InnoCare Pharma Limited 諾誠健華醫藥有限公司 於開曼群島註冊成立的有限公司 股份代號 9969 2020 中期報告
2 8 9 10 26 33 34 35 36 38 39 41
Ba/F3 3B B B BT B BCR BB BTK BTK CD20 BCD20MS4A1 B 2
CDE NMPA CLL CNSL 9969 CYP3A4 P450 3A4 CYP450s P450 DLBCL B DLT FGFR 3
FL GCB B B GMP HCC herg Kv11.1Kv11.1 α IBD ICP-022 ICP-105 ICP-192 IND ITP 4
KM12 NCI-60 KM12 TPM3-NTRK1 LMNA Lamin A/C LMNA Lamin A/Clamin LN LVC Loyal Valley Capital Advantage Fund LP Loyal Valley Capital Advantage Fund II LP LVC Lion Fund LP MCL B MS MTD MZL NMPA 5
NTRK OBD FGFR (FGFR) TRK PD PK R/R r/r RA RP2D 2 SD (Sprague Dawley) 6
0.000002 SHP2 RAS SLE SLL T T T B NK TRK TRKA G595R G595R595(G) (R) TRKA TYK2 2 UC FDA WM 7
88 248 40 Ogier Global (Cayman) Limited 89 Nexus Way Camana Bay Grand Cayman KY1-9009 Cayman Islands Ogier Global (Cayman) Limited 89 Nexus Way Camana Bay Grand Cayman KY1-9009 Cayman Islands 183 17 1712-1716 29 20 1 9969 1 22 www.innocarepharma.com 8
4,409,823 2,291,773 4,804,561 2,615,693 1,377,666 5,563,439 3,426,895 (2,947,746) 748 593 50,574 51,207 (7,629) (669) (231,157) (94,831) (47,483) (16,084) (32,831) (23,714) (485) (1,400) (141,579) (236,962) (409,842) (321,860) 0.531.65 9
NMPA I/II INDIND IND 10
IND I II (2) III CLL/SLL MCL MZL CNSL ICP-022/ BTK (1) WM 1L: CLL/SLL GCB DLBCL MIL-62 B SLE ICP-192 (3) FGFR ICP-105 (4) FGFR4 HCC ICP-723 (5) TRK NTRK ICP-332 (6) TYK2 (8) ICP-189 (7) SHP2 ICP-490 (7) E3 1. (ICP-022) 2. NMPA CLL/SLL MCL WM IIIII NMPAIII 3. IIICP-192 INDFDAI 4. HCC I 5. NTRK IND NMPA 6. NMPAIND 7. NMPAICP-189 ICP-490 IND 8. IND 11
BTKB B 300 CLL/SLL MCL 12 MZL CNSL WM IIWM II CDE MIL-62CD20 NMPA CLL/SLL III IIGCB DLBCL B I II SLE SLEIIa ICP-192 ICP-192 FGFR FGFR 7.1% ICP-192FGFR 12
IOBD PK/PD FGFRFGFR IIFGFR IND ICP-192 ICP-105 ICP-105FGFR4 FGFR4 HCC HCC50% FGFR4FGFR4 ICP-105HCCI PK/PD ICP-105 ICP-723 ICP-723TRKTRK TRK NTRK ICP-723 INDNMPA ICP-723 PKICP-723 NTRK TRK3 TRKA TRKB TRKCNTRK1 NTRK2 NTRK3 TRKNTRK NTRK NTRK ICP-723 TRK TRK 13
ICP-723 TRK ICP-723 TRKA/B/C G595R G667C TRKA100 nm ICP-723 KINOMEscan(DiscoverX) 468ICP-723 TRKA/B/C100% (ROS1/-JAK3/CASK) 90% ICP-723 TPM3-NTRK1 KM12LMNA-TRKA G595R Ba/F3ICP-723 KM12 Ba/F3 LMNA-NTRK1 G595R KM12 0.3BID ICP-72380% Caco-2 ICP-7237 ICP-723 ICP-723 ICP-723 CYP3A4 ICP-723 CYP450 ICP-723SD ICP-723 IC50>50µM herg SD 4 TRK TRKICP-723 ICP-723TRK TRK ICP-723 14
IND ICP-332 ICP-332TYK2 T NMPAIND ICP-189 ICP-189 SHP2 ICP-189 SHP2 RAS NMPAICP-189 IND ICP-490 ICP-490 CRL4 CRBN -E3ICP-490Ikaros Aiolos ICP-490 DLBCL NMPAICP-490 IND 50,000 GMP 15
120 140 300200 800 20 40 B BCLL/SLL MCL IIBMZL CNSL WM GCB DLBCL CLL/SLLIII MIL-62 ICP-192 ICP-105 FGFR ICP-192IIICP-192 FDA IND I FGFR4 ICP-105 FGFR4 HCC ICP-105FGFR4 HCC 16
ICP-192 ICP-105FGFR ICP-192 ICP-105 ICP-192 IND ICP-723 I/II ICP-723 NTRK PKI ICP-723 PKDLT MTD RP2D II ICP-723NTRKTRK ICP-723 IIa SLE ITP LN MSRA T TYK2 ICP-332 TIBD SLE BICP-332T IND 17
% % () 748 100 593 100 0.6 17% 0.7 % % () 748 100 593 100 0.6 0.7 () 5,661 16,172 40,091 26,857 1,199 8,178 3,454 169 50,574 51,207 18
16.2 65% 5.7 26.9 49%40.1 3.5 32,222 18,222 152,900 30,860 9,144 14,584 20,469 16,898 2,718 2,368 13,704 11,899 231,157 94,831 94.8 144% 231.2 18.214.0 32.2 14.65.5 9.1 16.93.6 20.5 16.1 195% 47.5(i) 7.3 13.0(ii) 20.4 (iii) 3.0 5.2 19
13,008 7,287 2,377 2,335 2,180 2,314 20,370 4,381 1,196 5,167 2,952 47,483 16,084 23.7 38% 32.8 23.6 8.2 31.8 1,000 1 155 31,831 23,558 32,831 23,714 () 3,546 106 2,696 558 1,008 379 5 7,629 669 20
0.7 986% 7.6 58 37 61,515 36,590 30,137 80,347 4,409,823 2,291,773 4,501,533 2,408,747 9,532 8,197 50,510 41,528 645 645 5,506 6,204 9,098 66,193 65,672 4,435,340 2,343,075 4,738,368 2,550,021 4,435.3 4,409.8 30.1 50.5 36.6 61.5 (i) 13.814.328.1(ii) 7.611.7 19.3 (iii) 13.21.3 11.9 21
3.48% 3.58% 3.57% 3.81% 1,149.0 1,117.2 930 6.5% 41.5 50.5 (i) 16.120.4 (ii) 14.7 22.4 6,710 9,543 22,380 14,672 20,441 16,106 979 1,207 50,510 41,528 22
5,506 6,204 1,510 3,394 7,016 9,598 16 7.09.6 68.0 36.7 2,291.84,409.8 80.3 30.1 23
4,409.8 2,291.8 8.95250,324,000 0.0000023,8832,240.4 H.10 37,548,000 15%322.59 100%24%43% 24
287 173 60.3% 46 16.0% 19 6.6% 49 17.1% 287 100% 25
13.51B(1) (i) (ii) (iii) 26
2,415.67 50% 1,207.82 1,207.82 25% 603.92 603.92 IND 4.5% 108.71 108.71 10.5% 253.65 253.65 10% 241.57 241.57 100% 2,415.67 2,415.67 2410 27
XV (a)xv78 (b)352(c) (1) 114,129,916 (2) 8.85% 155,574,893 (3) 12.07% 155,574,893 (4) 12.07% 7,631,000 (5) 0.59% 124,727,447 (6) 9.68% 11,111,111 (7) 0.86% (1) 1,289,165,235 (2) (1)Sunland BioMed Ltd94,129,916(2) 20,000,000 (3) (1)Sunny View Holdings Limited108,260,375(2) Wellesley Hill Holdings Limited 27,778,300 Wellesley Hill Holdings Limited 18 (3)19,536,218 (4) XV (5) Hankang Biotech Fund I, L.P.7,631,000 (6) LVC 120,911,447Golden Valley Global Limited3,816,000 (7) (1) 7,777,778(2)3,333,333 28
XV XV7 8 352 XV2 3 XV336 (1) TMF (Cayman) Ltd. 136,509,788 (2) 10.59% GIC Private Limited 119,404,645 (3) 9.26% Vivo Capital VIII, LLC 104,133,118 (4) 8.08% LVC 124,727,447 (5) 9.68% Hebert Pang Kee Chan 161,444,332 (6) 12.52% (1) 1,289,165,235 (2) Golden Autumn Group Limited Strausberg Group Limited74,161,52562,348,263Golden Autumn Group Limited Strausberg Group LimitedLakeview Trust Summit TrustTMF (Cayman) Ltd Lakeview Trust Summit TrustTMF (Cayman) Ltd74,161,525 62,348,263136,509,788 (3) Highbury Investment Pte Ltd56,859,355 Highbury Investment Pte Ltd Loyal Valley Capital Advantage Fund II LP 45,487,484 LVC Lion Fund LP Loyal Capital Advantage Fund II LP LVC Lion Fund LP 17,057,806 Highbury Investment Pte LtdGIC (Ventures) Private Limited GIC Special Investments Private Limited GIC Special Investments Private LimitedGIC Private LimitedGIC (Ventures) Private Limited GIC Special Investments Private Limited GIC Private Limited Highbury Investment Pte Ltd 119,404,645 29
(4) (i) Vivo Capital Fund VIII, L.P.74,733,339(ii) Vivo Capital Surplus Fund VIII, L.P.10,319,779 Vivo Capital Fund VIII, L.P. Vivo Capital Surplus Fund VIII, L.P. Vivo Opportunity Fund, L.P. Vivo 19,080,000Vivo Capital VIII, LLC Vivo Capital Fund VIII, L.P. Vivo Capital Surplus Fund VIII, L.P. Vivo Opportunity, LLC Vivo Opportunity Fund, L.P. Vivo Capital Vivo Capital VIII, LLC Vivo Capital VIII, LLC Vivo Capital LLC Vivo Capital VIII, LLC Vivo Capital 104,133,118 (5) LVC120,911,447Golden Valley Global Limited LVC 3,816,000 (i) Prosperous Wealth Global Limited Loyal Valley Capital Advantage Fund LP 58,366,157 (ii)loyal Valley Capital Advantage Fund LPLoyal Valley Capital Advantage Fund Limited58,366,157 (iii)loyal ValleyCapital Advantage Fund II LPLoyal Valley Capital Advantage Fund II Limited 45,487,484(iv)LVC Lion Fund LimitedLVC Lion Fund Limited 17,057,806LVC Holdings Limited LVC Holdings LimitedLVC Innovate Limited LVC Innovate LimitedJovial Champion Investments Limited Vistra Trust (Singapore) Pte. LimitedJovial ChampionInvestments Limited LVC LVC Holdings Limited LVC Innovate Limited Jovial Champion Investments Limited Vistra Trust (Singapore) Pte. LimitedLVC 124,727,447 (6) Hebert Pang Kee Chan161,444,332Success Growth Limited55,500,000 King Bridge Investments Limited104,807,1451,137,187Success Growth Limited55,500,000Success Growth Limited King Bridge Investments Limited Hebert Pang Kee Chan Hebert Pang Kee Chan Golden Sage Investments Limited XV2 3 XV336 30
1. (i) (ii) (iii) 2. 3. 274,586,514 21.3% 138,076,726 136,509,788 Golden Autumn Group Limited Strausberg Group LimitedGolden Autumn Group Limited Strausberg Group LimitedLakeview Trust Summit TrustTMF (Cayman) Ltd. (10%) 31
69,295,3365.38% 17 0.178 8,700,000 0.178 8,700,000 16 3240(2) 32
Ernst & Young 22/F, CITIC Tower 1 Tim Mei Avenue Central, Hong Kong Tel : +852 2846 9888 Fax : +852 2868 4432 ey.com 34 64 3434 34 2410 34 33
4 748 593 748 593 4 50,574 51,207 (7,629) (669) (231,157) (94,831) (47,483) (16,084) (32,831) (23,714) 14 (141,579) (236,962) (485) (1,400) (409,842) (321,860) 6 (409,842) (321,860) (407,183) (321,306) (2,659) (554) (409,842) (321,860) 8 0.531.65 34
(409,842) (321,860) 13,977 (3,164) (395,865) (325,024) (395,865) (325,024) (393,206) (324,470) (2,659) (554) (395,865) (325,024) 35
9 160,855 48,479 3,125 3,125 36,936 37,011 82,849 86,311 1,159 1,159 18,104 30,861 303,028 206,946 58 37 10 61,515 36,590 11 30,137 80,347 12 4,409,823 2,291,773 4,501,533 2,408,747 13 9,532 8,197 50,510 41,528 645 645 5,506 6,204 19 9,098 66,193 65,672 4,435,340 2,343,075 4,738,368 2,550,021 36
14 4,213,772 15 1,149,007 1,117,176 1,510 3,394 154,920 157,389 6,036 6,036 1,311,473 5,497,767 3,426,895 (2,947,746) 16 16 4 3,372,574 (3,004,714) 3,372,590 (3,004,710) 54,305 56,964 3,426,895 (2,947,746) 37
16 16 4 9,341 (19,292) 143,873 (6,036) (52,205) (3,080,395) (3,004,710) 56,964 (2,947,746) (407,183) (407,183) (2,659) (409,842) 13,977 13,977 13,977 13,977 (407,183) (393,206) (2,659) (395,865) 4 2,048,394 2,048,398 2,048,398 1 307,456 307,457 307,457 7 4,355,350 4,355,350 4,355,350 (100,676) (100,676) (100,676) 159,977 159,977 159,977 16 6,619,858 (19,292) 303,850 (6,036) (38,228) (3,487,578) 3,372,590 54,305 3,426,895 16 16 3 (19,292) 78,069 (6,036) (18,038) (939,007) (904,301) 65,927 (838,374) (321,306) (321,306) (554) (321,860) (3,164) (3,164) (3,164) (3,164) (321,306) (324,470) (554) (325,024) 32,615 32,615 32,615 3 (19,292) 110,684 (6,036) (21,202) (1,260,313) (1,196,156) 65,373 (1,130,783) 38
(409,842) (321,860) 485 1,400 4 (40,091) (26,857) 31,831 23,559 141,579 236,962 834 706 4,272 2,891 118 52 159,977 32,615 (110,837) (50,532) (21) (25) (13,283) (11,488) 1,335 880 6,693 (3,652) (2,469) 5,002 (118,582) (59,815) 28,449 26,857 (90,133) (32,958) 1,062 8,178 (135,000) (497,500) 184,150 550,829 (110,921) (2,824) (43) (9) 12,757 (4,670) (1,819,052) 205,183 (1,867,047) 259,187 39
2,355,855 (100,676) 412,672 (9,098) (50,000) (485) (1,752) (3,393) (3,279) 2,242,203 357,641 285,023 583,870 1,594,153 1,245,204 13,975 89 12 1,893,151 1,829,163 12 4,409,823 2,255,394 12 (2,516,672) (426,231) 1,893,151 1,829,163 40
1. Ogier Global (Cayman) Limited, 89 Nexus Way, Camana Bay, Grand Cayman KY1-9009 Cayman Islands 2.1 34 2.2 3 9 39 7 16 1 8 Covid-19 41
2.2 (a) 3 (b) 9 39 7 (c) 16 covid-19 covid-19 (i) (ii) (iii) covid-19 covid-19 150,000 42
2.2 (d) 1 8 3. 8 10% A 427 207 B 40 467 207 43
4. 748 593 748 593 90 5,661 16,172 40,091 26,857 1,199 8,178 3,454 169 50,574 51,207 44
5. 834 706 4,272 2,891 118 52 31,831 23,559 141,579 236,962 159,977 32,615 6. 16.5% 16.5% 2,000,000 2,000,0008.25%16.5% 27.5% 21%8.7% 25% 15% 45
7. 8. (407,183) (321,306) 774,854 194,462 46
8. 16 9. 113,210,000 2,824,000 10. 28,108 13,836 19,262 7,620 11,853 13,200 2,292 1,934 61,515 36,590 47
11. 30,137 80,347 3.48% 3.58% 3.57% 3.81% 12. 4,409,823 2,291,773 (2,516,672) (697,620) 1,893,151 1,594,153 1,112,253 1,087,220 578,370 315 202,166 502,957 362 3,661 1,893,151 1,594,153 48
13. 3 3,187 5,090 3 6 4,371 6 12 2,216 1 1,974 891 9,532 8,197 14. 29 532,244,771 0.000002 A B C D 168,570 388,619 548,871 828,690 1,934,750 412,672 412,672 194,570 442,178 521,062 656,208 1,814,018 4,364 10,009 13,291 24,668 52,332 367,504 840,806 1,083,224 1,922,238 4,213,772 86,652 190,053 107,453 (242,579) 141,579 (454,156) (1,030,859) (1,190,677) (1,679,659) (4,355,351) 49
14. 8.95 8.18 15. 1,149,007 1,117,176 957,269 159,907 1,117,176 31,831 1,149,007 930 6.5% 21 50
16. 50,000 500,000,000 0.0001 25,000,000,000 0.000002 0.000002 16 4 300,256 4 9,341 (a) 32,282 (b) 250,324 4 2,048,394 (c) 532,245 7 4,355,343 (d) 37,548 1 307,456 (100,676) (e) 136,510 1,289,165 16 6,619,858 51
16. a) 32,282,611 0.000002 b) 250,324,000 0.0000028.95 2,240,400,000 2,048,398,000 c) 532,244,771 d) 8.95 37,548,000 0.000002 336,055,000 307,457,000 e) 136,509,788Golden Autumn Group Limited Strausberg Group Limited TMF (Cayman) Ltd. Golden Autumn Group Limited Strausberg Group Limited Lakeview Trust Summit Trust 17. A 0.000002 A B 0.000002 B 10 183,888,050 B 52
17. 10 22,200,000 B 10 68,498,464 B 52,144,445 52,144,445 53
17. 0.055 0.178 45 (1) 45 (a) 25% 50% (b) 40% 50% (c) 60% (2) 54
17. a b c 113,545,451 113,545,451 15,405,555 15,405,555 128,951,006 128,951,006 77,301,336 3,140,000 80,441,336 16,792,599 15,540,012 4,804,000 37,136,611 (16,000,000) (16,000,000) (16,792,599) (15,490,012) (32,282,611) 61,301,336 50,000 7,944,000 69,295,336 (a) 16,000,000 0.000002 16,792,599 16,792,599 61,301,336 128,951,006 (b) 15,490,012 0.05550,000 15,490,012 50,000 (c) 4,804,000 0.178 7,944,000 55
17. 16,792,599 15,490,012 50,0004,804,000 (%) 57.0-64.0 59.0-61.0 (%) 0.6-1.8 1.93-2.05 10 10 1.42 0.49 160.0 32.6 56
18. 185,340 180,904 19. (a) King Bridge (i) 231 King Bridge (i) 9,098 (i) King Bridge Investments Limited King Bridge 22,000,000 B 1,275,0471% (i) (ii) (b) King Bridge 9,098 57
19. (c) 7,086 3,769 38 46 132,880 28,576 140,004 32,391 20. 58 58 21,554 21,554 30,137 30,137 4,409,823 4,409,823 4,431,435 30,137 4,461,572 58
20. 9,532 9,532 43,197 43,197 7,016 7,016 1,149,007 1,149,007 59,745 1,149,007 1,208,752 37 37 9,554 9,554 80,347 80,347 2,291,773 2,291,773 2,301,364 80,347 2,381,711 59
20. 8,197 8,197 31,456 31,456 9,598 9,598 9,098 9,098 4,213,772 4,213,772 1,117,176 1,117,176 58,349 5,330,948 5,389,297 21. 60
21. 30,137 30,137 80,347 80,347 1,149,007 1,149,007 61
21. 4,213,772 4,213,772 1,117,176 1,117,176 5,330,948 5,330,948 (i) 15 (%) 1,149,007 2.52~4.67 1,117,176 2.82~4.97 62
21. (i) 2.52% 1% (42,308) 44,639 2.82% 1% (45,534) 48,270 4.67% 1% (6,664) 7,024 4.97% 1% (7,101) 7,519 63
22. 8,700,000 0.178 64