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2 SNP A5 Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Loishi K, Nakanishi I, Fujita T, Ymayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H. Polymorphism in annexin A5 gene promoter in Japanese women with recurrent pregnancy loss. Molecular Human Reproduction. in press. Nozaki M, Wakae K, Tamaki N, Sakamoto S, Ohnishi K, Uejima T, Minato N, Yanagihara I*, Agata Y. Regulation of T cell receptor V2 gene rearrangement by the Helix-Loop-Helix protein, E2A. International Immunology, in press Ohnishi K, Nakahira K, Unzai S, Mayanagi K,

3 Hashimoto H, Honda T, Yanagihara I* Relationship between heat-induced fibrillogenicity and hemolytic activity of thermostable direct hemolysin and a related hemolysin of Vibrio parahaemolyticus. FEMS Microbiology letters, in press Yanagihara I*, Nakahira K, Yamane T, Kaieda S, Mayanagi K, Hamada D, Fukui T, Ohnishi K, Kajiyama S, Shimizu T, Sato M, Ikegami T, Ikeguchi M, Honda T, Hashimoto H. Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin. The Journal of Biological Chemistry, 285(21), pp , 2010 Nishihara M, Sonoda M, Matsunami K, Yanagihara K, Yonemoto N, Ida S, Namba F, Shimomura I, Yanagihara I*, Waguri M. Birth length is a predictor of adiponectin levels in Japanese young children. Journal of Pediatric Endocrinology & Metabolism, 23, pp , 2010 Nishihara M, Yamada M, Nozaki M, Nakahira K, Yanagihara I*. Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene. Biochemical and Biophysical Research Communications, 393(1), pp111-7, 2010 Namba F, Hasegawa T, Nakayama M, Hamanaka T, Yamashita T, Nakahira K, Kimoto A, Nozaki M, Nishihara M, Mimura K, Yamada M, Kitajima H, Suehara N, Yanagihara I*. Placental features of chorioamnionitis colonized with Ureaplasma species in preterm delivery. Pediatric Research, 67(2), pp166-72, 2010 Hamada D, Hamaguchi M, Suzuki KN, Sakata I, Yanagihara I. Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagic Escherichia coli: a case for EspB as an intrinsically less-ordered effector. FEBS J, 277(11), pp , Review, 2010 Mimura K, Tomimatsu T, Sharentuya N, Tskitishvili E, Kinugasa-Taniguchi Y, Kanagawa T, Kimura T. Nicotine restores endothelial dysfunction caused by excess sflt1 and seng in an in vitro model of preeclamptic vascular endothelium: a possible therapeutic role of nicotinic acetylcholine receptor (nachr) agonists for preeclampsia. Am J Obstet Gynecol. 202(5), pp464.e Kinugasa-Taniguchi Y, Tomimatsu T, Mimura K, Kanagawa T, Shimoya K, Murata Y, Kimura T. Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage: a preliminary study. Reprod Sci. 17(5), pp Sharentuya N, Tomimatsu T, Mimura K, Tskitishvili E, Kinugasa-Taniguchi Y, Kanagawa T, Kimura T. Nicotine suppresses interleukin-6 production from vascular endothelial cells: a possible therapeutic role of nicotine for preeclampsia. Reprod Sci. 17(6), pp Tskitishvili E, Sharentuya N, Temma-Asano K, Mimura K, Kinugasa-Taniguchi Y, Kanagawa T, Fukuda H, Kimura T, Tomimatsu T, Shimoya K. Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells. Mol Hum Reprod. 16(3), pp TDH. 52, , A TDH & thermostable direct hemolysin 57

4 LPS ATL Allergy TRX Ureaplasma parvum multiple banded antigen (MBA) Ureaplasma parvum & 1st trimester & A D & Lipopolysaccharide(LPS) TRX bhlh E2A V2 20 Kyoto T cell Conference A Hiroshi Hashimoto, Kumiko Nakahira, Tsutomu Yamane, Takashi Fukui, Kiyouhisa Ohnishi, Toshiyuki Shimizu, Takeshi Honda, Mitsunori Ikeguchi, Mamoru Sato, Itaru Yanagihara. Structural study of thermostable direct hemolysin from Vibrio parahaemolyticus Masatoshi Nozaki, Nobuyuki Tamaki, Shuji Sakamoto, Itaru Yanagihara, Yasutoshi Agata. Regulation of V2 gene rearrangement by the helix-loop-helix protein, E2A14 th International Congress of Immunology Itaru Yanagihara, The pathological findings and molecular mechanisms of Ureaplasma spp. infection in preterm delivery 7 th European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG), , Trieste, Italy, Invited Speaker Mitsuhide Hamaguchi, Yoshinori Murao, Masahiro Tanaka, Noriko Tsuda, Toshihumi Uejima, Katsuyuki Maruyama, Itaru Yanagihara, Ikuhiro Sakata. The mrna expression of fatty acid amide hydrolase in human whole blood may correlate with recovery in patients with sepsis

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: MRI Brain Imaging and Psychiatric Research in Major Depressive Disorder and Panic Disorder Important lessons in geriat

: MRI Brain Imaging and Psychiatric Research in Major Depressive Disorder and Panic Disorder Important lessons in geriat 1. 3/19 Monoamine hypothesis in depression:has it finished? 2. 4/9 Pharmacological Strategies in Treating Major Depressive Disorder 3. 4/11 1. 2. 3 11 1. 102 3 5 2012 2. 102 3 12 3. 102 3 25 4. 102 3 26