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1 臺灣藥用植物雜誌 Journal of Taiwan Medicinal Plants 第十二期大陸天津中國特色商店街

2 臺灣藥用植物雜誌 Journal of Taiwan Medicinal Plants 目錄 ( )...16 ( ) / / 23 / / /(04) /(04) /(04) /(04) / / / / ( ) / / / / /(04) wenhsin.press@msa.hinet.net 5,000 3,000 3,000 1,500 1,500 本雜誌內文所載醫藥知識僅供參考, 使用前務必請教有經驗之醫師, 以免誤食誤用影響身體健康

3 Journal of Taiwan Medicinal Plants 總編輯的話? ( ) ( ) ( 23 ) ( ( ) ) 1

4 有毒植物概說 / ( ) ( ) ( ) !

5 Journal of Taiwan Medicinal Plants 5 ( ) Furocoumarin( ) Coumarin( ) psoralen( )

6 5 DNA 6 7 DNA DNA ( 4

7 Journal of Taiwan Medicinal Plants 吃少顧肝, 吃多顧山 - 以含吡咯裏西啶類生物鹼植物為例介紹 / / 1 P450 2 (1) (pyrrolizidine alkaloids PAs) (2) (3) PAs 3% ( 6000 ) PAs (herbivory) PAs PAs PAs 5

8 PAs 1 2 PAs (monocrotaline) (clivorine) PAs PAs (hepatotoxic PAs HPAs) PAs (Hepatic venoocclusive disease HVOD) (Hepatic sinusoidal obstruction syndrome HSOS) PAs PAs ( P450 ) PAs P450s (tissue-bound pyrroles) ( 7-GSH-DHR) (dehydroretronecine DHR) PAs clivorine PAs PAs (determined unequivocally) PAs PAs (Senecio) ( ) Senecio scandens Buch.-Ham. ex D. Don ( ) 1 (Lespedeza cuneata (Dumont d. Cours.) G. Don.)

9 Journal of Taiwan Medicinal Plants ( ) PAs PAs (adonifoline) (senecionine) (seneciphylline) (Tussilago) ( ) Tussilago farfara L. coltsfoot( ) 1 2 PAs senecionine integerrimin s e n k i r k i n n e o s e n k i r k i n e senkirkine PAs PAs( ) tussilagine tussilaginine isotussilagine isotussilaginine 3 (senecionine) 0.001% (g/g) 2010 (5g) ( ) 7

10 50 g 180 g (1 g) 4 OTC (Eupatorium) ( ) Eupatorium fortunei Turcz. 1 2 PAs ( s u p i n i n e ) r i n d e r i n e 7-acetylrinderine PAs 3 (Gynura) Gynura divaricata (L.) DC. subsp. formosana (Kitam.) F. G. Davies 1 20~50 cm PAs integerrimine mucronatinine 8

11 Journal of Taiwan Medicinal Plants Gynura bicolor (Roxb. & Willd.) DC PAs integerrimine n i l g i r i n e r e t r o r s i n e h y d r o x y i n t e g e r r i m i n e mucronatinine PAs( ) petasinine 9 macrophylline ( ) Gynura japonica (Thunb.) Juel (syn. Gynura segetum (Lour.) Merr.) ( ) ( ) 1 35~100 cm 2 m (Gynura segetum) 1~2 3 (senecionine)1.13 g/ml (seneciphylline)0.83 g/ ml (RUCAM) 6 (probable) PAs

12 PAs (Crassocephalum) ( ) Crassocephalum crepidioides (Benth.) S. Moore ( ) PAs jacoline jacobine (Emilia) ( ) Emilia sonchifolia (L.) DC. ( ) 1 2 PAs senecionine seneciphylline integerrimine senkirkine o t o s e n i n e n e o s e n k i r k i n e acetyl senkirkine petasitenine d e s a c e t y l d o r o n i n e a c e t y l p e t a s i t e n i n e d o r o n i n e Senkirkine PAs (Farfugium) Farfugium japonicum (L.) Kitamura var. formosanum (Hayata) Kitamura ( ) 10

13 Journal of Taiwan Medicinal Plants 1 2 (Petasites formosanus Kitamura) (Farfugium japonicum (L.) Kitam.) 2700 (Farfugium japonicum (L.) Kitamura var. formosanum (Hayata) Kitamura) 800~ PAs petasitenine senkirkine (Ageratum) ( ) Ageratum conyzoides L. 1 2 ( ) ( ) ( ) 3 PAs lycopsamine echinatine (Crotalaria) (monocrotaline) ( ) Crotalaria verrucosa Linn. ( ) 1 2 ( ) ( ) 3 PAs (monocrotaline) anacrotine crotaverrine O 12 - acetyl-crotaverine ( ) C r o t a l a r i a p a l l i d a A i t. [Crotalaria mucronata Desv.] ( ) 1 (Astragalus complanatus R. Br.) 11

14 ( Crotalaria pallida Ait. var. obovata (G. Don) Polhill) 2 ( ) PAs (mucronatine) (mucronatinine) (usaramine) (nilgirine) (crotastriatine) (integerrimine) Crotalaria sessiliflora Linn ( ) PAs monocrotaline trichodesmine integerrimine (Mimosa) Mimosa pudica Linn. 1 PAs 9-angeloyltrachelanthamidine 9 - t i g l o y l t r a c h e l a n t h a m i d i n e 9 - t i g l o y l p l a t y n e c i n e 9-angeloyldihydroxyheliotridane 9-angeloylretronecine 9-angeloyltrachelanthamidine PAs 2 (mimosine) (Heliotropium) 12

15 Journal of Taiwan Medicinal Plants Heliotropium indicum L. 1 PAs indicine lycopsamine 3'- acetylindicine / 3'- acetyllycopsamine indicine 2 PAs heliotrine echinatine supinine heleurine lasiocarpineru N-oxide 3 -acetylindicine 3 (Heliotropium) ( ) Heliotropium formosanum Johnst. 1 (Euchresta formosana (Hayata) Ohwi) (Helicteres angustifolia L.) (Cajanus cajan (Linn.) Millsp.) ( ) 2 (Heliotropium indicum L.) (Heliotropium procumbens Mill. var. depressum (Cham.) H. Y. Liu ) 3 PAs PAs (Arnebia) ( ) Arnebia euchroma (Royle) Johnst. ( ) 1 PAs O 7 - A n g e - l o y l r e t r o n e c i n e O 9 - Angeloylretronecine

16 2000 (Lithospermum erythrorhizon Sieb. et Zucc.) intermedine myoscorpine hydroxymyosorpine PAs / (Symphytum) Symphytum officinale Linn. Comfrey 1 burt's bee (Res-Q Ointment) 2 3 PAs PAs (Echium) (Borago) (Symphytum) (Senecio) (Eupatorium) 1. (http //sealioler.pixnet. net/blog) 2. (http //web2.nmns. edu.tw/publib/newsletter/88/135/06. html) 3. (http // 14

17 Journal of Taiwan Medicinal Plants tw/~kmcj/data/8803/4190.htm) 4. P l a n t S o u r c e s o f H e p a t o t o x i c Pyrrolizidine Alkaloids, L. W. Smith, C. C. J. Culvenor, J. Nat. Prod., 1981, 44(2), pp (http // taibif.tw/zh) 10.Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum, Ge Lin et al., Journal of hepatology, 2011, 54, (http // asp?systemid=1405) 12.Medicinal plants in China containing pyrrolizidine alkaloids, E. Roeder, (http //hf.fda.gov.tw/ TDRF_HUAS/Huas/Home.aspx) 14.Plants containing pyrrolizidine alkaloids used in the Traditional Indian Medicineincluding Ayurveda, E. Roeder, H. Wiedenfeld, Pharmazie, 68,

18 有毒中草藥臨床應用 ( Ⅰ ) / / - Centipeda minima (L.) A. Br. et Aschers. 4 2~3 ( ) ( ) 1 2 Datura metel Linn. 1 ( ) 16

19 Journal of Taiwan Medicinal Plants 2 3 Breynia ( ) Erycibe henryi Prain 2~3 (Cocculus) Cocculus orbiculatus (L.) DC. officinalis Hemsley 2~3 ( ) 3 ( ) 17

20 1 Euphobia tirucalli Linn. 1~2 ( 4 ) 1~2 18 Euphorbia neriifolia L. ( ) ( ) ( ) 18

21 Journal of Taiwan Medicinal Plants Catharanthus roseus (L.) G. Don 2 3~4 Wikstroemia indica C. A. Meyer 1 3 ( ) ( ) Typhonium blumei Nicolson & Sivadasan 5~7 19

22 有毒中草藥臨床應用 ( Ⅱ ) / / Catharanthus roseus (L.) G. Don 2 Chamaesyce hirta (L.) Millsp. 4 ( ) 5 3 ( 1800mL) 1 ( 250mL) 1 ( ) 2 Chamaesyce thymifolia (L.) Millsp ( Polygonum aviculare L.) 8 2 ( ) 20

23 Journal of Taiwan Medicinal Plants 3 1 ( ) 2 ( ) Tithonia diversifolia (Hemsl.) A. Gray 1 2 Abrus precatorius Linn. 7 ( ) ( )2 4~

24 2 1 1 ( ) 2 3 (lectin) (abrin) (abrus agglutinin) (6 20 ) 22

25 Journal of Taiwan Medicinal Plants 急性毒性有毒植物綠珊瑚的應用實例 / / (diterpene ester) Euphobia tirucalli Linn. ( ) ( ) 1645 ( ) 23

26 8 ( ) ( ) 2 2 ( ) ~3 3 1 ( ) 2 ( ) 3 ( ) 4 ( ) ( ) ( ) 1 ( tw/2011/12/euphorbia-tirucalli.html) 2 ( content.edu.tw/junior/scouting/tc_ jr/213/brief01.htm) 3 24

27 Journal of Taiwan Medicinal Plants 有毒植物青花炮仔草應用實例 / / Crotalaria verrucosa Linn. 4 3~ ( ) ( ) 3 (Crotalaria) (Monocrotaline) anacrotine crotaverrine O12- acetyl-crotaverine ( ) 25

28 有毒植物烏面馬應用實例 / / Plumbago zeylanica L (plumbagin) 4 ( ) 1 ( ) : 5~10 3 ( ) ( ) ( ) ( ) 26

29 Journal of Taiwan Medicinal Plants 2 3 5~ 山源藥草行青草藥材批發粉碎加工電話 :(04) 台中市大肚區沙田路 3 段 734 巷 25 號 27

30 驗方分享園地 / / ( ) 1 ( ) 8 2 ( ) ( ) 8~ ~2 ( ) 1 ( ) ( 2~3 ) 2 ( ) 3 ( ) ( ) 28

31 Journal of Taiwan Medicinal Plants ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) 6 ( ) 29

32 ( ) 3 ( ) ( ) ( ) ( ) 30

33 Journal of Taiwan Medicinal Plants 產業動態蓮的故鄉 - 白河 / / ( ) ( ( ) 4~6 ) ( ) 31

34 ( ) ( ) 32

35 Journal of Taiwan Medicinal Plants ( ) ( ) ( )

36 易混淆中藥材鑑別 : 沙苑子 / / ( ) ( ) Astragalus complanatus R. Br. Crotalaria pallida Ait. ( Crotalaria pallida Ait. var. obovata (G. Don) Polhill) PAs (monocrotaline) 9 15g Astragalus adsurgens Pall. Astragalus sinicus L. ( ) 34

37 Journal of Taiwan Medicinal Plants 2 mm 1.5 mm 1.5 mm 1mm 2.5~3.5mm 2.0~2.5mm 2.5~3.5 mm 2~2.5 mm 保險買對是資產, 買錯變負債! (0919)

38 36

39 昇隆參藥行中藥批發道地藥材貨真價實 : 249 :(04) :(04)

臺灣藥用植物雜誌 Journal of Taiwan Medicinal Plants 目錄 / / 23 / (04) / (04) / / / (04) / (04)2475-7

臺灣藥用植物雜誌 Journal of Taiwan Medicinal Plants 第十期 2012 3 1 墾丁社頂公園臺灣藥用植物雜誌 Journal of Taiwan Medicinal Plants 2012 3 1 目錄...01...08 1...09...28 / / 23 / (04)2473-4001 / (04)2475-7301 / / / (04)2473-4385

臺灣藥用植物雜誌 Journal of Taiwan Medicinal Plants 目 錄 ( )...16 ( ) / / 23 / / /(04) /(0

臺灣藥用植物雜誌 Journal of Taiwan Medicinal Plants 目錄 ( )...16 ( ) / / 23 / / /(04) /(0