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防疫學苑系列 006 實驗室生物安全管理法規及行政指導彙編 Laboratory Biosafety Management: A Compilation of Regulations and Administrative Guidance 衛生福利部疾病管制署編衛生福利部疾病管制署出版 2014 年 4 月 ii

2003 年 12 Severe Acute Respiratory Syndrome, SARS 狀陸連 SARS World Health Organization, WHO 2005 年 58 World Health Assembly, WHA 6 行漏年 WHO 例 International Health Regulations, IHR 列 8 力福利參 WHO CDC NIH 見理 2005 年 9 料理 2014 年 3 料理料理理料理立料理 e e-learning 理 H7N9 流狀 2005 年 SARS 4 年 2010 年 i

5 年落年力不論料行理料理理理利了理勞福利年來行理福利識 2014 年 4 ii

錄 1 3 3 料理 4 福利料理 6 Q&A6 參理 10 10 10 11 13 Q&A13 料理 15 料 15 16 類 17 料 17 料 21 六料異 22 料 23 Q&A23 理 27 27 28 iii

29 BSL-3/ABSL-3 30 理 33 六 Q&A35 陸理 41 41 練 42 e e-learning42 欄 42 Q&A43 理 45 料 45 流 46 Q&A46 50 NDM-1 50 暴露 51 理狀 Middle East Respiratory Syndrome Coronavirus;MERS-CoV..55 理 H7N9 流類...65 理 70 1~ 2973 拾錄錄 1~ 錄 2203 iv

173 2 料理 95 3 福利料理 101 4 流 127 5 料 128 6 料 129 7()130 8 料 131 9 理 132 10 料臨 138 11 料理 146 12 BSL-2 例 147 13 BSL-3 例 166 14 183 15 立流 185 16 流 186 17 理流 187 18 188 19 189 20 練 195 v

21 e e-learning199 22 欄 201 vi

錄錄 1 例 203 錄 2 理料漏 223 vii

2003 年 2 6 Severe Acute Respiratory Syndrom SARS 年 12 不不 SARS SARS SARS 2013 年 7 行 2003 年 12 行立 Biosafety Level 3 BSL-3 2004 年 1 World Health Organization, WHO 3 來了 2004 年 2005 年度 Centers for Disease Control and Prevention, CDC 立 National Institute of Infectious Diseases, NIID BSL-3 理理度參 1

2005 年 58 World Health Assembly, WHA 理零率流理落力流 8 略行理 2005 年 9 料理理落料理理料理理立料 BSL-3 料理異 2006 年 3 行理 2006 年 3 歷 8 年 2

理理不不 2014 年 3 料理理便立精神理行利理更類料理見 1 料理見 2 料理理行 4 4 料 34 3

1 料度立理度 2 料料不 3 1 料理行 64 1 5 34 2 9 45 理 69 1 1 2 34 3 料理 1 15 令行理福利理理料理 4

料理料理 2005 年 9 26 2006 年理行 4 4 料 34 理便理料理料理理六理練理立理 5

福利料理料理 3 5 10 14 料料福利料理見 3 福利料理 Q&A Q1 A1 理參 1. 理料理理參 ( > > > > 料理 ) 2. 參 ( > > > ) 參 2013 年理理 - NDM-1 暴露 () 6

Q2 A2 理狀 Middle East Respiratory Syndrome Coronavirus; MERS-CoV () 理 H7N9 流類 2013-2014 理料漏料理理 SARS 領年來立理度理 ( 類勞理 ) 力料理立理來利行理立理參行來 7

參 Q3 A3 1. 行 HEPA PAO 漏度率 0.01% HEPA 漏 0.01%? 2. 錄 2 率濾 High Efficiency Particulate Air filter, HEPA 濾濾濾流量 0.3μm 粒 DOP 粒率 99.97 PAO <0.03% HEPA 濾? 3. BSL-2 Class IIA2 A1 行 HEPA 濾漏 2 數 0.01%( 0.01%) 0.03% 漏不 HEPA 濾 0.3μm 粒 DOP 粒率 99.97 4. PAO 漏 >0.01% HEPA 更行 >0.03%() 5. HEPA 更? 例 3 年 5 年 PAO 更 1. 1.0 粒 PAO 行濾漏粒度度 0.01% 濾漏不不行 8

Q3 A3 2. 率濾 High Efficiency Particulate Air filter, HEPA 濾率濾粒 0.3μm 粒率 99.97% 不 HEPA 濾漏率 HEPA 濾漏 HEPA 濾異 HEPA 濾漏行漏濾不良 HEPA 濾漏漏不行 3. HEPA 漏不行 4. HEPA 濾率不 HEPA 濾漏率數不 HEPA 濾漏粒度度 0.01% 漏 5. HEPA 濾更不年 HEPA 濾漏更 HEPA 濾年不年行 ( ) liposome () 不行不行? ( 行 ) 9

理 02-2737-7541 Q4 A4 RG2? 行流理參理料行料 RG1 BSL-1/ABSL-1 理理 PI 行理 RG2 理數 5 數 5 10

理理理識參識 16 3 年 1 行異理理行更理流見 4 流 11

1. 1 5 料理 2. 理 5 復 3. 復 5 理 https://biobank.cdc.gov.tw 4. 3 5. 7 行料料料料類數量異異異 1 行料更行不行理 12

理更見理六年理練料理理 Q&A Q1 A1 什不料理 6 13

Q2 A2 Q3 A3 數 5 () 立理理數 5 行理 () 數 1. 料料料年理練理料理 2. 數數 3 異行 1. 立料行理參理行理 14

Q4 A4 Q5 A5 Q6 A6 2. 理 https://biobank.cdc.gov.tw 行理異異行更行理異率年利理利 3 料理行 A RG2 B BSL-2 行行? RG2 料 A 行 B BSL-2 B 料理料 4 4 料 15

料列類例離例泌例例類例類不例尿不療 Risk Group 1 RG1 Risk Group 4 RG4 RG1 類見 3 16

RG1 RG2 類療見 3 RG2 RG3 類療見 3 RG3 RG4 類療見 3 RG4 類泌列類量見 3 類量料料 3 類料 17

行離料料料行料行理便精神料理 RG1 例行理 RG2 1. 行 2. 行行 3. 行 18

數量 3 理行數量 4. 數量理料更料料參理說 RG3 料 1. 理行行 2. 料料理行行 3. 19

料 3 料 (1) (2) (3) 不 4. 理行 (1) 3 料 (2) 3 料 (3) 3 料 5. 3 6. 理 3 20

料行 7. 行 3 料行料 8. 理見理參理說料料理 6 料理 7 理流料料理理料料 8 料理 21

療料料類六類六料異 RG2 理列理錄料理 9 理理 3 RG2 數量行不異立 RG3 異 24 7 異 3 22

料料漏 3 六料行參 10 料臨理料理 http://www.caa.gov.tw/big5/content/index.asp?sno=542 料立立參 11 料理 Q&A Q1 A1 什料料料類度 Risk Group, RG RG1 RG4 1. RG1 類 2. RG2 類 23

Q2 A2 Q3 A3 Q4 A4 療 3. RG3 類療 4. RG4 類療料泌料不料料料度料參理理理錄度行料異 RG2 料 ( ) 行 RG3 料 RG3 料料異行參例 ( > > > > 料理 24

Q5 A5 Q6 A6 Q7 )( ) 理 https://biobank.cdc.gov.tw 理理流參 (>> > 料理 >) 參料 RG 行行 BSL-2 行 RG 例不 BSL-1 行料量度行 WHO 漏 95 kpa 力裡參聯 Requirements for the construction and testing of packagings, intermediate bulk containers (IBCs), large packagings, portable tanks, multiple-element gas containers (MEGCs) and bulk containers >> >> 理 RG3 RG3 25

料? RG3 ( HIV ) RG3 料? A7 TB 例行 BSL-2 行 TB TB BSL-3 行理 RG3 不 RG3 料 RG3 不 RG3 Q8 料 ()( 林 ) 練類料? A8 料理不列理 Q9 理? A9 料 1. 類 2. 類來 3. 4. 行 Q10 料? 冷切林不度精行料異理? 26

A10 Q11 A11 便不列料? 4 料料不理理度例例福林不理 () 行 IVD (1)DIAGNOSTIC KIT FOR IgM ANTIBODY TO HEPATITIS E VIRUS (ELISA )(2)Hepatitis B virus surface antigen ELISA 論 TFDA 理料 Biosafety level 1 BSL-1 Biosafety level 4 BSL-4 行類例 27

Animal biosafety level 1 ABSL-1Animal biosafety level 4 ABSL-4 BSL-1 BSL-4 見 3 1 ABSL-1 ABSL-3 1 BSL-1 不料 BSL-2 暴露類料 BSL-3 暴露類料 BSL-4 類療料 ABSL-1 ABSL-4 行 BSL ABSL 28

行 RG BSL/ABSL 行量 BSL/ABSL 行不行 / BSL-1 RG1 理行落料理 BSL-2 RG2 年行行落料理 BSL-3 RG3 年行年不類 ( 例 TB 29

RG3 料 ) 不例理理 12BSL-2 例 13BSL-3 例理年度落料理見 14 BSL-3/ABSL-3 類 BSL-3/ABSL-3 BSL-3 ABSL-3 不流立 BSL-3/ ABSL-3 15 立流理 1. 流類 BSL-3/ABSL-3 30

2. BSL-3/ABSL-3 https://biobank.cdc.gov.tw 1 2 3 BSL-3/ABSL-3 行 3. 理 2 年 BSL-3/ABSL-3 16 流理 1. 年度例行狀流理 2. 更更 3. 異 (1) 更 31

(2) 不狀行例不良行 4. 5. 1 年 6. 年度行立 BSL-3/ABSL-3 1. 兩年領 7 6 2. BSL-3/ABSL-3 參 3. 行料見 3 32

1 行理數 4. 參 5. 行離 6. 論識理料漏度度度度度料漏度料漏度料漏 33

說理 3 說理理流 17 理流 18 料理異年理練練行參 19 理理療 34

六理年理練六 Q&A Q1 A1 Q2 A2 Q3 A3 行 (BSL-3) RG3 料例 TB TB 理 BSL-2 BSL-3? BSL-2 BSL-3 BSL-3 BSL-3 流參 ( >> > > 料理 >) 參行行 PCR 料 BSL-2 HIV RG3 行行 BSL-2 理 35

Q4 A4 Q5 A5 Q6 A6 Q7 TB PCR TB PCR TB BSL-3 行料 BSL-1 行 PCR 例便不不不兩不異例行理理年度 >>>> 參行行參? BSL-2 行理 aerosol 行臨 NALC-NaOH TB 16S rrna PCR BSL-3 行? 36

A7 Q8 A8 Q9 A9 Q10 臨 NALC-NaOH 不 BSL-1 行 BSL-2 行行例行狀? 若異狀 1~2 例行流? 1 行例行 Check List( BSL-1~BSL-3) TB? BSL-1~BSL-3 Check List 參 2004 年 Laboratory Biosafety ManualThird Edition 8 >> >> 參 99 年度 3-1 >>>> BSL-3 BSL-3 參 >> >> BSL-2 37

? A10 BSL-2 參 ()Basic laboratoriesbiosafety Levels 1 and 2 CDC () IV Laboratory Biosafety Level Criteria () Q11 BSL-2? A11 3 療理理理 Q12 BSL-2 BSL-2 兩 BSC BSL-2? A12 1. BSL-2 參 >>> > BSL-2 2. BSL-2 BSL-2 良理 BSC BSL-2 38

Q13 A13 Q14 A14 Q15 A15 Q16 A16 行 RNA? Tuberculosis Mycobacterium tuberculosis 淋量行 RNA BSL-2 行良 RNA 不 BSL-1 行? 金 TAF 了 () 離 BSL-3? BSL-3 理行理不理行 BSL-2, 了療類 ()? 量 / 列療? BSL-2 39

Q17 A17 Q18 A18 Q19 A19 類理例 BSL-2? BSL-2 離 // 參 1.0 21 24 60 例例行 BSL-3 理年度? BSL-3 年行行行 BSL-3 年不 BSL-3? BSL-3 不 BSL-3 行 RG3 BSL-3 40

Q20 A20 理 H7N9 流類臨行 H7N9 流流行理 H7N9 流類 H7N9 流類行臨 /() BSL-2 流類 BSC 行 BSC ( 例 N95 ) 陸理益 BSL-2 理立狀異狀異例 TB X 參狀益留 BSL-2 留離 10 年量不留益 RG2 41

練練降 8 年 4 BSL-3/ABSL-3 練 15 見 20 練練行理參練領 e e-learning 利行列數數 http://e-learning.cdc.gov.tw/index.jsp 21 數欄歷年理練參理 2011 年 7 2013 年 2 42

欄列念理讀歷年見 22 欄 Q&A Q1 A1 練 1. 年不 BSL-2 BSL-3 練 2. 99 年陸列數類讀讀 () () 論練 () ( 識 ) Biosafety in Microbiological Laboratory( ) 43

Q2 A2 Q3 A3 Q4 料理 (1) 料理 (2) (1) (2) 良理流數 ( http://e-learning.cdc.gov.tw/index.jsp) 年行數練 BSL-3 練 15 BSL-2 8 年 4 料理料練年練兩年?? 料練年行練年 4 練年 1 年料 44

A4 練數? 練理練數練理料理狀理行料更料理理料復 1 料料異異異 1 理行異更 RG3 料 45

1 理行數量 RG2 料 / RG2 料 / 理行數量流理說料更說 (>> >> 料理 > ) 行 Q&A Q1 A1 Q2 A2 Q3 料理行 BSL-2 RG2 料料行更異行異異理行料更行 PCR HIV 異理? 46

A3 PCR HIV 不料理 Q4 理 : BSL-2 ()? ( 見? 料?) A4 2 料 2 料理料 Q5 理 : 更?? 什? A5 1. 料料 2. 料更 3. 料 Q6 理料 : 1. 料數量數? 2. 來料了料異?? 47

A6 Q7 A7 Q8? 3. ( 料没料料??? 1. RG3 狀數數量 2. RG3 行料料行 3. RG3 料 1 料 ( 異數量 ) 理? 理 1. 理料料料 2. 料料料 3. 理理料留臨留來 ( 48

A8 ) 力留來 Escherichia coli. 金綠料錄理錄理 1. 理料理列行 Escherichia coli. 金綠料列料行 2. vei@cdc.gov.tw 行行來 49

NDM-1 2013/07/23 NDM-1 ( 例 Escherichia coliklebsiella pneumoniae Klebsiella oxytoca 料 ) 行列 1. 行 2. 3. 理離 4. aerosol 度量行 5. 利 6. 行 7. 參 (Transportation of Dangerous Goods Act and Regulations) 理 50

暴露 2013/07/23 罹見不料 78 年 75 年數粒不狀行暴露粒行行行暴露暴露 1. 行離 2. 行離 5 1.5 3. 行暴露 51

暴露行暴露暴露數狀暴露 1. Doxycycline 100mg Rifampin 600mg 連 21 2. Doxycycline trimethoprimsulfamethoxazole 3. 4. 暴露暴露 baseline serum sample 若暴露 live attenuated vaccine RB51 strain 19 REV-1 B. abortus RB51 不 baseline serum sample 刺 Doxycycline 100 mgbid21 Trimethoprim-sulfamethoxazole 160 / 800 mg 療 21 4 年狀 Rifampin Rifampin 療暴露 246 24 行暴露 RB51 參 52

暴露暴露狀狀暴露暴露 4 狀暴露 6 狀不不不易怒便臨暴露不狀療臨 Biosafety in Microbiological and Biomedical Laboratories (BMBL), 5th edition. 行 primary barriersaerosols 行離 secondary barriers 行理量六離蘭蘭異離行 BSL-3 行 53

行暴露 BSL3 行暴露若 BSL3 暴露理 BSL2 行參 1. Centers for Disease Control and Prevention. Biosafety in Microbiological and Biomedical Laboratories (BMBL). 5th ed., 2009;22-59. 2. Centers for Disease Control and Prevention. Brucellosis. Available at: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/brucellosis_g.htm 54

理狀 Middle East Respiratory Syndrome Coronavirus;MERS-CoV 2013/07/23 理狀離參 2012 年 WHOLaboratory biorisk management for laboratories handling human specimens suspected or confirmed to contain novel coronavirus 2012 Interim recommendations2013 年 CDCInterim Guidelines for Collection, Processing and Transport of Clinical Specimens from Patients Under Investigation for Novel Coronavirus 量量參狀類狀類狀類狀 SARS 異狀列 Risk group 3, RG3 異料理理流行狀 ( http://www.cdc.gov.tw/professional/themanet.aspx?treeid=beac9c1 03df952c4&nowtreeid=73DCE9AAB0D28B06&did=720) 更 55

理理 Biorisk Management System Risk Assessment Biological Agents and Toxin Inventory and Information General Safety Personnel and Competency 1. 2. ( ) 3. 練 (1) 理 (2) (3) 例 (4) 例理 4. 例 5. 更流流例 6. 良來例 WHO 1. 理 2. 療狀 3. 異狀列理量 4. 例 1. 理更 2. 3. 易識 1. 良理 2. 行例 1. 練 SOP 2. 練 56

良 Good Microbiological Technique PPE Human Factors Health Care Emergency Response and Contingency Planning / 異 Accident / Incident Investigation 理 Facility Physical Requirements Equipment and Maintenance / 臨 3. 理練力 () 理料 1. 行例離 / 理 2. 更 SOP 1. PPE 行練福利力 2. 良 3. 狀狀流 1. 2. 練理 3. 立狀立理 1. 2. 量 3. 不 1. 異流 1. 1. BSCs 2. 零 1. 料 57

Decontamination, Disinfection and Sterilization Transport Procedures Security 2. 料 1. 2. 3. 4. 立 1. 狀例行 PCR 來狀臨行 PCR BSL-2 1. BSL-2 行 (1) 臨 (2) 理粒 / 不 BSL-2 理理不 (3) 行 2. 理良 GMT 58

(1) 理 (2) (3) 量 (4) 料料例離烈料力 BSCs 行 II BSCs 料 (5) 了行量不刺理 (6) (7) 利行 (8) 來理 59

行 (9) 理料離 (10) 離 PP 3. 流 BSCs 行 PPE 理 ( 例離 ) 離狀臨離 BSL-3 行 1. 流流 2. 不若 HEPA 濾離 HEPA 濾 3. BSCs 行 60

4. 行 5. BSL-3 6. 連度例 FFP2 NIOSH N95 更 ) 暴露 7. 8. 離離 BSC 行 9. 料裂例料 BSC 行 BSC 行離來 / 力行 61

行降 1. 不狀行 2. 行 3. 行狀 ABSL-3 行 1. 離狀臨行 2. 來 / 狀行流 1. 精類說行 2. 行行 62

六刺理 1. 狀若狀立 2. 暴露狀異立 / 行若暴露狀類行狀狀理 WHO 2013-2014 年陸參 1. Laboratory biorisk management for laboratories handling human specimens suspected or confirmed to contain novel coronavirus 2012 Interim recommendations. Available at 63

http://www.who.int/csr/disease/coronavirus_infections/novelcoro navirus2012_interimrecommendationslaboratorybiorisk/en/index.html. 2. WHO biosafety guidelines for handling of SARS specimens. Available at http://oba.od.nih.gov/oba/rac/sssept04/pdf/who%20biosafety%2 0guidelines%20for%20handling%20of%20SARS%20specimens.p df 3. Infection control advice- suspected or confirmed novel coronavirus cases: Version 1.1 September 25 2012, HPA. Available at http://www.hpa.org.uk/webc/hpawebfile/hpaweb_c/1317136232 722 4. Interim Laboratory Biosafety Guidelines for Handling and Processing Specimens Associated with Novel Coronavirus. Available at; http://www.cdc.gov/coronavirus/ncv/downloads/interim-ncv-lab -Biosafety-Guidelines.pdf 5. Interim Guidelines for Collection, Processing and Transport of Clinical Specimens from Patients Under Investigation for Novel Coronavirus. Available at; http://www.cdc.gov/coronavirus/ncv/downloads/interim-guideline s-ncv-collection-processing-transport.pdf 6. Guidance on regulations for the Transport of Infectious Substances 2013 2014. Available at; http://apps.who.int/iris/bitstream/10665/78075/1/who_hse_gcr _2012.12_eng.pdf 64

理 H7N9 流類 2013/07/23 理 H7N9 流 H7N9 流 candidate vaccine virus 列 Risk group 3, RG3H7N9 流列 Risk group 2, RG2 異料理理來類類不行理類類臨 / 1. BSL-2 行 65

2. 例 Biological Safety Cabine BSC 行 3. 暴露 N95 4. 理不 5. 良力 6. 漏 7. 離離 8. H7N9 流 9. 漏離 66

BSL-3 行 H7N9 流 BSL-3 行 H7N9 流 BSL-2 Enhanced 行參 H7N9 流類 H7N9 流理 H7N9 流 WHO 2013-2014 年 A 類理降 1 1% NaClO sodium hypochlorite 30 行 67

行陸 BSL-2 參 http://www.cdc.gov.tw/ 理參料 1. 5 http://www.cdc.gov.tw/professional/list.aspx?treeid=4c19a0252bb EF869&nowtreeid=6C7C52E7A7D5621A 2. WHO. Recommendations and laboratory procedures for detection of avian influenza A(H5N1) virus in specimens from suspected human cases. Available at: http://apps.who.int/csr/disease/avian_influenza/guidelines/labtests/e n/index.html 3. WHO. Laboratory Biosafety Manual 3 rd. Available at: http://www.who.int/csr/resources/publications/biosafety/who_cds _CSR_LYO_2004_11/en/ 4. Interim Guidance for Laboratory Testing of Persons with Suspected Infection with Highly Pathogenic Avian Influenza A (H5N1) Virus in the United States. Available at: http://www.cdc.gov/flu/avianflu/guidance-labtesting.htm 5. Public Health Agency of Canada.INFLUENZA A VIRUS SUBTYPES H5, H7 AND H9 PATHOGEN SAFETY DATA SHEET INFECTIOUS SUBSTANCES. Available at: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/influenza-grippe-aeng.php Public Health Agency of Canada. Joint Biosafety Advisory - Influenza A(H7N9) virus. Available at: http://www.phac-aspc.gc.ca/lab-bio/res/advi-avis/ah7n9-eng.php 68

7. WHO. Guidance on regulations for the Transport of Infectious Substances 2013 2014. Available at: http://apps.who.int/iris/bitstream/10665/78075/1/who_hse_gcr_ 2012.12_eng.pdf 8. WHO. Real-time RT-PCR Protocol for the Detection of Avian Influenza A(H7N9) Virus. Available at: http://www.who.int/influenza/gisrs_laboratory/cnic_realtime_rt_pcr _protocol_a_h7n9.pdf 9. WHO. Vaccine response to the avian influenza A(H7N9) outbreak - step 1: development and distribution of candidate vaccine viruses. Available at: http://afludiary.blogspot.tw/2013/05/who-h7n9-candidate-vaccine-vi ruses.html 10. WHO. WHO biosafety risk assessment and guidelines for the production and quality control of human influenza pandemic vaccine. Available at: http://www.who.int/biologicals/publications/trs/areas/vaccines/influe nza/annex%205%20human%20pandemic%20influenza.pdf 69

理 2013/12/31 理兩例例 aerosolized virus 年來 / 咽尿切理參暴露列 2 RG2 1. 臨 2. BSL-2 行 Biological Safety Cabine BSC 行不 BSC 行例切刺 70

陸 3. 例切行離行流行 4. 行度量行理 WHO 2013-2014 年 A 類理降 1 1% NaClO sodium hypochlorite 30 行行 BSL-2 參 http://www.cdc.gov.tw/ 理參料 71

1. 5 Available at: http://www.cdc.gov.tw/professional/list.aspx?treeid=4c19a0252bb EF869&nowtreeid=6C7C52E7A7D5621A 2. Public Health Agency of Canada.Rabies virus Pathogen Safety Data Sheet-infectious substances. Available at: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/rab-eng.php 3. Centers for Disease Control and Prevention and National Institutes of Health. Biosafety in Microbiological and Biomedical Laboratories, Fifth Edition 2009,220-221 4. WHO.WHO Expert Consultation on Rabies.Second report Available at: http://apps.who.int/iris/bitstream/10665/85346/1/9789241209823_en g.pdf 72

1 年六年令年令年六令例年六令年令年令年六令六年六令年令年六令六六六六行列率率度度類類類類 73

類行類流行立行列類行 102 年 6 7 類類 H5N1 流類類類類流行痢痢亂羅流行 () 流行淋類 (Hansen s disease) B 螺類 Q 流賈裂拉拉狀 H7N9 流流行例數 74

療料泌行流行理練行立金行理流六行諸行流行理練離 75

行理理理行理六理理離聯六陸陸來理 76

勞勞理令理流行流行類類流行利流行流行立不利益更立更歷料不漏離療益不不錄錄不不不 77

立療若療離療不若度療療療療行理六流行立行諸行理流行理行立流行流行理行量流行度 78

行立流行行流行練流行理療練療度理行行良行便流行切飼殺殺 79

殺理行理立理不行理六流流行立流行金理金來列益福利金不金 80

益列年列錄錄露金金理錄行練理行不行錄行行療療行不年不行年金金金 81

類金行療錄旅療行行不療行行類理行不料度立理度料料不料理行 82

六療行列數離六不行流行立理理不行里立行 83

例類類類類類說不良錄歷療料不流行料不不料不令行理里里列旅館理 84

理類理六旅行領來行不類離療行離療類類離療行離療類類行離療離療離療離療行離療列離療行離療離療不離不療 85

理離療療療離療離療離療離療離療離療六行列練不類類力不 86

行行理留令行離行留行行不理不流行行理不理不利益行理類類殮 87

行理理流行立流行流行立立療立離離離行流行立療理行流行立行不易 88

數六流行立不理理不理行理流行立行列行行離療理六 89

立理行不行列行理理不理行金行六行列行不旅令旅不旅不令不 90

六六流行立行年年金六罹類類類不行年金六流行不流行金六列料六列 91

六六六六列行六度理理行留令療行令六六行六年 92

六列令料理六令六行列令六療六六列 93

六流行立列行勵勵行類女行列理理理理行行六行行 94

2 料理料類金惡類療類類療拉類療亂神類量料 95

六理理識識六年異理六年理 96

練料理理理數量不異立異異料漏度度度度度料漏度料漏度料漏說 97

理料漏立理理療六理年理練理列理錄行料料料令 98

料行料料理料漏立立行行令六立料行識理聯理理立狀異 99

離年年參練理六行 100

3 福利料理料理料料類類例離例泌例泌例尿料療 Risk Group 1 RG1Risk Group 4RG4 料類料六行漏六料 Biosafety level 1BSL-1Biosafety level 4BSL-4 () (BSL-1) 不類料 (BSL-2) 暴露類料 101

(BSL-3) 暴露類料 (BSL-4) 類療料料漏度度度度例理 102

RG1 2 1 P620 P650 1 Actinoalloteichus spp. v 2 Actinosynnema mirum v 3 Adeno associated virus (Type 1, 2, v 3, 4) 4 Aeromicrobium spp. v 5 Alicyclobacillus spp. v 6 Alishewanella spp. v 7 Aneurinibacillus spp. v 8 Aquabacterium commune v 9 Aquabacterium citratiphilum v 10 Aquabacterium parvum v 11 Aquaspirillum itersonii v 12 Aquifex aeolicus v 13 Aquifex pyrophilus v 14 Arthrobacter globiformis v 15 Azomonas macrocytogenes v 16 Bacillus choshinensis v 17 Bacillus coagulans v 18 Bacillus cohnii v 19 Bacillus formosus v 20 Bacillus parabrevis v 21 Bacillus pumilus v 22 Bacillus reuszeri v 23 Bacillus thermocloacae v 24 Blastomonas spp. v 25 Brachybacterium spp. v 26 Brochothrix spp. v 27 Brevibacillus spp. v 28 Brevibacterium spp. v 29 Brevundimonas vesicularis v 30 Buttiauxella agrestis v 31 Butyrivibrio crossotus v 32 Carnobacterium pisciola v 33 Carnobacterium divergens v 34 Caulobacter spp. v 35 Cellulomonas cellulans v 36 Clostridium butyricum v 說 103

2 1 P620 P650 37 Clostridium tetanomorphum v 38 Collinsella intestinalis v 39 Collinsella spp. v 40 Collinsella stercoris v 41 Comomonas acidovorans v 42 Corynebacterium accolens v 43 Corynebacterium afermentans v 44 Corynebacterium argentoratense v 45 Corynebacterium genitalium v 46 Corynebacterium macginleyi v 47 Corynebacterium v tuberculostearicum 48 Deinococcus spp. v 49 Delftia spp. v 50 Dermacoccus nishinomiyaensis v 51 Desemzia spp. v 52 Dietzia spp. v 53 Dysgonomonas spp. v 54 Escherichia blattae v 55 Escherichia coli K 12 K12 v 56 Exiguobacterium spp. v 57 Fibrobacter spp. v 58 Filifactor spp. v 59 Finegoldia spp. v 60 Flavobacterium capsulatum v 61 Flavobacterium psychrophilum v 62 Fusobacterium prausnitzii v 63 Glycomyces tenuis v 64 Gracilibacillus spp. v 65 Granulicatella spp. v 66 Halobacterium salinarium v 67 Helicobacter hepaticus v 68 Helicobacter muridarum v 69 Holdemania spp. v 70 Intrasporangium calvum v 71 Klebsiella terrigena v 72 Kocuria spp. v 73 Kocuria rosea v 說 104

2 1 P620 P650 74 Kurthia gibsonii v 75 Kytococcus spp. v 76 Lactobacillus casei v 77 Lactobacillus delbrueckii v 78 Lactobacillus fermentum v 79 Lactobacillus leichmannii v 80 Lactobacillus oris v 81 Lactobacillus plantarum v 82 Lactobacillus vaginalis v 83 Lactococcus garvieae v 84 Lactococcus lacti v 85 Lautropia spp. v 86 Lechevaliera spp. v 87 Lentzia spp. v 88 Leuconostoc spp. v 89 Listeria innocua v 90 Listeria welshimeri v 91 Luteococcus spp. v 92 Macrococcus spp. v 93 Maricaulis spp. v 94 Megamonas spp. v 95 Methylobacterium amnivorans v 96 Methylobacterium mesophilicum v 97 Micrococcus diversus v 98 Micrococcus luteus v 99 Micrococcus roseus v 100 Micromonas spp. v 101 Micromonospora coerulea v 102 Mycoplasma orale v 103 Nesterenkonia spp. v 104 Obesumbacterium proteus v 105 Oerskovia spp. v 106 Oligella ureolytica v 107 Paracoccus spp. v 108 Planobispora rosea v 109 Pichia haplophila v 110 Porphyromonas endodontalis v 111 Porphyromonas gulae v 112 Pragia fontium v 說 105

2 1 P620 P650 113 Propioniferax spp. v 114 Proteus myxofaciens v 115 Rhodospirillum rubrum v 116 Rickenella spp. v 117 Ruminococcus spp. v 118 Ruminococcus productus v 119 Saccharomyces carlsbergensis v 120 Saccharomyces pastorianus v 121 Saccharothrix longispora v 122 Saccharothrix mutabilis v 123 Sanguibacter spp. v 124 Schineria spp. v 125 Schizosaccharomyces v 126 Sebaldella spp. v 127 Shewanella putrefaciens v 128 Slackia spp. v 129 Solobacterium spp. v 130 Sporosarcina ureae v 131 Staphylococcus carnosus v 132 Staphylococcus lentus v 133 Staphylococcus pulvereri v 134 Stomatococcus spp. v 135 Streptomyces albus v 136 Streptomyces corchorusii v 137 Streptomyces olivaceoviridis v 138 Streptosporangium roseum v 139 Tetragenococcus halophilus v 140 Terracoccus spp. v 141 Thermoanaerobacterium spp. v 142 Thermosaccharolyticum spp. v 143 Thermotoga maritima v 144 Thermus spp. v 145 Tissaracoccus spp. v 146 Turicella otitidis v 147 Vagococcus fluvialis v 148 Vagococcus salmoninarum v 149 Xenorhabdus nematophilus v 150 Yersinia ruckeri v 151 Zoogloea ramigera v 說 106

2 1 P620 P650 152 Zygosaccharomyces bailii v 153 Zygosaccharomyces rouxii v 1. 2. P620 P650 六說 107

RG2 2 1 P620 P650 1 Acidovorax spp. v v 2 Acinetobacter baumannii v 3 Actinobacillus spp. v v 4 Actinobacillus parasuis v v 5 Actinomyces pyogenes v v 6 Adenovirus v 7 Aeromonas hydrophila v 8 Akabanevirus v v 9 Amycolata autotrophica v 10 Ancylostoma ceylanicum v 11 Ancylostoma duodenale v 12 Arcanobacterium haemolyticum v 13 Arizona hinshawii v 14 Ascaris spp. v 15 Ascaris lumbricoides v 16 Ascaris suum v 17 Babesia divergens v v 18 Babesia microti v 19 Bacillus cereus v 20 Bartonella bigemina v 21 Bartonella bovis v v 22 Bartonella henselae v 23 Bartonella quintana v 24 Bartonella vinsonii v 25 Bebaru virus v v 26 Blastomyces dermatitidis v 27 Bocavirus v v 28 Bordetella spp. v 29 Bordetella bronchiseptica v v 30 Bordetella parapertussis v 31 Bordetella pertussis v 32 Borrelia burgdorferi v 說 Acinetobacter calcoaceticus Corynebacterium pyogenes Corynebacterium haemolyticum 108

2 1 P620 P650 33 Borrelia recurrentis v 34 Burgia spp. v 35 Brugia Malayi v 36 Brugia timori v 37 Buffalopox virus v v 38 Bunyamwera virus v 39 Burkholderia spp. v v 40 Cache Valley virus v v 41 Calicivirus v v 42 California encephalitis virus v 43 Campylobacter coli v v 44 Campylobacter fetus v v 45 Campylobacter jejuni v v 46 Candida albicans v v 47 Cellulomonas hominis v 48 Chlamydophila pneumoniae v 49 Chlamydophila psittaci v v 50 Chlamydophila trachomatis v 51 Cladosporium bantianum v 52 Cladosporium carrionii v 53 Cladosporium trichoides v 54 Clostridium botulinum v v( v ) 55 Clostridium chauvoei v v 56 Clostridium haemolyticum v v 57 Clostridium histolyticum v 58 Clostridium novyi v v 59 Clostridium septicum v v 60 Clostridium tetani v v 61 Clostridium tertium v 62 Coccidia spp. v 63 Colorado tick fever virus v v 64 Coltivirus v v 65 Coronavirus v v 說 Burkholderia mallei Burkholderia pseudomallei RG3 avian strains RG3 SARS Coronavirus RG3 109

2 1 P620 P650 說 66 Corynebacterium auris v 67 Corynebacterium diphtheriae v 68 Corynebacterium propinquum v 69 Corynebacterium v v pseudotuberculosis 70 Corynebacterium pseudodiphtheriticum v 71 Corynebacterium renale v v 72 Corynebacterium urealyticum v 73 Cowpox virus v v 74 Coxsackie virus v v 75 Curtobacterium flaccumfaciens v 76 Cryptococcus neoformans v 77 Cryptococcus grubii v 78 Cryptococcus gatti v 79 Cryptosporidium spp. v v 80 Cryptosporidium parvum v v 81 Cysticercus cellulosae v v 82 Cytomegalovirus v CMV 83 Dactylaria gallopava v 84 Dengue virus (serotypes 1, 2, 3, v( v 4) ) 85 Dermatophilus congolensis v v 86 Echinococcus granulosis v v 87 Echinococcus multilocularis v v 88 Echinococcus vogeli v v 89 Echo virus v v 90 Edwardsiella tarda v v 91 Elephantpox virus v v 92 Empedobacter brevis v 93 Entamoeba histolytica v v 94 Enterobius spp. v 95 Enterococcus spp. v 96 Enterococcus avium v 97 Enterococcus dispar v 98 Enterococcus durans v 99 Enterococcus faecalis v 100 Enterococcus faecium v 101 Enterococcus flavescens v 110

2 1 P620 P650 說 102 Enterococcus hirae v 103 Enterococcus raffinosus v 104 Enterovirus v v 105 Epidermophyton floccosum v 106 Epstein Barr virus v EBV 107 Erysipelothrix rhusiopathiae v v 108 Escherichia coli v v( E.coli ) v K1 109 Epidermophyton v 110 Exophiala dermatitidis v 111 Fasciola spp. v 112 Fasciola gigantica v 113 Fasciola hepatica v 114 Fonsecaea pedrosoi v 115 Giardia spp. v 116 Giardia lamblia v 117 Haemophilus ducreyi v 118 Haemophilus infuenzae v 119 Hazara virus v 120 Helicobacter pylori v 121 Hepatitis A virus v 122 Hepatitis B virus B v( ) v 123 Hepatitis C virus v 124 Hepatitis D virus v 125 Hepatitis E virus v 126 Herpes simplex viruses (Type 1, v 1 2 2) 127 Herpesvirus v v Herpesvirus simiae RG4 128 Herpesvirus zoster v 129 Heterophyes spp. v 130 Human B lymphotropic virus v 131 Human herpesvirus (Type 6, 7) v 132 Human metapneumovirus v 133 Human rhinovirus v 111

2 1 P620 P650 134 Hymenolepis spp. v 135 Hymenolepis diminuta v 136 Hymenolepis nana v v( 137 Influenza virus (Type A, B, C) v 類流 v ) 138 Isospora spp. v v 139 Japanese encephalitis virus v v( v ) 140 Klebsiella spp. v 141 Legionella spp. v 142 Legionella pneumophila v 143 Legionella anisa v 144 Legionella birminghamensis v 145 Legionella bozemanii v 146 Legionella cincinnatiensis v 147 Legionella feeleii v 148 Legionella hackeliae v 149 Legionella jordanis v 150 Legionella lansingensis v 151 Legionella longbeachae v 152 Legionella parisiensis v 153 Legionella sainthelensi v 154 Legionella tucsonensis v 155 Legionella wadsworthii v 156 Leishmania spp. v 157 Leishmania braziliensis v v 158 Leishmania donovani v v 159 Leishmania ethiopia v v 160 Leishmania major v v 161 Leishmania Mexicana v v 162 Leishmania peruvania v v 163 Leishmania tropica v v 164 Leptospira interrogans (all v v serotypes) 165 Listeria ivanovii v 說 H1N1 H5N2H6N1 H5N1 H7N9 RG3 Klebsiella terrigena RG1 112

2 1 P620 P650 166 Listeria monocytogenes v v 167 Loa Loa v 168 Lymphocytic choriomeningitis v v virus (non neurotropic strains) 169 Mannheimia spp. v 170 Mannheimia glucosidal v 171 Mannheimia granulomatis v 172 Mannheimia haemolytica v 173 Mannheimia ruminalis v 174 Mannheimia varigena v 175 Measles virus v 176 Microsporum spp. v 177 Milker's node virus v 178 Moraxella spp. v 179 Mumps virus v Murine leukemia virus ( 180 amphotropic strain v xenotropic strain) 181 Mycobacterium spp. v 182 Mycobacterium avium complex v v 183 Mycobacterium asiaticum v v 184 Mycobacterium bovis BCG vaccine strain v v 185 Mycobacterium chelonae v v 186 Mycobacterium fortuitum v v 187 Mycobacterium kansasii v 188 Mycobacterium leprae v 189 Mycobacterium malmoense v 190 Mycobacterium marinum v v 191 Mycobacterium v paratuberculosis 192 Mycobacterium scrofulaceum v 193 Mycobacterium simiae v v 194 Mycobacterium szulgai v 195 Mycobacterium ulcerans v v 196 Mycobacterium xenopi v v 說 M. tuberculosis complex M. tuberculosism. bovis RG3 113

2 1 P620 P650 197 Mycoplasma spp. v v 198 Naegleria fowleri v 199 Necator spp. v 200 Necator americanus v 201 Neisseria gonorrhoeae v 202 Neisseria meningitidis v 203 Newcastle disease virus v v 204 Nocardia asteroides v v 205 Nocardia brasiliensis v v 206 Nocardia otitidiscaviarum v v 207 Nocardia transvalensis v 208 Norovirus v 209 Onchocerca spp. v 210 Onchocerca volvulus v 211 O'Nyong Nyong virus v 212 Orbivirus v v 213 Orf virus v v 214 Paenibacillus popilliae v 215 Papillomavirus v 216 Paracoccidioides brasiliensis v 217 Parainfluenza virus (Type 1, 2, 3, 4) v v 218 Human Parvovirus (B19) v 219 Pasteurella spp. v v 220 Penicillium marneffei v 221 Plasmodium cynomologi v 222 Plasmodium falciparum 惡 v v 223 Plasmodium knowlesi v 224 Plasmodium malariae v 225 Plasmodium ovale v 226 Plasmodium vivax v 227 Poliovirus (attenuated strain) v 說 Mycoplasma mycoides Mycoplasma agalactiae Pasteurella multocida B RG3 114

2 1 P620 P650 說 228 Porphyromonas asaccharolytica v 229 Porphyromonas gingivalis v 230 Prospect Hill virus v 231 Prevotella spp. v 232 Pseudomonas aeruginosa v v 233 Pseudomonas alcaligenes v 234 Rabbitpox virus v v 235 Rabies virus (all strain) v v( ) v 236 Respiratory syncytial virus v RSV 237 Rhinovirus v v 238 Rhodococcus equi v v 239 Rift Valley Fever/ Zinga virus v v vaccine strain MP 12 240 Ross river virus v 241 Rotavirus v v 242 Rubella virus v 243 Rubivirus v 244 Salmonella spp. v 245 Salmonella arizonae v v 246 Salmonella cholerasuis v v 247 Salmonella enteritidis v 248 Salmonella gallinarum pullorum v v 249 Salmonella meleagridis v v 250 Salmonella paratyphi (Type A, B, C) v 251 Salmonella typhi v 252 Salmonella typhimurium v v 253 Sandfly fever virus v 254 Sarcocystis spp. v 255 Sarcocystis suihominis v v 256 Schistosoma spp. v 257 Schistosoma haematobium v 258 Schistosoma intercalatum v 259 Schistosoma japonicum v 260 Schistosoma mansoni v 261 Schistosoma mekongi v 262 Shigella boydii v 263 Shigella dysenteriae v( Type v 115

2 1 P620 P650 1 ) 264 Shigella flexneri v 265 Shigella sonnei v 266 Sindbis virus v 267 Sphaerophorus necrophorus v 268 Sphingomonas yanoikuyae v 269 Sporothrix schenckii v 270 Staphylococcus aureus 金 v 271 Staphylococcus caprae v 272 Streptobacillus moniliformis v 273 Streptococcus spp. v 274 Streptococcus acidominimus v 275 Streptococcus agalactiae v v 276 Streptococcus anginosus v 277 Streptococcus bovis v v 278 Streptococcus canis v v 279 Streptococcus constellatus v 280 Streptococcus difficilis v v 281 Streptococcus dysgalactiae v v 282 Streptococcus equinus v 283 Streptococcus equi v v 284 Streptococcus gallolyticus v 285 Streptococcus iniae v v 286 Streptococcus intermedius v 287 Streptococcus mitis v 288 Streptococcus mutans v 289 Streptococcus oralis v 290 Streptococcus parasanguinis v v 291 Streptococcus phocae v 292 Streptococcus pneumoniae v 293 Streptococcus porcinus v v 294 Streptococcus pyogenes v 295 Streptococcus salivarius v 296 Streptococcus sanguinis v 297 Streptococcus sobrinus v 298 Streptococcus somaliensis v 299 Streptococcus suis v v 說 116

2 1 P620 P650 300 Streptococcus uberis v 301 Strongyloides spp. v 302 Strongyloides stercoralis v v 303 Tacaribe virus complex v 304 Tatlockia maceachernii v 305 Tatlockia micdadei v 306 Tick borne orthomyxovirus v 307 Toscana virus v 308 Toxocara spp. v v 309 Toxocara canis v v 310 Toxoplasma spp. v v 311 Toxoplasma gondii v v 312 Treponema carateum v v 313 Treponema pallidum v v 314 Trichinella spiralis v v 315 Trichophyton spp. v v 316 Trypanosoma spp. v v 317 Trypanosoma brucei brucei v v 318 Trypanosoma brucei gambiense v v 319 Trypanosoma brucei v v rhodesiense 320 Trypanosoma cruzi v v 321 Vaccinia virus v v 322 Varicella zoster virus v Venezuelan equine 323 encephalomyelitis virus vaccine v strain TC 83 Vesicular stomatitis virus ( 324 VSV Indiana, v San Juan, Glasgow) 325 Vibrio alginolyticus v v 326 Vibrio cholera v 327 Vibrio cincinnatiensis v 328 Vibrio fluvialis v 329 Vibrio furnissii v 330 Vibrio hollisae v 331 Vibrio mimicus v 332 Vibrio parahaemolyticus v v 333 Vibrio vulnificus v 說 117

2 1 P620 P650 334 Wuchereria bancrofti filaria v worms 335 Yabapox virus (Tana and Yaba) v v 336 Yellow fever virus vaccine strain v 17D 337 Yersinia enterocolitica v 338 Yersinia pseudotuberculosis v v 說 1. 2. P620 P650 六 118

RG3 2 1 P620 P650 說 1 Bacillus anthracis v v() v 2 Bovine spongiform encephalopathy (prion) v v BSE v( B. 3 Brucella spp. v melitensis v ) 4 Brucella abortus v v() v 5 Brucella canis v v 6 Brucella suis v v() v 7 Burkholderia mallei v 8 Burkholderia pseudomallei v v() v() 9 Chlamydophia psittaci (avian strains) v v() v 10 Chikungunya virus v 11 Coccidioides immitis v() v v v Pseudomonas mallei Pseudomonas pseudomallei 12 Coxiella burnetii v v() v 13 Creutzfeldt Jacob disease (prion) v CJD 14 Eastern equine encephalomyelitis virus v v() v EEEV 15 Everglade virus v 16 Fatal Familial Insomnia (prion) v FFI 17 Flexal virus v 18 Francisella tularensis v v() v 19 Gerstmann Straussler Scheinker syndrome (prion) v 20 Hanta virus v v( v ) 21 Hantaan virus v v Korean haemorrhagic fever 22 Histoplasma capsulatum v v 23 Histoplasma duboisii v 119

24 25 Human Immunodeficiency virus (Type 1, 2) 類 Human T cell lymphotropic viruses (Type 1, 2) 26 Influenza A virus (H5N1, H7N9) v 2 1 P620 P650 說 v() v HIV v( 類流 ) v v HTLV 27 Kuru (Prion) v 28 Louping ill virus v v 29 Lymphocytic choriomeningitis virus (neurotropic strains) v v LCMV 30 Mayaro virus v 31 Monkeypox virus v v 32 Mopeia virus v 33 Mucambo virus v v 34 Murray Valley encephalitis v 35 Mycobacterium bovis v v BCG vaccine strain RG2 36 Mycobacterium tuberculosis v v() v 37 Mycobacterium tuberculosis complex v v() v 38 Nairobi Sheep Disease v v 39 Ndumu virus v 40 Oropouche virus v 41 Pasteurella multocida (Type B "buffalo") v v 42 Poliovirus (wild strain) v() v 43 Powassan virus v 44 Puumala virus v 45 Rickettsia akari v 46 Rickettsia australis v 47 Rickettsia Canada v 48 Rickettsia conorii v 49 Rickettsia prowazakii v() v 50 Rickettsia rickettsii v v() v 51 Rickettsia siberica v 52 Rickettsia tsutsugamushi v Orientia sutsugamushi 120

2 1 P620 P650 說 53 Rickettsia typhi (R. mooseri) v v 54 Rift Valley fever/ Zinga virus v v() v RG2 55 Rocio virus v 56 SARS coronavirus v SARS CoV 57 Semliki forest virus v 58 Seoul virus v v 59 Simian immunodeficiency virus v v SIV 60 St. Louis encephalitis virus v v 61 Tonate virus v 62 Variant Creutzfeldt Jacob disease (Prion) v v vcjd 63 Venezuelan equine encephalomyelitis virus v v() v 64 Vesicular stomatitis virus v v VSV IndianaSan JuanGlasgow RG2 65 Wesselsbron virus v 66 West Nile virus v v() v 67 Western equine encephalomyelitis virus v v 68 Yellow fever virus (wild strain) v v() v 69 Yersinia pestis v v() v 1. 2. P620 P650 六 121

RG4 2 1 P620 P650 說 1 Absettarov 3 v() v 2 Central European encephalitis 3 v() v 3 Crimean Congo hemorrhagic fever virus v v 4 Ebola virus 拉 v v 5 Guanarito virus v v 6 Hanzalova 3 v() v 7 Hendra virus (Equine morbillivirus) v v Herpesvirus simiae (Herpes B or Monkey v() 8 v B virus) v 9 Hypr virus 3 v() v 10 Junin virus v v 11 Kumlinge virus 3 v 12 Kyasanur forest disease virus 3 v 13 Lassa virus v v 14 Machupo virus v v 15 Marburg virus v v 16 Nipah virus v v 17 Omsk hemorrhagic fever 3 v 18 Russian spring summer encephalitis 3 v() v 19 Sabia virus v 20 Tick bome encephalitis virus complex v() 21 Variola (major and minor) virus v 22 Whitepox (Variola) v 1. 2. P620 P650 六 3. Tick borne encephalitis virus complex 122

類量 1. Cholera toxin 亂類量 1. Botulinum neurotoxins 神 0.5mg 2. Clostridium perfringens toxins 2. Diacetoxyscirpenol 1000mg 3. Corynebacterium diphtheriae toxin 3. Staphylococcal enterotoxins(subtypesab CD E) 4. Pertussis toxin 4. T-2 toxin 1000mg 5. Shiga toxinshiga-like toxins 6. Staphylococcus aureus toxins 7. Tetanus toxin 8. Verotoxin 5mg 123

六料錄 50 ml 不聯漏漏漏漏漏漏料落落刺度力例例漏例漏漏錄說例行 124

BSL-1 BSL-2 BSL-3 BSL-4 1. 不 2. BSL-1 1. BSL-1 1. 理 2. 行 3. 2. 4. BSL-2 1. BSL-2 1. 行 1. 理 2. 行 2. 2. 3. 行 3. 不 4. 5. 流 6. 7. BSL-3 BSL-3 1. 更 III 1. 離 II 連立 2. 淋 2. 3. 125

說理度度度說例理 1. 1. 1. 立料留逸理錄 2. 2. 立 2. 行不不狀不行療 3. 3. 理 4. 理 1. 立 1. 1. 料留異理錄 2. 2. 料逸行狀 2. 料行不療 3. 3. 3. 料不落理來 1. 留料理錄 2. 離離裂 126

4 流料理料復復行理理行料料料料類數量異異行料更 127

5 料年類療理立年類料聯 E-mail 聯數量 BSL-2 BSL-3 BSL-4 ABSL-2 ABSL-3 ABSL-4 1. 列 2. 1~3 3. 128

6 料 103.3.20 類說類 1 4 例不例 HIV 不論例類來例類類泌例類例不論例泌例尿類來 ( 不論 ) 例類 1. 2. 料 3. 說料 4. 2 1. 2. 料 3. 4. 數量 1. 2. 料 3. 說料 4. 料 1. 2. 料 3. 說料 1. 2. 料 3. 不說料 1. 1 4 見福利料理 2. 列料見福利料理 1 料料 2 理 2 立 3 料料行列 129

7 () 2013.7.23 來料理列數量例料理量量量行列列錄狀數量年度理更量療福利理 4 列量量 Botulinum neurotoxins 0.5 mg Diacetoxyscirpenol 1000 mg Staphylococcal enterotoxins 5 mg T-2 toxin 1000 mg 130

8 料 131

9 理 2013.7.23 1 2001 年 (laboratory biosecurity)who 2004 年行 Laboratorybiosafety manual 3 了 2006 年 Laboratorybiosecurity guidance 理 biorisk management 念料料料濫料利料理 9 2 料理列料理落理料 2 料理料料行理 2 料料度料度 1 料理行 2.1 2 料 132

2.1.1 料 2.1.2 立例 2.2 3 料 2.2.1 () 理理 2.2.2 理料錄利 2.3 度 4 料 2.3.1 () 度理理 2.3.2 理料錄利列 1 料 2 立立例識 3 度立不 4 度 5 24 6 錄料 3 理 133

3.1 識識識料 3.2 識識 3.3 度 Bacillus anthracisbrucella abortus Brucella melitensisbrucella suisburkholderia malleiburkholderia pseudomalleicoxiella burnetiieastern equine encephalomyelitis EEE virusfrancisella tularensismonkeypox virus1918 pandemic influenza virusrickettsia prowazekiirickettsia rickettsii Rift Valley Fever virusvenezuelan equine encephalomyelitis virus Yersinia pestis select agent 行理狀 3.4 離識 3.5 不論離不錄 4 理 4.1 不度 4.2 參理理 5 5.1 狀錄 5.2 5.3 134

5.4 行例料 5.5 練 ( 例療 ) 參 6 練識 6.1 理練 6.1.1 了料 6.1.2 行 6.1.3 6.1.4 6.2 年練 7 料 7.1 料 7.1.1 立度錄料列料理 7.1.2 錄 7.1.3 錄錄 7.1.4 料識落錄 7.1.5 料理 7.1.6 錄易識錄 135

7.1.7 料識 7.1.8 異狀立 7.2 7.2.1 立度錄料列料理 7.2.2 錄 7.2.3 理 7.3 料異料理理 8 行 ( 例 ) 3 料 8.1 料 8.1.1 例不料例不料 8.1.2 理 8.1.3 料料 136

8.2 8.2.1 料例列 8.2.2 料 9 料 9.1 9.1.1 4 料 9.1.2 3.3 4 料度度 9.2 9.2.1 料 CNS 6864 Z5071 參 WHO2013-2014 年 (Guidance on regulations for the Transport of Infectious Substances 20132014)International Air Transport AssociationIATADangerous Good Regulations 理 9.2.2 3 料理異 9.2.3 料理 137

10 料臨 2.13.8.19 料臨 2013-2014 年類 A 類類類暴露類料列 1. Bacillus anthracis (cultures only) 2. Brucella abortus (cultures only) 3. Brucella melitensis (cultures only) 4. Brucella suis (cultures only) 5. Burkholderia mallei Pseudomonas mallei glanders (cultures only) 6. Burkholderia pseudomallei Pseudomonas pseudomallei (cultures only) 7. Chlamydia psittaci avian strains (cultures only) 8. Clostridium botulinum (cultures only) 9. Coccidioides immitis (cultures only) 10. Coxiella burnetii (cultures only) 11. Crimean-Congo haemorrhagic fever virus 12. Dengue virus (cultures only) 13. Eastern equine encephalitis virus (cultures only) 14. Escherichia coli, verotoxigenic (cultures only) 15. Ebola virus 16. Flexal virus 17. Francisella tularensis (cultures only) 138

18. Guanarito virus 19. Hantaan virus 20. Hantaviruses causing haemorrhagic fever with renal syndrome 21. Hendra virus 22. Hepatitis B virus (cultures only) 23. Herpes B virus (cultures only) 24. Human immunodeficiency virus (cultures only) 25. Highly pathogenic avian influenza virus (cultures only) 26. Japanese encephalitis virus (cultures only) 27. Junin virus 28. Kyasanur forest disease virus 29. Lassa virus 30. Machupo virus 31. Marburg virus 32. Monkeypox virus 33. Mycobacterium tuberculosis (cultures only) 34. Nipah virus 35. Omsk haemorrhagic fever virus 36. Poliovirus (cultures only) 37. Rabies virus (cultures only) 38. Rickettsia prowazekii (cultures only) 39. Rickettsia rickettsii (cultures only) 40. Rift Valley fever virus (cultures only) 41. Russian spring-summer encephalitis virus (cultures only) 42. Sabia virus 43. Shigella dysenteriae type 1 (cultures only) 44. Tick-borne encephalitis virus (cultures only) 45. Variola virus 46. Venezuelan equine encephalitis virus (cultures only) 47. West Nile virus (cultures only) 48. Yellow fever virus (cultures only) 139

49. Yersinia pestis (cultures only) B 類 A 類料 (exemptions 類不類類料臨 1. 不 2. 不類 3. 便 4. 5. 類例糖列尿類例療精切類錄 A 類 P620 (Packing Instruction P620) 行 1. (1) () 漏 (2) 漏 (3) 度 2. (1) (2) () 95 kpa -40 55 不漏 (3) 9 m 落 7 kg 刺度 95 kpa 力 140

3. (1) (2) 見不列列 i. () ii. ( 度 ) iii. () iv. 聯列不列 ( 例 UN 2814 類 ) v. 列度 vi. 若列冷聯 vii. 聯 (3) i. 量 50 ml 兩 ii. (Hazard labels) 45 度 ( 菱 ) 類 (4) 量 i. 50 ml 50 g ii. 4 L 4 Kg (5) 錄 i. 141

(i) 若 (ii) 數量了 (iii) ii. (6) 例錄 50 ml 不聯 B 類 P650 (Packing Instruction P650) 行 1. (1) () 漏 (2) 漏 2. (1) (2) 不漏 95 kpa 力 () (3) 1.2 落 (drop test) 3. (1) () 142

(2) () (3) 聯 UN3373 (4) 量不 1 L 若不 4 L 量不來 (5) 列 i. ii. 度 iii. iv. 菱列例 B 類 v. 度列 vi. 若 () vii 若 (6) 錄 i. (i) 數量 143

( 若 (ii) ii. (7) 例漏錄漏 1. (1) 漏 (primary receptacle) (2) 漏 (secondary packaging) (3) 度量量 (outer packaging) 不 100mm 100mm 2. (1) 若料量若漏不不料 (2) 若數易來 3. (1) () (2) () (3) 類 144

(4) 例料臨理 145

11 料理料理參料理理理行量 5 % 30 易理刺行六漏理參 Guidance on regulations for the transport of infectious substances 2009-2010, Geneva, World Health Organization, 2009: p19-20. 146

12 BSL-2 例 2012.6.27 說料 RG2 7 15 1 說量 A~E 度若不 Not Applicable, NA A B C D E D C E C 說數識料不說識 1 落理 1.1 立 1 立 2 A B 1. 立不隸 3 2. B C 1. 3 2. 行 3. 料理 1. 料數立 2. 立行 3. 立隸立 4. B-3 度理料行 147

說識料 4 C 1. 立理 2. 數列 (1) 料異理 (2) 料 (3) 練 (4) (5) 理 (6) D C E C 料 7 A B 4 數 B C 148

說識料理料 C 1. 理理 2. D C E C 1.2 行立 A B 1. 理率 90%3 2. 理理良 3. 臨率錄錄列臨 5 B C 1. 年度 2 4 2. 錄錄論 3. 1. 數率理年 7 24 年歷錄利 2. 若錄理行 3. 數 8 率數 8 數數 3 C2 B1 A 數 4. 例行 3 149

說識理率 75%3 C 1. 行理 2. 年行錄錄 12 3. 行列行理 D C E C 5. 說 A-3 例行臨錄錄錄論若年臨說 A B 1. 理理良 2. 臨率錄錄列臨 5 B C 1. 年度 2 4 2. 錄錄 150

說識論 C 1. 行 2. 行錄錄 12 3. 行列行理 D C E C 1.3 理落行行 A B 5 1. 不行令理錄 2. 不 B C 5 1. 行理 2. 落行理良 C 1. 理不 2. 理列行 3. 理臨料例 4. C-2 度理落行 151

說識 1. 理列 1 (1) 錄 (2) 2 5. 度行行理 (3) 行料理異理 (4) 理 (5) 3 2. 理行 4 D C E C 2 2.1 A B 1. 行料料 PSDS5 1. 度 2. 理 152

說識 2. 聯聯例聯 B C 1. 錄 4 2. 理流讀理行 1 C 1. 2. 1 (1) (2) 識 (3) 理聯聯 2 3. 理料 3 D C E C 2.2 A B 流 4 聯聯聯 3. C-3 度 4. 行 5. 料 Pathogen Safety Data Sheet, PSDS 參 1. C-1 度 153

說識 B C 1. 2 2. 3 C 1. 易漏滑 1 2. C-2 C-4 度不行 3. 1 4. BSC 流 2. 2 3. 2 4. 2 D C E C 2.3 A B 1. 列 1. Class 2. 1 留 30 35 行 5 3. 留 5 6 B C 1. BSC 行列 NA 立行 2. C-2 度流行 3. 年不 15 4. B-1 154

說識行 4 2. C 1. BSC 2. 流不流 BSC 落 5. 量 BSC 留 6. SOP 2 3. 年 3 4. D C E C 2.4 A B 1. 力離 5 B C 1. 2. 淋流力 2. C-3 3. 不行 4. B-2 流力不 155

說識 4 3. C 1. 1 2. 3. 易 2 4. 3 5. D C E C 3 理 3.1 A B 料理刺 B C 1. 1 2. 5. 力離 1. 不 C-2B-1 (1) C-2BSC 年度行不 (2) B-1 例行 BSC 離不 2. 156

說識 2 C 1. 料 2. 行年度行錄 1 D C E C 3.2 A B 1. 理 autoclave 行流料讀錄錄 2. 立 3 B C 1. 不易漏行不 1. 洞量不 2. 理理流 3. 理 C-3B-3 A-2 (1) C C-3 (2) B 理行 157

說識 2. (3) A 理行流不漏 3. 理 3 C 1. 類量 1 2. 類類 3. 行漏 3 4. 5. 理 2 D C E C 4 料理 158

說識 4.1 料理料落料 1 A B 1. 年例行理行 1 料 2. 不行料理 B C 1. 年例行理年行 1 料 2. 料更理 3 C 1. 料行理料理立理度錄料 2. 料理 3. 料理料數量異錄 1. 料 (1) 4 料 (2) 行料 2. 料料 3 料理 3. B-2 度理料行料 7 159

說識 4. 料 2 5. 年料理 1 料錄 6. 列 D C E C 4.2 料理 A B 錄歷料漏 1 B C 料理理 C 1. 料行 2. 料不易裂漏 WHO 1. 2. C-3 律不 160

說識 1 3. 料錄 2 D C E C 5 理練 5.1 行料良行理 A B B C 1. 料 2. 不流 C 1. 料 1 2. 離例 3. 露 1. C-1 度料行 2. 料理 8 2 理立狀異 161

說識料離 4. 5. 料留行 6. 料理異理錄 2 D C E C 5.2 練 A B 1. 年理 4 練良錄 2 2. 理練 B C 1. 讀錄行 2. 1. C-3 不 2. 數 B-2 不理 A-1 理 162

說識料 2 2 C 1. 練練練數練行 2. 練 3. 1 D C E C 6 6.1 理 A B 理 B C 1. 理 2. 錄 C 1. 料 163

說識 2. 年料理錄 3. 行列 D C E C 7 7.1 落行行 A B 1. 行 2. 年理 1 練練錄練行行 3. 行 B C 練年理 1 練 C 1. 料理 164

說識 6 2. 3. 理流 D C E C 165

13 BSL-3 例 2013.5.7 說行 7 17 說量 A ENA 度 C 度度 BA C 數量 D1 E2 D E 不 NA Not Applicable 說數識欄索六料年度 101 年行行料 containment area 說識 1 落理 1.1 立 A. B 1. 參 6 2. 5 B. C 1. 3 5. 理 6. 說 C 2 度料行料 7 7. 說 B 1 166

說識 2. 行 4 C. 1. 2. 立料更理 12 D. C E. C 理參 8. 說 B 2 行例行料理 3 不 9. 說 A 2 (1) (2) 理 C 2 (3) 度 10. 說 A 1 參例 1.2 錄行 A. B 行數良 2 B. C 6. 說 B 率 (1) 數數 100% (2) 167

說識率 80%1 C. 4. 5. 年 1 錄 6. 行理 C D C 1 1.3 A. B 2 1. 良 2. 不行令理類錄異 B. C 1. 理 2. 不令 C. 1. 理 (3) 列利 7. 說 A 例行臨錄若年度臨立臨度 1. 說 C 1 不 (1) 異料 (2) 練 (3) 理 laboratory associated infections; LAIs 例勞料 (4) (5) 理 (6) 料 (7) 168

說識 1 2. 理 1 3. 留錄漏 D. C (8) 料理 2. 說 A 度行 E. C 1.4 理 A. B B. C 錄 2 C. 1. 1 2. 1. 說 C 1 理流行行料年理 1 行 D. C E. C 2. 說 B (1) 理 (2) (3) 理力 (4) (5) (6) 料理 (7) 理 (8) 2 169

說識 2.1 理 A. B 利路度 12 B. C 連更 1 C. 1. 識行 2. 路 anteroom interlock 1. 說 BA 度行 2. 說 A 例樓度樓便理 3. 說 A B 量益降率年年度參狀 3. 狀良裂洞露路 D. C E. C 2.2 A. B 行料 B. C 1. 錄 4 2. 見理 1. 說 C 2(4) 度 2 聯 2. 說 C 2(5) 識說說 C 2(5) 理例流流 170

說識 C. 1. 24 理 2. (1) Biosafety Level (2) 識 (3) 3. 說 C 2(6) 度料量不列列列利 4. 說 B 1 度行不行 (4) 理聯聯例聯 1 (5) 理 2 (6) 行類 3 D. C E. C 2.3 理行 A. B 1. 2. 15 離 B. C 理量 C. 1. 1. 說 C 1 2. 不說 C 2 度 3. 說 C 4 率數率 12 力不 171

說識路 1 2. 流 2 3. HEPA 濾 HEPA 濾度 15 不 4. 料率 ACH 12 3 5. 立切 HEPA 濾 6. HEPA 濾留漏量利行 7. 更 HEPA 濾更 HEPA 濾 4 8. 異異理立 D. C E. C 4. 說 C 7 HEPA 濾異更行 HEPA 濾年不年 172

說識 2.4 度力行 A. B 行行 2 B. C 力力利 C. 1. 24 流 1 2. 不異 3. 力 1. 說 C 1 流流流流易流留 2. 說 A 2 參 3.1.17p29 30 3. 說 C 4 識說力零力力利識 4. 25 Pa 度不立零 3 D. C E. C 2.5 A. B 立路不路路 B. C 留利 2 C. 1. 說 C 1 類 A2B1 B2 A2 canopy hood 2. 說 B 30 35 173

說識 1. Class 行行 1 2. 流不流 3. 量 4. 5. 年行 D. C E. C 2.6 行 A. B 1. 度數利錄 2. B. C 1. 度 4 2. 料 C. 1. 列 (1) 1. 說 C 1 (1) 2. 說 C 1(3) 識說說 C 1(3) 淋 3. 說 C 1 (6) 力離 4. 說 B 1 度 174

說識 1 (2) (3) 流力不行 2 (4) (5) (6) 不聯 3 2. 易 3. 4. 不輪離離老 5. 6. D. C E. C 3 理 3.1 A. B B. C 1. 不易 1. 說 C 2 (1) 175

說識理量 2. 錄 C. 1. 行 2. 行年度 1 3. 濾濾 (2) 塞漏 2. 說 C 3 量不 3. 說 C 6 不 4. 說 C 7 例簾行量 2 4. 5. 年度行 6. 行 3 7. 不易 4 D. C E. C 4 料理 176

說識 4.1 理料落 A. B 不行料理 B. C 料數量更理 4 C. 1. 料異理理落行 2. 理料錄料異 3. 料立行 1 4. 料 2 5. 料錄 3 6. 異料理 D. C C 1. 說 C 3 理數量異錄 2. 說 C 4 料料 3 料理不料 3. 說 C 5 律不 4. 說 B 理料行料 7 177

說識 4.2 料 A. B 料行理練 B. C 料料理 13 異料異料理 C. 1. 料落行 2. 料不易裂漏 WHO 3. 料理行 2 D. C E. C 5 勵 5.1 A. B 3 1. 說 C 3 練 1. 理練良 2. 不行令練年度參 101 年料練 178

說識良 B. C 1. 練 2. 2. 說 B 2 數 C 3 數 3. 說 A 度行年數練年 4 年 8 2 C. 1. 練練數練率理 2. 年 1 練 3. 料練數 1 D. C E. C 6 6.1 A. B B. C 179

說識 C. 1. 2. 不 N95 D. C E. C 6.2 立理 A. B 理料立理良 B. C 療 C. 1. 理 2. 料年理 3. 料留 180

說識理 D. C E. C 7 7.1 理 A. B 1. 理 2. 行理練 B. C 1. 理 2. 立 C. 1. 1 2. 理 3. 理練 2 1. 說 C 1 不列 (1) 聯 (2) (3) 理理流 (4) 理 (5) 療 (6) (7) (8) 復 2. 說 B 2 練不理練 181

說識 4. 年理 2 練 1 練 D. C E. C 182

14 2013.9.26 料理 11 1 2 1 理福利 BSL3 率年理 BSL-3 兩行年理 BSL-3 102 年行 103 年行 104 年行類年行 BSL-3 年年理理年度理行理六年 BSL3 不列年度年行列復復理 183

狀 69 1 1 料理 11 1 年度 BSL3 184

15 立流 185

16 流 186

17 理流 187

立理留錄度度度行行狀行療理立狀行療 24 理理 18 188

聯年數年理年 (02)23919524cdcbiosafe@cdc.gov.tw 19 年 189

2012.10.25 料料例立理暴露理離暴露療六暴露療暴露臨理流行復理度度例例行臨流行 190

列暴露行療離六暴露列例理理刺療療錄療立離暴露立行粒降例 1 例 24 行 191

裂立裂理理裂行理理列離離離裂離行離裂裂離離例 30 降離離裂立離例 30 兩行理裂行離離 192

離離度兩理理六離離裂離行離離行立參狀行練漏聯 1. 聯不 2. 193

3. 4. 行 5. 6. 療療 7. 8. 療 9. 10. 列 1. 2. 狀 1. 連 2. full-face respirator 粒濾 3. 4. 5. 例螺 194

6. 195

20 練 2014.03.27 料理 19 3 參練 BSL 3 13 15 練行數列數 1 1 2 料理 1 3 理 1 4 1 5 2 6 1 7 理 2 8 1 9 良 1 10 1 11 1 12 1 13 練 1 BSL 3 196

練數參數參數數數流 BSL 3 練練數練更 197

數 103.03.27 更利行列數數 http://e learning.cdc.gov.tw/index.jsp 數列數 1 2 3 4 5 料理理論 1 料理論 * 理 * 1 理流 1 料理 1 料理 2 2 類讀 2 1 1 1 1 1 1 198

數 6 7 8 9 10 11 12 13 理良練 1 2 讀 2 1 1 2 良 Biosafety in Microbiological Laboratory 1 1 1 練 1 識 1 1 1 1 1 * 103 年 3 11 料理行行 199

21 e e-learning 1. 類讀 2. 3. 4. 5. 率讀 6. 率. 7. () 8. () 9. (1) 10. (2) 良 11. 12. 料理 (1) 13. 料理 (2) 14. 練 () 15. ( 識 ) 16. 論 17. Biosafety in Microbiological Laboratory( 200

) 18. 19. 理流 20. 21. 22. 23. 201

22 欄年數 2011 7 27-13 論 2011 7 27-13 理 2011 7 27-14 力異理 2011 7 27-14 略 2011 8 27-15 行 2011 8 27-15 2011 8 27-16 料 2011 8 27-16 2011 9 27-17 2011 9 27-17 2011 9 27-18 料理論 2011 9 27-18 理 2011 10 27-19 2011 10 27-19 見 2011 10 27-20 立流 2011 10 27-20 2011 11 27-21 料 2011 11 27-21 理度 BATA 令 2011 11 27-22 料 2011 11 27-22 料理 2011 12 27-23 理度落 2011 12 27-23 2011 12 27-24 理 2011 12 27-24 陸度 2012 1 28-1 2012 1 28-1 省 2012 1 28-2 料 2012 1 28-2 料理 2012 2 28-3 理 2012 2 28-3 臨 2012 2 28-4 2012 2 28-4 2012 3 28-5 202

年數 2012 3 28-5 理 2012 3 28-6 2012 3 28-6 IFBA 2012 4 28-7 臨 2012 4 28-7 量 2012 4 28-8 2012 4 28-8 理 2012 5 28-9 參 54 年 2012 5 28-9 2012 5 28-10 2012 5 28-10 2012 6 28-12 療 2012 7 28-14 落練練 2012 8 28-16 省 2012 9 28-18 BSL-3 見 2012 10 28-20 (1) 2012 11 28-22 (2) 2012 12 28-24 立 (3) 2013 1 29-2 MMWR- 2013 2 29-4 203

錄 1 例料參例立理連落降理立聯料類理理理行行列更練理 204

立路樓路理立漏露理立理聯更理理練理理理理理年落 205

理理理理行行行行行行行行年易行列行理聯行更理類數量更行不行 206

易狀列廊樓不樓不易滑易廊樓度不易欄路立行立行理理理列 207

行狀不異狀理理不拾理立行濾立理行切落列不料離行 208

切數理行理易理列理練練練聯路理領行練行練練練練廊樓不濾 209

理離理連落離參參立行行聯行行行六不理行 210

理列立行聯理聯狀行理行列列落落易料狀落理參列切易 211

理理落異狀理行行列行列行料行利陸漏立漏樓數行例裡樓立聯 212

宅行力練落了念練行識力參練行領讀練數理年參行練練不年更理 213

精行理理理異立理說立立說列精狀列類 214

例 215

行錄樓不易料樓廊不樓度路狀狀狀理理異立理說立立 216

行便落老力力數量亮漏識亮行識落識零降降識識落亮識 217

狀理理異立理說立立 218

理數聯說若若若不不說不塞不塞不數量路降不說料料料 219

不說練練量不說料料不說漏量量爐離易理 220

不說理連度 221

樓說降樓樓 PCR 樓樓 222

錄理料漏料理漏料理料漏立立漏理料漏立漏行漏理理刺行行流行量料漏理行 223

料漏漏 5% 漏漏漏量 5% 漏漏漏 30 漏易理刺漏行漏漏理理理料漏理理行漏料漏聯立行料漏理錄行狀暴露 224

錄列暴露漏料行理不料漏理錄料漏理聯料漏理流 225

1RG1 2 1 P620 P650 1 Actinoalloteichus spp. v 2 Actinosynnema mirum v 3 Adeno associated virus (Type 1, 2, v 3, 4) 4 Aeromicrobium spp. v 5 Alicyclobacillus spp. v 6 Alishewanella spp. v 7 Aneurinibacillus spp. v 8 Aquabacterium commune v 9 Aquabacterium citratiphilum v 10 Aquabacterium parvum v 11 Aquaspirillum itersonii v 12 Aquifex aeolicus v 13 Aquifex pyrophilus v 14 Arthrobacter globiformis v 15 Azomonas macrocytogenes v 16 Bacillus choshinensis v 17 Bacillus coagulans v 18 Bacillus cohnii v 19 Bacillus formosus v 20 Bacillus parabrevis v 21 Bacillus pumilus v 22 Bacillus reuszeri v 23 Bacillus thermocloacae v 24 Blastomonas spp. v 25 Brachybacterium spp. v 26 Brochothrix spp. v 27 Brevibacillus spp. v 28 Brevibacterium spp. v 29 Brevundimonas vesicularis v 30 Buttiauxella agrestis v 31 Butyrivibrio crossotus v 32 Carnobacterium pisciola v 33 Carnobacterium divergens v 34 Caulobacter spp. v 35 Cellulomonas cellulans v 36 Clostridium butyricum v 說 226

2 1 P620 P650 152 Zygosaccharomyces bailii v 153 Zygosaccharomyces rouxii v 3. 4. P620 P650 六說 230

RG2 2 1 P620 P650 1 Acidovorax spp. v v 2 Acinetobacter baumannii v 3 Actinobacillus spp. v v 4 Actinobacillus parasuis v v 5 Actinomyces pyogenes v v 6 Adenovirus v 7 Aeromonas hydrophila v 8 Akabanevirus v v 9 Amycolata autotrophica v 10 Ancylostoma ceylanicum v 11 Ancylostoma duodenale v 12 Arcanobacterium haemolyticum v 13 Arizona hinshawii v 14 Ascaris spp. v 15 Ascaris lumbricoides v 16 Ascaris suum v 17 Babesia divergens v v 18 Babesia microti v 19 Bacillus cereus v 20 Bartonella bigemina v 21 Bartonella bovis v v 22 Bartonella henselae v 23 Bartonella quintana v 24 Bartonella vinsonii v 25 Bebaru virus v v 26 Blastomyces dermatitidis v 27 Bocavirus v v 28 Bordetella spp. v 29 Bordetella bronchiseptica v v 30 Bordetella parapertussis v 31 Bordetella pertussis v 32 Borrelia burgdorferi v 33 Borrelia recurrentis v 34 Burgia spp. v 231 說 Acinetobacter calcoaceticus Corynebacterium pyogenes Corynebacterium haemolyticum

2 1 P620 P650 35 Brugia Malayi v 36 Brugia timori v 37 Buffalopox virus v v 38 Bunyamwera virus v 39 Burkholderia spp. v v 40 Cache Valley virus v v 41 Calicivirus v v 42 California encephalitis virus v 43 Campylobacter coli v v 44 Campylobacter fetus v v 45 Campylobacter jejuni v v 46 Candida albicans v v 47 Cellulomonas hominis v 48 Chlamydophila pneumoniae v 49 Chlamydophila psittaci v v 50 Chlamydophila trachomatis v 51 Cladosporium bantianum v 52 Cladosporium carrionii v 53 Cladosporium trichoides v 54 Clostridium botulinum v v( v ) 55 Clostridium chauvoei v v 56 Clostridium haemolyticum v v 57 Clostridium histolyticum v 58 Clostridium novyi v v 59 Clostridium septicum v v 60 Clostridium tetani v v 61 Clostridium tertium v 62 Coccidia spp. v 63 Colorado tick fever virus v v 64 Coltivirus v v 65 Coronavirus v v 66 Corynebacterium auris v 67 Corynebacterium diphtheriae v 68 Corynebacterium propinquum v 69 Corynebacterium v v 232 說 Burkholderia mallei Burkholderia pseudomallei RG3 avian strains RG3 SARS Coronavirus RG3

2 1 P620 P650 說 pseudotuberculosis 70 Corynebacterium pseudodiphtheriticum v 71 Corynebacterium renale v v 72 Corynebacterium urealyticum v 73 Cowpox virus v v 74 Coxsackie virus v v 75 Curtobacterium flaccumfaciens v 76 Cryptococcus neoformans v 77 Cryptococcus grubii v 78 Cryptococcus gatti v 79 Cryptosporidium spp. v v 80 Cryptosporidium parvum v v 81 Cysticercus cellulosae v v 82 Cytomegalovirus v CMV 83 Dactylaria gallopava v 84 Dengue virus (serotypes 1, 2, 3, 4) 233 v( ) 85 Dermatophilus congolensis v v 86 Echinococcus granulosis v v 87 Echinococcus multilocularis v v 88 Echinococcus vogeli v v 89 Echo virus v v 90 Edwardsiella tarda v v 91 Elephantpox virus v v 92 Empedobacter brevis v 93 Entamoeba histolytica v v 94 Enterobius spp. v 95 Enterococcus spp. v 96 Enterococcus avium v 97 Enterococcus dispar v 98 Enterococcus durans v 99 Enterococcus faecalis v 100 Enterococcus faecium v 101 Enterococcus flavescens v 102 Enterococcus hirae v 103 Enterococcus raffinosus v 104 Enterovirus v v 105 Epidermophyton floccosum v 106 Epstein Barr virus v EBV 107 Erysipelothrix rhusiopathiae v v v

108 Escherichia coli v 2 1 P620 P650 234 v( E.coli ) v 說 K1 109 Epidermophyton v 110 Exophiala dermatitidis v 111 Fasciola spp. v 112 Fasciola gigantica v 113 Fasciola hepatica v 114 Fonsecaea pedrosoi v 115 Giardia spp. v 116 Giardia lamblia v 117 Haemophilus ducreyi v 118 Haemophilus infuenzae v 119 Hazara virus v 120 Helicobacter pylori v 121 Hepatitis A virus v 122 Hepatitis B virus B v( ) v 123 Hepatitis C virus v 124 Hepatitis D virus v 125 Hepatitis E virus v 126 Herpes simplex viruses (Type 1, v 1 2 2) 127 Herpesvirus v v Herpesvirus simiae RG4 128 Herpesvirus zoster v 129 Heterophyes spp. v 130 Human B lymphotropic virus v 131 Human herpesvirus (Type 6, 7) v 132 Human metapneumovirus v 133 Human rhinovirus v 134 Hymenolepis spp. v 135 Hymenolepis diminuta v 136 Hymenolepis nana v 137 Influenza virus (Type A, B, C) v v( 類流 ) v H1N1 H5N2H6N1 H5N1 H7N9 RG3

2 1 P620 P650 138 Isospora spp. v v 139 Japanese encephalitis virus v v( v ) 140 Klebsiella spp. v 141 Legionella spp. v 142 Legionella pneumophila v 143 Legionella anisa v 144 Legionella birminghamensis v 145 Legionella bozemanii v 146 Legionella cincinnatiensis v 147 Legionella feeleii v 148 Legionella hackeliae v 149 Legionella jordanis v 150 Legionella lansingensis v 151 Legionella longbeachae v 152 Legionella parisiensis v 153 Legionella sainthelensi v 154 Legionella tucsonensis v 155 Legionella wadsworthii v 156 Leishmania spp. v 157 Leishmania braziliensis v v 158 Leishmania donovani v v 159 Leishmania ethiopia v v 160 Leishmania major v v 161 Leishmania Mexicana v v 162 Leishmania peruvania v v 163 Leishmania tropica v v 164 Leptospira interrogans (all v v serotypes) 165 Listeria ivanovii v 166 Listeria monocytogenes v v 167 Loa Loa v 168 Lymphocytic choriomeningitis v v virus (non neurotropic strains) 169 Mannheimia spp. v 170 Mannheimia glucosidal v 171 Mannheimia granulomatis v 172 Mannheimia haemolytica v 173 Mannheimia ruminalis v 174 Mannheimia varigena v 175 Measles virus v 235 說 Klebsiella terrigena RG1

2 1 P620 P650 176 Microsporum spp. v 177 Milker's node virus v 178 Moraxella spp. v 179 Mumps virus v Murine leukemia virus ( 180 amphotropic strain v xenotropic strain) 181 Mycobacterium spp. v 182 Mycobacterium avium complex v v 183 Mycobacterium asiaticum v v 184 Mycobacterium bovis BCG vaccine strain v v 185 Mycobacterium chelonae v v 186 Mycobacterium fortuitum v v 187 Mycobacterium kansasii v 188 Mycobacterium leprae v 189 Mycobacterium malmoense v 190 Mycobacterium marinum v v 191 Mycobacterium v paratuberculosis 192 Mycobacterium scrofulaceum v 193 Mycobacterium simiae v v 194 Mycobacterium szulgai v 195 Mycobacterium ulcerans v v 196 Mycobacterium xenopi v v 197 Mycoplasma spp. v v 198 Naegleria fowleri v 199 Necator spp. v 200 Necator americanus v 201 Neisseria gonorrhoeae v 202 Neisseria meningitidis v 203 Newcastle disease virus v v 204 Nocardia asteroides v v 205 Nocardia brasiliensis v v 206 Nocardia otitidiscaviarum v v 說 M. tuberculosis complex M. tuberculosism. bovis RG3 Mycoplasma mycoides Mycoplasma agalactiae 236

2 1 P620 P650 說 207 Nocardia transvalensis v 208 Norovirus v 209 Onchocerca spp. v 210 Onchocerca volvulus v 211 O'Nyong Nyong virus v 212 Orbivirus v v 213 Orf virus v v 214 Paenibacillus popilliae v 215 Papillomavirus v 216 Paracoccidioides brasiliensis v 217 Parainfluenza virus (Type 1, 2, 3, 4) v v 218 Human Parvovirus (B19) v 219 Pasteurella spp. v v Pasteurella multocida B RG3 220 Penicillium marneffei v 221 Plasmodium cynomologi v 222 Plasmodium falciparum 惡 v v 223 Plasmodium knowlesi v 224 Plasmodium malariae v 225 Plasmodium ovale v 226 Plasmodium vivax v 227 Poliovirus (attenuated strain) v 228 Porphyromonas asaccharolytica v 229 Porphyromonas gingivalis v 230 Prospect Hill virus v 231 Prevotella spp. v 232 Pseudomonas aeruginosa v v 233 Pseudomonas alcaligenes v 234 Rabbitpox virus v v 235 Rabies virus (all strain) v v( ) v 236 Respiratory syncytial virus v RSV 237 Rhinovirus v v 238 Rhodococcus equi v v 239 Rift Valley Fever/ Zinga virus v v vaccine strain MP 12 240 Ross river virus v 237

2 1 P620 P650 241 Rotavirus v v 242 Rubella virus v 243 Rubivirus v 244 Salmonella spp. v 245 Salmonella arizonae v v 246 Salmonella cholerasuis v v 247 Salmonella enteritidis v 248 Salmonella gallinarum pullorum v v 249 Salmonella meleagridis v v 250 Salmonella paratyphi (Type A, B, C) v 251 Salmonella typhi v 252 Salmonella typhimurium v v 253 Sandfly fever virus v 254 Sarcocystis spp. v 255 Sarcocystis suihominis v v 256 Schistosoma spp. v 257 Schistosoma haematobium v 258 Schistosoma intercalatum v 259 Schistosoma japonicum v 260 Schistosoma mansoni v 261 Schistosoma mekongi v 262 Shigella boydii v v( Type v 263 Shigella dysenteriae 1 ) 264 Shigella flexneri v 265 Shigella sonnei v 266 Sindbis virus v 267 Sphaerophorus necrophorus v 268 Sphingomonas yanoikuyae v 269 Sporothrix schenckii v 270 Staphylococcus aureus 金 v 271 Staphylococcus caprae v 272 Streptobacillus moniliformis v 273 Streptococcus spp. v 274 Streptococcus acidominimus v 275 Streptococcus agalactiae v v 276 Streptococcus anginosus v 277 Streptococcus bovis v v 說 238

2 1 P620 P650 278 Streptococcus canis v v 279 Streptococcus constellatus v 280 Streptococcus difficilis v v 281 Streptococcus dysgalactiae v v 282 Streptococcus equinus v 283 Streptococcus equi v v 284 Streptococcus gallolyticus v 285 Streptococcus iniae v v 286 Streptococcus intermedius v 287 Streptococcus mitis v 288 Streptococcus mutans v 289 Streptococcus oralis v 290 Streptococcus parasanguinis v v 291 Streptococcus phocae v 292 Streptococcus pneumoniae v 293 Streptococcus porcinus v v 294 Streptococcus pyogenes v 295 Streptococcus salivarius v 296 Streptococcus sanguinis v 297 Streptococcus sobrinus v 298 Streptococcus somaliensis v 299 Streptococcus suis v v 300 Streptococcus uberis v 301 Strongyloides spp. v 302 Strongyloides stercoralis v v 303 Tacaribe virus complex v 304 Tatlockia maceachernii v 305 Tatlockia micdadei v 306 Tick borne orthomyxovirus v 307 Toscana virus v 308 Toxocara spp. v v 309 Toxocara canis v v 310 Toxoplasma spp. v v 311 Toxoplasma gondii v v 312 Treponema carateum v v 313 Treponema pallidum v v 314 Trichinella spiralis v v 315 Trichophyton spp. v v 316 Trypanosoma spp. v v 317 Trypanosoma brucei brucei v v 318 Trypanosoma brucei gambiense v v 239 說

2 1 P620 P650 319 Trypanosoma brucei v v rhodesiense 320 Trypanosoma cruzi v v 321 Vaccinia virus v v 322 Varicella zoster virus v Venezuelan equine 323 encephalomyelitis virus vaccine v strain TC 83 Vesicular stomatitis virus ( 324 VSV Indiana, v San Juan, Glasgow) 325 Vibrio alginolyticus v v 326 Vibrio cholera v 327 Vibrio cincinnatiensis v 328 Vibrio fluvialis v 329 Vibrio furnissii v 330 Vibrio hollisae v 331 Vibrio mimicus v 332 Vibrio parahaemolyticus v v 333 Vibrio vulnificus v 334 Wuchereria bancrofti filaria v worms 335 Yabapox virus (Tana and Yaba) v v 336 Yellow fever virus vaccine strain v 17D 337 Yersinia enterocolitica v 338 Yersinia pseudotuberculosis v v 說 3. 4. P620 P650 六 240

RG3 2 1 P620 P650 說 1 Bacillus anthracis v v() v 2 Bovine spongiform encephalopathy (prion) v v BSE v( B. 3 Brucella spp. v melitensis v ) 4 Brucella abortus v v() v 5 Brucella canis v v 6 Brucella suis v v() v 7 Burkholderia mallei v 8 Burkholderia pseudomallei v 241 v() v() 9 Chlamydophia psittaci (avian strains) v v() v 10 Chikungunya virus v 11 Coccidioides immitis v() v 12 Coxiella burnetii v v() v v v Pseudomonas mallei Pseudomonas pseudomallei 13 Creutzfeldt Jacob disease (prion) v CJD 14 Eastern equine encephalomyelitis virus v v() v EEEV 15 Everglade virus v 16 Fatal Familial Insomnia (prion) v FFI 17 Flexal virus v 18 Francisella tularensis v v() v 19 Gerstmann Straussler Scheinker syndrome (prion) v 20 Hanta virus v v( v ) 21 Hantaan virus v v Korean haemorrhagic fever 22 Histoplasma capsulatum v v 23 Histoplasma duboisii v Human Immunodeficiency virus 24 (Type 1, 2) 類 v() v HIV

25 Human T cell lymphotropic viruses (Type 1, 2) 26 Influenza A virus (H5N1, H7N9) v 2 1 P620 P650 242 v( 類流 ) v v 說 HTLV 27 Kuru (Prion) v 28 Louping ill virus v v 29 Lymphocytic choriomeningitis virus (neurotropic strains) v v LCMV 30 Mayaro virus v 31 Monkeypox virus v v 32 Mopeia virus v 33 Mucambo virus v v 34 Murray Valley encephalitis v 35 Mycobacterium bovis v v BCG vaccine strain RG2 36 Mycobacterium tuberculosis v v() v 37 Mycobacterium tuberculosis complex v v() v 38 Nairobi Sheep Disease v v 39 Ndumu virus v 40 Oropouche virus v 41 Pasteurella multocida (Type B "buffalo") v v 42 Poliovirus (wild strain) v() v 43 Powassan virus v 44 Puumala virus v 45 Rickettsia akari v 46 Rickettsia australis v 47 Rickettsia Canada v 48 Rickettsia conorii v 49 Rickettsia prowazakii v() v 50 Rickettsia rickettsii v v() v 51 Rickettsia siberica v 52 Rickettsia tsutsugamushi v Orientia sutsugamushi 53 Rickettsia typhi (R. mooseri) v v 54 Rift Valley fever/ Zinga virus v v() v RG2 55 Rocio virus v 56 SARS coronavirus v SARS CoV

2 1 P620 P650 說 57 Semliki forest virus v 58 Seoul virus v v 59 Simian immunodeficiency virus v v SIV 60 St. Louis encephalitis virus v v 61 Tonate virus v 62 Variant Creutzfeldt Jacob disease (Prion) v v vcjd 63 Venezuelan equine encephalomyelitis virus v v() v 64 Vesicular stomatitis virus v v VSV IndianaSan JuanGlasgow RG2 65 Wesselsbron virus v 66 West Nile virus v v() v 67 Western equine encephalomyelitis virus v v 68 Yellow fever virus (wild strain) v v() v 69 Yersinia pestis v v() v 3. 4. P620 P650 六 243

RG4 2 1 P620 P650 說 1 Absettarov 3 v() v 2 Central European encephalitis 3 v() v 3 Crimean Congo hemorrhagic fever virus v v 4 Ebola virus 拉 v v 5 Guanarito virus v v 6 Hanzalova 3 v() v 7 Hendra virus (Equine morbillivirus) v v Herpesvirus simiae (Herpes B or Monkey v() 8 v B virus) v 9 Hypr virus 3 v() v 10 Junin virus v v 11 Kumlinge virus 3 v 12 Kyasanur forest disease virus 3 v 13 Lassa virus v v 14 Machupo virus v v 15 Marburg virus v v 16 Nipah virus v v 17 Omsk hemorrhagic fever 3 v 18 Russian spring summer encephalitis 3 v() v 19 Sabia virus v 20 Tick bome encephalitis virus complex v() 21 Variola (major and minor) virus v 22 Whitepox (Variola) v 4. 5. P620 P650 六 6. Tick borne encephalitis virus complex 244

料漏理聯北北隆蘭玲金李連劉葉呂栗林劉林麗林金李麗蘭林蓮 245

料漏理錄聯 / 年理理 1. / 年 2. 3. 狀說 4. 理 5. 行不 RG1 RG2 RG3 RG4 不狀漏行理說 14 說理狀 6. 7. 5% 理易刺 8. 9. 理狀理理狀說理狀說理狀說 10. 暴露 11. 暴露 12. 理 13. 說 14. 年 15. 北北李林漏 246

年狀 : 年年 : 力力力聯聯行行行不理 247

聯北北李若林 248

料漏理流料漏 249