according to the Hazard Communication Standard (CFR ) HazCom 2012 Symptoms/injuries after eye contact Symptoms/injuries after ingestion : M

Transcription

1 according to the Hazard Communication Standard (CFR ) HazCom 2012 Date of issue: 05/08/2015 Revision date: 05/08/2015 Version: 1.0 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product name Product code : : Brefeldin A Solution (1,000X) 1.2. Relevant identified uses of the substance or mixture and uses advised against Use of the substance/mixture 1.3. Details of the supplier of the safety data sheet BioLegend Inc Pacific Heights Blvd. San Diego, CA USA T : Research use only 1.4. Emergency telephone number Emergency number : (7:00AM 5:00PM PT, M-F) SECTION 2: Hazards identification 2.1. Classification of the substance or mixture GHS-US classification Flammable Liquid Label elements GHS-US labelling Hazard pictograms (GHS-US) Signal word (GHS-US) Hazard statements (GHS-US) Precautionary statements (GHS-US) : Not applicable. : Warning : Combustible liquid. : Keep away from flames and hot surfaces. No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations Other hazards SECTION 3: Composition/information on ingredients 3.1. Substance Not applicable Mixture Name Product identifier % GHS-US classification Dimethyl sulfoxide (CAS No) ( ) Flam. Liq. 4 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6- methyl-, (1R,2E,6S,10E,11aS,13S,14aR)- (CAS No) Acute Tox. 3 (Oral) * The exact percentage (concentration) of composition has been withheld as a trade secret in accordance with paragraph (i) of SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion 4.2. Most important symptoms and effects, both acute and delayed Symptoms/injuries after inhalation Symptoms/injuries after skin contact : If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. : In case of contact, immediately flush skin with plenty of water. Call a physician if irritation develops and persists. : In case of contact, immediately flush eyes with plenty of water. Remove contact lenses, if worn. If irritation persists, get medical attention. : If swallowed, do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical advice/attention if you feel unwell. : May cause respiratory tract irritation. : May cause skin irritation. Symptoms may include redness, drying, defatting and cracking of the skin. 05/08/2015 EN (English) 1/17

2 according to the Hazard Communication Standard (CFR ) HazCom 2012 Symptoms/injuries after eye contact Symptoms/injuries after ingestion : May cause eye irritation. Symptoms may include discomfort or pain, excess blinking and tear production, with possible redness and swelling. : May be harmful if swallowed. May cause stomach distress, nausea or vomiting Indication of any immediate medical attention and special treatment needed Symptoms may not appear immediately. In case of accident or if you feel unwell, seek medical advice immediately (show the label or SDS where possible). SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media Unsuitable extinguishing media : Water spray, alcohol-resistant foam, dry chemical, carbon dioxide. : None known Special hazards arising from the substance or mixture Fire hazard : Combustible liquid. Products of combustion may include, and are not limited to: oxides of carbon, oxides of sulfur Advice for firefighters Protection during firefighting : Keep upwind of fire. Wear full fire fighting turn-out gear (full Bunker gear) and respiratory protection (SCBA). Use water spray to cool exposed surfaces. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures General measures 6.2. Methods and material for containment and cleaning up For containment Methods for cleaning up 6.3. Reference to other sections : Eliminate sources of ignition. Use personal protection recommended in Section 8. Isolate the hazard area and deny entry to unnecessary and unprotected personnel. Use special care to avoid static electric charges. : Contain and/or absorb spill with inert material (e.g. sand, vermiculite), then place in a suitable container. Do not flush to sewer or allow to enter waterways. Use appropriate Personal Protective Equipment (PPE). : Scoop up material and place in a disposal container. Vapors may be heavier than air and may travel along the ground to a distant ignition source and flash back. Provide ventilation. See section 8 for further information on protective clothing and equipment and section 13 for advice on waste disposal. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Keep away from sources of ignition - No smoking. Avoid contact with skin and eyes. Avoid breathing vapour or mist. Do not swallow. Handle and open container with care. When using do not eat, drink or smoke. : Launder contaminated clothing before reuse. Wash hands before eating, drinking, or smoking Conditions for safe storage, including any incompatibilities Technical measures Storage conditions 7.3. Specific end use(s) Not available. : Proper grounding procedures to avoid static electricity should be followed. : Keep container tightly closed. Store in dry, well-ventilated area. Store under inert gas. Hygroscopic product. SECTION 8: Exposure controls/personal protection 8.1. Control parameters Dimethyl sulfoxide ( ) AIHA AIHA - Workplace Environmental Exposure Levels (WEELs) - TWAs 250 ppm 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-, (1R,2E,6S,10E,11aS,13S,14aR)- ( ) ACGIH Not applicable OSHA Not applicable 05/08/2015 EN (English) 2/17

3 according to the Hazard Communication Standard (CFR ) HazCom Exposure controls Appropriate engineering controls Hand protection Eye protection Skin and body protection Respiratory protection Environmental exposure controls Other information : Use ventilation adequate to keep exposures (airborne levels of dust, fume, vapor, etc.) below recommended exposure limits. : Wear suitable gloves. : Safety glasses or goggles are recommended when using product. : Wear suitable protective clothing. : In case of insufficient ventilation, wear suitable respiratory equipment. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. : Maintain levels below Community environmental protection thresholds. : Do not eat, smoke or drink where material is handled, processed or stored. Wash hands carefully before eating or smoking. Handle according to established industrial hygiene and safety practices. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Appearance : Clear Colour : Colourless Odour Odour threshold ph Melting point Freezing point Boiling point Flash point : 87 C (189 F) Closed cup Relative evaporation rate (butylacetate=1) Flammability (solid, gas) : Flammable Explosive limits Explosive properties Oxidising properties Vapour pressure Relative density Relative vapour density Solubility Partition coefficient: n-octanol/water Log Kow Auto-ignition temperature Decomposition temperature Viscosity Viscosity, kinematic Viscosity, dynamic 9.2. Other information SECTION 10: Stability and reactivity Reactivity No dangerous reaction known under conditions of normal use Chemical stability Stable under normal storage conditions Possibility of hazardous reactions No dangerous reaction known under conditions of normal use Conditions to avoid Heat. Incompatible materials. Sources of ignition. 05/08/2015 EN (English) 3/17

4 according to the Hazard Communication Standard (CFR ) HazCom Incompatible materials Acid chlorides. Phosphorus halides. Strong acids. Strong oxidizing agents. Strong reducing agents Hazardous decomposition products May include, and are not limited to: oxides of carbon, oxides of sulfur. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity : Not classified. Brefeldin A Solution (1,000X) LD50 oral rat LD50 dermal rabbit LC50 inhalation rat Dimethyl sulfoxide ( ) LD50 oral rat LD50 dermal rabbit Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity Specific target organ toxicity (single exposure) > 2000 mg/kg > 2000 mg/kg No data available mg/kg 40 g/kg Specific target organ toxicity (repeated exposure) Aspiration hazard Symptoms/injuries after inhalation Symptoms/injuries after skin contact Symptoms/injuries after eye contact Symptoms/injuries after ingestion SECTION 12: Ecological information Toxicity Ecology - general : May cause respiratory tract irritation. : May cause skin irritation. Symptoms may include redness, drying, defatting and cracking of the skin. : May cause eye irritation. Symptoms may include discomfort or pain, excess blinking and tear production, with possible redness and swelling. : May be harmful if swallowed. May cause stomach distress, nausea or vomiting. : This product is not expected to produce significant ecotoxicity upon exposure to aquatic organisms and aquatic systems Persistence and degradability Brefeldin A Solution (1,000X) Persistence and degradability Not established Bioaccumulative potential Brefeldin A Solution (1,000X) Bioaccumulative potential Mobility in soil Other adverse effects Effect on the global warming Not established. : No known ecological damage caused by this product. SECTION 13: Disposal considerations Waste treatment methods Waste disposal recommendations Additional information : This material must be disposed of in accordance with all local, state, provincial, and federal regulations. The generation of waste should be avoided or minimized wherever possible. : Handle empty containers with care because residual vapours are flammable. 05/08/2015 EN (English) 4/17

5 according to the Hazard Communication Standard (CFR ) HazCom 2012 SECTION 14: Transport information Department of Transportation (DOT) In accordance with DOT UN-No.(DOT) Proper Shipping Name (DOT) Department of Transportation (DOT) Hazard Classes Packing group (DOT) Additional information Other information Special transport precautions : NA1993 : Combustible liquid, n.o.s. (Dimethyl sulfoxide) : Combustible liquid : III : No supplementary information available. : Do not handle until all safety precautions have been read and understood. SECTION 15: Regulatory information US Federal regulations All components of this product are listed, or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory except for: Tetradecanoyl phorbol acetate (TPA) CAS No ,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro- CAS No '-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)- 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-, CAS No (1R,2E,6S,10E,11aS,13S,14aR) US State regulations Brefeldin A Solution (1,000X) State or local regulations This product does not contain a chemical known to the State of California to cause cancer, birth defects or other reproductive harm. SECTION 16: Other information Date of issue : 05/08/2015 Other information : None. Disclaimer: We believe the statements, technical information and recommendations contained herein are reliable, but they are given without warranty or guarantee of any kind. The information contained in this document applies to this specific material as supplied. It may not be valid for this material if it is used in combination with any other materials. It is the user s responsibility to satisfy oneself as to the suitability and completeness of this information for the user s own particular use. 05/08/2015 EN (English) 5/17

6 according to Regulation (EC) No. 453/2010 Date of issue: 08/05/2015 Revision date: 08/05/2015 : Version: 1.0 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product name : Brefeldin A Solution (1,000X) Product code : Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Main use category Use of the substance/mixture : Industrial use : Research use only Uses advised against 1.3. Details of the supplier of the safety data sheet BioLegend Inc. 4B Highgate Business Centre 33 Greenwood Place London, NW5 1LB - UK T +44 (0) infoeurope@biolegend.com Emergency telephone number Emergency number : +44 (0) (9:00AM - 5:00PM GMT, M-F) SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP]Mixture: SDS < 2015 : Show CLP information + DPD classification insection 2.1 Not classified. Classification according to Directive 67/548/EEC [DSD] or 1999/45/EC [DPD] Not classified. Adverse physicochemical, human health and environmental effects 2.2. Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] No labelling applicable Other hazards SECTION 3: Composition/information on ingredients 3.1. Substance Not applicable Mixture Name Product identifier % Classification according to Regulation (EC) No. 1272/2008 [CLP] 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6- methyl-, (1R,2E,6S,10E,11aS,13S,14aR)- (CAS No) (EC no) Acute Tox. 3 (Oral), H301 Name Product identifier % Classification according to Directive 67/548/EEC 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6- methyl-, (1R,2E,6S,10E,11aS,13S,14aR)- Full text of R- and H-phrases: see section 16 (CAS No) (EC no) T; R25

7 according to Regulation (EC) No. 453/2010 SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. : In case of contact, immediately flush skin with plenty of water. Call a physician if irritation develops and persists. : In case of contact, immediately flush eyes with plenty of water. Remove contact lenses, if worn. If irritation persists, get medical attention. : If swallowed, do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical advice/attention if you feel unwell Most important symptoms and effects, both acute and delayed Symptoms/injuries after inhalation Symptoms/injuries after skin contact Symptoms/injuries after eye contact Symptoms/injuries after ingestion : May cause respiratory tract irritation. : May cause skin irritation. Symptoms may include redness, drying, defatting and cracking of the skin. : May cause eye irritation. Symptoms may include discomfort or pain, excess blinking and tear production, with possible redness and swelling. : May be harmful if swallowed. May cause stomach distress, nausea or vomiting Indication of any immediate medical attention and special treatment needed Symptoms may not appear immediately. In case of accident or if you feel unwell, seek medical advice immediately (show the label or SDS where possible). SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media Unsuitable extinguishing media : Water spray, alcohol-resistant foam, dry chemical, carbon dioxide. : None known Special hazards arising from the substance or mixture Fire hazard : Combustible liquid. Products of combustion may include, and are not limited to: oxides of carbon, oxides of sulfur Advice for firefighters Protection during firefighting : Keep upwind of fire. Wear full fire fighting turn-out gear (full Bunker gear) and respiratory protection (SCBA). Use water spray to cool exposed surfaces. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures General measures 6.2. Environmental precautions : Eliminate sources of ignition. Use personal protection recommended in Section 8. Isolate the hazard area and deny entry to unnecessary and unprotected personnel. Use special care to avoid static electric charges. Keep out of drains, sewers, ditches, and waterways. Minimize use of water to prevent environmental contamination Methods and material for containment and cleaning up For containment Methods for cleaning up 6.4. Reference to other sections : Contain and/or absorb spill with inert material (e.g. sand, vermiculite), then place in a suitable container. Do not flush to sewer or allow to enter waterways. Use appropriate Personal Protective Equipment (PPE). : Scoop up material and place in a disposal container. Vapors may be heavier than air and may travel along the ground to a distant ignition source and flash back. Provide ventilation. See section 8 for further information on protective clothing and equipment and section 13 for advice on waste disposal. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures 7.2. Conditions for safe storage, including any incompatibilities Technical measures Storage conditions 7.3. Specific end use(s) Not available. : Avoid contact with skin and eyes. Avoid breathing vapour or mist. Do not swallow. Handle and open container with care. When using do not eat, drink or smoke. : Launder contaminated clothing before reuse. Wash hands before eating, drinking, or smoking. : Proper grounding procedures to avoid static electricity should be followed. : Keep container tightly closed. Store in dry, well-ventilated area. Store under inert gas. Hygroscopic product. 08/05/2015 EN (English) 7/17

8 according to Regulation (EC) No. 453/2010 SECTION 8: Exposure controls/personal protection 8.1. Control parameters 8.2. Exposure controls Appropriate engineering controls Hand protection Eye protection Skin and body protection Respiratory protection Environmental exposure controls Other information : Use ventilation adequate to keep exposures (airborne levels of dust, fume, vapor, etc.) below recommended exposure limits. : Wear suitable gloves. : Safety glasses or goggles are recommended when using product. : Wear suitable protective clothing. : In case of insufficient ventilation, wear suitable respiratory equipment. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. : Maintain levels below Community environmental protection thresholds. : Do not eat, smoke or drink where material is handled, processed or stored. Wash hands carefully before eating or smoking. Handle according to established industrial hygiene and safety practices. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Appearance : Clear Colour : Colourless Odour Odour threshold ph Relative evaporation rate (butylacetate=1) Melting point Freezing point Boiling point Flash point : 87 C (189 F) Closed cup Auto-ignition temperature Decomposition temperature Flammability (solid, gas) : Not flammable by EU criteria Vapour pressure Relative vapour density at 20 C Relative density Solubility Partition coefficient: n-octanol/water Viscosity, kinematic Viscosity, dynamic Explosive properties Oxidising properties Explosive limits 9.2. Other information SECTION 10: Stability and reactivity Reactivity No dangerous reaction known under conditions of normal use Chemical stability Stable under normal storage conditions Possibility of hazardous reactions No dangerous reaction known under conditions of normal use Conditions to avoid Heat. Incompatible materials. Sources of ignition Incompatible materials Acid chlorides. Phosphorus halides. Strong acids. Strong oxidizing agents. Strong reducing agents. 08/05/2015 EN (English) 8/17

9 according to Regulation (EC) No. 453/ Hazardous decomposition products May include, and are not limited to: oxides of carbon, oxides of sulfur. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity : Not classified. Brefeldin A Solution (1,000X) LD50 oral rat LD50 dermal rabbit LC50 inhalation rat Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity Specific target organ toxicity (single exposure) > 2000 mg/kg > 2000 mg/kg No data available. Specific target organ toxicity (repeated exposure) Aspiration hazard SECTION 12: Ecological information Toxicity Ecology - general : This product is not expected to produce significant ecotoxicity upon exposure to aquatic organisms and aquatic systems Persistence and degradability Brefeldin A Solution (1,000X) Persistence and degradability Not established Bioaccumulative potential Brefeldin A Solution (1,000X) Bioaccumulative potential Not established Mobility in soil Results of PBT and vpvb assessment Other adverse effects SECTION 13: Disposal considerations Waste treatment methods Waste disposal recommendations Additional information SECTION 14: Transport information In accordance with ADR UN number Not regulated for transport UN proper shipping name Not applicable Transport hazard class(es) Not applicable Packing group Not applicable. : This material must be disposed of in accordance with all local, state, provincial, and federal regulations. The generation of waste should be avoided or minimized wherever possible. : Handle empty containers with care because residual vapours are flammable Environmental hazards Dangerous for the environment : No. 08/05/2015 EN (English) 9/17

10 according to Regulation (EC) No. 453/2010 Marine pollutant Other information Special precautions for user Special transport precautions : No. : No supplementary information available. : Do not handle until all safety precautions have been read and understood Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code Not applicable. SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU-Regulations Contains no substances with Annex XVII restrictions. Contains no REACH candidate substance. Contains no REACH Annex XIV substances National regulations Chemical safety assessment No chemical safety assessment has been carried out. SECTION 16: Other information Indication of changes: None. Data sources Other information : REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. : None. Full text of R-, H- and EUH-phrases: Acute Tox. 3 (Oral) Acute toxicity (oral), Category 3 H301 Toxic if swallowed R25 T Toxic if swallowed Toxic Disclaimer: We believe the statements, technical information and recommendations contained herein are reliable, but they are given without warranty or guarantee of any kind. The information contained in this document applies to this specific material as supplied. It may not be valid for this material if it is used in combination with any other materials. It is the user s responsibility to satisfy oneself as to the suitability and completeness of this information for the user s own particular use. 08/05/2015 EN (English) 10/17

11 1. 化学品及企业标识产品名称 :Brefeldin A Solution [ 布雷菲德菌素一个解决方案 ] 产品英文名 : Brefeldin A Solution 产品编码 : 产品推荐用途及限制用途 : 工业用途 ( 仅用于试验 ) 不得用于有可能污染食品或伤及人体的用途 厂家 / 供应商 :BioLegend Inc 地址 :4B Highgate Business Centre,33 Greenwood Place, London, NW5 1LB UK. 电话 :+44 (0) 电子邮箱 :infoeurope@biolegend.com 更多信息请联系 :BioLegend Inc 紧急事故联络信息 : 紧急联络电话 :+44 (0) 危险性概述 GHS 危险性类别 : 根据 化学品分类和危险性公示通则 (GB ) 及化学品分类 警示标签和警示性说明规范系列标准, 该产品危害分类信息如下 : 物理性危害 : 无相关分类 健康危害 : 急性毒性, 口服 -5; 急性毒性, 皮肤 -5 水生环境危害 : 生水环境危险 ( 慢性 )4 标签要素 : 象形图 : 无 警示词 : 警告 危险信息 : H303: 吞咽可能有害 ( 口服 ) H313: 接触皮肤可能有害 ( 皮肤 ) H413: 可能对水生生物产生长期持续有害影响 预防措施 : P273: 禁止排入环境 事故响应 : P312: 如感觉不适, 呼叫中毒控制中心或就医 P391: 收集泄漏物 储存注意事项 : 废弃处置 : P501: 参照地方, 区域, 国家, 国际法规 ( 规定 ) 处置 3. 成分 / 组成信息产品描述 : 物质 (); 混合物 ( ) 成分名称 CAS No. 重量百分比 (%) 二甲基亚砜 Dimethyl sulfoxide 布雷菲德菌素 A 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13- dihydroxy-6-methyl-, (1R,2E,6S,10E,11aS,13S,14aR)

12 Brefeldin A Solution 安全数据表 成分名称 CAS No. 重量百分比 (%) 其他无害成分 Non-hazardous ingredients 商业机密 < 急救措施如果在使用该产品时造成对人体的危害, 请咨询医师或专业人士 具体措施如下 : 吸入 : 皮肤接触 : 眼睛接触 : 误食 : 接触该化学品的主要症状和对健康的影响 : 对施救者的忠告 : 医生的特别提示 : 将患者转移至空气新鲜处, 休息, 保持利于呼吸的体位 如感觉不适, 呼叫中毒控控制中心 立即脱掉所有被污染的衣服 用水及肥皂清洗 污染的衣服洗净后方可重新使用 如果发生皮肤刺激, 就医 用水细心冲洗数分钟, 如戴隐形眼镜并可方便地取出, 取出隐形眼镜, 继续冲洗 如果发生眼睛刺激, 就医 请勿给予食物给无意识的吞咽者 请勿催吐 如感觉不适, 就医 急性效应 : 吞咽可能有害 接触皮肤可能有害 迟发效应 : 无 请勿给予意识不清者任何食物, 及时送往医院医治 根据具体症状及接触量处理 5. 消防措施 灭火方法及灭火剂 : 特别危险性 : 无 特殊灭火方法 : 保护消防人员的防护设备 : 6. 泄漏应急处理 作业人员防护措施 防护装备和应急处置程序 : 作业人员防护措施 防护装备 : 环境保护措施 : 应急处置程序 : 泄漏化学品的收容 清除方法及所使用的处置材料 : 少量泄漏 : 可使用二氧化碳 泡沫 干粉灭火 请勿使用柱状水灭火, 以免引起熔融物飞溅 切断空气源 在上风向灭火 喷水容器冷却, 在没有危险的前提下, 尽可能将容器从火场转移至空旷处 禁止非相关人员出入 消防人员应在上风向灭火, 佩戴合适的防护设备 在有可能接触到皮肤的情况下, 佩戴防渗透手套 灭火时应佩戴防毒面罩, 以免吸入一氧化碳和其他有毒气体 佩戴防护手套 ( 如 : 橡胶手套 )/ 穿防护服 ( 如 : 合成纤维材质防静电防护服 )/ 佩戴防护眼镜 / 面罩 在需要的情况下 ( 比如 : 空气中污染物浓度较高或有蒸气的情况下 ), 佩戴防毒口罩, 眼罩 作业人员必须经过专业培训之后方可操作 请勿将清洗残余物倾入城市下水道及开放性水域 遵循当地及国家相关法律法规 隔离泄漏污染区, 周围设警告标志进行隔离, 限制非相关人员出入 不要直接接触泄漏物 在没有危险的情况下, 尽可能切断泄漏源 用砂土 干燥石灰等惰性材料吸附泄漏液体 收集至专门的容器, 贴上标签以便合理处置 29/05/2015 Chinese(Simplified) 12/17

13 Brefeldin A Solution 安全数据表 大量泄漏 : 隔离泄漏污染区, 周围设警告标志, 建议应急处理人员穿化学防护服, 佩戴防护手套等 不要直接接触泄漏物 构筑围堤或挖坑收容 喷雾状水冷却和稀释蒸汽 保护现场人员 把泄漏物稀释成不燃物, 请勿直接接触泄漏物 用防爆泵转移至槽车或专用收集器内, 回收或运至废物处理场所处置 防止发生次生危害的预防措施 : 清除过程中产生的废水需无害处理后再排放 7. 操作处置与储存操作处置 : 得到专门指导后操作 在阅读并了解所有安全预防措施之前, 切勿操作 远离热源 / 火花 / 明火 / 热表面 - 禁止吸烟 避免吸入烟气 气体 烟雾 蒸气 喷雾 操作后彻底清洗双手 作业场所不得进食 饮水或吸烟 仅在户外或通风良好处使用 污染的工作服不得带出工作场所 戴防护手套 搬运时要轻装轻卸, 防止包装及容器损坏 储存 : 安全储存的条件 : 禁配物 : 包装材料 : 其它信息 : 储存于阴凉, 通风良好, 干燥处 避免长时间日照, 上锁保管, 置于儿童接触不到的地方 远离引火源 ( 如 : 热表面, 火花等 ) 卤化物 强酸 强氧化剂 强还原剂 一般采用密封的塑料容器 仓库应配备合适的意外泄露收集设备及消防设备 8. 接触控制和个人防护职业接触限值 : 无相关数据 监测方法 : 生物限值 : 工程控制 : 工作场所有害物质的测定按 GBZ159 工作场所空气中有害物质监测的采样规范 进行检测, 也可采用国内外公认的测定方法执行 无相关数据 严格按照程序操作, 保持良好的通风 如果操作过程中产生蒸气或烟雾, 请使用通风装置确保空气接触值不超过所规定的限值 个人防护设备 ( 针对操作工人 ): 手部防护 : 佩戴不渗透防护性手套 ( 如 : 橡胶手套 ) 眼睛防护 : 在可能产生蒸气或烟雾的情况下或长时间作业场所, 佩戴安全防护镜 29/05/2015 Chinese(Simplified) 13/17

14 Brefeldin A Solution 安全数据表 呼吸系统防护 : 若接触空气中的浓度超出所规定极限值或出现不适症状, 使用经许可的防毒口罩 身体防护 : 穿着防护服 ( 如 : 合成纤维材质防静电防护服 ), 防渗透手套, 靴子等 一般防护及卫生措施 : 在休息期间及结束工作前清洗双手 避免吸入加工过程中可能引起的蒸气 避免接触眼睛及皮肤 9. 理化特性基本信息 形态 颜色 气味 ph 值 沸点 / 沸点范围 熔点 / 熔点范围 液体 无色 闪点 87 (189 ) 燃烧 / 爆炸极限值 - 下限值体积百分比 % 燃烧 / 爆炸极限值 - 上限值体积百分比 % 相对密度 蒸气压 蒸气密度 溶解性 n- 辛醇 / 水分配系数 自燃温度 分解温度 气味阈值 蒸发速率 粘度 易燃性 ( 固体 气体 ) 10. 稳定性和反应性稳定性 : 不属于易燃液体 正常条件下, 稳定 29/05/2015 Chinese(Simplified) 14/17

15 Brefeldin A Solution 安全数据表 危险反应 : 应避免的条件 : 应避免的物质 : 能与酰氯 三氯硅烷等卤化物发生剧烈的化学反应 过高温度, 长时间阳光直射 卤化物 强酸 强氧化剂 强还原剂 危险的分解产物 : 遇明火 高热可燃 受热分解产生有毒烟气 ( 如 : 碳氧化物, 氮氧化物 ) 11. 毒理学信息 产品毒性数据 : 产品名称 CAS LD50/LC50( 半数致死剂量 ) 布雷菲德菌素一个解决方案 -- 急性毒性 ( 经皮 )LD50>2000mg/kg( 大鼠 ) ( 数据来源于厂家仅供参考 ) 产品分类 : 区分 5 急性毒性 ( 经口 )LD50>2000mg/kg( 家兔 ) ( 数据来源于厂家仅供参考 ) 产品分类 : 区分 5 急性毒性 ( 吸入 ): 无相关数据 严重眼损伤 / 眼刺激 : 无相关分类 皮肤腐蚀 / 刺激 : 无相关分类 致癌性 : 无相关分类 致敏性 : 无相关分类 生殖细胞致变性 : 无相关分类 生殖毒性 : 无相关分类 吸入危险 : 无相关分类 特定靶器官系统毒性 : 无相关分类 毒代动力学 代谢和分布信息 : 无相关信息 12. 生态学信息生态毒性 : 持久性和降解性 : 潜在的生物积累性 : 土壤中的迁移性 : 二甲基亚砜 (CAS: ): 鱼类 LC50:32300 mg/l 96 hr 蓝色太阳鱼 (OECD Screening Information Data Set) 甲壳类 EC50:24600 mg/l 48 hr 大型蚤 OECD( Screening Information Data Set) 藻类 EC50: mg/l 96 hr 中肋骨条藻 (IUCLID) 二甲基亚砜 (CAS: ): 持久性 :log Kow ICSC 降解性 : 无相关资料 二甲基亚砜 (CAS: ): 累积性 :BCF<0.4 IUCLID 可分解性 :3.1(%) 28 day(chemical Risk Information Platform ) (CHRIP) 液体状态下, 可在土壤中迁移 29/05/2015 Chinese(Simplified) 15/17

16 Brefeldin A Solution 安全数据表 13. 废弃处置 废弃处置方法 : 残余废弃物 : 受污染的容器和包装 : 废弃注意事项 : 废弃前尽可能使用中和, 反应等方式进行无害化处理, 使其危害性降到最低 送至专门的废弃物处置中心处理 在送至废弃物处置中心时, 有必要告知该废弃物可能存在的危害性 建议在装备有加力燃烧室和洗刷设备的化学焚烧炉内燃烧处理 容器或包装可能残留有害物, 作为有害废弃物处理 请勿丢弃至下水道 请勿丢弃至水域中 废弃物的处置应该根据当地相关废弃物处理当局的要求进行处理 14. 运输信息 DOT. 交通运输部 /IATA/ICAO 空运 ( 国际航空运输协会 / 国际民航组织 )/IMO/IMDG. 海洋运输 ( 国际海运组织 / 国际海上危险货物规则 ) 正确装运名称 : 不适用 UN 编号 : 不适用 危害分类 : 不适用 包装类别 : 不适用 包装标志 : 不适用 是否海洋污染物 ( 是 / 否 ): 否 注意事项 : 装运前检查包装是否完好或密封, 运输过程中要确保容器不泄漏 不倒塌 不坠落 不损坏 运输时运输车辆应配备相应品种和数量的消防器材及泄漏应急处理设备 请勿与会与其发生危险反应的化学品一起运输, 中途停留时应远离火种 热源 15. 法规信息国内相关法规 : 化学品分类和危险性公示通则 (GB ): 物理性危害 : 无相关分类 健康危害 : 急性毒性, 口服 -5; 急性毒性, 皮肤 -5 水生环境危害 : 生水环境危险 ( 慢性 )-4 危险货物运输包装类别划分方法 (GB/T ): 不适用危险货物品名表 (GB ): 不适用中华人民共和国安全生产法 : 安全生产经营, 事故应急处理, 法律责任等相关内容须符合该法规的相关规定 中华人民共和国职业病防治法 : 该产品对人体有害, 有关前期预防, 劳动过程中的防护与管理, 职业病诊断相关内容可参考该法规的相关规定 中华人民共和国环境保护法 : 在防治环境污染等方面要遵守该法规的相关规定 该产品虽然水生环境危害无相关分类, 但对水生环境可能会产生影响, 切勿任意排放至水域中 国际相关法规 : TSCA 有毒物质控制法案 : 该产品成分中二甲基亚砜 (CAS: ) 在该法案规定的现存物质清单中 危险警语及安全术语 (67/548/EEC 附录 Ⅰ): 该产品中各成分无相关资料致癌性相关法规 : 无相关分类 空气污染法案 : 该产品不含有该法案下的一类臭氧层破坏物质 该产品不含有该法案下的二类臭氧层破坏物质 29/05/2015 Chinese(Simplified) 16/17

17 Brefeldin A Solution 安全数据表 16. 其他信息免责声明 : 以上所有信息仅供参考且真实可靠, 我司不会控制他人的使用方式且不对因此造成的后果承担任何责任 应由使用者来决定如何正确使用该产品或者采用出于某种特殊目的的生产方式 采纳上述所提到的注意事项有助于避免在操作及使用产品时可能引起的对财产和人生安全造成的危害 参考资料 :GB/T GB GB/T GB GB/T GHS 技术文件等法规资料 SDS 最新修订日期 :2015 年 05 月 29 日 SDS 版本 :1.0 29/05/2015 Chinese(Simplified) 17/17