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1 SINO BIOPHARMACEUTICAL LIMITED :

2 FCCA,CPA 166 1

3 43 SMP Partners (Cayman) Limited Royal Bank House 3rd Floor, 24 Shedden Road P.O. Box 1586 Grand Cayman KY Cayman Islands Codan Trust Company (Cayman) Limited Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY Cayman Islands Conyers Dill & Pearman, Cayman Boundary Hall, 2nd Floor Cricket Square Hutchins Drive P.O. Box 2681 KY Cayman Islands 1 C2 308A

4 748, % 107,634110, % 25.7% % 25.7% 11.6% 385,

5

6 GMP PVC GMP GMP 5

7 GMP CN MSCI

8 6.9% 0.2 VEGFR PDGFR FGFR c-kit,

9 748, % 107, , %25.7% %25.7% 385, , % 5,445 20,009 98, % 8

10 17, , % 19, % 5, % 152, % 77, % 8,336 32, % 29, % 9

11 (DDS) GMP 58,487 16, % 80, % 14,084 16, % 10,694 7, % 8, % 8, % 5, % 10

12 91, % DDS 71, % 17, % 60, % 41, % 10, % 45, % 35,4547, % 11

13 35, % 25,072 9,882 33, % 21, % 8,588 31, % 11, % 16, % 12

14 5, % 1 4, % 53,097 36, ,559212,236 62,700 57,363 52,000 38,000 21,000 51, % 13

15 (i) 16,02514,793Karolinska Development AB 272,858,2948%(ii) 70,374 40,856 6,772 2, , %

16 385, ,579 99, ,947163, ,897 42,276 45,952 1,960,637 1,834,008,869, , % 41.4% 16, ,134, ,394,000 15

17 16

18 3 7,482,859 6,768,203 (1,568,413) (1,452,802) 5,914,446 5,315, , ,687 (3,169,426) (2,830,705) (254,581) (417,999) (1,173,558) (954,357) 4 (34,127) (27,862) 177, , ,684,269 1,381,459 6 (285,637) (219,617) 1,398,632 1,161,842 1,100, , , , ,398,632 1,161,

19 1,398,632 1,161,842 (113,300) 108,491 (113,300) 108,491 1,285,332 1,270, , , , ,731 1,285,332 1,270,333 18

20 2,866,296 2,658, , , , ,061 99,384 99, , ,203 1,017, , , , , , , , ,671 40,013 6,374,915 5,585, , , ,399,646 1,995,827 2,568,941 3,195, ,199 2,825,588 2,122, , , ,859,639 3,765,786 13,231,455 12,754, ,165, ,734 96, ,024 4,641,820 3,271, ,823 1,369,474 6,902,165 5,660,726 6,329,290 7,094,192 12,704,205 12,679,357 19

21 133, ,603 1,632,527 1,678,968 25,683 56,875 1,792,196 1,937,446 10,912,009 10,741, , ,033 8,474,044 7,813,402 8,644,077 7,983,435 2,267,932 2,758,476 10,912,009 10,741,911 20

22 170,033 1,128,455 (169,686) 185,993 22,691 1,420,955 (83,207) 5,213,051 95,150 7,983,435 2,758,476 10,741,911 1,100,582 1,100, ,050 1,398,632 (112,054) (112,054) (1,246) (113,300) (112,054) 1,100, , ,804 1,285, (788,046) (788,046) (95,150) (95,150) (95,150) (232,736) (232,736) (232,736) 14,022 (14,022) 170,033 1,128,455 (169,686) 185,993 22,691 1,434,977 (195,261) 6,066,875 8,644,077 2,267,932 10,912, ,033 1,128,455 (169,686) 169,037 22,691 1,074,912 (325,396) 4,335,530 90,121 6,495,697 2,246,168 8,741, , , ,246 1,161, , , , , , , ,731 1,270,333 (546,228) (546,228) (90,121) (90,121) (90,121) (190,663) (190,663) (190,663) 170,033 1,128,455 (169,686) 169,037 22,691 1,074,912 (217,390) 5,020,463 7,198,515 1,986,671 9,185,186 21

23 3,218,565 1,440,863 (1,585,214) 251,039 (1,389,331) (802,576) 244, ,326 3,498,538 2,121,086 (154,594) 122,659 3,587,964 3,133,071 1,696,909 1,808,248 1,891,055 1,324,823 3,587,964 3,133,071 22

24 1. (a) (b) (c) 23

25 1. (i) (ii)(iii)(i) (ii)(iii) 2. (a) (b) (c) (i) (ii) 24

26 2. 7,266,830 1, ,094 7,482,859 1,496,927 96,615 37,261 1,630,803 22, ,776 (146,612) 1,684,269 (285,637) 1,398,632 13,146,270 4,585, ,582 18,343,636 1,017, ,522 19,606,370 5,560,958 2,712, ,031 8,572, ,976 8,694, ,116 15,125 9, , , ,

27 2. 6,550,516 1, ,873 6,768,203 1,460,899 (125,838) 14,754 1,349,815 15, ,294 (156,185) 1,381,459 (219,617) 1,161,842 10,277,943 3,116, ,865 14,357,541 1,132, ,296 15,726,985 4,336,810 1,759, ,477 6,360, ,730 6,541, ,161 14,126 8, , , , , % 90% 10% 26

28 3. 7,297,582 6,583, , ,101 7,482,859 6,768,203 22,302 15,535 8,364 8,567 6,207 9,384 14,714 15,555 2, ,359 50,694 2,686 2,556 13,612 19, , , ,721 25,219 1,855 93,916 2, , ,687 27

29 4. 34,127 27, ,568,413 1,452, , ,745 11,509 10, ,587 4,066 1,155, ,606 (976) (249) (22,302) (15,535) (6,207) (9,384) (59,359) (50,694) (25,219) (1,855) 978 1,735 1,921 1, , , ,707 93, , ,394 16, (70,165) 32,655 28

30 6. 299, ,820 (13,421) (27,203) 285, , %16.5% 15% 25% ,100,582, ,596,000 7,412,192,209 7,412,192,209 29

31 ,196,235 1,657, , , ,842 23,920 2,399,646 1,995, ,696,909 1,472,778 1,891,055 2,025, , , ,859,639 3,765, , , , , ,119 37,852 1,165, ,734 30

32 12. 7,412,192, ,412,192, , , a a 1,800 1,800 b 1,557 1,415 (a) (b) 31

33 571 XV (1) 140,400,000 1,082,126,722 1,222,526, % (2) 63,371,000 1,800,000,000 1,863,371, % 61,257,000 61,257, % (1) Validated Profits Limited1,082,126,722 (2) Remarkable Industries Limited 1,050,000,000750,000,000 32

34 (1) 288,000, % 229, % 26, % (1) 1 XV XV

35 XV Validated Profits Limited (1) 1,082,126, % (2) 1,050,000, % Remarkable Industries Limited (2) 750,000, % (1) Validated Profits Limited (2) Remarkable Industries Limited XV

36 494,146,14710% 1% (i)0.1% (ii)

37 (i) (ii) (iii)

38 A (A) ,000,000 37

39 38

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