<B0AAA5ABC2E5BB F E706466>

Size: px

Start display at page:

Download "<B0AAA5ABC2E5BB F E706466>"

注卜
4 years ago
Views:

1 䏝恩䔀䫟ᶉ 㮓映䕂ⶸ娮 ӕңᚃᕜᙐϯі ښݳ ८ ޠ ឋ ݔ Ϗസᚃ Ҁᚃ ϵ ġ બਫߞ Ʊℋ墾 ᜰȂζਛፏᚂ ᔖԤ ޟ ઉȄғ ҳ ݲ Ԫ Σᓺӑ ݲ ਰȃፏᕗ ۏ ষ ད ԑ ޟ ᚂᕛ ቄኺ ғቷࢥԪ ݲ ਰ ޟ ᜰᗤਢ ړ ȂҏМკၐ υȉᒛ ኅ ᖂ Kalousek ᘈӪΟϤ ᚄ پڏ ᓸў ȂоЅᄇ ሴ Ϟ σሴ ԙ ҡᚂ ޟ ᗴ ࠅל Ȉ ఖၐყ ΙᙏϭЅ ដȄ Ӕ ҡ ᚂᕛሴ ѓ ಠफᕛ ݲ ȃཆಠ फȃiPS ȂএΡϽᕛ ݲ ๖ӫஅӰᔮ 孱Ʊ 䏝恩䔀恩䔀䀥娵䕂墐儰 กȃσኵᐃЅ AI ඪଽ ݽ ᕛᆠ Ȃ ջ ಠफዴ ݲ ԃ CAR-TȂGoogle Smart Κȃᚃᕜ ៗ ޠ ᄻ LensȂЅҡ ސ խ ȄശߖΠԑ پ Ȃ ᚂᕛ ϛȃ ٺ Ң ಛ ސ ȃ Ϛᆓ ᚂ ȃҡ Ȃ ޟ ᚂᕛᏢ ȃҡ ސ ᇧᏘȂᄺԙΟ ר ঈ ܚ Ιএ ᚠ ܚ ᒝ ޟ ӔҡᚂᕛȄ ڏ ᄂ ዣ ޟޣ ᚂᕛȄծߖԑᑹଔ ޟ ಠफ ݽ এӪ ᄇ ಛᚂ ᗶԤᘈ ᘀȂ ᕛȂѓ அӰ ݽ ᕛȃಢᙑ१ ȃջ ծӕҡᚂᕛѫ ᚂᕛ ڏޟ ϛιএωഋ ᕛ ݲ ȂցҢՌᡝಠफȞautologousȟȃ ϷȂѫϚ ж Ө ԃछ ȃрҏȃ ӣᆍ ᡝಠफȞallogeneicȟȃ ᆍ ዉ ߖԑ ёо ጒȂՄ ר ፏᆋഋ ᡝಠफȞxenogeneicȟ پޟ ȂՄ ٺܚ ᚂ ٱ ѧȃॵ ဍζϷտ ٲ ੫ Ң ޟ ᚂᕛ Ȃџ ငҥᖝ ח Ρᡝၐ ȃоѕ კၐёоᆓ౩Ȟ108 ԑ ᡛȃҡ ސ ـ Մ پ Ȅಠफ ݽ ϴ ᄂ Ϟ੫ᆓᒲ ݲ ȂоЅӔҡᚂᕛ ᕛ ϛ ޟܒ ᚂᕛऋ ȂՄ Ο ᇧ ᆓ౩న ٽ ૩ਰȟȄҏన ٽ ૩ਰ ޟ ႀ ڗ ᐌᚂᕛ ȃቨ Ρցઉ ޟ ও ݲ Ȃߨல ڗڧ Ӓᖒ ౩ ߙߝٱ Ҭ ޟ Ȃϗ ցң ޟ ᚂᕛԆӵ ۏ ষ ޟ ᜰϸȂϚ મӵ Ρ ઉ װ ޟ ཎဎȄȞԃყΙȟ

2 榖斂恩㗁奊 -2851$/ 2).$2+6,81* 0(',&$/ $662&,$7,21 92/ жक ݽ ᕛ ޟݲ ဎȂ Ο ݽ ᕛȃ ᡐȃଛᙽ ݽܖ ᘾ १ ܖ ӠЅҡ ޟ ܖ ڼ Ҭ ޟ Ȃߑ ᖝ ח ᜌᐃ ߒ ᇧ Ԥџ Ґᅖ ޟ ᚂᕛ Cell therapies Medical devices Biologics Pharmaceuticals Healthcare need ሯ (unmet medical need)ȃմᄇஅӱȃ ಠफȃಢᙑ๖ᄺёώ ޟ Ȃѓ ಠ फᕛ ݲ ȃ ݽ ᕛ ܒ ಢᙑώแȃΡᡝಠफ ڷ ಢᙑȃЅ ٺ ҢӈդԪ ᕛ ܖݲ Infrastructure ޟ ಢӫȄᄇ ಒӫΰक़నӇϞ Ȃ ΟჂᓾ оѕ ΰѿȂछ FDA Ϡ פ ၾᇯᜌȃएક ܒ ᕛ ݲ ᇯᜌȃӔҡᚂᏰ ݽ ᕛ (Regenerative Healthcare need Cell therapies Medical devices Biologics Pharmaceuticals Medicine Advanced Therapy, RMAT) Infrastructure ư䯮侜㭹䔀㓭ἣ 䀥娵䕂䧪㛷㚯Ʋ 䟌ⶸ士塍㣟垻廞侻⅙Ʊ弧䐴㮓塍䪂Ʊ㐏㺝垚㤝 Ʊᶣ 傦ⵈⶡ㮙ḽ䏦Ʋℋ 㛷㚯Ⲱ䱑ノ⅝䕂ⶸ䦉濕Ḅᶋ㿴㗇㗨㶽山䕂恩䔀斾㬀濕䧪㛷㚯Ĩ䯮侜㭹䔀㣟ⷍ䕂ⶸ䦉濕 ṙ 㐲恩䔀䀥娵濕㖾䰀㽸ᵄ䒃ᵸ 䖈濑䄅Ṅ㵎 5HJHQ 0HG 濒Ʋ ᇯᜌȃᓺӑቷਯᇯᜌȃЅё ቷ Ϥᆍё ȃ ΰѿ פޟ หȄᄠՍ 2018 ԑ 3 Т ۻ ȂԤ 15 ᆍ ᕕ RMAT ᇯᜌȂ8 ᆍ ᕕ ق ڋ ऋ ᇯᜌȄ Ʊ ハ䕂䯮侜㭹䔀ㄾ圑䩟䋄Ʊ 䏝恩䔀垻䩟䋄 ፏᆋഋӵ 107 ԑ 9 Т 6 Рওғ Ҁ ȶ੫ ᚂᕛ ᔮࢥᔮᡛᚂᕛ ΡȃӕҢᚃᕜпІӕҢᚃᕜᇨ ϟ ဏ ቈᏢ ٺܖ Ңᆓ౩ᒲ ݲ ȷ( ᙏᆎ੫ Ӕҡᚂᕛ ቄ ڹ ȉӕҡᚂᕛȃ ᆓᒲ ) ݲ Ȃк Ҭ ޟ ϞΙ Ӱᔖᚂᕛ Ӫ ဎȂ Ρ ঈ Ӱ Ղ Ͻȃ Ȃ ٺ ಠफ ݽ ᕛ ԞРၼҢ १ȂՄ౪Ԥᚂ ಛᚂᕛЙࢲᡗณ Ԥሯ Ϟ ΡȂ Ռᡝಠफ ݽ ᕛ ฒఖਢȂ ஊ ڏٺ १ᕕҡᐠȃଔԫӱ ઽΣ੫ᆓᒲ ݲ Ȃ ٮ ӵߣߒέғ७ߒӗ ҡ ޟ ᚂᕛȄՄӔҡᚂᕛᇧ Ȃਲ਼ᐃछ Ϟ Ҭᇄᎌᔖ ȞԃߒΙȟȄ

3 䏝恩䔀䫟ᶉ 㮓映䕂ⶸ娮 ߒ Ιȁ੫ᆓᒲ ߒߣݲ έϟռᡝಠफ ݽ ᕛғ७ߒӖ Ҭᇄᎌᔖ Ҭ ᎌᔖ Ռᡝ CD34+ selection ں Ֆཆ ɖֆశඌ ܒ ရዴȞhematological malignanciesȟ ಠफಋ Ȇ ҩֆ ȞϚѓ ᄚ ܒ ᡜҩՖ Ϟᄚ ܒ ȟ Ȇ Бዴ Ȇ ӻ ܒ ᡜዴ ɖᄚ ܒ Ֆ ܒ သϛॳ ɖ १ή Ֆ Ռ ᡝ ջ ಠ फ ݽ ᕛȞ ѓ ɖֆశඌ ܒ ရዴȞhematological malignanciesȟင CIKȃNKȃDCȃDC-CIKȃ ݽ ᕛฒਝ TILȃgamma-delta T Ϟ adoptive ɖ ΙՍ έ ᄂᡝᕜȞsolid tumorȟȃင ݽ T ಠफᒯΣᕛ ݲ ȟ ᕛฒਝ ɖᄂᡝᕜ Ѳ Ռᡝ ཆಠफಋ ɖᄚ ܖܒ ᅖϲ ҐᘾӫϞ ο ɖћᖂᡝߒ७ᑖիϸϟπ Ȟ ȟоΰϟσ७ᑖ ᐶ ܖ Ҫጳഺ ཬڧ ɖҫήѕ ಢᙑ ཬ ɖଝͻ ܒ ᜰ އ Ѕጱᜰ ཬ ɖ ڏ тߒ७ ܒ ཌഺ Ϟӫ ܖځ ሄօᕛ ݲ ՌᡝᡊᆰҔಠफಋ ɖҫጳ ഞȈዹ ȃэ Ѕ Ϟ༲၄Ѕওඈ ɖҫήѕ ಢᙑ ཬ ɖ ڏ тߒ७ ܒ ཌഺ Ϟӫ ܖځ ሄօᕛ ݲ Ռ ᡝ ᡜ ፴ ཆ ಠ फȞbone ɖଝͻ ܒ ᜰ އ Ѕጱᜰ ཬ marrow mesenchymal stem cellȟ ɖᄚ ܒ Ֆ ܒ သϛॳ ಋ ɖ ᡜཬ Ռᡝ ಠफಋ ɖጱᜰ ཬ Մᄇ ߣߒέоѴϞΡᡝಠफಢᙑ ސ Ϟಠफ ݽ ᕛ Ȃџо ٷ ᚂᕛ ݲ Ρᡝ ၐᡛ ᜰ ݲ ҧ ΡᡝၐᡛȂ ٷޱܖ ҏᒲ ݲ Ȃᔣ หȂөፏᆋ ഋҧ ਯটȄҧ ห ޟ నӇШଔߣߒέ੫տӻΟΙ ȶϐ ߒϞ ϱȃѵ ᜰ

4 榖斂恩㗁奊 -2851$/ 2).$2+6,81* 0(',&$/ $662&,$7,21 92/ 12 Мᝦ ȷȂѓ ݽ ᕛ หȃಠफᇧ Ӱ ݽ ᕛᇧ ઽ ҡ ސ ᇧᏘ ήᆓ౩ȃ ԙȃ ᜰᄂᜌМᝦȃΡᡝၐᡛஈ ๖ ՄӔҡᚂᕛᇧ ࠌӰ ΡϞ੫ ሯ ݎ ᇄ ᜰМᝦ Ȅငଚॵ ဍஈ Ϡ੫տϞߣనӇȞΰѿȟ೨џȄ౪ ᚂᕛᐠᄺϞಠफᇧര ( ܚ CPU) ࢥਯ ࠌ ᠒ ࡐ ח ȂоΙএάΙএ ޟ ᒲ Ѕਝ ᇯџȂඪҺȶӔҡᚂᏰᒚដ ȷ ݲ ȃ ڼ хȃ Սആ ݲޟݿ ቷដӣཎ Ȃ หਝ ਯ Ȃө ௲ Ȃӻԑ پ ᖝ ח ၐᡛ ࢥڗ ᡛ ӴПፏҡ ϞȄ Ռ ᆓ౩Ȅ ᄇ ޟ ᖝ ח Ռᡝಠफ ݽ ᕛȂΡ ᡝၐᡛ๖ ڏݎ ԊӒ ܒ ጂ и ڎ Ԥߑ ΡȃӕҢᚃᕜᇨ ϛ ಜ ᕛਝ ޱ Ȃፏᆋഋ૩ᔣ ޟ ᆓ౩ ᄺȂғ ᄇ ҡ ސ ᇧ Ꮨ Ϟ Ȃ ـ ത ᔣሠ Ӕҡᚂᕛᇧ ޟ ᖝ ח ၐᡛ ᇄ ಛ ಒȉΙૡ ಛ ࢲȂծ ޱڍ ޟ ᜰ Ȃϫณ३ გ ȂΝ ငҥϽᏰӫԙП ݲ Ȃ ڏ ԙϸ ࢲȄ Ԥጂ ϞϽᏰ๖ᄺȇՄҡ ސ ᇧᏘϞ ܒ Ȃ ڏ ԙϸ Ρᡝಠफಢᙑ ސ ȃ Ԥ 佄Ʊ䦉㮓ⶸ娮㗙 அӰ ݽ ᕛਝ Ϟ ސ ȃ ܖ ᇄᚂᕛᏢ ๖ӫ ޱ Ȃ ڏ ಢԙ ڷ ፒᚕՄϚΙ Κȃ! ፐᆌഌЏ ॶڐ ဎϟ ݳ ᄻХ ஊ੫ ڏ ԙϸȅմи ΰҥ ҡ ސ ᐍᡞ ܓ ᇧᏘᄇዥ ཐȃ ڧ ཌҡ ސ ԯ Ϟ੫ Ս Ӕҡᚂᕛᇧ Ϟᆓ౩ȂҬࠉ ܒ Ȃӵᇧര ߑޟ ᒳԈฒ Ȃ ॵ ဍඪюϞӔҡᚂᕛᇧᏘᆓ౩న ٽ ζᇄ ಛ ԤտȄԪѴȂಠफಢᙑ ૩ਰȂғӵҳ ݲ ፏᕗ ۏ ষ ቷដȂ ޟސ ᇧര ᒳԈᓺ ي ಢᙑҡ ծ ތڏ ដᘈሳӻȂЎ ڏ ᄇ Ӕҡᚂ ጒ (GTP) Ȃᇄ ϚӣȄҡ ސ ᇧᏘ ᕛᇧ Ϟ Ȃ೨ӻ ۏ ষѓ Ӓᖒ ၶ ಛ ڎސ Ԥ ଽ ॳޟ ᓎȂ ٽ ԃȉ ߙ౩ ߝٱ Ȃᄇ ஊ ޢ ᎌҢ ԩ ΣΡᡝ ڏ ҡ ސ ਝᔖ ߝ ޟݲٱ ȂሳԤᅸኌȄ ਖ਼ ڗ Ι ޟ Ս ತҡȃಠफЅஅӰџ ӵ এ ଽ ޟ ቹԩȂ ፏᆋഋᄇ ಠफ ݽ Ρᡝ ፒᇧϷϽ ՍᙽϽԙရ ᕛᇄஅӰ ݽ ᕛϞ ᇄ Ϟᆓ౩Ȃ ዴȃߨՌᡝᇧ ڎ Ԥଽ Еଔջ І ᔖ ᄺΙএ ᐌ ݲޟ ਰ ᄺȂѓ ᔖ ޟ џ ȃሯ ܒ ΣΡᡝ ಛ ȃᚂᕛᏢ ȃֆశᇧᏘȃ Ȅᖝ ח ၐᡛП७Ȃᖝ ח ೩ Ѕ ܚ ሯ ҡ ސ ᇧᏘϞএտ ݲ ਰȄಠफ ݽ ᕛЅஅ ၐᡛၥਟ ޱڍ ζϛ ӣȃ ٽ ԃȉ ސ

5 䏝恩䔀䫟ᶉ 㮓映䕂ⶸ娮 ҳ ݲ แϛȂҏ ݲ ૩ਰϱߣనӇ೨ ޟ ຟեȃ ڋ ᎌᔖ ޟ ຟեแ ו ȃၐ џȟconditional approvalȃ խ छ ᡛಢᇄᄇ ಢ ޟ ೩ ȃ ڧ กတᡝኵȃ RMAT ᇯᜌȟȂᡱ џоϛң ၐᡛ ХనӇȃၐᡛತᘈϚӣ Ȅ າ ၥ ޟ έ ᖝ ח ၐᡛ џо ڏ ԩȂ१ಢஅӰᇧ Ȃछ ᄂ ڗ ΰѿ೨џȄᄇ ᜰϴѧџ Ӱ ᡛࡉ ࢲ ငᐣᐠᄺҡ ސ ԊӒ ۏ Ԫᕕ ޟ ѼσցઉȂ ר ঈ Ԥ ষ ȞIBCȟȃ ـ গ౩ቷࢥ ۏ ষ ޟ ౩ҥᇳ ޥ Ө Ȃ Ϡ ኺցઉ ȞIRBȟȃNIH ၥօ หϞᅿᆓȃFDA ޟ ӫ౩౩ҥȅ ޟ CBER ޟ ᖝ ח ၐᡛቷࢥ IND ҧ छ FDA ᄇ RMAT ᇯ ᜌ ȃࢥᡛ ቷࢥ ᅿᆓȂԃ ݎ லѓ Ȉ(1) ಒӫӔҡᚂᏰ ဎ ਖ਼Ρᡝतप ܖ ଢ଼ ސ ᄂᡛȂ Ԥ ᜰഋ ޟ ౩ҥȂ(2) Л ಒӫ ܖ ߞ ޟ ᅿ౩Ȅ १ ޟ ଆ Ȃ(3) ᖂ๖ӈդ౪Ԥᕛ ॳޟݲ ҥΰџ ޣ Ȃ ᎌӫо ސ ΰѿ ᓎ ڷ ઉ Ȃ(4) ජक़џ ޟ Ґᅖ ޟ แ ו Ȟᖝ ח ၐᡛ I~III ȟ پ ᆓ౩Ȃ ޟ ᚂᕛሯ Ȃ(5) ߑ ᖝ ח ᜌᐃЛ ᚂ ᄇ ҡ ސ ᇧᏘ ޢ ઽᆓ ٱ १ Ґᅖ ᚂᕛሯ ޟ ዖΨȄ ݲ Ȃ ٮ ᄇӴ Ϡ ୦ȃ ৱ੫ छ FDA ٮ ӵԝ ڗ ҧ 60 Јϱ ራ ޟ Ӵ Ȃ о ޟڧ ȂЎ ڏ ७ᖝ ᄇҧ հю Ȅоΰ ר ঈӵҳ Ԫ ऋ ޟ ήȃ೨ӻᚂৱ ۦ иϛ ݲ แ ޟ Ι ՃȄ ҡ ސ ᇧᏘȂդ ݷ Ιૡ ޟ ৱȉԃ ݎ ר ঈӱ ᓞ پ ᔮຜॵ ဍ ޟ ಢԙȂछ ѳȃӕңᚃᕜᇅᇨ ޠ ॴᓏ ܓ ፵ FDA ޟ ೨ӻ१ ഋߞкᆓȂϚм೨ ȶջ ಠफᕛ ݲ ᄇ ᕜґ ޱ ӻᚂৱȃ ݲ Ᏸடড়Ᏸ ޱ ᐊӈȂѮᢊ Մ Ȃ Ыਢ ڗ ግ૩հ ਗ਼ Пॵ ဍᡗณӵ ᔣ оѕρষಢ УȄȷѮѕᄸᖂᚂৱጾ ᇳȂᕜґ ԙΰȃ ё ޟ ኄઽӨ ȂϚ ޱ ΙጣҡᐠȂϧቄᓀ ཎ ৱ ޟ 㛅Ȅ ߆Ȅᖝ ۦח Ґ ᜌᄂ ޟ ջ ಠफᕛ ݲ Ȃ ޱ ϫณࠉϩ Ӵເ ڗ Рҏ ήȃ!ӕңᚃᕜᇨ ૪ ϡϵѩѽτ ݽڧ ᕛȂҬࠉζ ᛰϚ๘Ӵເ ڗ ϛ ւઊ ޠ Ӭ౪ ܓ ݽڧ ᕛȂ Ϟࠉ ൲ ތ ដ ޟܒ Р Ӕҡᚂᕛ ܚ ҡ ޟ ਝઉႱ ԃ ҏጸ ٱ ӇȂоЅϛ ਖ਼Ѕᚂᕛ ԪϞѼσȂծ ڏ բᓍϟॳᓎһณȅӵ ລ Ѕᆩၯཪ ϴѧ ӈ ޟ ᚭࠌՙ ٱ ଢ଼ΨᏰၥਟȂ ΣПԒ ޟ ຟեȃᏘ໔

6 榖斂恩㗁奊 -2851$/ 2).$2+6,81* 0(',&$/ $662&,$7,21 92/ 12 ΡϞ ઉᔖϠ М ራȂѓ ᄇ ӇȄ Ꭺ ҡ ഺᒲΡ ь ρӵ ڧ Ӕҡᚂᕛฒਝ ޟޱ ၄ᓻᐠ ڙ ȃоѕ ўԑ 11 Т 27 РѕᚂᖞᒲϞȶӒ౨ ବᄇ ڧ Ӕҡᚂᕛ Ϛ ي Іᔖ ޱ ೩ ȃջ ᕛ ݲ ᗍ Ѕ ᙽ ညᐿҳ ٱ ၄ᓻஅߜȄᐿҳ၄ᓻஅߜ ଆ ȷ юȃҭࠉΰѿ ޟ ջ ᕛ Ϟ೩ညȂଶΟӰӔҡᚂᕛ ᇄ ݲ Ȃ ڏ ҁ ᕛਝϚ 30%Ȃष ܒ ፴ϚӣѴȂ ڏ ցዜᛁσȃиॳᓎ ܒ ᄂ ӫ ځ ᕛ ݲ ȂԙҏඪЀоѴ Ρ Ѕџ അԙ ཬޟ ߜ ଽ Ιૡ ᐊζቨёȂCAR-T ᕛ ݲ П७ȂଶΟ Ȃԃ ޢ ઽΣ Ԥ ᔼஅߜȂ ଽ ቋϞѴȂ ΡᗙԆӵଽඈ ॳ ܚ Ȅ ᓎȄ Prochymal ᖝ ח έ ၐᡛ ޡ Ѷ Ʊ䳻䰎僅ⶸ娮 ٱ ӇȂCell Communication and Signaling ѐўԑιт ၷᜰ ፴ཆಠफџ Ο ራ Ρ ޟ ઉȂ о Ѕ ᄇ ߴ ᕜᙽಋ ޟ ᖝ ॳח ᓎ ޟ МȂ ސٱ ᆓ౩ ޟ გϷȂӔҡᚂᕛ ޟ ΰএТछ ޱ Ӱ ڧ Ґင FDA ਯট Ȃ আᎬ ড়ӫ౩Ԥਝ ݲޟ ΰѿϞ Genetech ᙝளՖཆಠफ ᒯ ᄺȂӵ ራҕ ஶ ઉ ࠉޟ ඪ ݧ Ӱಠ ཐ Ȃᎏ ڗ FDA ޟ ήȃᡱ ஊ ஶ פ Ȅ ҳ ࢥЅѢӱ ȃឌ խ ᜰ ޱ ݲ แ၇ᓞȂ ר ঈ ౪ ف ಛ ޟ ҏ ᆸȂඪᒺ ר ঈӔҡᚂᕛ ޟ ଽ кဎᐨࠔȃᐗөᖒᛮ Ϸ мȃᄇ ॳᓎ ܒ ȂЧஷညᅸȄ ᑹ ޟސٱ ᆓ౩ζல ᓞฮᚂᓞȃ ယฮᚂယȂ мᐌᡝ ޟ ᄺȄҥωᢎ ϥȃᄈ ઊ ߴޠ ሬᇅ ᔽ௪ σȃѯᢊԃ ݎ оռ ω Ԥ३ ޟ ၥ ζ Ӱ ԪȂ ҥ Ӕ ҡ ᚂ ᕛ Ѕ Ȃᇄж Өএσ ᝯ ތ Ȃࠌ ޟ ॳᓎ ଽȂ Ρ ڧ ӔҡᚂᕛȂ ད ᏲȂ ᏰӒП ޟ ӫհᇄ ߆າᛁσ ޟ າҢȂծ ථႱ Ϸ१ ޟ Ȃ ࠌάԃդᇄ ᕛਝȂ ڎ Ԥଽ Ϛጂ ܒ ȂӰԪ т Ιၶߝ ڹ ȉ

new高市醫誌100_0801.pdf

new高市醫誌100_0801.pdf е ע ᚃ ࢨϧᚃଲ ℋ墾僅䬊ὗ ҥϛ ऋσଉॴᇄϛ σᏰᖒй അȂശߑ೩ Ң پ Ϸ ݙ ߖ ԑ پ Ȃ Ρ ώ ස ኋ $UWL FLDO ᘞၥଉ ޟ AI ᐠᏢΡȶω ȷȂѺߖ,QWHOOLJHQFH $, ӵөএሴ ӴȂ σചᖝ ח ஈ ᚂৱᆣӫ ၐຟ Ρ խн ଝ! Ґ پ ж х กȂӵӫ Ϸኵ 360 Ϸ ήο 456 Ϸ ȶΡȷ ѴᐊЖȂ Ս ܐ ȊϚџᗗ ޟ ଽϷȂ Ι ᜌ AI