Journal of Nanchang University Medical Sciences 2018 Vol.58 No.6 G6PD glucose-6-phosphate dehydrogenase G6PD Xq28 G6PD G6PD Ⅱ N

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1 Journal of Nanchang University Medical Sciences 2018 Vol.58 No.6 G6P glucose-6-phosphate dehydrogenase G6P Xq28 G6P G6P Ⅱ NPH GSH G6P G6P G6P G6P G6P G6P -6- R556.6 OI /j.cnki.ncdm Research dvances in Selection dvantage and Resistance Mechanism of G6P eficiency and Malaria YI Hao-an H Yong-shu epartment of ell iology and Medical Genetics Kunming Medical University Kunming hina STRT The glucose-6-phosphate dehydrogenase G6P deficiency is a common hereditary hemolytic disease.g6p gene is located at Xq28.G6P gene mutation induces the decrease in G6P activity and red blood cell NPH and GSH levels resulting in oxidative cell damage and hemolytic reaction.malaria is a serious insect-borne disease endangering human health.malaria-endemic areasare consistent with the high prevalence regions of G6P deficiency. It is widely believed that G6P deficiency has a resistance to malaria under the selective pressure of malaria.however the resistance mechanism is unclear.this article reviews the progress in mechanism of G6P deficiency against malaria to further explore the complicated relationship between G6P deficiency and malaria. KY WORS glucose-6-phosphate dehydrogenase deficiency malaria selection advantage resistance mechanism -6- glucose-6-phosphate dehydrogenase G6P G6P G6P G6P Xq bp mail yongshuhe@ hotmail.com

2 G6P 77 2 G6P Ⅱ NPH GSH G6P G6P 31 G6P 1376G>T 1388G> 95>G 70% WHO G6P G6P Ⅱ Ⅲ G6P % uffy O 34 G6P α- β- HbS Hb Hb 3 G6P G6P G6P 4 G6P G6P G6P 1.3 G6P 1.1 G6P G6P G6P G6P G6P X 12 G6P G6P 13 G6P NPH NPH GSH 5 G6P NPH G6P GSH 6 GSH G6P G6P G6P G6P

3 G6P G6P 24 G6P 14 G6P G6P G6P 15 2 G6P G6P G6P G6P G6P G6P G6P Santana 16 G6P G6P- 376>G /202 G> G6P G6P Louicharoen 14 G6P Mahidol 487G> ~3800 G6P G6P G6P Li 17 G6P Mahidol 487G> 26 ROS 27 G6P G6P NPH G6P GSH G6P G6P V X 20 G6P 29 G6P G6P G6P 21 Heinzbody 30 G6P 31 G6P 22 T G6P G6P a 2+ a G6P G6P 16 G6P 34 G6P

4 G6P iol hem harati K GSH GSSG 8-10 GSSG NPH J 2017 NP NPH Wilson M L Krogstad J rinaitwe seven diverse IMR network sites J Suppl Howes R attle K Satyagraha W G6P global distribution dv Parasitol G6P G6P 15 Manganelli G Masullo U Passarelli S J.ardiovasc Hematol isord rug Targets G6P Santana M S Monteiro W M Siqueira M G6P susceptibility to malaria in the razilian mazon J Trop Med Hyg Li Q Yang F Liu R 1 appellini M Fiorelli G.Glucose-6-phosphate dehydrogenase deficiency J.Lancet G6P 2.G-6-P J. J Gomez F Ko W Y avis et al.impact of natural selection due to malarial disease on human genetic variation M / /rinkworth J F Pechenkina K.Primates Pathogens and volution.new York NY Springer New York Sirugo G.Reassessing an old claim natural selection of hemizygotes and heterozygotes for G6P deficiency in frica by resistance to severe malaria J.m J Hematol Yang H Wu Y H Liu H Y et al.what has passed is prolog new cellular and physiological roles of G6P J. Free Radic Res Gomez Manzo S Marcial Quino J Vanoye arlo et al.glucose-6- Phosphate dehydrogenase update and analysis of new mutations a- round the world J.Int J Mol Sci Pii Yang Y Li Z Nan P et al.rug-induced glucose-6-phosphate dehydrogenase deficiency-related hemolysis risk assessment J.omput Ganguly N K.Tackling the malaria problem in the southeast asia region need for a change in policy J.Indian J Med Res Mconald R Tran V Kain K. omplement activation in placental malaria J.Front Microbiol J et al.urban malaria understanding its epidemiology ecology and transmission across. m J Trop Med Hyg et al.g6p deficiency genetic variants and primaquine therapy J. 14 Louicharoen Patin Paul R et al. Positively selected G6P- Mahidol mutation reduces plasmodium vivax density in southeast asians J.Science et al.glucose-6-phosphate dehydrogenase deficiency disadvantages and possible benefits et al.glucose-6-phosphate dehydrogenase deficient variants are associated with reduced.trans R Soc et al.prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency at the china-myanmar border J.PLoS One e Guindo Fairhurst R M oumbo O K et al.x-linked G6P deficiency protects hemizygous males but not heterozygous females against severe malaria J.PLoS Med e Wang J Xiao Q Z hen Y M et al.n hypermethylation and X chromosome inactivation are major determinants of phenotypic variation in women heterozygous for G6P mutations J. lood ells Mol is hen X He Y Miao Y et al. young man with severe acute haemolytic anaemia J.MJ j Lalloo G Shingadia ell J et al. UK malaria treatment guidelines 2016 J.J Infect Gyr K Speck Ritz R et al. erebral tropical malaria with blackwater fever. current diagnostic and therapeutic problem J.Schweiz Med Wochenschr Luzzatto L Seneca.G6P deficiency a classic example of pharmacogenetics with on-going clinical implications J.r J Haematol ilgin R Yalcin M S Yucebilgic G et al.oxidative stress in vivax malaria J.Korean J Parasitol

5 Foth J Zhang N haal K et al.quantitative time-course profiling of parasite and host cell proteins in the human malaria parasite Plasmodium falciparum J. Mol ell Proteomics M Toler S.The plasmodial apicoplast was retained under evolutionary selective pressure to assuage blood stage oxidative stress J.Med Hypotheses Tang H Y Ho H Y Wu P R et al.inability to maintain GSH pool in G6P-deficient red cells causes futile MPK activation and irreversible metabolic disturbance J. ntioxid Redox Signal Klonis N Tan O Jackson K et al.valuation of ph during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum J.iochem J Ronquist G Theodorsson.Inherited non-spherocytic haemolysis due to deficiency of glucose-6-phosphate dehydrogenase J. Scand J lin Lab Invest dachi H.Pathological study on experimental Heinz body anemia intracellular changes of phagocytized red cells in macrophages of the spleen and liver J.cta Pathol Jpn Wu J Tian L Yu X et al.strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality J.Proc Natl cad Sci U S Foller M Huber S M Lang F.rythrocyte programmed cell death J.IUM Life Fang Z Jiang Tang J et al. comprehensive analysis of membrane and morphology of erythrocytes from patients with glucose- 6-phosphate dehydrogenase deficiency J. J Struct iol uez J Holleran J P Ndour P et al. Mechanical clearance of red blood cells by the human spleen Potential therapeutic applications of a biomimetic R filtration method J. Transfus lin iol Thornalley P J Stern annister J V. mechanism for primaquine mediated oxidation of NPH in red blood cells J.iochem Pharmacol Zyad Tilaoui M.More insights into the pharmacological effects of artemisinin J 櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐櫐 HIV rapid test among men who have sex with men in eijing hina J HIV HV HV J HV 16. HIV J J J HIV HV J HIV HV HV 18. HIV HV HV J. J J J. 21. HIV HV J HIV J J. J Xu Y Zhang Z Li et al.willingness to use the oral fluid HIV J.PLoS One e Pai N P arick R Tulsky J P et al.impact of round-the-clock rapid oral fluid HIV testing of women in labor in rural India J.PLOS Med e HIV HV HV Meta J. 22. HIV HV

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20110420 愛滋病與結核病防治台北榮民總醫院感染科國立陽明大學醫學系王永衛醫師它是什麼? 愛滋病毒 (HIV) 後天免疫缺乏病毒愛滋病 (AIDS) 後天免疫缺乏症候群愛滋病 1980 年迄今 Million 50 45 40 35 30 25 20 15 1 First cases of