Microsoft Word 赵婷二校 % 4352

Size: px

Start display at page:

Download "Microsoft Word 赵婷二校 % 4352"

贰晶柴
5 years ago
Views:

1 7 11 Vol. 7 No Journal of Food Safety and Quality Nov., 2016 赵婷 1, 周明强 1,2*, 徐聪 1, 刘伟丽 1,2, 赵新颖 1,2 (1.,, ; 2., ) 摘要 :,,,,,,,, 关键词 : ; ; ; Application of inductively coupled plasma mass spectrometry in drug elemental analysis ZHAO Ting 1, ZHOU Ming-Qiang 1,2*, XU Cong 1, LIU Wei-Li 1,2, ZHAO Xin-Ying 1,2 (1. Beijing Centre for Physical and Chemical Analysis, Beijing Key Laboratory of Organic Materials Testing Technology & Quality Evaluation, Beijing , China; 2. Beijing Academy of Science and Technology Key Laboratory of Analysis and Testing Technology, Beijing , China) ABSTRACT: Heavy metals and harmful metals in drugs and pharmaceutical raw materials such as As, Hg, Pb, Cr, Cd, etc. do harm to human health, while the excessive or insufficient intake of microelements and mineral elements in drugs and pharmaceutical raw materials such as Fe, Cu, Zn, Mn, Se, Si, etc. can cause different levels of human physiological abnormalities. Therefore, it is important to detect elements in drugs for quality control. Atomic absorption spectrometry, inductively coupled plasma spectrometry, atomic fluoresce spectrometry, colorimetry and inductively coupled plasma mass spectrometry (ICP-MS) are common detection methods of elements. The article summarized the applications of ICP-MS in drug testing, such as heavy metals and harmful metals, microelements and mineral elements, conventional elements, isotopic elements, and element speciation test. The results showed that the 基金项目 : Ⅲ-1( ) Fund: Supported by the Innovation Project Ⅲ-1 of Beijing Academy of Science and Technology ( ) * 通讯作者 :,, aaaddd@163.com *Corresponding author: ZHOU Ming-Qiang, Research Assistant, Beijing Centre for Physical and Chemical Analysis, Beijing , China aaaddd@163.com

2 11, : 4353 liner relationships, precisions, detection limits and recoveries could meet the detect requirements completely. Due to low detection limit, wide linear range, multi-element determination and isotope detection at the same time, and accomplishment of element speciation analysis when combined with other separation equipments, ICP-MS has been widely applied in the detection of elements in drugs. KEY WORDS: drug; element; heavy metal; inductively coupled plasma mass spectrometry 1 引言,, (As) (Hg) (Pb) (Cr) (Cd) [1],,, (Fe) (Cu) (Zn) (Mn) (Se) (Si) [2] [3,4] [5] [6,7] [7] (inductively coupled plasma mass spectrometry, ICP-MS) [8-10], ICP-MS,, ICP-MS 2 ICP-MS 概述 (ICP) (MS), ICP, (atomic absorption spectroscopy, AAS) (inductively coupled plasma atomic emission spectrometry, ICP-AES) (atomic fluorescence spectrometry, AFS), ICP-MS, ICP-MS,, ICP-MS, (μg/ml ) (7~9 ),,, ICP-MS [2], 3 ICP-MS 在药品检测中的应用 3.1 重金属及有害元素检测中药及中药制剂,,,,, [11] ICP-MS 5,, 0.8%~1.4%, 88.79%~109.36%, [12] ICP-MS 5,, [13] ICP-MS 14, 14 10%, 96.49%~114.04%, 西药及其原料药,,,, [14] ICP-MS B 2,,, ng/ml,, 92.4%~101.7%, 3.2 微量及矿物质元素检测,, [15] Bi Sc

3 In Y, ICP-MS 12,, 0.999, 2.30 μg/l, 91.1%~107.1%, 7, 3.7%,, 12 [16] ICP-MS 9 [17] ICP-MS Li Mg K Ca V Cr Mn Fe Cu Zn As Rb Sr Cs Pb 15, 0.999, 8%,,, 3.3 常规元素检测 ICP-MS,,, [18] ICP-MS 23 Be Al V Cr Mn Fe Co Ni Cu Zn As Se Mo Ru Pd Ag Cd Sn Sb Te Ba Nd Dy Er Ir Hg Tl Pb U 29,,,,, 3.4 同位素元素检测 ICP-MS,, (B) 10 B 11 B 2, 10 B, 10 B, [19] NIST SRM 951, ICP-MS,,,, [20] ICP-MS, ICP-MS,,, 3.5 元素形态检测, ICP-MS, [21], ICP-MS , 98.3% 98.7%,,, ICP-MS B 2,,, 4 ICP-MS 在本单位的应用 4.1 药品的定性检测, ICP-MS,,, 1, 1 表 1 半定量测试结果 Table 1 Results of semi-quantitative analysis Li <66.3 µg/kg Cd <2.17 µg/kg Be <75.8 µg/kg In 31.6 µg/kg B <121 µg/kg Sn 30.3 mg/kg Na <7.69 µg/kg Sb <0.744 µg/kg Mg <15.3 mg/kg Te <17.0 µg/kg Al <43.7 µg/kg I 41.3 µg/kg Si <191 mg/kg Cs <0.308 µg/kg P 50.6 mg/kg Ba <2.09 µg/kg S <9.14 mg/kg La <0.209 µg/kg K 3.65 mg/kg Ce <0.168 µg/kg Ca <3.48 mg/kg Pr <0.123 µg/kg Sc <3.52 µg/kg Nd <0.608 µg/kg Ti <60.7 µg/kg Sm <0.675 µg/kg V 203 µg/kg Eu <0.176 µg/kg

4 11, : 4355 续表 1 Cr <0.890 µg/kg Gd 4.24 µg/kg Mn <1.74 µg/kg Tb < µg/kg Fe <1.16 µg/kg Dy <0.328 µg/kg Co <0.521 µg/kg Ho < µg/kg Ni 100 µg/kg Er <0.236 µg/kg Cu <0.689 µg/kg Tm < µg/kg Zn <3.82 µg/kg Yb 11.6 µg/kg Ga <1.19 µg/kg Lu <0.118 µg/kg Ge <5.48 µg/kg Hf <0.460 µg/kg As <5.85 µg/kg Ta < µg/kg Se <64.5 µg/kg W <0.354 µg/kg 续表 1 Br 410 µg/kg Re <0.286 µg/kg Rb 12.2 µg/kg Os <0.784 µg/kg Sr <1.24 µg/kg Ir <0.160 µg/kg Y <0.481 µg/kg Pt <0.491 µg/kg Zr 78.7 µg/kg Au <0.416 µg/kg Nb <0.349 µg/kg Hg <1.24 µg/kg Mo <1.32 µg/kg Tl <0.150 µg/kg Ru <0.786 µg/kg Pb <0.216 µg/kg Rh <0.144 µg/kg Bi <0.148 µg/kg Pd <0.814 µg/kg Th <0.197 µg/kg Ag <0.325 µg/kg U <0.127 µg/kg 1 Fig.1 Results of semi-quantitative fitting 4.2 药品的方法学研究 ICP-MS, [22],,, 5 结论 ICP-MS,, ICP-MS,,, ICP-MS,, ICP-MS 参考文献 [1],,.

5 [J]., 2016, 25(5): Zhang J, Wang ZX, Li XM. Content determination of 5 detrimental elements in propolis by inductively coupled plasma mass spectrometry with microwave digestion [J]. China Pharm, 2016, 25(5): [2],,,. [J]., 2013, 20(1): Dai XD, Xu YB, Liu ZW, et al. Application of inductively coupled plasma mass spectrometer in elemental analysis of traditional Chinese medicine and its preparation [J]. Chin J Inf Tradit Chin Med, 2013, 20(1): [3],,,. [J]., 2014, 21(3): Jiang Y, Su LL, Zhu MY, et al. Determination of elements content in the original drug and its decoction of three processed Chinese medicinal herb [J]. Guangdong Trace Elements Sci, 2014, 21(3): [4],,,. 3 [J]., 2010, 11(2): Xu JB, Liu F, Wang P, et al. Determination of calcium, magnesium, sodium in glucose electrolyte injection by flame atomic absorption spectrometry [J]. Drug Stand China, 2010, 11(2): [5],,,. -ICP-AES [J]., 2013, 33(2): He JW, Chang JM, Yao J, et al. Determination of elements in branches and leaves and the fruits of Sorbus tianschanica Ruper. from different habitats in Xinjiang by microwave digestion-icp-aes [J]. Spectrosc Spect Anal, 2013, 33(2): [6],,,. 6 [J]., 2016, 38(7): Huang SQ, Zhang W, Peng Y, et al. Determination of six elements in the skins of Equus asinus from different areas [J]. Chin Tradit Pat Med, 2016, 38(7): [7],,. [J]., 2015, 43(36): Zan YL, Teng HM, Wang L. Research on differences of mineral elements content in Astragalus membranaceus tablets from different places [J]. Anhui Agric Sci, 2015, 43(36): [8]. [J]., 2014, 10(17): Yue YH. Research on quality detection of realgar herbs [J]. Asis-Pacific Tradit Med, 2014, 10(17): [9],,,. 15 [J]., 2016, 19(5): Yao CY, Li B, Jia HT, et al. Rapid determination of fifteen elements in ibuprofen injection by ICP-MS [J]. China Pharm, 2016, 19(5): [10],,. [J]., 2015, 24(3): Luo XQ, Yang J, Qin XR. Simultaneous determination of multiple trace elements in ligusticum Chuanxiong by ICP-MS [J]. China Pharm, 2015, 24(3): [11],. [J]., 2014, 26(4): Shang S, Yu Q. Determination of heavy metals in Biyankang pills by ICP-MS [J]. Strait Pharm J, 2014, 26(4): [12],,. (ICP-MS) [J]., 2012, 31(3): Wang Y, Chen MH, Cao L. Determination of harmful elements Pb, As, Cd, Hg, Cu in Yinzhihuang injection by inductively coupled plasma-ms spectrometry [J]. China's Wild Plant Resour, 2012, 31(3): [13],,. 14 [J]., 2010, 19(22): Liu HJ, Zhang J, Luo S. Determination of fourteen elements in shenshuaining capsules by ICP-MS [J]. J China Pharm, 2010, 19(22): [14],,,. B 2 [J]., 2012, 43(4): Gan S, Shi XG, Han T, et al. Determination of cadmium, arsenic and lead in vitamin B 2 injection by inductively coupled plasma-mass spectrometry [J]. Chin J Pharm, 2012, 43(4): [15],,,. 12 ICP-MS [J]., 2007, 23(7): Liang W, Dai JJ, Lin YZ, et al. ICP-MS Rapid determination of 12 trace elements in mineralized traditional Chinese medicine [J]. Occup Health, 2007, 23(7): [16],,,. 9 [J]., 2015, 33(4): Sun J, Chen ZH, Nie JH, et al. Determination of 9 trace elements in Syngnathus acus Linnaeus by inductively coupled plasma mass spectrometry [J]. J Sichuan Agric Univ, 2015, 33(4): [17],,,. ICP-MS [J]., 2016, 37(14): Sun J, Zhang J, Zhao YL, et al. Determination of mineral elements of wild Wolfiporia extensa collected from Yunnan by ICP-MS [J]. Food Sci, 2016, 37(14): [18],, 甦,. 29 [J]., 2015, 46(9): Li LM, Xia J, Zhang S, et al. Simultaneous determination of 29 elements in traditional Chinese medicines by inductively coupled plasma mass spectrometer(icp-ms) [J]. Chin J Pharm, 2015, 46(9): [19],,,. [J]., 2006, 34(9): Bai P, Li XF, Wu J, et al. Determination of boron isotope abundance by inductively coupled plasma mass spectrometry [J]. Chin J Anal Chem, 2006, 34(9): [20],,,. [J]., 2003, 24(3): Huang ZY, Shen JC, Yang CY, et al. Study on accuracy and precision of isotope ratios measured by inductively coupled plasma mass spectrometry

11, : 4357 [J]. J Chin Mass Spectrom Soc, 2003, 24(3): 441 445. [21]. HPLC [J]., 2014, 45(5): 567 570. Sun T.

Chinese Pharmacopoeia Commission. Chinese pharmacopoeia [M]. Beijing: Chinese Medical Science and Technology Press, 2015.

6 11, : 4357 [J]. J Chin Mass Spectrom Soc, 2003, 24(3): [21]. HPLC [J]., 2014, 45(5): Sun T. Determination of different valence chromium in carrageenan vacant capsules by HPLC [J]. J China Pharm Univ, 2014, 45(5): [22] 22. [M]. :, Chinese Pharmacopoeia Commission. Chinese pharmacopoeia [M]. Beijing: Chinese Medical Science and Technology Press, ( 责任编辑 : 姚菲 ) 作者简介赵婷, 助理研究员, 主要研究方向为光谱质谱分析 zhaoting2018@sina.com 周明强, 助理研究员, 主要研究方向为药物材料分析 aaaddd@163.com 益生菌在食品加工中的应用专题征稿函,,,,,,, ,,, , 投稿方式 : : jfoodsq@126.com 食品安全质量检测学报编辑部

五花八门宝典（一）.doc

五花八门宝典（一）.doc BBS...5... 11...23...26...31...46...49...54...55...57...59...62... 110... 114... 126... 132... 149 I "108" 1 2 3 4 BBS 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 M ( ) Kg S ( ) A ( ) K (

Microsoft Word 赵 婷 二校 % 4352

Microsoft Word 赵婷二校 % 4352