國家圖書館典藏電子全文

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宰邑国
7 years ago
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1 ,,,,,

2 t

3 Aspiring (cyclooxygenase), (prostaglandin endoperoxide),pgg PGH Aspirin E2 (preoptic hypothalamic region),,,,

4 , ( ), ( ), ( ),, (27~49) ;,,, kg Wistar g ICR 20 2g,

5 SPF Fig. 1~3 Fig mg/kg 500mg/kg 1000mg/kg Aspirin 500mg/kg, 1. Pyrogen (C.M.C) 2. Acetylsalicylic.acid.(Aspirin) (Sigma) 3. Sodium.pentobarbital (Sigma) 4. PICB7 (Waters) 5. N-butanol,n-methanol,n-heptane (Sigma) 6. Distilled water

6 1. 2. Hall open-field(fig.5) 60cm 50cm 80cm 19 80cm 100W 3. High-performance-liquid-chromatography: (HPLC,Waters)Model440 Absorbance Detector Data Module Model 746 Model 717 Autosampler(Fig.6). Detector UV 280nm;Column Phenyl, Digital Plethysmometer LE7500 :(Letica-scientific instruments) (Fig.7) 5. Tail-Flick Analgesia Meter :(Columbus Instruments Columbus, Ohio, U.S.A)( Fig.8) 1. : open-field test (47)

7 20 2g ICR 10, Hall open-field 3 (ambulation ) 5ml/kg( ), Aspirin 500mg/kg( ) ( ) 250 mg/kg 500mg/kg 1000mg/kg g Wistar 10, ( Fig.7)Digital plethysmometer LE7500 5ml/kg( ), Aspirin 500mg/kg( )

8 ( ) 250 mg/kg 500mg/kg 1000mg/kg (W/L)Carrageenin kg

9 5ml/kg( ), Asiprin 500mg/kg ( ),, ( ) 250mg/kg, 500mg/kg, 1000mg/kg ml/kg pyrogen, g Wistar Tail-Flick Analgesia Meter ( Fig.8 ) 5ml/kg( ) Aspirin 500mg/kg( ) ( ) 250 mg/kg 500mg/kg 1000mg/kg

10 - ( % )= 100% g Wistar ml/kg( ) Aspirin 500mg/kg( ) ( ) 250 mg/kg 500mg/kg 1000mg/kg 30 (51) (cortex) (hypothalamus) ( Fig.9) Waters( ) HPLC Model 440 Absorbance Detector, Data.Model 746 Model 717 Autosampler (monoamine DA, 5-HT, NE ) 100

11 (Mean S.E.) One Way Anova P 0.05, P 0.01, P 0.001, Fig.10~Fig.12 Aspirin 500mg/kg (ambulation) 24 0~ ~ Fig mg/kg (P 0.05) 150 (P 0.01) 180 (P 0.001) Fig mg/kg 240 (P 0.05) Fig.12

12 250mg/kg 30,90,120,150,180 (p<0.05),240,300 (p<0.01) 500mg/kg 180 (P 0.05) 1000mg/kg 360 (P 0.001) Fig.13~Fig.15 Aspirin 500mg/kg Fig mg/kg 180 (P 0.05) 1000mg/kg 240 (P 0.01) Fig mg/kg (P 0.05) ) Fig mg/kg 30 (P 0.01) 1000mg/kg 30 (P 0.001) 300

13 (P 0.01) Fig.16~Fig ~39.5 pyrogen 60~180 (40.6 ~41 ) Fig mg/kg (P 0.05) Aspirin 500mg/kg Fig mg/kg 60, (P 0.05) Aspirin 500mg/kg Fig.19~Fig.21 Aspirin 500mg/kg

14 30~45 (P 0.05) 60 ~240 (P 0.01) Fig mg/kg (P 0.05) 500mg/kg (P 0.05) 45 ~24 (P 0.01) Fig mg/kg 30~ mg/kg 30 ~24 (P 0.05) 1000mg/kg (P 0.05) 45~120 (P 0.01) Aspirin 500mg/kg Fig mg/kg 30~ mg/kg mg/kg (P 0.05) 500mg/kg mg/kg (P 0.01) Aspirin 500mg/kg

15 Milton Wendlande (PG) (pyrogen) (10,11,49,50) 1963 Feldberg Meyer norepinephrine(ne) serotonin (5 HT) (17,19,20) NE 5 HT NE 5 HT (16,17.,51,52) (14,15,18,,20) PGE 2 (18) noradrenergic locus coeruleus neuron serotonergic raphe nucleus neuron

16 (12~20,53) (14,18) NE 4ug 4ug (20) DA (20,54) (5 HT) (15,16) (19,20) PG (25~46) : (1),,, (2), (3), (4),

17 . E2, PGH2, (26,27,35,45,46,) (26,27), (1), (45,55,56) (2), (26),,, 1000mg/kg mg/kg 1000mg/kg,

18 1. 250mg/kg 500mg/kg 1000mg/kg mg/kg 1000mg/kg Aspirin500mg/kg mg/kg 4. Aspirin500mg/kg Aspirin mg/kg

19 1000mg/kg. ( ). Aspirin 6.

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