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1 Feline Infectious Peritonitis ; FIP 林 玲玲 狀 臨 狀 率 療 FIPV 狀 列 臨 見 率 FIP 力 數 例 度 離 類 類 feline infectious peritonitis; FIP 臨 狀 Coronaviridae 狀 (Coronavirus) (transmissible gastroenteritis virus ; TGEV 流行 痢 (porcine epidemic diarrhea virus ; PEDV) 狀 (canine coronavirus ; CCV) 類 狀 (human coronavirus 229E) 狀 (feline enteric coronavirus ; FECV) (crossreaction) 行 來 罹 臨 狀 率 1963 Holzworth 度 例 1968 Zook 1968 Ward 狀

2 1972 Montail & Stranberg 臨 狀 1978 Pederson FIPV TGEV CCV HCV 229E 1979 Black 離 1981 Pederson 狀 臨 狀 論 FIPV 狀 不 異 了 不 痢 了數 數 異 狀 了 療 例 FIP 例 例 狀 若 了 狀 例 不 (pyogranuloma) FIP 例 見 了 臨 度不 狀 (anterior uveitis) FIP 數 例 例 例 臨 FIP 例 了 異 狀 金 度 參 了 狀來 例 淋 量 降 0.7

3 ( ) 錄 鍊 RT-nPCR 便 狀 度 列 度 留 3 不 non-translated region ; NTR 異 spike protein gene 不 狀 率 列 狀 FECV [ 見 ] NTR 臨 狀來 率 ( ) in situ hybridization RNA 行 例 例 ( ) ELISA 狀 力 力 率 臨 狀 狀 力 FIP 例 力 不 來 兩 年 狀 CCV CCV ( ) 離 felis catus whole fetus-4 ; Fcwf-4 兩 狀 離 crandell feline kidney cell ; Crfk cell 離 ( ) cdna peripheral blood mononuclear leukocyte ; PBML FIPV FECV 異 理 理 FIP 切 ( ) 理 見 不 數量不 mm

4 連 淋 ( ) 理 FIPV 粒 見 狀 離 FIPV 便 尿 泌 FAPN feline aminopeptidase N 行 力 cellmediated immune response 力 FIPV 量 humoral immune response FIPV immune complex 3 complement 3 C3 macrophage FIPV monocyte 不 C3 殺 T cytotoxic T cell Tc cell 更 C3 更 來 proteolytic enzyme 量 不 淋 FIPV 異 FIPV Th2 cell B cell Th1 cell Tc cell FIPV 流 IL-6 IL-4 流 IL-2 interferon-gamma IFNgamma FIP delay-type hypersensitive ; DTH FIP

5 流行 狀 % 狀 25% 率 狀 六 兩 例 了 度 1982 年 零 臨 類 FIP 狀 類 TGEV 狀 feline leukemia virus ; FeLV 不 feline immunodeficiency virus ; FIV 力 易 例 年 不 FIPV 臨 不 狀 FIPV FIPV 力 數 FIPV 若 FIP 離 來 FIPV FECV 來 說 1985 年 度 來 不 行 列 說 療 療 狀 降 年 率 量 類 行 療 ribavirin in vitro 不 in vivo 療 不 療 不 離 量 若 FIPV 離 12

6 10-12 FeLV FIV FIP FIPV 力 7 便 力 數 DF-2 IgA 不 IgG 臨 力 不 FIPV 參 1. ANDREW S.E. (2000).- Feline infectious peritonitis. Vet. Clin. Of North America, 30, BERNARD F. (1996).- Fields of virology, 4 th edition. 3. CORAPI W.V. et al. (1995).- Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibodydependent enhancement. J. Virol., 69, EVERMANN J.F. et al. (1991).- Perspective on the epizootiology of feline enteric coronavirus and the pathogenesis of feline infectious peritonitis. Vet. Microbio., 28, FRANCES BARR (1998).- Feline infectious peritonitis. J. small animal practice, 39, GAMBLE D.A. et al. (1997).- Development of a nested PCR assay for detection fo feline infectious peritonitis virus in clinical specimens. J. Clin. Microbio., 35, GERBER J.D. (1995).- Overview of the development of a Modified live temperature-sensitive FIP virus vaccine. Feline Prac., 23, GLANSBEEK H.L. et al. (2002).- Adverse effect of feline IL-12 during DNA vaccination against feline infectious peritonitis virus. J. General Virol., 83, GUNN-MOORE D.A. et al. (1998).- Antibody and cytokine responses in kittens during the development of feline infectious peritonitis. Vet. Immunol.

7 Immunopathol., 65, GUNN-MOORE D.A. et al. (1998).- Detection of feline coronavirus by culture and RT-PCR of blood samples from healthy cats and cats with clinical feline infectious peritonitis. Vet. Microbio., 62, HARVEY C.J. et al. (1996).- An uncommon intestinal manifestation of feline infectious peritonitis: 26 cases ( ). JAVMA, 209, HERREWEGH A.A. P.M. et al. (1995).- Detection of feline coronavirus RNA in feces, tissues, and body fluids of naturally infected cets by RT-PCR. J Clin. Microbio., 33, KIPAR A. et al. (1998).- Cellular composition, coronavirus antigen expression and production of specific antibodies in lesions in feline infectious peritonitis. Vet. Immunol. Immunopath., 65, MARTINEZ M.L. et al. (1993).- Detection of feline infectious peritonitis virus infection in cell cultures and peripheral blood mononuclear leukocytes of experimentally infected cat using a biotinylated cdna probe. Vet. Microbio., 34, MURPHY et al. (2000).- Veterinary virology. 16. OLSEN C.W. (1993).- A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination. Vet. Microbio., PALTRINIERI S. et al. (1998).- Some aspects of humoral and cellular immunity in naturally occurring feline infectious peritonitis. Vet. Immunol. Immunopathol., 65, PEDERSON N.C. (1995).- An overview of feline enteric coronavirus and infectious peritonitis virus infection. Feline Prac., 23, POLAND A.M. et al. (1996).- Two related strains of feline infectious peritonitis virus isolated from immunocompromised cets infected with a feline enteric coronavirus WIESS R.C. (1991).- The diagnosis and clinical management of feline infectious peritonitis. Vet. Med., ZENGER E. (2000).- FIP, FeLV, FIV: making a dignosis. Feline practice, 28,

8 4-1 Feline infectious peritonitis 4-2 Feline infectious peritonitis

9 4-3 Feline infectious peritonitis 量 4-4 Feline infectious peritonitis 淋 H&E

10 4-5 Feline infectious peritonitis 淋 H&E 4-6 Feline infectious peritonitis 量淋 H&E

11 4-7 Feline infectious peritonitis 量 見 in situ hybridization