DJ` DM 50, DJ 4Q: C D C D C D BC D C D ` " 40,C D_BCD ` 30_ 50, `N % `N Q DJEN C D C D C D_ BCD%ENN 11 3/ /10 6 0

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1 BCDEC D'F GHIJKLMNO 乔林霞王华袁玉峰朱文英黄玉香汤庆娅 FPQRSDJ (BCDEC D) T GHI JKLMNO UVWX Y PQRSJ DJ ( BCDEC D)NF 10, Z[\]RS^ DJ ( _ 1 00mg)N F`ab (25 )c 3d,[\ 3d NGH+ >0 5μm FN ph E ]RSDJNF`RS NGH+,M (F=0 32,P=0 7836;F=1 73,P=0 1321) 72h GHI+ < 0 5μm, >5μmNGH,]RSDN TNA`RSGH > 0 5μmN ph E, ( :F=1 47,P=0 3467;F=1 04, P= ph :F=0 63,P=0 5942;F=0 46,P= :F=1 37,P=0 3648; F=0 65,P=0 6023) 1%BCDEC D 'F KLN F;BCD;C D;GHIJ;KLM R722 6!"#$ A %& X(2013) Efectsofirondextranorironsucroseonthestabilityoffatemulsionintotalnutrientadmixturesfor pediatricpatients QIAOLin xia,wanghua,yuanyu feng,zhuwen ying,huangyu xiang,tang Qing ya. DepartmentofPediatrics,KunshanFirstPeople shospitalafiliatedtojiangsuuniversity,kun shan,jiangsu215300,china Corespondingauthor:TANGQing ya,departmentofclinicalnutrition,xinhuahospital,schoolofmedicine, ShanghaiJiaotongUniversity,Shanghai200092,China,E mail:tangqingya@163.com Abstract Objective Toevaluatetheefectsofirondextranorironsucroseonthestabilityoffatemul sionintotalnutrientadmixture(tna)inpediatricsetings.methods TNAwithdiferentintravenousdoses ofironsucroseorirondextran(0 25,0 5,0 75,or1 00mg)wereprepared,andeachdosewasprepared10 bags.thetnaswerestoredat25 for3days,andthestabilityoffatemulsionwasobservedbyelectron scanningmicroscopy.meanwhile,thephandosmolalitywerealsomeasured.results Theparticlesizesoffat emulsionsintnawithdiferentconcentrationsofironsucroseorirondextranatdiferenttimepointswerenot significantlydiferent(f=0 32,P=0 7836;F=1 73,P=0 1321,respectively).Themeanparticlesize ofthefatemulsionineachgroupwas<0 5μmwithin72hours.ForTNAcontainingdiferentconcentrationsof iron,thepercentageofparticles>0 5μm,pH,andosmoticpresureshowednosignificantdiferenceatdif ferenttimepoints(percentage:f=1 47,P=0 3467;F=1 04,P= pH:F=0 63,P=0 5942; F=0 46,P= osmoticpresure:F=1 37,P=0 3648;F=0 65,P=0 6023).Conclusion TheTNAaddededwithironsucroseorirondextranwithanconcentrationsof<1% isstable. Keywords Totalnutrientadmixture;Ironsucrose;Irondextran;Fatemulsion;Stability DOI: /cma.j.isn X :!"#$%&' (KS1124) (:215300)*+,-.! /01' ( :5;);200092,+, -. (<=>)?:<=>,E mail:tangqingya@163.com

2 DJ` DM 50, DJ 4Q: C D C D C D BC D C D ` " 40,C D_BCD ` 30_ 50, `N % `N Q DJEN C D C D C D_ BCD%ENN 11 3/ / / /10 6[1] 20,N FY J NDJ, D N C D BCD F (totalnutrientadmixture,tna) T NKLM!" #$8%&' [2 4], FC D` N! " [5 6] DJ 0,BCD % C D [7 8], (,)!"*` # TNABCD C DTKLMNO, + N,-M+./ 1 ' 1 1 WJE TNAV0 20%1 GHIJ ( 2),C34F ( 5 2),6%6 (1781!W 2),$Q9 :;34F 5_<=>?34F (@W2),25% C34F ABC_ C D (?E 2),AB? ( 2),BCD34F (D,FG HI!W2);C D ('JK,L M Pharmacosmosa/s),PQDJ,N O F (,IPQ RST 2) TNAV0 1,`U V0 B C D E C D (D ^ ) _ 1 00mg,J /NO N VWE X Y 100~200μg/(kg d) [9 10] 1 2 Q XL 30 9 ( Z[ \ 2 ]);HCP 2^ _4 (` 2);pH (PHS 3Ca,bc', Q 2 Q );- (FM 8Pa, + Q ) 1 3 VW0 USV0 VW 10, 0 U /EFVW0 _VW [9] BCD 10 T,URSJ ` GHIJ F [4] 1 4 [\V VW N TNAU 5 ab (25 ) c 3d, Z[\ TNANM ( GHIJ /GH) B VT 1 2 3d[\abc GH+ >0 5μm F ph E ml 0 20ml FT, ab 1h, N T, I U #NP,U_ 0 _ 100 GH+, GH >0 5μm N [11] ph_l Q 10min,T F _,Q F ph, _ 2, 1 TNAF Table1 SourceingredientsusedinTNA 20%1 6% 25% $Q9 <=>? C GHIJ 6 C C 5 :;34F 34F ABC AB? D ( ) 1 ] / ] / :TNA:-F

3 _L Q L T, 1ml N,U QX_, FN,_ 2, 1 5, SAS6 12` Windows,M ±, 0 0 P<0 05, GH+ ]D TNAGH, ` 1H+NGH,` 3H _ GH μm ( 1 2) ]RS ^ BCDEC DN TNA,`RS GH + N, M (F= 0 32,P=0 7836;F=1 73,P=0 1321) 72h GHI+ <0 5μm,U + 5μmNGH ( 2) 2 2 GH >0 5μmN `RSNGH >0 5μm N,,NRS, (F=1 47,P= ;F=1 04,P=0 4758)( 3) 2 3 ph `RSN ph,,nrs ph ph N,,,P DJ #, (F=0 63, P=0 5942;F=0 46,P=0 6825)( 4) 1 ]D TNAN 1HGHN+ Fig1 Thesizesoffatemulsionparticlesiniron containing TNAonthefirstday 2 ]D TNAN 3HGHN+ Fig2 Thesizesoffatemulsionparticlesiniron containing TNAonthethirdday 2 ]RS^ DN TNA`RSGH+# (x±s,μm) Table2 SizesofthefatemulsionparticlesbyelectronscanningmicroscopyinTNAwithdiferentintravenousdoses ofironatdiferenttimepoints(x±s,μm) DJJ 24h 48h 72h BCD (mg) ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0 143 C D (mg) ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± :,F=1 73,P=0 1321;_,F=0 53,P=0 6452;RSD^,F=0 32,P=0 7836

4 ]RS^ DN TNA`RS GH >0 5μmN (%) Table3 Thepercentagesofthefatemulsionparticleswithadiametersof>0 5μminTNAwithdiferentintravenousdoses ofironatdferenttimepoints(%) DJJ 24h 48h 72h BCD (mg) C D (mg) :,F=1 47,P=0 3467;_,F=0 72,P=0 5263;RSD^,F=1 04,P= ]RS^ DN TNA`RS N ph (x±s) Table4 ThepHvaluesinTNAwithdiferentintravenousdosesofironatdiferenttimepoints(x±s) DJJ 24h 48h 72h BCD (mg) ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0 31 C D (mg) ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0 25 3:,F=0 63,P=0 5942;_,F=1 84,P=0 1043;RSD^,F=0 46,P= DT ` 650~708kPa, (678±15) kpa,]rsbcdec DN TNA`RSN,,NRS, (F =1 37, P =0 3648; F =0 65, P=0 6023) 3 Vaughan [12]!"`] C DN TNAGH,)!" Z[\ 3d% 0 N R K L M! " ] B C D N TNAGHIJNKLM [4] D]U ]D (D^ )2 5~10mg, ` Vaughan [12] N!" D]U 50mg Knutsen [13] N!" TNAC D GHN, Tu [2] _ Mayhew _ Quick [3] N!" 0 NRKLM )!"[\, BCDTGHN+ ` 3dB )!" [\GHIJ+, ` [\GH,E GH Mayhew_ Quick [3] N!" ^6+ 2%D 48h TNA KLN,/LN6 GHIJ_ ^ ( D D ) KL,)!"6N 1 8%, % TNARKL 0 / 6~8μm,H I 9 N` 0 5~1 0μm ^GHIJ >

5 ~6μm, F TNAGH >5μmNGH!] >0 4%, " TNA# KLM,R$ 3 %&W TNAGH + ' )!"NV0 3d GHN` 0 3μm, >0 5μmN 0 2% ~0 6%, /0 DJN TNAab 3dKLN pho TNAKLMN / ;,/ TNAN ph ` 5~7^KL, TNAN ph 6,C TNA N ph,((eklm,)! " ph 6 21~6 65,CN 6 5%, DT ph N BRS#,,`)!"V0` ph)k LN * TNA^ B, N, - M )! " G H I J 650~708kPa, `_L)+, -L,, ` ) GH IJ KLN.,)!"] 0 25% ~1 00%BCD C DN '-F KLN, /+DT TNANKLM 01/!"! [1] ChertowGM,MasonPD,Vaage NilsenO,etal.Ontherelative safetyofparenteralironformulations[j].nephroldialtrans plant,2004,19(6): [2] TuYH,KnoxNL,BiringerJM,etal.Compatibilityofirondex tranwithtotalnutrientadmixtures[j].am JHospPharm, 1992,49(9): [3] MayhewSL,QuickMW.Compatibilityofirondextranwithneo natralparenteralnutrientsolutions[j]. Am JHealth Syst Pharm,1997,54(5): [4] 2,<=>,8,. ' FB CD GHIJKLMNO [J]., 2010,18(2): [5] 2,789,3.DJ 2] D34O N!" [J].*5+,,&,2012,32(4): [6] FrielJK,AndrewsWL,HalMS,etal.Intravenousironadmin istrationtovery low birth weightnewbornsreceivingtotaland partialparenteralnutrition[j].jpenjparenterenteralnutr, 1995,19(2): [7] SilversteinSB,RodgersGM.Parenteralirontherapyoptions [J].AmJHematol,2004,76(1): [8] ChertowGM,MasonPD,Vaage NilsenO,etal.Updateonad versedrugeventsasociatedwithparenteraliron[j].nephrol DialTransplant,2006,21(2): [9] SobotkaL. X [M] : :+,;9#,2007: [10] KoletzkoB,GouletO,HuntJ,etal.Guidelinesonpaediatric parenteralnutrition[j].jpediatrgastroenterolnutr,2005,41 (2):S1 S87. [11],.-VFFGHIJKLMO N! " [J].N O N,2006,13 (3): [12] VaughanLM,SmalC,PlunketV.Incompatibilityofirondex tranandatotalnutrientadmixture[j].am JHospPharm, 1990,47(8): [13] KnutsenCV,EppsDR,McCormickDC,etal.Totalnutrient admixtureguidelines[j].drugintelclinpharm,1984,18 (3): ( < : )

中華民國青溪協會第四屆第三次理監事聯席會議資料

中華民國青溪協會第四屆第三次理監事聯席會議資料 - 1 - 中華民國第八屆第四次理監事聯席會議程序表日期中華民國 1 0 4 年 1 2 月 1 9 日 ( 星期六 ) 地點臺南南紡夢時代雅悅會館五樓 ( 臺南東區中華東路一段 366 號 ) 項次程序起訖時間使用時間主持人或報告人報到 16:30~17:00