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1 2015

2

3

4 IMS Health Inc.IMS 41.0% IMS 64.9% IMS 43.0% ,10038,000 1,000 4,000 1,

5 16 pegsiticase 3

6 David Ross PARKINSON Codan Trust Company (Cayman) Limited Cricket Square, Hutchins Drive PO Box 2681 Grand Cayman, KY Cayman Islands Codan Trust Company (Cayman) Limited Cricket Square, Hutchins Drive PO Box 2681 Grand Cayman, KY Cayman Islands 4

7 Conyers Dill & Pearman Cricket Square Hutchins Drive PO Box 2681 Grand Cayman, KY Cayman Islands

8 * 541, , ,396 1,130,854 1,673, , , ,217 1,043,373 1,431,215 EBITDA 141, , , , ,705 EBITDA 141, , , , , , ,877 96, , , , , , , , , ,666 95, , ,280 1,311,110 1,476,301 1,268,326 2,306,441 6,630,432 65,904 97, ,523 1,362, ,967 1,245,206 1,379,239 1,081, ,592 5,635,465 * 6

9

10 95% 97.78% 48.0% 9.1% Sirton Pharmaceuticals S.p.A Sirton GMP 12 8

11 9

12 6.96%1, %53.64% (1)(2) HER2CD20B 8,00030,000 (i) 1,800 (ii) (1) 38.5%41.69% (2) 0.73% 1,033.3 (1)43.42% 2, ,765,500 (2) 10

13 12.04% 1, % CIT ITPCIT ITP CIT CIT ITP 10% 10% Etanercept Etanercept IMS64.9% CKD CIA 36,000 IU 10,000 IU(1) CKD(2) CIA

14 CKD (1) (2)

15 HER2 Apexigen Inc.Apexigen SSS07 Apexigen 350 IMS Alteogen Inc.Alteogen KS ALT-P7 ALT-P7 HER2 TAS102 13

16 NuPIAO Voclosporin PEG-EPO HIF-PH DJ5 ADPKD 1 TAS102 IAP 3 PEG Bcl-2/xL 3 Leukotuximab Tanibirumab DIG-KT ALT-P7 2 TNF Pegsiticase

17 Anti-il-17 1, ,270 3, ,600 1,002 15

18 NuPIAOSSS07Apexigen Pegsiticase NuPIAO SSS07 Pegsiticase Selecta Biosciences, Inc.Pegsiticase1a Voclosporin Aurinia Pharmaceuticals Inc.Voclosporin PEG Her2Her2 16

19 38, GMP Sirton1, , , %(1) (2) Sirton(3) 17

20 % 36.0% % 40.6% % % % Sirton

21 % (1) (2) Sirton (3) 1, , % 85.5%92.3% Sirton 92.0% %6.96% 102.8Pegsiticase %(1)(2) Sirton(3) 19

22 38.2%35.0% Sirton % (1) (2) (3) (4) Sirton(5) %6.5% % % 20

23 % 10.5% 19.0% 6.96% EBITDA EBITDAEBITDA(1) (2) (3)(4)(5)6.96% EBITDA %734.1 EBITDA %660.7 (1) (2) (3) (4) (5) 6.96% % %

24 , , ,

25 % 7.2% (1)Sirton(2) %Sirton (1) (2)

26 2,1771,

27 25

28 53 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 26

29 13) 14) 15) Fordham University 43 1) 2) 3) 4) 5) 6) 7) 27

30 8) Grand Path Holdings Limited 9) 10) 11) Globe Metals & Mining Limited GBE TPI 45 (i) (ii) (iii) 28

31 55 (i) (ii) (iii) (iv) Biosensors International Group, Ltd.B

32 WOWO Limited WOWO UTStarcomUTSI China Nuokang Bio-Pharmaceutical Inc.NKBP David Ross PARKINSON 66 Parkinson ESSA Pharma Inc.EPIX Cerulean Pharma, Inc.CERU Threshold Pharmaceuticals, Inc.THLD ESSA Pharma Inc. DeNovo Biosciences, Inc. Tocagen Inc.New Enterprise Associates ParkinsonNodality, Inc. Amgen Inc.AMGN Parkinson(AACR) Parkinson USFDA 12 Andrew H. WeinbergParkinson 30

33 53 Cornell Law School

34 35 Sirton Sirton 37 Perlos (Beijing) Electronic and Telecommunication Component Co., Ltd. 32

35

36

37 6 5,036.0 (1)622.0* (2)1,631.1* (3)2, %34.9% 10.3%10.8% 45.6%49.3% 17.9%13.3% 5% *

38 , , ,882,

39 4, David Ross PARKINSON 84(1) 37

40 83(3) David Ross PARKINSON

41

42 13.51(2) (a) (e) (g) XVXV (1) (2) 659,367,030 (L) 26.21% (L) (3) 115,549,920 (L) 4.59% (L) (4) 26,403,630 (L) 1.05% (L) (5) 33,919,350 (L) 1.35% (L) (L) 1. 2,515,313, Century Sunshine LimitedCSL Decade Sunshine LimitedDSL100% 58.50%DSL 659,367, Triple Talent Enterprises LimitedTTE TTE115,549, Joint Palace Group LimitedJPG JPG26,403, Known Virtue International LimitedKVI KVI33,919,350 40

43 XVXV XV23 (1) DSL 659,367,030 (L) 26.21% (L) CSL (2) 659,367,030 (L) 26.21% (L) CS Sunshine Investment Limited (3) 712,258,360 (L) 28.32% (L) CPEChina Fund, L.P. (3) 712,258,360 (L) 28.32% (L) CITIC PE Associates, L.P. (3) 712,258,360 (L) 28.32% (L) CITIC PE Funds Limited (3) 712,258,360 (L) 28.32% (L) 41

44 (L) 1. 2,515,313, DSL CSL CSLDSL 659,367, CS Sunshine Investment Limited CPEChina Fund, L.P.CPECPE CITIC PE Associates, L.P.CITIC PE Funds Limited XV ,439, %9 42

45 43

46 47 44

47 % 45

48 46

49 David Ross PARKINSON 3.10(1) 3.10(2) 3.10A 47

50

51 A B A B A B A B A B A B David Ross PARKINSON A B A B A B A B 49

52 A

53 A.1.1 1/1 1/1 1/1 1/1 1/1 1/1 1/1 David Ross PARKINSON 1/1 1/1 51

54 A.6.4 (a) (b) (c) (d) (e) 52

55 1) 2) 3) 4) 5) 6) 7)

56 C.3.3(e)(i) 1/1 1/1 1/

57 A.5.2(a)

58 ,000, ,000,0011,500, ,500,0012,000,

59

60 1,873 1,016 4,322 7,

61 ir@3sbio.com 59

62

63 61

64 5 1,673,126 1,130,854 6 (241,911) (87,481) 1,431,215 1,043, ,618 47,763 (585,585) (431,432) (301,044) (170,770) 6 (142,651) (98,185) 7 (26,545) (29,182) 19 3,848 (1,383) 587, , (61,626) (68,456) 526, , , ,728 (50) 526, ,

65 526, ,728 (4,829) (439) (4,829) (439) 134,898 (7,495) 130,069 (7,934) 130,069 (7,934) 656, , , ,794 (50) 656, ,794 63

66 14 450, , ,908 86, , , , ,545 13,326 1, , ,729,219 3, , , ,411 11, ,698 1,619 3,867,465 1,363, , , , , ,025 76, ,585 56, ,299, , , , ,558 2,762, , ,444 25, , , ,959 1, , ,429 10,215 3, ,610 1,251,889 1,990,357 (309,262) 5,857,822 1,054,552 64

67 5,857,822 1,054, ,567 17, ,790 73, ,000 20, , ,960 5,635, , ,355, ,448 1,268, ,919 5,624, ,367 11,175 11,225 5,635, ,592 65

68 * * * * * * ,636 47,392 85, ,333 6,971 (161,179) 1,070,578 11,225 1,081, , , ,728 (439) (439) (439) (7,495) (7,495) (7,495) 291,728 (439) (7,495) 283, , , , , (359,014) (300,000) (659,014) (659,014) (1,500) (1,500) (1,500) 133, , , , ,575 85, ,061 6,532 (168,674) 932,367 11, , , ,575 85, ,061 6,532 (168,674) 932,367 11, , , ,280 (50) 526,230 (4,829) (4,829) (4,829) 134, , , ,280 (4,829) 134, ,349 (50) 656,299 39,953 (39,953) 34 46,581 46,581 46, (119) 35 4,132,853 4,132,888 4,132,888 (143,895) (143,895) (143,895) 154 4,355, , , ,388 1,703 (33,776) 5,624,290 11,175 5,635,465 * 1,268,849, ,919,000 66

69 587, , (3,848) 1,383 5,19 (102,818) 5,19 (13,093) 5 (33,525) (24,092) 7 26,545 29,182 5,6 23,022 (637) 34 46, , ,863 30, ,500 2, , (8,917) (2,188) 25 (437) (180) (1,730) , (21,811) (9,911) 580, ,182 1,367 (10,424) 305 (20) (121,691) (59,296) (86,823) (13,517) , , , , ,037 (65,535) (133,448) 455, ,589 67

70 33,369 33,038 (61,040) (19,931) (36,483) (6,000) (49,738) (137,356) 70,000 (3,500) (5,651) 2,128 (117) (519,488) 245,859 29, 36 (835,014) (378,184) 37 21,754 (20,474) (1,363,676) (1,568) (505,883) (1,500) 1, (3,248,243) (289,217) 4,132,888 (179,011) (659,014) 222,769 (152,204) 752,362 1,389,972 (1,034,791) (800,543) (25,919) (28,601) 3,868,298 (250,390) 1,075,329 (153,018) 107, , ,457 (7,572) 1,299, , ,298, , ,026 1,651 1,299, ,612 68

71 1. Cricket Square, Hutchins Drive, P.O. Box 2681, Grand Cayman, KY1 1111, Cayman Islands (a) 1 100% (a) 2 100% (a) 100% 2,185,000,000 (a) 100%(b) 15,000,000 69

72 1. (a) 100% 1,000,000 (a) 80% 250,000,000 (a) 1 100% Sirton Pharmaceuticals S.p.A. Sirton 300, % (a) % (a) 500, % 70

73 1. (a) 100% 53,000,000 (a) 10,000, % (a) 56,500, % (a) (b) (1) (2) (3)(4) 15,000,0001,500,000 13,500,000 71

74 (a) (b) (c) 72

75 2.1 (i) (ii) (iii) (i)(ii) (iii) (a) 19 73

76 2.2 (b) (c)

77 2.2 (c)

78 (a) 9 (b)

79

80 2.3 1 (i) 1 (ii) (iii) (iv)

81 2.4 20% 5 79

82 2.4 80

83 2.4 81

84 2.4 82

85 2.4 (a) (i) (ii) (iii) (b) (i) (ii) (iii) (iv) (v) 83

86 2.4 (b) (vi) (a) (vii) (a)(i) (viii)

87 2.4 IP

88

89 2.4 87

90 2.4 (a) (b) 88

91 2.4 (a)(b) 89

92 2.4 漖 90

93 2.4 91

94

95 2.4 93

96 2.4 (i) (ii) 94

97 2.4 95

98 2.4 96

99 2.4 (a) (b) (c) (d) 97

100

101 2.4 99

102

103

104

105 3. 560,883, ,597,

106 3. 104

107

108 4. (a) 1,582,588 1,106,093 90,538 24,761 1,673,126 1,130,854 (b) 3,637,066 1,004, ,388 98,298 3,851,454 1,102, ,907, ,206, %10.8% 106

109 5. 1,683,018 1,140,179 (9,892) (9,325) 1,673,126 1,130,854 33,525 24,092 (a) 6, (b) 9,889 6,440 11, ,607 3,114 3,975 6, ,896 37,215 21,811 9, , , ,722 10, ,618 47,

110 5. (a) 30 (b) ,911 87, ,863 30, ,500 2, , ,744 3,962 7,211 4, , ,941 46,581 64,055 15,082 11,144 28,701 17, , , ,324 96,375 2, (437) (180) ,022 6,723 1, ,651 98,

111 7. 26,545 29, (1)(a) (b) (c) (f)2 3,232 1,986 1,865 2, ,628 5,654 45,

112 8. * David Ross Parkinson * David Ross Parkinson * 110

113 8. (a) , , ,066 * ,445 2,812 1, ,

114 8. (a) 737 1, ,316 24, ,312 19, ,249 1, ,628 43,733 * ,839 1,986 2, ,628 45,572 * (a) Century Sunshine

115 ,744 1, (a) 51,245 1,827 53,380 1,500,0002,000, (a) Century Sunshine % 15,639,000 11,542,

116 11. 25% 15% Sirton31.4% 10% 5% 69, , (7,854) (62,637) 61,626 68,

117 , ,184 25% 146,964 90,046 (42,060) (42,939) (12,446) (8,978) (43,504) 20,521 22,240 (3,676) 3,676 (6,144) (2,261) 1,284 6, (94) 61,626 68, %19.0% , ,152,00019,000 Decade Sunshine LimitedDecade Sunshine 115

118 13. 2,255,271,762 1,939,518, , ,728 2,255,271,762 1,939,518,570 43,462,623 2,298,734,385 1,939,518,

119 , ,831 56,053 6,831 12, ,017 (49,498) (68,023) (32,116) (4,390) (154,027) 201, ,808 23,937 2,441 12, , , ,808 23,937 2,441 12, ,990 1,378 10,381 5, ,417 43, ,800 19,314 3, , ,813 (1,224) (1,914) (201) (136) (3,475) 37 (39,787) (4,927) (986) (147) (3,968) (49,815) (17,358) (25,085) (6,649) (771) (49,863) 3, (3,516) (988) (1,004) (21) (3) (2,016) 256, ,810 25,085 2,293 33, , , ,327 65,344 8,333 33, ,972 (85,902) (89,517) (40,259) (6,040) (221,718) 256, ,810 25,085 2,293 33, ,254 3,613,000 3,796,000 8,679,000 74,217,

120 14. 49,538,000 98,990, , ,153 50,896 4,987 46, ,346 (39,299) (53,764) (28,409) (3,936) (125,408) 84,010 94,389 22,487 1,051 46, ,938 84,010 94,389 22,487 1,051 46, , ,830 1,267 11,620 17, ,433 45,441 3, , ,964 (62) (325) (387) 37 (539) (4) (15) (289) (847) (10,300) (14,587) (5,548) (454) (30,889) 44,351 7, (51,969) 201, ,808 23,937 2,441 12, , , ,831 56,053 6,831 12, ,017 (49,498) (68,023) (32,116) (4,390) (154,027) 201, ,808 23,937 2,441 12, ,

121 15. 88,670 27,381 (10,022) (9,237) 18,200 71,290 (2,466) (764) 94,382 88, (2,474) (2,295) 91,908 86, ,775,000 7,128, , , , , , , ,

122 % 3% 120

123 17. 4, ,884 35,229 29, ,545 36,483 36, ,100 17,152 83, (13) (13) (1,290) (18,840) (7,370) (27,500) (14) (14) 39, ,144 35,229 38, ,753 5,500 42, ,897 35,229 46, ,382 (5,500) (2,802) (38,753) (7,574) (54,629) 39, ,144 35,229 38, ,

124 17. 4,695 2,392 35, , ,700 28, ,659 (378) (2,208) (15) (2,601) 4, ,884 35,229 29, ,545 5,500 5, ,797 35,229 29, ,533 (5,500) (1,512) (19,913) (63) (26,988) 4, ,884 35,229 29, , % 122

125 Injenerics SrlInjenerics 10,

126 ,614,262 10,272 3,903 3,718 1,374,375 1,568 3,848 (1,383) , ,818 13,093 1,729,219 3,

127 19. % (a) 5,000, (a)(b) 2, (a)(d) 7,500, (c) 510,223, (a)(c)

128 19. (a) (b) 6,857,000 5,574,000 1,283,000 1,286,000 (c) 21.84% 1.29% 1.81% 1.81%79,980,000112,220, ,125, % 57.75% 41.69%1,053,324, % (d) % 1,676, % 126

129 19. 3,848 (1,383) 3,848 (1,383) 1,729,219 3, ,845 2,468 (1,845) (2,119)

130 20. 2,119 1,644 (274) 475 1,845 2, (i) 70,690 42,000 (ii) 10,895 14,052 81,585 56, ,

131 21. (i) (ii) ,098 1,019 2,698 1,

132 23. 3, , , (932) (93) (442) 1, , , ,467 5,834 8, ,244 11,551 8, ,244 11, ,366 (259) (899) (148) ,641 1,012 2,865 9, (28) 2,119 3,191 15,

133 23. (a) 5,412 4,450 (b) 55,011 50,685 2,916 2,338 63,339 57,473 (a) (b) 131

134 23. 65,000 65, (61,324) (61,324) 36 69,945 69,945 69,945 3,676 73,621 69,945 3,676 73, (3,183) (3,676) (6,859) 36 15,028 15,028 81,790 81,790 10% 5% 10% 132

135 23. 65,000, ,640, ,194, ,859 22,648 77,880 57,108 26,664 13,953 9,971 8, , ,791 (983) (1,390) 134, ,401 1,730, ,

136 , , , , , ,700 (14,631) (4,722) 549, , , , ,335 74,943 12,127 12,599 9,992 5,983 12,483 3,070 2, , ,

137 25. 4,722 3,214 3,332 (3,769) (180) (2,084) 52 (645) 10,939 3,772 14,631 4, , ,772 12,127 12,300 10,026 5, , ,

138 ,110 7,619 2,474 2,295 19,654 20,033 42(b) 115,628 51, ,025 81,718 (5,692) 147,025 76,026 5,692 5,692 (5,692) 5,692 42(b) 17,

139 27. 1,298, ,961 1,026 1, , ,558 1,850, ,170 (1,149) (1,454) (900) 31 (30,335) (252,204) (519,488) 1,299, , , , ,297 26, , , ,850, ,

140 27. 31,484, ,558, ,262 22,152 3,442 3,401 7, ,444 25,

141 29. 78,694 51,363 51,523 30,045 6,084 11,768 1,709 19,608 18,837 15,557 3, ,181 13,610 7,082 3,578 42(b) 113,324 77,711 16,411 15, , ,477 18,000 20, , ,

142 30. 18,734 22,440 (a) (b) ,847 7, (9,138) (8,672) (a) (8,247) (581) (b) (670) (1,607) 135,526 18,734 (12,959) (976) (670) 122,567 17,088 (a) (b) DaVita China Pte. LtdDaVita China4,822,

143 , ,429 (a) 4.35% 7% (i) 56,313, ,118,000 (ii) 30,335, ,204,000 (b) 2.20% 2.29% (c) 32. TFR TFR TFR TFR TFR19 141

144 32. TFR % 1.7 % 3.0 % %

145 , (473) (135) 6,600 (334) 5,727 6,

146 32. 6, (473) (135) (334) 5,

147 33. 2,515,313, , , ,939,518, (119) 575,795, ,132,853 4,132,888 (143,895) (143,895) ,515,313, ,355,287 4,355,

148 34. 10,000,000 10% 22,500, ,439, % 146

149 34. 1, ,882, % % 37.5 % ,581, ,683,

150 %50% 148

151 % 520,000,000 8,000, ,813 18,200 83, ,865 34,127 80,226 11,953 30,000 62,167 (6,144) (36,892) (70,000) (906) (134,847) (15,028) 197, , ,000 8, ,

152 ,000 (62,167) 457, ,267,00015,075,000 1,812,731,000507,200, % 9.43% 76,716,00036,000,000 40,716,000 34,390,000 13,338,000 21,052,000 5,002,000 1,710,

153 36. 13,600,000 85,556 71, , ,554 35,810 47,122 5,302 3,265 2,296 5,687 1,656 (10,092) (64,253) (28,000) (3,646) (7,154) (63,314) 443, , ,

154 ,622 (5,687) 227,935 1,249,078,000311,440,000 Sirton Sirton Sirton 25,250,00024,500,000750,000 9,737,

155 36. Sirton Sirton 55,408 7, ,280 4,325 14,461 1, (7,609) (66,455) (754) (6,631) (6,600) (1,818) , ,

156 36. Sirton 150,295 (46) 150,249 1,191,631,000286,415, % 100,000,

157 37. 49,815 10, , , , ,749 (9,138) (4,150) (100,000) (21,811) 21,811 (10,471) (10,471) 155

158 37. 32,225, ,237 20, (114) (8,672) 22,314 9,911 32,225 (20,474) (20,474) 156

159 , , ,

160 ,182 24,109 15,141 3,200 27,382 39, Decade Sunshine Injenerics Davita 158

161 42. (a) (i) 4, DaVita 5,651 3,500 1, ,000 32,225 10,000 (ii) 100,000 (i) 4,000, , ,000 (ii) 100,000,

162 42. (b) 8, ,500 32,225 Injenerics ,323 11, ,628 51,768 DaVita 17,424 10,726 Century Sunshine 102,598 77, ,324 77,711 (c)

163 , , , ,441 81,585 81,585 1,299,398 1,299, , ,488 31,484 31,484 2,536,007 81,585 2,617,592 34, , , ,

164 , , , ,978 89,228 89,228 56,052 56, , , , , , ,234 1,087,559 25, , ,429 1,142,

165 44. 38,583,000 11,880,

166 45. 10,895 10,895 70,690 70,690 10,895 70,690 81,

167 45. 14,052 14,052 42,000 42,000 14,052 42,000 56,

168

169 , , , ,

170

171

172 46. 23,262 8,323 2,859 34,444 39,156 18,952 95, , ,000 5, , ,418 32,275 98, ,263 22,061 3,577 25, ,321 91, , , , , ,006 91,362 1,142,

173 46. 13,010 15,451/12,696 14,632 15,658/13, / ,046/

174 46. 10% * 10,014 1,001/(1,001) 13,458 1,346/(1,346) * 172

175 , ,429 5,635, , % 65.4% ,000, % 3.85%890,094,00098,899, %44,326,000 25,000, ,000,

176 47. (i) 43.42% (ii) 1,085,230, ,000,000 2,200,000, % (i)43.42% (ii) 1,085,230,0002,713,750, ,765,500 30%1,217,994, ,000, % 75,000,000 8% 174

177 48. 1,619 1,619 92,183 92,183 67,783 67, , ,585 10,014 13, ,165, , ,591 3,788 4,365, ,491 11, , ,353, ,042 4,515, ,627 12,273 13,651 12,273 13,651 4,503, , ,283, , ,860 (22,184) 4,503, ,

178 , ,971 (222,000) (64,978) 295,226 (439) 1, , ,823 11,801 (11,801) 11,158 11,158 (359,014) (300,000) (659,014) 67,783 67, ,160 6,532 (220,265) 191, ,976 (5,129) 255,344 (9,171) 241,044 (119) (119) 4,132,853 4,132,853 (143,895) (143,895) 4,283,999 1,403 35, ,378 4,502,

(3S Bio) AR(chi)_.indb

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