,000, A.2.1 A B E I G E N E, L T D

35 3.21 C.3.3 C.3.7 SEC Thomas Malley Thomas Malley 3.10 (2) B.1.2 Ranjeev Krishana A.5.2 Donald W. Glazer Michael Goller Donald W. Glazer B E I G E N E, L T D

36 B.8 Scott A. Samuels Scott A. Samuels 13.51B(1) 13.51B(1) ,107, B E I G E N E, L T D

37 (i) (ii) (iii) (i) 27 (ii) 27 (iii) 27 B E I G E N E, L T D

38 Thomas Malley Thomas Malley B E I G E N E, L T D

39 , ,672 85,348 (10,806) (273,951) (90,018) (74,075) (19,546) (375) (359,207) (109,564) (273,859) (109,564) 3,444 (1,796) (269,611) (110,922) 12 6,780 (381) (262,831) (111,303) (1,348) (135) BeiGene, Ltd. (261,483) (111,168) BeiGene, Ltd. 19 (0.38) (0.22) ,586, ,054,109 (4.97) (2.80) 52,660,468 39,773,393 B E I G E N E, L T D

40 (262,831) (111,303) 2, ,048 7 (259,478) (110,652) (1,326) (108) BeiGene, Ltd. (258,152) (110,544) 39 B E I G E N E, L T D

41 , , , , , ,171 29, , ,322 10, ,293 35,623 1,516, , ,510 62, ,132 12, ,875 7, ,071 7, ,452 42, , ,982 1,653,856 1,046, ,878 69, ,037 49,598 15,302 12, ,151 9, ,067 9, , ,988 B E I G E N E, L T D

42 ,467 9, , ,271 18,297 24, ,772 31, , , , , ,500,000, ,563, ,072, ,804,942 1,000,747 3,114 (480) (594,929) (330,517) BeiGene, Ltd. 1,213, , ,471 14,422 1,226, ,231 1,653,856 1,046, B E I G E N E, L T D

43 ,072, ,000,747 (480) (330,517) 669,809 14, , (2,929) (2,666) 375 (2,291) ,072, ,000,747 (217) (333,446) 667,143 14, , ,970, , , , ,927 36,037 36,037 36,037 5,792, ,581 10,582 10,582 (261,483) (261,483) (1,348) (262,831) 3,331 3, , ,563, ,804,942 3,114 (594,929) 1,213,197 13,471 1,226, ,833, ,213 (946) (237,412) 352, , ,471 14,527 14,527 13,074 13,074 13,074 2,576, (111,168) (111,168) (135) (111,303) ,902, ,603 (322) (348,580) 255,753 14, ,172 B E I G E N E, L T D

44 (262,831) (111,303) 4,580 1, ,037 13, ,000 4,115 2,232 (8,413) (4,059) (2,336) (3) (3,743) 3,605 4,608 (27,669) (5,036) (3,694) (139) 10,308 13,242 25, (8,005) 2,302 (3,442) (197) 559 (221,638) (87,597) (20,309) (8,881) (12,124) (1,198,922) (27,646) 869, ,900 1 (10,000) (360,220) 113, B E I G E N E, L T D

45 ,001 (414) 15 42,315 2,470 (2,470) 14, ,757 10, , ,600 1, , , ,602 87, , , , ,006 31,591 11, ,006 1,373 2,291 B E I G E N E, L T D

46 Celgene Switzerland LLCCelgene Switzerland ,107, BeiGene (Hong Kong) % Co., Limited % BeiGene AUS PTY LTD % BeiGene % % BeiGene USA, Inc % % * % 45 B E I G E N E, L T D

47 % * % % BeiGene Switzerland GmbH % BeiGene Ireland Limited % * B E I G E N E, L T D

48 K B E I G E N E, L T D

49 EITF SEC ASC S B E I G E N E, L T D

50 1. (i) (ii) (iii) (iv) (v) ,307, B E I G E N E, L T D

51 BeiGene (Hong Kong) Co., Limited 28,588, ,990, ,591, % 4 B E I G E N E, L T D

52 (1) (2) ,307 16,307 42,915 (28,588) 14,327 31,959 (9,990) 21,969 (480) 263 (217) (330,517) 16,307 (19,236) (333,446) 14, , B E I G E N E, L T D

53 ,275, B E I G E N E, L T D

54 B E I G E N E, L T D

55 ,415 17,621 10,172 9, ,423 1,068,619 B E I G E N E, L T D

56 ,327 17,663 18,924 44, , Celgene Switzerland Celgene Switzerland PD-1 tislelizumab (BGB-A317) PD Celgene Switzerland PD-1 A&R PD-1 55 B E I G E N E, L T D

57 3. Celgene Switzerland A R PD-1 263,000,000 92,050, ,950, Celgene Switzerland 12 13,000,000 Celgene Holdings East Corporation A&R PD-1 tislelizumab A&R PD-1 tislelizumab tislelizumab tislelizumab ,730 4,942 30,672 B E I G E N E, L T D

58 3. Celgene Switzerland ,672, ,730,000 16,307, ,442, pamiparib 3 1,500, ,138,000 Celgene Holdings East Corporation Celgene Switzerland ,532,000 23,606, ,000 7,500,000 20,529, B E I G E N E, L T D

59 ,591, , ,415 17, ,621 10,172 10, , , , ,327 17, ,663 18,924 18, , , B E I G E N E, L T D

60 ,171 29,428 33,171 29, ,171 18, ,521 33,171 29, , B E I G E N E, L T D

61 ,322,000 10,930, ,986 15,596 16,272 15,298 15,534 15,737 1,718 1,597 1,260 1,244 1, ,738 26, ,746 76,195 (17,236) (13,627) 90,510 62, ,738,000 26,125, ,633, ,174,000 8,348, ,083,000 1,404,000 B E I G E N E, L T D

62 ,000,000 95% 100,000,000 5% ,000, ,830,000 2,415, ,000, ,000, % 100% 95% ,652, ,000, ,315, % 5% ,279, B E I G E N E, L T D

63 ,422 12,633 (290) (168) 12,132 12, , , , , , , ,016,000 B E I G E N E, L T D

64 ,500 (625) 6,875 7,500 (250) 7,250 7,500 (625) 6,875 7,500 (250) 7,250 ABRAXANE REVLIMID VIDAZA CC , , , , , , ,500, B E I G E N E, L T D

65 ,780,000 (381,000) ,552, , B E I G E N E, L T D

66 ,106 65, ,364 3, , ,878 69, ,723 21,156 14,469 9,894 1,791 1,557 5,310 3,016 63,293 35, B E I G E N E, L T D

67 ,306 12,867 28,588 5,146 1,460 11,452 42, ,201 17,051 41,601 18, ,997 14,548 9,829 75,037 49, ,449 31, ,772 31,959 B E I G E N E, L T D

68 % 18,134, ,134,000 19,585,000 9,067, ,067, ,652, ,000, ,132, ,315, % ,337, , ,067 9,222 9,067 9,222 2,554 39,846 60,534 18, B E I G E N E, L T D

69 ,000, ,000,000 8% ,000,000 8% ,609,000 1,568,000 B E I G E N E, L T D

70 17. ABRAXANE REVLIMID VIDAZA ,155 (479) 54, , (3,789) B E I G E N E, L T D

71 ,806 4,580 1, ,951 90,018 3,870 1, ,406 22,103 36,037 13,074 4,947 1, ,390 36, (3,228) 13 8,226 1, ,051,000 67,545,000 B E I G E N E, L T D

72 BeiGene, Ltd. (261,483) (111,168) 684,586, ,054,109 BeiGene, Ltd. (0.38) (0.22) ,029, ,977, ,465,886 1/13 9,254, ,918,184 10,526, B E I G E N E, L T D

73 ,000, (c)(4) 5635(c)(4) , , ,500, ,774 9,278 13,263 3,796 36,037 13,074 B E I G E N E, L T D

74 ,471, % 1,348, , ,797 (1,348) , B E I G E N E, L T D

75 S ,425,750 96,534, ,050 6,435, ,587,000 A&R PD ,000, Celgene Switzerland 32,746,416 72,000 4(a)(2) D ,640,000 29,920,000 B E I G E N E, L T D

76 ,870,000 1,421, , , , , , ,456 38, ,957, B E I G E N E, L T D

77 25. (a) (b) ,090 1, ,206 4,860 13,336 6, ,176 18,962 10,210 85,348 B E I G E N E, L T D

78 (i)) (ii)) (iii)) (273,951) (14,228) (288,179) (74,075) (8,644) (82,719) (269,611) (22,872) (292,483) 6,780 (6,810) (30) (262,831) (22,872) (6,810) (292,513) BeiGene, Ltd. (261,483) (22,872) (6,810) (291,165) 77 B E I G E N E, L T D

79 (i)) (ii)) (iii)) (90,018) (9,726) (99,744) (19,546) (2,244) (21,790) (110,922) (11,970) (122,892) (381) 2,453 2,072 (111,303) (9,517) (120,820) BeiGene, Ltd. (111,168) (9,517) (120,685) B E I G E N E, L T D

80 (i)) (ii)) (iii)) 16,071 5,184* 8,617* 27,197 (2,675) 1,653,856 5,184* 5,942 1,664,982 1,804,942 22, ,894* (2,675) 2,196,573 46,047* 6,810 10,683* (594,929) (22,872) (307,894)* (6,810) (975,396) (40,825)* (2,066)* 13,471 (38)* 13,433 1,226,668 5,184 5,942 1,237,794 * B E I G E N E, L T D

81 (i)) (ii)) (iii)) (iv)) (v)) 42,915 (26,090) (2,498) 14,327 7,675 5,184 8,617 21,476 1,046,479 5,184 8,617 (26,090) (2,498) 1,031,692 31,959 (9,990) 21, ,248 (9,990) 352,258 1,000,747 46, ,894* 10,683 1,365,371 (480) 263 (217) (330,517) (40,825) (307,894)* (2,066) (26,090) 6,854 (700,538) 14,422 (38) , ,231 5,184 8,617 (26,090) 7, ,434 * B E I G E N E, L T D

82 27. (i) ,228,000 8,644, ,726,000 2,244, ,453, ,047, ,184,000 38, ,825, (ii) 81 B E I G E N E, L T D

83 27. (ii) ,894, ,894,000 (iii) ,617, ,675, ,066, ,810, ,617,000 2,066,000 10,683, B E I G E N E, L T D

84 27. (iv) % 26,090, ,090, (v) 9,990, ,498, , , B E I G E N E, L T D

85 27. (v) (iv) ,990,000 2,498, , , K B E I G E N E, L T D

86 (i) (ii) (iii) 16,307 16,307 42,915 (26,090) (2,498) 14,327 1,046,479 16,307 (26,090) (2,498) 1,034,198 31,959 (9,990) 21, ,248 (9,990) 352,258 (480) 263 (217) (330,517) 16,307 (26,090) 6,854 (333,446) 14, , ,231 16,307 (26,090) 7, ,940 (i) ,307, B E I G E N E, L T D

87 28. (ii) % 26,090, (iii) ,990, ,498, , , B E I G E N E, L T D

88 % 5% B E I G E N E, L T D

89 BeiGene, Ltd zanubrutinib (BGB-3111) tislelizumab (BGB-A317) PD-1 pamiparib (BGB-290) PARP1 PARP B E I G E N E, L T D

90 GEM % 89 B E I G E N E, L T D

91 BRAF B-raf BTK BTK BCR NSCLC PARP ADP DNA DNA PD-1 1 T pro-b PD-L1 PD-L2 PD-1 T RAF RAF BRAF-BRAF BRAF-CRAF CRAF-CRAF T T T B TIM-3 T 3 Th1 WM B E I G E N E, L T D

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