CHINATROPICALMEDICINEVol. No. November,,,., ml,,, - ELISA. HBV -HBs, HBsAg -HBs - HBc, HBV., SPSS.... HBV, HBV,. %;HBsAg,. %, HBV. %; -HBs,. %; -HBc,.

Size: px

Start display at page:

Download "CHINATROPICALMEDICINEVol. No. November,,,., ml,,, - ELISA. HBV -HBs, HBsAg -HBs - HBc, HBV., SPSS.... HBV, HBV,. %;HBsAg,. %, HBV. %; -HBs,. %; -HBc,."

射金
7 years ago
Views:

1 * CHINATROPICALMEDICINEVol. No. November [ ] 曾雪霞, 曾昭长, 孙莲英, 潘婷婷, 李位鸿, 何剑, 闫秀娟, 邓海英, 符振旺摘要 : 目的了解海南省现阶段人群乙型病毒 (HBV) 性肝炎 ( 以下简称乙肝 ) 感染状况, 评价年我国乙肝疫苗推广接种和年纳入儿童计划免疫实施效果方法采用多阶段随机抽样方法, 随机抽取 ~ 岁人群进行问卷调查, 同时采集静脉血标本, 标本由中国疾病预防控制中心统一检测乙肝感染标识物结果海南省 ~ 岁人群 HBV 感染率为.%, HBsAg 携带率为. %, 分别较年前自然感染期下降了. 个和. 百分点人群中有乙肝疫苗免疫史者占. % ~ 岁和 ~ 岁儿童乙肝疫苗全程接种率分别为. % 和. %, 及时接种率分别为. % 和.%, HBV 感染率为.% 和. %, HBsAg 携带率分别为. % 和. % ~ 岁人群 HBV 感染率和 HBsAg 携带率分别为. % 和. %, HBV 感染率随年龄增长而升高除 ~ 岁组外, 城市人群乙肝疫苗接种率首针及时接种率高于农村, 人群 HBV 感染率 HBsAg 携带率远低于农村农民工人 HBV 感染率 HBsAg 携带率高于其它职业人群, 人群感染率和 HBsAg 携带率有随文化程度提高而下降趋势人群乙肝感染存在家庭聚集性, 聚集率为. % 结论海南省自年推广应用乙肝疫苗后, 特别纳入儿童计划免疫实行免费接种后, 有效控制了乙肝的传播, 岁以下儿童乙肝接种率和首针及时接种率大幅提高, HBV 感染率 HBsAg 携带率大幅下降, 母婴垂直传播导致的家庭聚集感染是海南省人群乙肝感染率高的主要因素关键词 : 人群 ; 乙肝 ; 血清 ; 流行病学 ; 调查中图分类号 :R. 文献标识码 :A 文章编号 : - ( ) - - Sero-epidemiologicalsurveyofhepatitisB virusinfectionindiferentpopulationsinhainanprovince.zeng Xue-xia, ZENGZhao- chang, SUN Lian-ying, etal.(hainanprovincialcenterfordiseasecontrolandprevention, Haikou, Hainan, P.R.China). Abstract:Objective TounderstandthecurentinfectionstatusofhepatitisBvirusinHainanProvinceandevaluatethe efectsofuseofhepatitisbvaccineinchildrensince. Methods QuestionairesurveyofinfectiousstatusofhepatitisB virusindifetentpopulaitonsaged - yearswasmadeandveinousbloodsamplesweremeatimerandomlycolectedandassayedbynationalcdc. Results TheprevalentrateofHBVwas. % andthehbsagpositiveratewas. %, which droppedby. % and. % ascomparedwiththatof.thefulcourseofhepatitisbvaccinationrateinchildrenaged - yearsand - yearschildrenwere. % and. %.Whilethevaccinationratewas. % and. %.HBVinfectionratewas.% and. %, HBsAgcaryingratewas.% and. %.TheHBVprevalenceandHBsAgcarying ratewas. % and.% inpopulationof - yearsold.thehepatitisbvaccinationrateandintimerateofruralpopulationsweresignificantlyhigherthanurbanonesexceptthe - yeargroup, hehbvprevalencerateandhbsagpositive rateweresignificantlylowerthanurbanones.theinfectionrateofhbv andhbsagpositiveratesinworkersandpeasants weresignificantlyhigherthanothers, anddescendingalongwiththe increaseofeducationallevelsthefamilialclusteringof HBVInfectionwasfounded(about. %). Conclusion HepatitisBvirusinfectionwasefectivelycontroledafterapplicationofhepatitisBvaccinefreely, theinfectionrate, HBsAgcaryingrateandtimelyvaccinationrateinchildrenunder yeatsoldaregreatlyincreased. Keywords:Population;HepatitisB;Sero-epidemiology;Survey,,,. %(. %), ( HBsAg). %,. %, [ ],,, ~.,,,., * 作者单位 : 海南省疾病预防控制中心, 海南海口作者简介 : 曾雪霞, 女, 学士. 主管医师, 主要从事免疫规划方向的研究

2 CHINATROPICALMEDICINEVol. No. November,,,., ml,,, - ELISA. HBV -HBs, HBsAg -HBs - HBc, HBV., SPSS.... HBV, HBV,. %;HBsAg,. %, HBV. %; -HBs,. %; -HBc,. %;,.%;. %,. %( ) HBsAg -HBs -HBc HBeAg -Hbe 注 : 未检测出单 HBsAg 阳性者.. HBV ~ HBV HBsAg,,, HBsAg ~ HBV HBsAg. %. %, HBV, HBsAg HBV (χ =., P <. ) HBsAg (χ =., P <. ) -HBs. %, ~ -HBs.%,. %( ).. HBV HBsAg, (χ =., P<. ), HBV - HBs (χ =., P >., χ =., P >. ),.. HBV HBV HBsAg, ~ HBsAg, %,. %, -HBs HBV (P >. ), ~ HBsAg HBV, -HBs (P <. ); HBV (P <.), -HBs (P <. ), HBsAg (P>. )() HBsAg -HBs HBV ~ (. ) (. ) (.) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) (. ) (. ) (. ) (. ) ()HBsAg -HBs HBV (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) 注 :χ =., P <., χ =., P >., χ =., P >. HBV HBsAg -HBs HBV ~..... ~ ~ ()HBsAg (%) () -HBs ()HBV (%) (%) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) 注 :χ =., P <. ;χ =., P <. ;χ =., P =<... HBV HBV HBsAg -HBs (P

3 CHINATROPICALMEDICINEVol. No. November P P <. ) HBV HBsAg, ; -HBs, ().. HBV, HBV HBsAg,, (P P <. ); -HBs (P <. )().. HBV, HBV ( ), HBV ( ),. %,,. %, HBV. %, (%) (%) ( χ =., P <. ),, >, ( ) (%) ()HBsAg (%) () -HBs ()HBV (%) (%) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) (. ) 注 :χ =., P =. ;χ =., P =. ;χ =., P =. HBV (%) (%) (%) (%) (.) (.) (.) (.) (.) (.) (.) (.) (. ) (. ) (.) (.) (.) (. ) (. ) (.) (.) (.) (.) (.) (.) (.) (.) (. ) (.) (. ) (.) (.) (.) (.) (%) > (.) (.) (.) (.) (. ) (. ) (.) (.) (.) (. ) (. ) (. ).., ~ HBsAg HBeAg. %. %, ~. %, ( ). %; ~ HBsAg.% %, -.%, ( ).% ~ HBsAg. %( ). (%) (%) (%) ~ (.) (. ) (. ) ~ (. ) (. ) (. ) (.) ~ (. ) (. ) (. ) (.) (.) (. ) (. ) (.)...% ~,. %; ~,. %, ~. %, % (χ =., P<. ) ~ %,,,, ~ (.) (.) (. ) ~ (.) (.) (. ) ~ (.) (. ) (.) ~ (. ) (. ) (. ) ~ (. ) (. ) (.) ~ (.) (.) ~ (.) (. ) (.) ~ (.) (.) ~ (. ) (. ) ~ (. ) (. ) (. ) ~ (. ) (. ) ~ (. ) (. ) (.) (.) (. ).. ~,.%,. %,.%;.%,.%,. %; (P, P <. ) ~

4 CHINATROPICALMEDICINEVol. No. November, ~ ( ) ~ (%) (%) (%) ~ ~ 注 : 两地区住院出生率差异检验, χ =., P <. ; 两地区乙肝疫苗首针及时率差异检验, χ =., P <.,, HBV. %,, HBsAg. %, [ ],,,, HBV. %,. %, HBsAg. %,.% [ ],, ~. %,.%, HBsAg.%, < < %, ~ HBsAg. %. %,, HBsAg,, HBsAg [ ], HBV HBsAg %,,, HBV., HBsAg.,,. HBsAg, %, [ ],.., HBV, HBV [ ] HBsAg HBeAg. %, ~ ( ).%, ~ ( )HBsAg. %, ~ ( )HBsAg.%, HBsAg % ~ % HBV [ ], ~ HBsAg, % ~ -HBs HBV, ~,, HBsAg HBV [ ],, HBsAg,,,, HBV HBsAg, HBV HBsAg,,,,,,,,,, HBV, HBV HBsAg ( = HBV %) [ ],.%, [ ] HBsAg,, HBV, HBsAg,, ~ HBsAg. %, ~ < <% HBsAg,, HBsAg, HBsAg ( 下转第页 )

5 CHINATROPICALMEDICINEVol. No. November rdna, rdna, AgNORs, rdna [ ], rdna,,,,, rdna [ ], T rdna (TNFR), TNFR, TNFR-Ⅰ stnfr-Ⅰ TNFR-Ⅱ stnfr-Ⅱ [ ] stnfr TNF,, TNF, stnfr-, stnfr- [ ~ ],, stnfr- (P <.), T rdna (P <. ); stnfr- T rdna (P >. ),,,,,, : [ ],,,. [ J].,, : ~. [ ],,,. [ J].,, : ~. [ ],,,. rdna [ J].,, : ~. [ ],.[ J].,, : ~. [ ],. [ J].,, : ~. [ ],,,. T rdna [ J].,, : ~. [ ],,,. rdna [ J].,, : ~. [ ] NikolaidisMG, MichailidisY, MougiosV.Variationofsolubletransferrinreceptorandferitinconcentrationsinhumanserumduringrecovery from exercise[ J].EurJA plphysiol,, : ~. [ ],. IL- stnfr [ J].,, ( ): ~. [ ],,,. stnfr CEA NSE [ J].,, ( ): ~. [ ].stnfr MOF [ J].,, : ~. 收稿日期 : - - ( 上接第页 ), HBsAg.%,,, HepB % ~ % HBV [ ], ~.% HBsAg,, (HBIG), [ ] : [ ] ( )[ M]. :,,. [ ],,,. [ P]. ( )[ M]. :,, ~. [ ],, Alison,. [ J].,, ( ): ~. [ ] SeegerC, MasonW S.HepatitisBVirusBiology[ J].MicrobiolMol BiolRev,, : ~. [ ] GhendonY.PerinataltaransmisionofhepatitisBvirusinhighincidencecountries[ J].JVirolMethods,, ( - ): ~. [ ],,,. [ J].,, : ~. [ ],,,. [ P]. ( )[ M]. :,, ~. [ ],,,. [ J].,,. [ ],,. [ J].,, ( ): ~. [ ] KoyamaT, MatsudaI, SatoS, etal.preventionofperinatalhepatitisb virustransmisionbycombinedpasive/activeimmunoprophylaxisin Iwate, Japan( / )andepidemiologicalevidenceforitseficacy [ J].HepatolRes,, ~. 收稿日期 : - -

1 乙肝病毒的真面目乙肝病毒的英文简写为 HBV 体积极其微小人眼如果不借助电子显微镜是看不到它的但是它无处不在公共汽车上超市的手推车上银行的柜台上菜市场的门帘上电梯的扶手上钞票上都能找到它的影子乙肝病毒侵入人体后会进入肝细胞进行复制繁衍

1 乙肝病毒的真面目乙肝病毒的英文简写为 HBV 体积极其微小人眼如果不借助电子显微镜是看不到它的但是它无处不在公共汽车上超市的手推车上银行的柜台上菜市场的门帘上电梯的扶手上钞票上都能找到它的影子乙肝病毒侵入人体后会进入肝细胞进行复制繁衍第一部分乙肝来了 1 乙肝病毒的真面目乙肝病毒的英文简写为 HBV 体积极其微小人眼如果不借助电子显微镜是看不到它的但是它无处不在公共汽车上超市的手推车上银行的柜台上菜市场的门帘上电梯的扶手上钞票上都能找到它的影子乙肝病毒侵入人体后会进入肝细胞进行复制繁衍乙肝病毒很容易发生变异因此如果用药不合理吃吃停停或者不遵医嘱用药