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1 Hua Han Bio-Pharmaceutical Holdings Limited 華瀚生物製藥控股有限公司 (於開曼群島註冊成立之有限公司) (股份代號: 587) 年報 2014/2015

2

3

4 (CPA, ACCA) Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY Cayman Islands

5 1 22 Royal Bank of Canada Trust Company (Cayman) Limited 4th Floor, Royal Bank House 24 Shedden Road, George Town Grand Cayman KY Cayman Islands

6 1,820,631 1,860, ,600,311 1,860, , , , (%) ,959,000 2,687, ,000,000 1,500,000 1,754, % 1,860, % 1,820,631 1,600,000 1,400,000 1,200, % 1,367,360 1,342, % 1,250,222 1,000,000 1,000, , , , , , , , , , , , , , % 341, % 648, , , , , , , , , , % 658, % 793, , , ,320 (12.1%) 1,600,311 (87.9%) (0%) 1,860,189 (100%) 4

7 1,820,631,000 1,860,189, % 648,617, ,314, % TIOT OTC 5

8 1. TIOT GMP 6

9 4. GMP 5. 7

10 36, % 23, %2, % 17,1368.8%1, % 2 15% 95% GDP 8

11 100 GMP 9

12 2014 TIOT6+1 + GMP 10

13 1,820,600,0001,860,200,000 1,600,300, % 220,000, ,600, % TIOT6+1 TIOTTIOT 8 5, % 70% 100%2,560 11

14 VIPOTC ++ 3,000 5,

15 ,

16 GMP

17 7,590 31, %GDP GDP5.5%17.9% 9.7%

18 TIOT6+1 OTC 1. TIOT %

19 + A. + B. + DNA+ + 4p AATB 17

20 C. D. E. PC APP F. 18

21 G. 2. VIP + + +OTC+ 3. GAPGMP 19

22 GMP

23

24 6,598,800,000 2,725,300, %0.7% 6,947,900,0003,316,300, ,100,0001,700, % 0.1% Design Time Limited Driven Innovation Limited 620,000, ,000, ,457,346, ,144,800, ,400, ,700,000 22

25 31,300,000 38,000,000 23

26 1,617, ,865 62,530 62, ,680, ,586 TIOT 4,367, , ,278 6,413, ,864 3,223 3,247 1, ,044 70,600,000131,900, %7.1% 24

27 ,045,000 25

28 53 Bull s-eye Limited 26.29% 51 Bull s-eye Limited 0.06% 26

29 % % % 27

30 65 40 Circulation Research

31 EMBA GCDF 29

32

33 GMP 31

34

35 (b) 33

36 226 3,822,526,0001,611,980,000199,045,000 4,365,840,000 37(b) 30% 30.5% 11.0% 5% 34

37 108A

38 42 XV352 36

39 1 1,933,342,643 (L) 2a 26.23% 4,095,144 (L)2b 0.06% 4,095,144 (L)2b 0.06% 4,095,144 (L)2b 0.06% 4,095,144 (L)2b 0.06% 149,300(L) 0.002% 2e 12,774,403(L) 2c 0.17% 2e 1,586,000 (L) 0.02% 2e 2,258,524 (L)2d 0.03% 1. L 2a. 1,933,342,643 Bull s-eye LimitedBEL XV7 8 BEL 2b c. 12,774,403 (2b)4,095,144 2d. 2,258,524 (2b)682,524 2e. 37

40 ,039, % (a) (b) 3,000,000 1,095,144 4,095,144 3,000,000 1,095,144 4,095,144 3,000,000 1,095,144 4,095,144 3,000,000 1,095,144 4,095,

41 (a) (b) c 3,000,000 (3,000,000) 3,000,000 (3,000,000) c 3,000,000 1,095,144 4,095,144 c 3,000,000 (3,000,000) c 3,000, ,524 (2,500,000) 682, ,000,000 5,658,244 (11,500,000) 21,158,244 (a) (b) (c)

42 336 5% 1 BEL2 1,933,342,643 (L) 26.23% 3 1,937,437,787 (L) 26.28% Haw Par Pharmaceutical Holdings Pte. Ltd 721,492,564 (L) 9.79% 4 721,492,564 (L) 9.79% 1. L 2. BEL XV 2 3 BEL BEL 3. XV Haw Par Pharmaceutical Holdings Pte. Ltd. XV 2 3 Haw Par Pharmaceutical Holdings Pte. Ltd

43 25%

44 42

45 (1) (2) (3) (4) D

46 6/6 6/6 6/6 6/6 2/6 3/6 6/6 2/6 2/6 2/6 3/6 3/6 3/6 Bull s-eye Limited

47 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 45

48 1/2 1/2 1/2 1/2 1/2 1/2 2/2 1/2 46

49 2,000, ,000,000 (1) (2) (3) (4) 47

50 1/3 1/3 1/3 2/3 2/3 2/3 2/

51

52

53

54 6 1,820,631 1,860,189 (570,409) (518,075) 1,250,222 1,342, ,338 24,858 (447,992) (643,620) (116,693) (118,298) 36 (83,650) 15 (11,913) 17 (53,767) (8,386) 18 (51,385) , (4,571) (534) (249) 7 (38,076) (1,736) 8 1,058, , (375,928) (144,963) 683, , , ,314 34,395 12, , ,

55 683, ,157 (7,200) (496) 2, (5,023) 94 (62,276) 10,405 (158) 78 (263,314) (325,748) 10,483 (330,771) 10, , , , ,922 29,597 11, , ,734 53

56 15 1,091, , ,602 28, , , , , , ,744 18, , , , , ,202 2,470,072 2,168, ,201 43, , , ,370 17,293 5, ,598,816 2,725,335 7,632,678 3,708, ,746 59, , , ,265 37, , , , ,137 6,947,868 3,316,271 9,417,940 5,485, , ,825 48, , ,376 61,542 8,792,564 5,423,708 54

57 35 737, ,408 37(a) 7,822,469 4,812,440 8,559,674 5,220, , ,860 8,792,564 5,423,708 55

58 317,009 1,135,052 45, , ,032 7,694 (8,410) 2,233, ,716 4,546, ,048 4,737, , ,314 12, ,157 10,483 10,483 10, (1,400) (496) ,125 10, , ,922 11, , ,809 (63,809) 35 27, ,174 (83,352) 438, , ,650 83,650 83, (1,278) (199,716) (200,994) (200,994) 13 (147,027) 147, ,408 1,417,112* 46,959* 100,781* 526,515* 7,992* (8,410)* 2,574,464* 147,027* 5,220, ,860 5,423,708 56

59 408,408 1,417,112 46, , ,515 7,992 (8,410) 2,574, ,027 5,220, ,860 5,423, , ,617 34, ,012 (57,975) (57,975) (4,459) (62,434) (263,314) (263,314) (263,314) 15 (6,723) (6,723) (477) (7,200) 33 2,039 2, ,177 (4,684) (321,289) 648, ,644 29, ,241 40,770 40, (26,307) (100,781) 127,088 (40,337) (40,337) (3,182) 3, ,912 (81,912) 35 1,150 20,654 (3,404) 18,400 18, ,735 2,948,816 3,194,551 3,194, (49,742) (49,742) (49,742) 13 (147,027) (147,027) (147,027) 13 (199,045) 199, ,205 4,055,883* 12,786* * 205,226* 4,588* (8,410)* 3,353,351* 199,045* 8,559, ,890 8,792,564 * 7,822,469,000 4,812,440,000 57

60 1,058, ,120 6 (35,283) (19,805) 7 38,076 1, ,082 19, ,301 33, , ,767 8,386 8 (2,469) 8 11,913 8 (359) (2,432) (464,398) 32 4, (17,609) (5,053) 36 83, , ,171 (62,976) (1,715) 39,371 (252,919) 39 (894) 25,644 (7,173) 7, ,956 (18,984) 789, ,673 (100,709) (94,144) 688, ,529 58

61 35,283 19,805 27, (14,441) (306,096) 23(c) 192,749 (192,749) (86,896) 7, ,060 (736,988) (141,150) (9,951) 15,255 (18,267) (457,660) (625,648) 35 18, , ,194, (49,742) ,325 40,770 31,265 37,884 (25,256) (31) (89) (147,027) (200,994) (12,246) (1,736) 3,693, ,221 3,924,570 (79,898) 2,725,335 2,799,436 (51,089) 5,797 6,598,816 2,725,335 59

62 27 6,173,612 2,720, ,204 4,571 6,598,816 2,725,335 60

63 20 133, , ,015,895 2,162, ,300 6,738 5,353,375 2,169, , , , , ,409 5,039,166 1,894,677 5,172,869 2,028, ,551 4,564,318 2,028, , ,408 37(b) 3,628,068 1,472, , ,027 4,564,318 2,028,380 61

64

65 2.1 (i) (ii) (iii)(i) (ii) (iii)

66

67 2.4 (a) (b) (c) 20% 65

68 2.4 66

69

70 2.4 68

71 2.4 69

72 2.4 (a) (i) (ii) (iii) (b) (i) (ii) (iii) (iv) (v) (vi) (a) (vii) (a)(i) 70

73 2.4 2% 10% 20% 25% 5% 20% 12.5% 20% 71

74 2.4 72

75 2.4 73

76 2.4 74

77 2.4 75

78 2.4 (a) (b) 76

79

80 2.4 78

81

82 2.4 80

83 2.4 81

84 2.4 (a) (b) (c) 36 82

85 2.4 83

86 2.4 84

87 2.4 85

88 3. (1)(2) (3) 86

89 3. TIOT TIOT 20 TIOT TIOT TIOT TIOT5 2,469, ,291, ,018,

90 ,128, ,874, ,632, ,273, ,767,000 8,386,000 51,385,000 37,518, ,110,00051,651,

91 4. (i) (ii) TIOTTIOT 1,600, ,320 1,820,631 17,609 17,609 2,432 2,432 1,620, ,320 1,840, ,967 72, ,426 35,283 2, ,398 (4,571) (534) (38,076) 1,058,940 89

92 4. 9,469, ,950 9,716,772 18, ,234 10,102, ,407 17, , , ,551 16,825 1,310,186 18,082 18,082 31,301 31, ,385 51,385 53,767 53,767 (359) (359) (2,432) (2,432) * 748, ,928 * 90

93 4. 90% 242,976, ,438, TIOT TIOTTIOT 20 TIOT TIOT 91

94 6. 1,659,031 1,907,755 (58,720) (47,566) 1,600,311 1,860,189 28, ,571 1,820,631 1,860,189 35,283 19,805 17,609 5,053 2,014 54,906 24,858 2,432 57,338 24, ,500 1,730 29, ,698 38,076 1,736 92

95 8. 570, , ,082 19, ,301 33, ,010 3,067 2,677 2,563 3,000 2, ,227 57,037 67, ,328 7,505 70, , , ,767 8, (2,469) 15 11,913 3 (359) 884 (2,432)

96 ,000 1, ,840 3,640 7, ,505 12,297 5,505 13,

97 , ,345 * 252 1, , , , ,505 ** ** ** ** , , ,505 95

98 , ,233 * 252 1, , , , ,640 3, ,857 ** , , ,776 2,176 ** ,088 ** ,088 ** , ,664 3,264 1, ,640 7, ,297 * ** 96

99 ,298 43, ,431 1,000,000 7,500,001 8,000,0009,000,0019,500,000 9,500,001 10,000,

100 11. 25% 364, ,568 2, ,939 2, , ,963 15% 15% 15% 98

101 11. 1,058, , , ,780 (129,376) (52,589) 2, (116,100) (711) 354,031 75,711 (2,466) 375, , ,244,000 90,729,00037(b) 99

102 ,027 73, , , , , , ,045, ,027, ,115,

103 , ,314 35,575 4, ,763* 341,314 5,039,138 4,732,772 3,194 16, ,685 5,150,017* 4,748,939 * 648,617,000 5,042,332,

104 15. (a) (b) 235,874 7, ,231 26, , ,935 13,352 4, , ,928 (23,311) (9,957) (33,268) 38 (60,412) (6,663) (47,330) (16,033) (130,438) (18,242) (18,242) 64,621 31,333 (95,954) (2,402) (344) (1,855) (403) (2,457) (7,461) 196, ,774 14, ,040 1,134,454 4,481 77,604 20, ,911 11, , ,082 (9,114) (9,114) 38 (3,502) (39,503) (12,593) (55,598) (11,042) (11,042) (288) (1,295) (318) (1,901) ,694 8,766 43, ,128 81,080 5, ,040 1,091, ,874 3,404 51,627 5, , , ,774 14, , , , , , ,774 14, ,040 1,134,

105 15. (a) (b) 247,852 7,682 96,466 26,291 66, , , , ,150 (194) (194) (12,896) (12,896) , ,874 7, ,231 26, , ,935 4,142 59,420 20,104 83,666 12, , ,496 (183) (183) (c) 11,913 11,913 (12,400) (12,400) ,481 77,604 20, , ,874 3,404 51,627 5, , , ,852 3,540 37,046 6,187 66, ,560 7, ,231 26, , , , , ,874 7, ,231 26, , ,

106 15. (a) 196,128, ,874,000 7,200, , ,393, ,434,000 29,000 17,884,000 38,425, ,753, ,575,

107 15. (a) 196, , , ,874 4,002 5,795 2,293 5, , ,079 1,251 19,197 1,260 19,

108 15. (b) 90,766,000113,512,000 70,000,000 88,186,000 23(b) (i)535,936,000 (ii) 143,905,000 23(b) (c) 11,913,000 11,913, ,810 30,548 (815) (848) (987) 38 (3,228) (502) ,278 29, (676) (846) 23,602 28,964 10,673,000 1,046,

109 17. 5, ,136 7, , (5,025) (22,817) (7,520) (35,362) (79) (3,375) (134) (3,588) 403, ,944 4, ,877 7, , ,455 31, (5,025) (22,817) (7,520) (35,362) 53,767 53,767 (74) (2,856) (134) (3,064) 366, ,426 37,518 37, , ,

110 17. 5, ,634 7, , , ,547 5, ,136 7, ,894 2, ,533 7, ,127 1,279 31,926 33,205 8,386 8, , ,066 4, ,877 7, , , ,110 2, , ,

111 17. 37,518,000 0%17% 53,767,000 DNA 8,386,

112 18. 51,651 51,471 (51,385) (266) ,651 51,385,

113 , (17,641) 92, %0% 3% 18%21% 1,603 16,038 92,632 92,632 92, ,

114 , ,703 Intended Features Limited 375, ,909, ,000, ,000,

115 ,000, ,000, ,000, ,000, ,000, ,450, ,770, ,000, ,390,

116 NCI NCI 3 NCI NCI 4 38 Intended Features Limited ,134 18,267 18,744 18,

117 21. * * 49 60** 49 * ** (i) (ii) 50%

118 22. 9,562 10, , , , ,557 * 46.76% * (534) (249) (158) 78 (692) (171) 367, ,

119 23. (a) 494, ,045 (b) 333, ,960 (c) 192,749 7,504 7,559 3, , ,313 (a) 175,698, ,321, ,730, ,052,000 (b) , ,000, ,000, ,120, ,960,000 62,740,00083,764,000 15(b) (c) 153,000,000193,000,

120 24. 23,825 19,270 24,376 23,969 48,201 43, , ,082 (5,064) 857, ,018 7%21%37% 41% 513, , , ,582 64, , , ,

121 25. 5,064 7,497 (4,988) (76) 36 8 (2,469) 5,064 5,064,0005,064, , ,801 64, , , ,

122 26. 38(c) 113,887 7,031 4,591 (2,973) (3,332) 117,945 1,259 6,118 11, ,631 3, ,370 17, ,887,000 2,973,000 3,332,0002,973,000 3,332, ,173,612 2,720, ,300 6, ,204 4,571 6,598,816 2,725, ,300 6,738 5,499,972,000 2,717,127,

123 ,820 41,309 8,037 5,089 1,043 9, ,270 51,746 59, ,039 3,395 3, ,806 49, ,060 68,473 63,293 40, , ,320 40,

124 (31) 122

125 31. (%) 120% 31, ,794 31,265 37,794 (a) (b)

126 ,578 88, ,551 Design Time Limited Driven Innovation Limited 620,000, ,000, % 4.5% 124

127 ,000, ,000, ,598 84, ,000 (36,152) (36,152) 29,877 29,877 (9,745) (9,745) 4,571 4, ,578 88, ,

128 33. 33,913 15,031 48,944 (2,177) (2,177) 11 (22,369) (22,369) 38 (6,993) (6,993) (580) (580) 11,544 5,281 16,825 41,589 14,279 55,868 (590) (590) 11 (7,672) (7,672) (4) 1,342 1,338 33,913 15,031 48,

129 33. 34,202 34, (31,308) (31,308) 38 (2,360) (2,360) (534) (534) 41,158 2,757 43, (6,805) (3,086) (9,891) (151) ,202 34,202 10% 10% 127

130 ,243, ,514, ,637 22,598 (17,609) (5,053) (28) 92 17, (5,039) 12,

131 35. 8,000,000,0008,000,000, , ,000 7,372,040,2924,084,077, , ,408 4,000,000, ,000,000800,000,000 3,170,094, ,009 1,245,964 (a) 275,904,000 27, ,174 (b) 638,079,656 63,809 (63,809) (1,278) (147,027) 4,084,077, ,408 1,528,024 (c) 11,500,000 1,150 20,654 (d) 819,115,588 81,912 (81,912) (e) 2,457,346, ,735 2,948,816 (49,742) (199,045) 7,372,040, ,205 4,166,

132 35. (a) (b) (c) (d) (e) ,904, ,412,000275,904, ,079, ,500,000 18,400,000 11,500, ,115, ,457,346,7642,604,620, ,457,346, ,194,551,

133 (i) (ii) (iii) 10% 30% 12 1% %5,000,000 21,158,00027,000,

134 , , ,600 * 5, (11,500) (275,904) , ,000 * ,500,000 18,600, ,600,000 21,158, * 21,

135 36. * 27, * 83,650, ,650,000 11,500,00011,500,000 1,150,000 17,250, ,158,000 21,158,0002,116,000 22,677,

136 37. (a) 10% 50% 134

137 37. (b) 1,245,964 7,694 27,658 1,281, (63,809) (63,809) ,174 (83,352) 410, ,650 83,650 (90,729) (90,729) (1,278) (1,278) 13 (147,027) (147,027) 1,528,024 7,992 (63,071) 1,472, (81,912) (81,912) 35 2,948,816 2,948, (49,742) (49,742) 35 20,654 (3,404) 17,250 (480,244) (480,244) 13 (199,045) (199,045) 4,166,795 4,588 (543,315) 3,628,068 (i) (ii) 4,079,955,000 1,441,184,000 86,840,000 86,840, (iii)

138 38. (a) 100% 4,000,0004,961,200 20,356 1,210 2,138 (106) (24,197) (144,554) (16,713) (161,866) 13, ,543 4,961 4,961 4,961 (2,138) 2,

139 38. (b) 100% 20,000,00024,758,000 10,559 3,228 1, ,427 38,420 (469) (2,037) (37,137) (1,142) (26,387) (7,136) (199,092) 230,986 24,758 24,758 24,758 (38,420) (13,662) 137

140 38. (c) 99.7% 92,000,000113,887,000 64,281 16,038 2,360 57,338 2,560 3,602 (15,504) (16,063) (5,851) 2, ,524 (77,506) 79, ,887 39(b) 113,887 39(b) (3,602) (3,602) 138

141 39. (a) 11,940,000 (b) 38143,606, ,887,000 (c) 32620,000,000 41,850,000 39,175, ,117 2, ,720 2,519 3,

142 ,617, ,865 62,530 62, ,680, ,586 TIOT 4,367, , ,278 4,733, ,278 6,413, ,864 3,223 3, (a) (b) 9 14A 140

143 , ,018 18,134 18, , , ,576 5,154 6,598,816 2,725,335 7,953,489 4,026,077 5,015,895 2,162, ,300 6,738 5,353,195 2,168,

144 43. 51,746 59, ,749 37, ,265 37, , , , , ,586 40, , , ,

145

146 44. 51,746 51, , ,749 32,128 32,128 27, , , , ,438 1,115,961 59,494 59,494 37,828 37,828 39,369 39, , ,

147 , ,586 40,623 40,623 27, , , ,586 68, ,438 1,072, , , , ,

148 44. 31,265 37, , ,816 37,794 8,559,674 5,220, % 0.7% 146

149 45. (a) TIOT 20 (b) TIOT 20 (c) (d)

150 1,820,631 1,860,189 1,754,392 1,312,127 1,157,263 1,058, , , , ,825 (375,928) (144,963) (97,766) (79,278) (73,478) 683, , , , , , , , , , , , , , , ,838 34,395 12, ,743 33, , , , , ,291 10,102,750 5,877,387 5,154,142 4,404,381 3,659,108 (1,310,186) (453,679) (416,236) (314,711) (333,028) (232,890) (202,860) (191,048) (183,203) (143,462) 8,559,674 5,220,848 4,546,858 3,906,467 3,182,

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