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1 RNAi mirna...8 BRCA1 BRCA Cytokinetics Ispinesib

2 mg 15mg GMT H5N H5N1 WHO Nature Biotechnology α2 6 α FDA FDA 2005 H5N1 90µg/ml 2007 CSL

3 2 2 H5N1 GSK ViroClinics WHO 3. H5N ,000 1,200 1,000 5, , GE Healthcare Novavax GE Healthcare Bioprocess Ready To Process Novavax VLP Novavax I/IIa 12

4 3 Department of Health Alan Johnson Clean, safe care: Reducing infections and saving lives meticillin-resistant Staphylococcus aureus MRSAClostridium difficile healthcare associated infections HCAIs 1. HCAIs MRSA MRSA MRSA 40 MRSA 1,000 MRSA 90 National Health Service NHSMaidstone and Tunbridge Wells NHS BuckinghamshireStoke Mandeville HCAIs NHS MRSA 2. NHS

5 / NHS NHS 5, NHS NHS NHS Operating Framework NHS MRSA MRSA 3. MRSA MRSA MRSA 2009 the Care Quality Commission 4,500 MRSA HCAIs NHS MRSA HCAIs Health Protection Agency HPA MRSA 10 7

6 5 RNAi 50 1/ ,000 RNAi Science Citation Index Expanded SCI-E RNAi 1. RNAi SCI-E RNAi ( ~2007 SCI-E RNAi 2. RNAi 2.1 RNAi HBV 2003 RNAi 2 RNAs(shRNAs) RNAi HBV (McCaffrey A P et al, 2003) RNAi HBV

7 6 2 shrnas sirna HBV HBV HBV shrna anti-hbx anti-hbx lhrnas shrnas HBV shrnas HBV HBV HBV dsaav2/8 lhrnas sirna shrna HBV HBV anti-hbsag HBV RNAi HBV sirna HBV (Konishi M et al, 2003) HBV (Giladi H et al, 2003) RNAi HBV psuper/hbvs1 HBV shrna A B C HBV (Wu HL et al, 2005) RNAi RNAi HBV HBx Pol III U6 shrnas HBx U6 shrna 5 U6 shrna 6 HBV (Carmona S et al, 2006) lhrnas sirnaslhrna (Carmona S et al, 2006) shrna HBV Morrissey, DV et al, 2005) anti-hbsag sirnas sirna HBV Morrissey DV et al, 2005) shrna

8 7 shrna (dsaav2/8) shrna 120 HBV (Chen, CC et al, 2007) RNAi 2.3 HBV RNAi HBV polymerase II shrnas psilencer4.1/hbv HBV HBV(Ren GL et al, 2007) 3 RNAi HBV RNAi (dsaav2/8) RNAi (Suda T et al, 2007) RNAi [1] Carmona S, et al. Molecular Therapy, 2006, 13(2): [2] Chen CC. Gene Therapy, 2007, 14(1): [3] Giladi H, et al. Molecular Therapy, 2003, 8(6): [4] Konishi M, et al. Hepatology, 2003, 38(4): [5] Konishi M. Hepatology, 2003, 38(4): [6] McCaffrey AP et al. Nature Biotechnology, 2003, 21(6): [7] Morrissey DV. Hepatology, 2005, 41(6): [8] Ren GL, et al. Antiviral Therapy, 2007, 12(6): [9] Suda T, et al. Molecular Therapy, 2007, 15(12): [10] Weinberg MS. Molecular Therapy, 2007, 15(3): [11] Wen WH, et al. Hepatology, 2007, 46(1): [12] Wu HL. Gastroenterology, 2005, 128(3): [13] Ying CX, et al. Biochemical and Biophysical Research Communications, 2003, 309(2):

9 8 2 University of Texas Health Science Center lab-on-a-chip Cancer Investigation 25 2,500 1,000 X mirna - MSKCC RNA(miRNA) Nature mirna mirna

10 9 mirna RNAs mirna mir-335 mir-126 mir-206 mir-335 SOX4 tenascin-c mir-126 mir-335 mir can block breast cancers ability to spread/735 BRCA1 BRCA2 Journal of the American Medical Association BRCA1 BRCA2 BRCA1 BRCA2 BRCA1 BRCA2 BRCA1 BRCA2 Memorial Sloan-Kettering Cancer Center Colin B. Begg BRCA1 BRCA2 BRCA1 BRCA , % 42 BRCA1 31 BRCA % 67 BRCA1 41 BRCA2 BRCA1 BRCA2 BRCA1 BARCA2

11 10 2 BRCA1 BRCA2 can block breast cancers ability to spread/ Journal of the National Cancer Institute docetaxel (doxorubicin) Peter MacCallum Cancer Centre Prudence Francis III 5 78% 5 74% 5 73% Cytokinetics Ispinesib Cytokinetics ispinesib IIIB IV I/II ispinesib Cytokinetics E CENP-E I ispinesib MTD MTD II (RECIST) I MTD Cytokinetics II

12 Cytokinetics GSK ispinesib / anthracyclines taxanes II 21 18mg/m 2 ispinesib the Salk Institute for Biological Studies Journal of Cell Biology ductal carcinoma in situ DCIS 16 5 DCIS ERK1/2 MAP boll weevil

13 12 2 Agricultural Research Service ARS Crop Protection and Management Research Unit Patricia Glynn Tillman Fruit and Nut Research Laboratory Ted Cottrell Euschistus servus Nezara viridula Psychological Science McGovern Institute for Brain Research John Gabrieli functional magnetic resonance imaging fmri 10 10

14 13 Gabrieli attention machinery Arizona State University s Biodesign Institute DNA Science DNA RNA DNA DNA DNA M13 M % RNA DNA RNA DNA-RNA RNA

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untitled Chikungunya...1...3 RNAi...5...8 2...8...9...9...10...11...11...12...13 1 Chikungunya Chikungunya Alphaviruses 1952 1953 3 7 1. 39 7 2 5 3 20 50 60 1965 200 30 1987 1 2006 2 10 WHO 8 151 125 75 26 2. La