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1 85 ISSN F W TO

2 I (02) (02) (02) E - m a i l coopr@nlfd.gov.tw NT ~50 51~ $ $ $1275

3 87 G M P cgmp current Good Manufacturing Practices I S O c l e a n r o o m s and associated controlled environments 209 E U S - F S E G M P C l e a n r o o m I E S Institute of environmental sciences contamination control division Recommended Practice 006, 2 Testing Cleanrooms A i r f l o w v e l o c i t y, Volume, and uniformity test

4 88 H E PA filter installation leak test H E PA Airborne particle count Temperature and moisture uniformity test Room pressurization test Vibration test A i r f l o w Parallelism test Enclosure integrity test Recovery Test Particle Fallout Count Lighting level test Noise level test Laminar flow

5 89 Discrete-particle counter Aerosol photometer 0. 5 u m H E PA P I C / S G M P

6 90 Academia Sinica Chinese Journal of Physics Institute for Scientific Information, ISI J o u r n a l S t u d i e s J o u r n a l Citation Report 2001 Science Edition Impact Factor Journal of Food Science & Te c h n o l o g y 9 4 the Chinese Institute of Engineers 7 0 Pharmacology & P h a r m a c y Science and Engineering T h e Impact Factor J C R 2001 Science E d i t i o n 2000 Journal of Biomedical Science Terrestrial, Atmosphere and Oceanic Sciences Chinese Journal of Physiology Journal of the Chinese Chemical Society Journal of Polymer Research ) S t a t i s t i c a S i n i c a Journal of Food and Drug Analysis Information Service(FSTA ) I S I Journal of the Formosan Medical A s s o c i a t i o n Taiwanese Journal of Mathematics Botanical Bulletin of Z o o l o g i c a l of Chinese Institute of Chemical Engineers Journal of Information Chinese Journal of Mechanics BIOSIS Previews E M B A S E Excerpta Medica) C h e m i c a l A b s t r a c t s International Food P r o d u c t s Research Alert Biochemistry & Biophysics Citation Index

7 91 h t t p :// w w w. n l f d. g o v. tw/jfda/index_e.html JCR impact factor C l a s s - I I m i n i g e n e s d o m a i n C l a s s - I

8 92 B T CD8 + T T h 1 T h 2 C T L s v a c c i n i a C D 4 + T Irvine et al., 1996 M H C I L - 2 I L - 6 I L - 7 polytope I L - 12 G M - C S F D N A M H C - I D N A c D N A M H C - I D N A DNA D N A C D 8 + T B B T T A P C s D N A T M H C / p e p t i d e T P. Berg h e i C S P costimulatory molecules H 2 - K d C D 8 + B 7 T P b C S P T D N A D N A A P C P b C S P - B 7. 1 B 7. 2 DNA C D 28 T C T L A - 4 T B 7

9 93 B 7. 1 T h - 1 B 7. 2 A P C D N A B 7. 1 B 7. 2 T A P C s B 7 B 7. 1 B 7. 2 I L - 2 T C p G - O D N T Complete Freund s Adjuvant D N A B 7 D N A o l i g o n u c l e o t i d e s B 7. 2 B 7. 1 D N A C p G - O D N B 7. 1 D N A P b- C S P D N A B 7. 1 h e t e r o l o g o u s p r i m e - b o o s t - r e g i m e n homologous boosting CpG-oligodinucleotides C p G - O D N D N A D N A B T h 1 T h 2 D N A i m m u n o s t i m u l a t o r y P. Berg h e i DNA sequences, ISS C p G - O D N D N A Irvine et al.

10 94 R N A R N A a n t i - sense RNA R N A R N A D N A 4 20 R N A 25 % D N A a n t i g e n D N A R N A R N A CD8 + T R N A D N A Alphavirus genus Sindbis virus Semliki Forest virus S F V Veenezuelan equine e n c e p h a l i t i s V E E v i r u s R N A D N A R N A R N A R N A n a n o g r a m D N A p o l y p r o t e i n CD8 + T n s P 1-4 R N A R N A R N A S F V m o d e l c m v R N A D N A

11 95 R N A 2-5 A R N A s e P K R I N F - R N A D N A R N A ; i t E 3 L D N A vaccinia E3L H I V-1 Ta t D N A P 85 I P K R N A D N A D N A R N A a p o p t o s i s R N A d s R N A R N A D N A R N A R N A 2-5 oligoadenylate 2-5A R N A P r o t e i n K i n a s e - R N A P K R 2-5 A 2-5 A R N A s e R N A e I F 2 L e i t n e r, W. W., Yi n g, H. and Restifo, N. P.(2000) DNA and R N A P K R RNA-based vaccines:princeples, progress P K R and prospects. Vaccine, 18:

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1 2 EI ( 2005) 3 EI ( 2005) 4 2006 3 1 2 3 EI ( 2005) http://www.ei.org.cn/twice/coverage.jsp ISSN 0567-7718 Acta Mechanica Sinica/Lixue Xuebao 1006-7191 Acta Metallurgica Sinica (English Letters) 0253-4827